Tau protein pathology in neurodegenerative diseases

Neuropathological stageing of Alzheimer-related changes

1991 • 14,533 citations

Alzheimer's disease: Initial report of the purification and characterization of a novel cerebrovascular amyloid protein

1984 • 5,166 citations

Amyloid plaque core protein in Alzheimer disease and Down syndrome.

1985 • 4,276 citations

Association of missense and 5′-splice-site mutations in tau with the inherited dementia FTDP-17

1998 • 3,377 citations

Neurofibrillary tangles but not senile plaques parallel duration and severity of Alzheimer's disease

1992 • 2,520 citations

Multiple isoforms of human microtubule-associated protein tau: sequences and localization in neurofibrillary tangles of Alzheimer's disease

1989 • 2,308 citations

Frequency of Stages of Alzheimer-Related Lesions in Different Age Categories

1997 • 1,599 citations

Mutation in the tau gene in familial multiple system tauopathy with presenile dementia

1998 • 1,440 citations

A68: a Major Subunit of Paired Helical Filaments and Derivatized Forms of Normal Tau

1991 • 1,397 citations

Tau is a candidate gene for chromosome 17 frontotemporal dementia

1998 • 1,344 citations

Tau proteins of alzheimer paired helical filaments: Abnormal phosphorylation of all six brain isoforms

1992 • 1,058 citations

Assembly of microtubule-associated protein tau into Alzheimer-like filaments induced by sulphated glycosaminoglycans

1996 • 974 citations

Abnormal tau phosphorylation at Ser396 in alzheimer's disease recapitulates development and contributes to reduced microtubule binding

1993 • 856 citations

Altered microtubule organization in small-calibre axons of mice lacking tau protein

1994 • 742 citations

A sequence of cytoskeleton changes related to the formation of neurofibrillary tangles and neuropil threads

1994 • 726 citations

A preparation of Alzheimer paired helical filaments that displays distinct tau proteins by polyacrylamide gel electrophoresis.

1990 • 715 citations

Tau protein and the neurofibrillary pathology of Alzheimer's disease

1993 • 710 citations

Frontotemporal dementia and parkinsonism linked to chromosome 17: A consensus conference

1997 • 626 citations

Proline-directed and Non-proline-directed Phosphorylation of PHF-tau

1995 • 549 citations

RNA stimulates aggregation of microtubule‐associated protein tau into Alzheimer‐like paired helical filaments

1996 • 502 citations

Genetics of Aging

1997 • 493 citations

Lithium Reduces Tau Phosphorylation by Inhibition of Glycogen Synthase Kinase-3

1997 • 459 citations

Somatodendritic localization and hyperphosphorylation of tau protein in transgenic mice expressing the longest human brain tau isoform.

1995 • 427 citations

Polymerization of τ into Filaments in the Presence of Heparin: The Minimal Sequence Required for τ ‐ τ Interaction

1996 • 387 citations

Functional implications for the microtubule-associated protein tau: localization in oligodendrocytes.

1995 • 366 citations

Detection of Phosphorylated Ser262 in Fetal Tau, Adult Tau, and Paired Helical Filament Tau

1995 • 345 citations

Localization of disinhibition-dementia-parkinsonism-amyotrophy complex to 17q21-22.

1994 • 342 citations

Familial multiple system tauopathy with presenile dementia: A disease with abundant neuronal and glial tau filaments

1997 • 334 citations

Lithium inhibits Alzheimer's disease‐like tau protein phosphorylation in neurons

1997 • 315 citations

Phosphorylation of microtubule‐associated protein tau by stress‐activated protein kinases

1997 • 294 citations

Neurodegenerative disorders with extensive tau pathology: A comparative study and review

1996 • 280 citations

Functional interactions between the proline-rich and repeat regions of tau enhance microtubule binding and assembly.

1997 • 270 citations

Alzheimer's disease: a re-examination of the amyloid hypothesis

1998 • 256 citations

Cloning of a big tau microtubule-associated protein characteristic of the peripheral nervous system.

