Regulation of Amyloid Precursor Protein Secretion by Glutamate Receptors in Human Ntera 2 Neurons (NT2N)

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

1987 • 64,270 citations

Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction

1987 • 45,673 citations

Alzheimer-type neuropathology in transgenic mice overexpressing V717F β-amyloid precursor protein

1995 • 2,456 citations

Amyloid deposition as the central event in the aetiology of Alzheimer's disease

1991 • 2,375 citations

Familial Alzheimer's Disease–Linked Presenilin 1 Variants Elevate Aβ1–42/1–40 Ratio In Vitro and In Vivo

1996 • 1,467 citations

Cleavage of Amyloid β Peptide During Constitutive Processing of Its Precursor

1990 • 1,388 citations

Amyloid, the presenilins and Alzheimer's disease

1997 • 1,370 citations

Mutant presenilins of Alzheimer's disease increase production of 42-residue amyloid β-protein in both transfected cells and transgenic mice

1997 • 1,259 citations

Release of Excess Amyloid β Protein from a Mutant Amyloid β Protein Precursor

1993 • 909 citations

Release of Alzheimer Amyloid Precursor Derivatives Stimulated by Activation of Muscarinic Acetylcholine Receptors

1992 • 899 citations

Evidence that β-Amyloid Protein in Alzheimer's Disease Is Not Derived by Normal Processing

1990 • 895 citations

Normal and Abnormal Biology of the beta-Amyloid Precursor Protein

1994 • 813 citations

Processing of the Amyloid Protein Precursor to Potentially Amyloidogenic Derivatives

1992 • 737 citations

Amyloid precursor protein processing and Aβ ₄₂ deposition in a transgenic mouse model of Alzheimer disease

1997 • 624 citations

Pure, postmitotic, polarized human neurons derived from NTera 2 cells provide a system for expressing exogenous proteins in terminally differentiated neurons

1992 • 612 citations

Mutation of the pancreatic islet inward rectifier Kir6.2 also leads to familial persistent hyperinsulinemic hypoglycemia of infancy

1996 • 442 citations

Potentially Amyloidogenic, Carboxyl-Terminal Derivatives of the Amyloid Protein Precursor

1992 • 432 citations

Enhanced Production and Oligomerization of the 42-residue Amyloid β-Protein by Chinese Hamster Ovary Cells Stably Expressing Mutant Presenilins

1997 • 283 citations

The Role of APP Processing and Trafficking Pathways in the Formation of Amyloid β‐Proteina

1996 • 244 citations

Human neurons derived from a teratocarcinoma cell line express solely the 695-amino acid amyloid precursor protein and produce intracellular beta-amyloid or A4 peptides.

1993 • 223 citations

β-Amyloid and the Pathogenesis of Alzheimer's Disease

1991 • 201 citations

Agonist analysis of 2‐(carboxycyclopropyl)glycine isomers for cloned metabotropic glutamate receptor subtypes expressed in Chinese hamster ovary cells

1992 • 189 citations

Muscarinic Regulation of Alzheimer's Disease Amyloid Precursor Protein Secretion and Amyloid β-Protein Production in Human Neuronal NT2N Cells

1995 • 188 citations

Amyloid precursor protein processing is stimulated by metabotropic glutamate receptors.

1995 • 182 citations

Inducible expression of neuronal glutamate receptor channels in the NT2 human cell line.

1993 • 179 citations

1-Aminoindan-1,5-dicarboxylic Acid: A Novel Antagonist at Phospholipase C-Linked Metabotropic Glutamate Receptors

1995 • 173 citations

Expression patterns of β‐amyloid precursor protein (β‐APP) in neural and nonneural human tissues from alzheimer's disease and control subjects

1991 • 148 citations

New phenylglycine derivatives with potent and selective antagonist activity at presynaptic glutamate receptors in neonatal rat spinal cord

1995 • 105 citations

Glutamate receptor update

1994 • 95 citations

Diacylglycerol Hydrolysis to Arachidonic Acid Is Necessary for Insulin Secretion from Isolated Pancreatic Islets: Sequential Actions of Diacylglycerol and Monoacylglycerol Lipases

1994 • 88 citations

Secretagogue-induced diacylglycerol accumulation in isolated pancreatic islets. Mass spectrometric characterization of the fatty acyl content indicates multiple mechanisms of generation

1989 • 83 citations

Metabolism of Alzheimer beta-amyloid precursor protein: regulation by protein kinase A in intact cells and in a cell-free system.

1996 • 82 citations

Cloning and expression of a human metabotropic glutamate receptor 1 alpha: enhanced coupling on co-transfection with a glutamate transporter.

1995 • 71 citations

Molecular Cloning and the Functional Expression of Two Isoforms of Human Metabotropic Glutamate Receptor Subtype 5

1994 • 71 citations

Expression of Non‐NMDA Glutamate Receptor Channel Genes by Clonal Human Neurons

1994 • 56 citations

Stimulation of amyloid precursor protein synthesis by adrenergic receptors coupled to cAMP formation

1997 • 48 citations

Ionotropic glutamate receptors: new types and new concepts

1997 • 46 citations

Intracellular Cyclic AMP Inhibits Constitutive and Phorbol Ester‐Stimulated Secretory Cleavage of Amyloid Precursor Protein

1996 • 44 citations

Metabotropic Glutamate Receptors Increase Amyloid Precursor Protein Processing in Astrocytes: Inhibition by Cyclic AMP

1997 • 39 citations

cDNA Cloning of a Short Type of Multidrug Resistance Protein Homologue,SMRP,from a Human Lung Cancer Cell Line

1997 • 39 citations

Metabotropic glutamate receptor agonists increase release of soluble amyloid precursor protein derivatives from rat brain cortical and hippocampal slices.

1997 • 38 citations

Production of Amyloid β Protein from Normal Amyloid β‐Protein Precursor (βAPP) and the Mutated βAPPS Linked to Familial Alzheimer's Diseasea

1993 • 33 citations

Ionotropic glutamate receptors: new types and new concepts

1997 • 29 citations

Glutamate-stimulated secretion of amyloid precursor protein from cortical rat brain slices

1997 • 28 citations

Amyloidogenesis in Alzheimer's disease: basic biology and animal models

1992 • 20 citations

Intracortical Glutamate Perfusionin VivoInduces Cellular Alterations in Specific Protein Kinase C Isoforms and Amyloid Precursor Protein

1997 • 6 citations