Structural model for the β-amyloid fibril based on interstrand alignment of an antiparallel-sheet comprising a C-terminal peptide

<scp>CHARMM</scp>: A program for macromolecular energy, minimization, and dynamics calculations

1983 • 14,615 citations

Dominant forces in protein folding

1990 • 3,682 citations

The molecular pathology of Alzheimer's disease

1991 • 2,603 citations

Seeding “one-dimensional crystallization” of amyloid: A pathogenic mechanism in Alzheimer's disease and scrapie?

1993 • 2,146 citations

The carboxy terminus of the .beta. amyloid protein is critical for the seeding of amyloid formation: Implications for the pathogenesis of Alzheimer's disease

1993 • 1,951 citations

Amyloid β-peptide is produced by cultured cells during normal metabolism

1992 • 1,888 citations

Amyloid Deposits and Amyloidosis

1980 • 1,787 citations

Isolation and quantification of soluble Alzheimer's β-peptide from biological fluids

1992 • 1,701 citations

Visualization of Aβ42(43) and Aβ40 in senile plaques with end-specific Aβ monoclonals: Evidence that an initially deposited species is Aβ42(43)

1994 • 1,700 citations

An Increased Percentage of Long Amyloid β Protein Secreted by Familial Amyloid β Protein Precursor (βApp ₇₁₇ ) Mutants

1994 • 1,463 citations

Production of the Alzheimer Amyloid β Protein by Normal Proteolytic Processing

1992 • 1,438 citations

Empirical correlation between protein backbone conformation and C.alpha. and C.beta. 13C nuclear magnetic resonance chemical shifts

1991 • 1,072 citations

Release of Excess Amyloid β Protein from a Mutant Amyloid β Protein Precursor

1993 • 909 citations

Prediction of Protein Structure and the Principles of Protein Conformation

1989 • 814 citations

An investigation of the structure of silk fibroin

1955 • 698 citations

Occurrence and role ofcis peptide bonds in protein structures

1990 • 516 citations

Amyloid Deposits and Amyloidosis

1980 • 506 citations

Conformation of twisted β-pleated sheets in proteins

1973 • 487 citations

Three-dimensional structure of the alkaline protease of Pseudomonas aeruginosa: a two-domain protein with a calcium binding parallel beta roll motif.

1993 • 468 citations

New Domain Motif: the Structure of Pectate Lyase C, a Secreted Plant Virulence Factor

1993 • 450 citations

Secondary and Tertiary Structural Effects on Protein NMR Chemical Shifts: an ab Initio Approach

1993 • 448 citations

Resolution in 13C NMR of organic solids using high-power proton decoupling and magic-angle sample spinning

1981 • 420 citations

Theory and simulations of homonuclear spin pair systems in rotating solids

1990 • 407 citations

Conformation‐dependent ¹³C chemical shifts: A new means of conformational characterization as obtained by high‐resolution solid‐state ¹³C NMR

1986 • 384 citations

AMYLOIDOSIS

1992 • 348 citations

The Protein Folding Problem

1993 • 309 citations

Crystal Structure of P22 Tailspike Protein: Interdigitated Subunits in a Thermostable Trimer

1994 • 309 citations

Molecular determinants of amyloid deposition in Alzheimer's disease: conformational studies of synthetic .beta.-protein fragments

1990 • 288 citations

Alzheimer's disease: a cell biological perspective

1992 • 274 citations

Determination of Membrane Protein Structure by Rotational Resonance NMR: Bacteriorhodopsin

1991 • 244 citations

β-Amyloid and the Pathogenesis of Alzheimer's Disease

1991 • 201 citations

Structural properties of protein β-sheets

1983 • 193 citations

Carbon-13-NMR of peptides and proteins

1978 • 189 citations

Solvent- and mechanical-treatment-induced conformational transition of silk fibroins studies by high-resolution solid-state carbon-13 NMR spectroscopy

1990 • 189 citations

Influence of molecular packing on solid-state 13C chemical shifts: The n-alkanes

1981 • 177 citations

APP717 missense mutation affects the ratio of amyloid beta protein species (A beta 1-42/43 and a beta 1-40) in familial Alzheimer's disease brain

1994 • 166 citations

Structure of β-sheets

1982 • 155 citations

In pursuit of the molecular structure of amyloid plaque: new technology provides unexpected and critical information

1992 • 146 citations

Side‐chain entropy and packing in proteins

1994 • 142 citations

Location of .beta.-sheet-forming sequences in amyloid proteins by FTIR

1991 • 140 citations

Rotational Resonance Solid-State NMR Elucidates a Structural Model of Pancreatic Amyloid

1995 • 137 citations

Solid-State Nitrogen- 15 Nuclear Magnetic Resonance Study of the Schiff Base in Bacteriorhodopsin

1983 • 133 citations

Specific recognition in the tertiary structure of β-sheets of proteins

1980 • 115 citations

Nuclear magnetic resonance methods for measuring dipolar couplings in rotating solids

1993 • 114 citations

Measurement of internuclear distances in polycrystalline solids. Rotationally enhanced transfer of nuclear spin magnetization

1989 • 102 citations

An unusual peptide conformation may precipitate amyloid formation in Alzheimer's disease: application of solid-state NMR to the determination of protein secondary structure

1991 • 95 citations

Origin of the right-handed twist of beta-sheets of poly(LVal) chains.

1982 • 92 citations

Chemical shielding anisotropy of protonated and deprotonated carboxylates in amino acids

1993 • 91 citations

Twisted single crystals of Bombyx mori silk fibroin and related model polypeptides with β structure

1982 • 88 citations

The structural basis of pancreatic amyloid formation: isotope-edited spectroscopy in the solid state

1992 • 73 citations

Structural effects of hydration: Studies of lysozyme by ¹³C solids nmr

1990 • 58 citations

Tertiary Structure Prediction

1989 • 54 citations

The influence of hydration on the conformation of lysozyme studied by solid‐state ¹³C‐nmr spectroscopy

1993 • 51 citations

The Alzheimer's disease sphinx: a riddle with plaques and tangles.

1994 • 34 citations

The β structure: Inter-strand correlations

1977 • 30 citations

Parallel β-domains: a new fold in protein structures

1994 • 30 citations

Models of the .beta. Protein C-Terminus: Differences in Amyloid Structure May Lead to Segregation of "Long" and "Short" Fibrils

1994 • 28 citations

On a (β-) roll

1993 • 15 citations