The prolyl isomerase Pin1 restores the function of Alzheimer-associated phosphorylated tau protein

Association of missense and 5′-splice-site mutations in tau with the inherited dementia FTDP-17

1998 • 3,377 citations

Mutation in the tau gene in familial multiple system tauopathy with presenile dementia

1998 • 1,440 citations

A68: a Major Subunit of Paired Helical Filaments and Derivatized Forms of Normal Tau

1991 • 1,397 citations

Tau proteins of alzheimer paired helical filaments: Abnormal phosphorylation of all six brain isoforms

1992 • 1,058 citations

Mutation-Specific Functional Impairments in Distinct Tau Isoforms of Hereditary FTDP-17

1998 • 954 citations

A human peptidyl–prolyl isomerase essential for regulation of mitosis

1996 • 891 citations

Abnormal tau phosphorylation at Ser396 in alzheimer's disease recapitulates development and contributes to reduced microtubule binding

1993 • 856 citations

Sequence-Specific and Phosphorylation-Dependent Proline Isomerization: A Potential Mitotic Regulatory Mechanism

1997 • 762 citations

Role of abnormally phosphorylated tau in the breakdown of microtubules in Alzheimer disease.

1994 • 704 citations

Structural and Functional Analysis of the Mitotic Rotamase Pin1 Suggests Substrate Recognition Is Phosphorylation Dependent

1997 • 681 citations

Tau protein pathology in neurodegenerative diseases

1998 • 674 citations

Function of WW Domains as Phosphoserine- or Phosphothreonine-Binding Modules

1999 • 663 citations

Hydrofluoric acid-treated tau PHF proteins display the same biochemical properties as normal tau.

1992 • 509 citations

Pathogenic implications of mutations in the tau gene in pallido-ponto-nigral degeneration and related neurodegenerative disorders linked to chromosome 17

1998 • 464 citations

Frontotemporal Dementia and Parkinsonism Linked to Chromosome 17: A New Group of Tauopathies

1998 • 459 citations

Aberrant Expression of Mitotic Cdc2/Cyclin B1 Kinase in Degenerating Neurons of Alzheimer’s Disease Brain

1997 • 444 citations

Mitotic mechanisms in Alzheimer's disease?

1996 • 384 citations

The essential mitotic peptidyl-prolyl isomerase Pin1 binds and regulates mitosis-specific phosphoproteins

1998 • 340 citations

The Endogenous and Cell Cycle-dependent Phosphorylation of tau Protein in Living Cells: Implications for Alzheimer’s Disease

1998 • 296 citations

A Conformation‐ and Phosphorylation‐Dependent Antibody Recognizing the Paired Helical Filaments of Alzheimer's Disease

1997 • 247 citations

τ in Paired Helical Filaments Is Functionally Distinct from Fetal τ: Assembly Incompetence of Paired Helical Filament‐τ

1993 • 228 citations

Expression of cell division markers in the hippocampus in Alzheimer's disease and other neurodegenerative conditions

1997 • 227 citations

The mitotic peptidyl-prolyl isomerase, Pin1, interacts with Cdc25 and Plx1

1998 • 188 citations

Role of Phosphorylation in Determining the Backbone Dynamics of the Serine/Threonine-Proline Motif and Pin1 Substrate Recognition

1998 • 162 citations

Alzheimer paired helical filaments Restoration of the biological activity by dephosphorylation

1994 • 151 citations

Phosphorylation-dependent prolyl isomerization: a novel cell cycle regulatory mechanism

2000 • 83 citations

Mitotic phosphorylation of tau protein in neuronal cell lines resembles phosphorylation in Alzheimer's disease

1998 • 65 citations

A protein kinase associated with paired helical filaments in Alzheimer disease.

1992 • 65 citations

Alzheimer's Disease Neurofibrillary Tangles Contain Mitosis‐Specific Phosphoepitopes

1996 • 63 citations

Cellular Signaling Pathways and Cytoskeletal Organization

1996 • 10 citations