Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease

Basic local alignment search tool

1990 • 87,358 citations

A simple method for displaying the hydropathic character of a protein

1982 • 22,471 citations

A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes

1993 • 7,941 citations

Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease

1991 • 4,533 citations

Apolipoprotein E: high-avidity binding to beta-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer disease.

1993 • 4,145 citations

Identification of the Cystic Fibrosis Gene: Genetic Analysis

1989 • 4,105 citations

Association of apolipoprotein E allele ϵ4 with late‐onset familial and sporadic Alzheimer's disease

1993 • 3,693 citations

The 1993–94 Généthon human genetic linkage map

1994 • 1,870 citations

Structural features in eukaryotic mRNAs that modulate the initiation of translation.

1991 • 1,849 citations

A second-generation linkage map of the human genome

1992 • 1,721 citations

Combining evolutionary information and neural networks to predict protein secondary structure

1994 • 1,471 citations

Early-onset Alzheimer's disease caused by mutations at codon 717 of the β-amyloid precursor protein gene

1991 • 1,191 citations

A mutation in the Amyloid Precursor Protein Associated with Hereditary Alzheimer's Disease

1991 • 1,121 citations

Genetic Linkage Evidence for a Familial Alzheimer's Disease Locus on Chromosome 14

1992 • 941 citations

A new bacteriophage P1–derived vector for the propagation of large human DNA fragments

1994 • 857 citations

Normal and Abnormal Biology of the beta-Amyloid Precursor Protein

1994 • 813 citations

Alzheimer's Disease

1986 • 772 citations

A novel, rapid method for the isolation of terminal sequences from yeast artificial chromosome (YAC) clones

1990 • 650 citations

The mec-4 gene is a member of a family of Caenorhabditis elegans genes that can mutate to induce neuronal degeneration

1991 • 548 citations

β-Amyloid precursor protein metabolites and loss of neuronal Ca2+ homeostasis in Alzheimer's disease

1993 • 520 citations

Ryanodine receptor gene is a candidate for predisposition to malignant hyperthermia

1990 • 508 citations

Genetic evidence for a novel familial Alzheimer's disease locus on chromosome 14

1992 • 458 citations

Construction and characterization of a yeast artificial chromosome library containing seven haploid human genome equivalents.

1990 • 408 citations

Genetic linkage studies suggest that Alzheimer's disease is not a single homogeneous disorder

1990 • 396 citations

Continuum of overlapping clones spanning the entire human chromosome 21q

1992 • 393 citations

Identification of a mutation in the gene causing hyperkalemic periodic paralysis

1991 • 382 citations

A Comprehensive Genetic Linkage Map of the Human Genome

1992 • 355 citations

Mapping of a gene predisposing to early–onset Alzheimer's disease to chromosome 14q24.3

1992 • 332 citations

The identification and suppression of inherited neurodegeneration in Caenorhabditis elegans

1990 • 304 citations

Calcium Ionophore Increases Amyloid .beta. Peptide Production by Cultured Cells

1994 • 237 citations

A Family With Histologically Confirmed Alzheimer's Disease

1983 • 176 citations

Genetic linkage studies in Alzheimer's disease families

1988 • 163 citations

Mutation of a putative sperm membrane protein in Caenorhabditis elegans prevents sperm differentiation but not its associated meiotic divisions.

1992 • 159 citations

Potassium channel dysfunction in fibroblasts identifies patients with Alzheimer disease.

1993 • 124 citations

Molecular and prospective phenotypic characterization of a pedigree with familial Alzheimer's disease and a missense mutation in codon 717 of the β‐amyloid precursor protein gene

1992 • 123 citations

Restriction endonuclease fingerprinting (REF): a sensitive method for screening mutations in long, contiguous segments of DNA.

1995 • 122 citations

Familial Alzheimer's disease in two kindreds of the same geographic and ethnic origin

1981 • 103 citations

Isolation of chromosome 21–specific yeast artificial chromosomes from a total human genome library

1992 • 88 citations

[Alzheimer's presenile dementia transmitted in an extended kindred].

1985 • 63 citations

Chromosome 14 and late-onset familial Alzheimer disease (FAD).

1993 • 59 citations

A transcription map of the region containing the Huntington disease gene

1993 • 40 citations

Familial Alzheimer Disease: A Large, Multigeneration German Kindred

1991 • 29 citations

Analysis of the c‐FOS gene on chromosome 14 and the promoter of the amyloid precursor protein gene in familial Alzheimer's disease

1993 • 22 citations

Hannah's heirs: the quest for the genetic origins of Alzheimer's disease

1993 • 12 citations

Mutation of the gene for the human lysosomal serine protease cathepsin G is not the cause of aberrant APP processing in familial Alzheimer disease

1993 • 7 citations

Hannah's Heirs: The Quest for the Genetic Origins of Alzheimer's Disease

1994 • 4 citations