1992 • 249 citations

Abnormal Tau proteins in progressive supranuclear palsy

1991 • 235 citations

Vulnerable neuronal subsets in Alzheimer's and Pick's disease are distinguished by their τ isoform distribution and phosphorylation

1998 • 231 citations

τ in Paired Helical Filaments Is Functionally Distinct from Fetal τ: Assembly Incompetence of Paired Helical Filament‐τ

1993 • 228 citations

Specific Pathological Tau Protein Variants Characterize Pickʼs Disease

1996 • 218 citations

Glial Inclusions in CNS Degenerative Diseases

1996 • 209 citations

Neurofibrillary tangles in Niemann—Pick disease type C

1995 • 202 citations

Alzheimer-like Changes in Microtubule-associated Protein Tau Induced by Sulfated Glycosaminoglycans

1997 • 199 citations

Paired helical filament tau (PHFtau) in Niemann-Pick type C disease is similar to PHFtau in Alzheimer's disease

1995 • 190 citations

Ultrastructure and biochemical composition of paired helical filaments in corticobasal degeneration.

1994 • 183 citations

Neurofibrillary tangles in Niemann-Pick disease type C

1995 • 179 citations

Pick's disease: hyperphosphorylated tau protein segregates to the somatoaxonal compartment

1996 • 176 citations

Sequestration of RNA in Alzheimer's disease neurofibrillary tangles and senile plaques

1997 • 165 citations

Comparison of the neurofibrillary pathology in Alzheimer's disease and familial presenile dementia with tangles

1996 • 157 citations

Specific tau variants in the brains of patients with myotonic dystrophy

1996 • 144 citations

Identification of 3- and 4-repeat tau isoforms within the PHF in Alzheimer's disease.

1991 • 143 citations

The Neuropathology of a Chromosome 17-Linked Autosomal Dominant Parkinsonism and Dementia (“Pallido-Ponto-Nigral Degeneration”)

1998 • 142 citations

Neurofibrillary degeneration in amyotrophic lateral sclerosis/parkinsonism-dementia complex of Guam. Immunochemical characterization of tau proteins.

1995 • 124 citations

Chromosome 17 and hereditary dementia

1997 • 114 citations

Different distribution of phosphorylated tau protein isoforms in Alzheimer's and Pick's diseases

1997 • 114 citations

Localization of the Gene for Rapidly Progressive Autosomal Dominant Parkinsonism and Dementia with Pallido-Ponto-Nigral Degeneration to Chromosome 17q21

1996 • 111 citations

Argyrophilic grain disease: widespread hyperphosphorylation of tau protein in limbic neurons

1997 • 107 citations

Somatodendritic localization of phosphorylated tau in neonatal and adult rat cerebral cortex

1997 • 95 citations

PHF‐tau from Alzheimer's brain comprises four species on SDS‐PAGE which can be mimicked by in vitro phosphorylation of human brain tau by glycogen synthase kinase‐3β

1994 • 92 citations

The neuropathology of chromosome 17‐linked dementia

1996 • 88 citations

Neurofibrillary Tangles in Progressive Supranuclear Palsy Contain the Same Tau Epitopes Identified in Alzheimerʼs Disease PHFtau

1996 • 76 citations

Familial Multiple-System Tauopathy with Presenile Dementia Is Localized to Chromosome 17

1997 • 76 citations

Two‐Dimensional Characterization of Paired Helical Filament‐Tau from Alzheimer's Disease: Demonstration of an Additional 74‐kDa Component and Age‐Related Biochemical Modifications

1997 • 72 citations

Pathological τ proteins in postencephalitic parkinsonism: Comparison with Alzheimer's disease and other neurodegenerative disorders

1997 • 68 citations

Cationic dyes reveal proteoglycans structurally integrated within the characteristic lesions of Alzheimer's disease

1989 • 67 citations

A68 is a component of paired helical filaments of Gerstmann-Sträussler-Scheinker disease, Indiana kindred

1993 • 53 citations

Histological and biochemical pathology in a family with autosomal dominant Parkinsonism and dementia

1993 • 42 citations