Correlative Memory Deficits, Aβ Elevation, and Amyloid Plaques in Transgenic Mice

Developments of a water-maze procedure for studying spatial learning in the rat

1984 • 6,896 citations

The Consortium to Establish a Registry for Alzheimer's Disease (CERAD)

1991 • 4,669 citations

Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease

1991 • 4,533 citations

Physical basis of cognitive alterations in alzheimer's disease: Synapse loss is the major correlate of cognitive impairment

1991 • 4,120 citations

Secreted amyloid β–protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease

1996 • 2,543 citations

Neurofibrillary tangles but not senile plaques parallel duration and severity of Alzheimer's disease

1992 • 2,520 citations

Diagnosis of Alzheimer's Disease

1985 • 2,482 citations

Alzheimer-type neuropathology in transgenic mice overexpressing V717F β-amyloid precursor protein

1995 • 2,456 citations

Mutation of the β-amyloid precursor protein in familial Alzheimer's disease increases β-protein production

1992 • 1,723 citations

An Increased Percentage of Long Amyloid β Protein Secreted by Familial Amyloid β Protein Precursor (βApp ₇₁₇ ) Mutants

1994 • 1,463 citations

ON THE BINDING OF CONGO RED BY AMYLOID

1962 • 1,128 citations

A mutation in the Amyloid Precursor Protein Associated with Hereditary Alzheimer's Disease

1991 • 1,121 citations

Presenile dementia and cerebral haemorrhage linked to a mutation at codon 692 of the β–amyloid precursor protein gene

1992 • 725 citations

Amyloid β Protein (Aβ) in Alzheimeri's Disease Brain

1995 • 646 citations

Dominant and differential deposition of distinct β-amyloid peptide species, AβN3(pE), in senile plaques

1995 • 554 citations

Age-related CNS disorder and early death in transgenic FVB/N mice overexpressing Alzheimer amyloid precursor proteins

1995 • 521 citations

Age-related learning deficits in transgenic mice expressing the 751-amino acid isoform of human beta-amyloid precursor protein.

1995 • 333 citations

Chimeric prion protein expression in cultured cells and transgenic mice

1992 • 240 citations

Differential expression of amyloid precursor protein mRNAs in cases of Alzheimer's disease and in aged nonhuman primates

1990 • 121 citations

Spontaneous Alternation Behavior

1989 • 117 citations

Transgenic mouse brain histopathology resembles early Alzheimer's disease

1994 • 110 citations

Polyclonals to β-amyloid(1–42) identify most plaque and vascular deposits in Alzheimer cortex, but not striatum

1994 • 79 citations

Monoclonal antibody to the C-terminus of β-amyloid

1994 • 43 citations