Activation of microglial cells by β-amyloid protein and interferon-γ

Oxidative Stress, Glutamate, and Neurodegenerative Disorders

1993 • 3,746 citations

Release of reactive nitrogen intermediates and reactive oxygen intermediates from mouse peritoneal macrophages. Comparison of activating cytokines and evidence for independent production.

1988 • 2,865 citations

Hydrogen peroxide mediates amyloid β protein toxicity

1994 • 2,065 citations

Neurotrophic and Neurotoxic Effects of Amyloid β Protein: Reversal by Tachykinin Neuropeptides

1990 • 1,975 citations

Neurodegeneration induced by beta-amyloid peptides in vitro: the role of peptide assembly state

1993 • 1,422 citations

Activated microglia mediate neuronal cell injury via a nitric oxide mechanism.

1992 • 1,121 citations

A model for beta-amyloid aggregation and neurotoxicity based on free radical generation by the peptide: relevance to Alzheimer disease.

1994 • 1,085 citations

Microglial-produced nitric oxide and reactive nitrogen oxides mediate neuronal cell death

1992 • 939 citations

A radical hypothesis for neurodegeneration

1993 • 727 citations

Tumor necrosis factors protect neurons against metabolic-excitotoxic insults and promote maintenance of calcium homeostasis

1994 • 672 citations

An in vivo model for the neurodegenerative effects of beta amyloid and protection by substance P.

1991 • 516 citations

Interleukin 10 (IL-10) inhibits the release of proinflammatory cytokines from human polymorphonuclear leukocytes. Evidence for an autocrine role of tumor necrosis factor and IL-1 beta in mediating the production of IL-8 triggered by lipopolysaccharide.

1993 • 504 citations

Conservation of Brain Amyloid Proteins in Aged Mammals and Humans with Alzheimer's Disease

1987 • 472 citations

Macrophages and inflammation in the central nervous system

1993 • 390 citations

Interleukin 10 inhibits macrophage microbicidal activity by blocking the endogenous production of tumor necrosis factor alpha required as a costimulatory factor for interferon gamma-induced activation.

1992 • 352 citations

β-Amyloid stimulates glial cells in vitro to produce growth factors that accumulate in senile plaques in Alzheimer's disease

1992 • 291 citations

Inducible nitric oxide synthase activity of cloned murine microglial cells

1993 • 218 citations

Neuroprotective role of IL-4 against activated microglia.

1993 • 214 citations

β-Amyloid and the Pathogenesis of Alzheimer's Disease

1991 • 201 citations

Genetics and molecular advances in Alzheimer's disease

1993 • 183 citations

Human and rodent Alzheimer beta-amyloid peptides acquire distinct conformations in membrane-mimicking solvents

1993 • 118 citations

Immune functions of tumor necrosis factor. I. Tumor necrosis factor induces apoptosis of mouse thymocytes and can also stimulate or inhibit IL-6-induced proliferation depending on the concentration of mitogenic costimulation.

1993 • 113 citations

Heterotypic and homotypic cellular interactions influencing the growth and differentiation of bipotential oligodendrocyte-type-2 astrocyte progenitors in culture

1991 • 45 citations

The role of pyruvate in neuronal calcium homeostasis. Effects on intracellular calcium pools.

1994 • 34 citations

GABA accumulating neurons are relatively resistant to chronic hypoxia in vitro: An autoradiographic study

1990 • 7 citations