The HHQK Domain of β-Amyloid Provides a Structural Basis for the Immunopathology of Alzheimer's Disease

Reactive microglia are positive for HLA‐DR in the substantia nigra of Parkinson's and Alzheimer's disease brains

1988 • 2,754 citations

Hydrogen peroxide mediates amyloid β protein toxicity

1994 • 2,065 citations

Characterization of ameboid microglia isolated from developing mammalian brain

1986 • 1,287 citations

Cytotoxicity of microglia

1993 • 1,042 citations

[41] Modification of histidyl residues in proteins by diethylpyrocarbonate

1977 • 813 citations

Structural alterations in the peptide backbone of beta-amyloid core protein may account for its deposition and stability in Alzheimer's disease.

1993 • 775 citations

The role of mononuclear phagocytes in wound healing after traumatic injury to adult mammalian brain

1989 • 504 citations

Peptide Compositions of the Cerebrovascular and Senile Plaque Core Amyloid Deposits of Alzheimer′s Disease

1993 • 489 citations

Mass spectrometry of purified amyloid beta protein in Alzheimer's disease.

1992 • 461 citations

Brain glia release factors with opposing actions upon neuronal survival

1993 • 437 citations

Physiological production of the β-amyloid protein and the mechanism of Alzheimer's disease

1993 • 423 citations

Reversible modification of arginine residues. Application to sequence studies by restriction of tryptic hydrolysis to lysine residues

1975 • 385 citations

Inhibition of mononuclear phagocytes reduces ischemic injury in the spinal cord

1990 • 373 citations

Amyloid peptides are toxic via a common oxidative mechanism.

1995 • 372 citations

An important role of heparan sulfate proteoglycan (perlecan) in a model system for the deposition and persistence of fibrillar aβ-amyloid in rat brain

1994 • 304 citations

The Profile of Soluble Amyloid β Protein in Cultured Cell Media

1996 • 293 citations

Amino-terminal Deletions Enhance Aggregation of β-Amyloid Peptides in Vitro

1995 • 288 citations

Specific Domains of β-Amyloid from Alzheimer Plaque Elicit Neuron Killing in Human Microglia

1996 • 268 citations

Ultrastructure of the microglia that phagocytose amyloid and the microglia that produce ?-amyloid fibrils

1992 • 267 citations

Senile plaques stimulate microglia to release a neurotoxin found in Alzheimer brain

1995 • 244 citations

Morphologic association between microglia and senile plaque amyloid in Alzheimer's disease

1990 • 238 citations

High affinity interactions between the Alzheimer's beta-amyloid precursor proteins and the basement membrane form of heparan sulfate proteoglycan

1991 • 211 citations

The possible contribution of microglia and macrophages to delayed neuronal death after ischemia

1993 • 197 citations

[44] Nitration with tetranitromethane

1972 • 194 citations

Soluble β-Amyloid Induction of Alzheimer's Phenotype for Human Fibroblast K ⁺ Channels

1994 • 168 citations

Phagocytosis and deposition of vascular beta-amyloid in rat brains injected with Alzheimer beta-amyloid.

1992 • 158 citations

Morphological and Biochemical Analyses of Amyloid Plaque Core Proteins Purified from Alzheimer Disease Brain Tissue

1993 • 145 citations

α₁‐Antichymotrypsin Binding to Alzheimer Aβ Peptides Is Sequence Specific and Induces Fibril Disaggregation In Vitro

1993 • 143 citations

pH‐Dependent Binding of Synthetic β‐Amyloid Peptides to Glycosaminoglycans

1993 • 140 citations

Transglutaminase-catalyzed cross-linking through diamines and polyamines.

1978 • 80 citations

Nonsteroidal antiinflammatory drug use in Alzheimer's disease

1994 • 76 citations

[54] Amidination

1972 • 65 citations

Cyclosporin A prevents ischemia-induced reduction of muscarinic acetylcholine receptors with suppression of microglial activation in gerbil hippocampus

1995 • 22 citations