Receptor-effector coupling by G proteins

Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches

1981 • 18,584 citations

G PROTEINS: TRANSDUCERS OF RECEPTOR-GENERATED SIGNALS

1987 • 6,374 citations

Multiple receptors for dopamine

1979 • 3,739 citations

The role of hormone receptors and GTP-regulatory proteins in membrane transduction

1980 • 1,750 citations

Molecular Genetics of Human Color Vision: The Genes Encoding Blue, Green, and Red Pigments

1986 • 1,702 citations

A ternary complex model explains the agonist-specific binding properties of the adenylate cyclase-coupled beta-adrenergic receptor.

1980 • 1,579 citations

Identification of a Family of Muscarinic Acetylcholine Receptor Genes

1987 • 1,439 citations

Is there a basis for distinguishing two types of P2-purinoceptor?

1985 • 1,353 citations

Progress in Clinical and Biological Research

1979 • 1,317 citations

Isolation of two proteins with high affinity for guanine nucleotides from membranes of bovine brain.

1984 • 1,300 citations

Cloning of the gene and cDNA for mammalian β-adrenergic receptor and homology with rhodopsin

1986 • 1,264 citations

A Cytoplasmic Protein Stimulates Normal N- ras p21 GTPase, But Does Not Affect Oncogenic Mutants

1987 • 1,197 citations

The βγ subunits of GTP-binding proteins activate the muscarinic K+ channel in heart

1987 • 1,186 citations

Cloning and expression of a rat D2 dopamine receptor cDNA

1988 • 1,125 citations

Rapid accumulation of inositol trisphosphate reveals that agonists hydrolyse polyphosphoinositides instead of phosphatidylinositol

1983 • 1,104 citations

Trends in the Development of Baculovirus Expression Vectors

1988 • 1,022 citations

G Proteins: A Family of Signal Transducers

1986 • 975 citations

Role of guanine nucleotide binding protein in the activation of polyphosphoinositide phosphodiesterase

1985 • 960 citations

Cloning, sequencing and expression of complementary DNA encoding the muscarinic acetylcholine receptor

1986 • 917 citations

The GTP-binding protein, Go9 regulates neuronal calcium channels

1987 • 910 citations

Highly potent and selective ligands for histamine H3-receptors

1987 • 890 citations

A G Protein Couples Serotonin and GABA _B Receptors to the Same Channels in Hippocampus

1986 • 870 citations

GTP-binding proteins couple cardiac muscarinic receptors to a K channel

1985 • 868 citations

The Glucagon-sensitive Adenyl Cyclase System in Plasma Membranes of Rat Liver

1971 • 811 citations

Cloning and expression of the human and rat m5 muscarinic acetylcholine receptor genes

1988 • 792 citations

Cloning, Sequencing, and Expression of the Gene Coding for the Human Platelet α ₂ -Adrenergic Receptor

1987 • 792 citations

Distinct primary structures, ligand-binding properties and tissue-specific expression of four human muscarinic acetylcholine receptors.

1987 • 766 citations

Molecular cloning of five GTP-binding protein cDNA species from rat olfactory neuroepithelium.

1987 • 751 citations

cDNA eloping of bovine substance-K receptor through oocyte expression system

1987 • 748 citations

Protein kinase C phosphorylates the inhibitory guanine‐nucleotide‐binding regulatory component and apparently suppresses its function in hormonal inhibition of adenylate cyclase

1985 • 736 citations

Molecular Characterization of a Functional cDNA Encoding the Serotonin 1c Receptor

1988 • 691 citations

Isolation, sequence analysis, and intron-exon arrangement of the gene encoding bovine rhodopsin

1983 • 689 citations

GTP-binding proteins mediate transmitter inhibition of voltage-dependent calcium channels

1986 • 666 citations

Lipoxygenase metabolites of arachidonic acid as second messengers for presynaptic inhibition of Aplysia sensory cells

1987 • 640 citations

Structure of the GDP Domain of EF-Tu and Location of the Amino Acids Homologous to ras Oncogene Proteins

1985 • 626 citations

Catecholamine-stimulated GTPase activity in turkey erythrocyte membranes

1976 • 623 citations

ADP ribosylation of the specific membrane protein of C6 cells by islet-activating protein associated with modification of adenylate cyclase activity.

1982 • 600 citations

The genomic clone G-21 which resembles a β-adrenergic receptor sequence encodes the 5-HT1A receptor

1988 • 594 citations

Purification and properties of the inhibitory guanine nucleotide regulatory unit of brain adenylate cyclase.

1984 • 585 citations

Identification of the predominant substrate for ADP-ribosylation by islet activating protein.

1983 • 583 citations

Odorant-sensitive adenylate cyclase may mediate olfactory reception

1985 • 583 citations

Islet-activating protein, pertussis toxin: a probe for functions of the inhibitory guanine nucleotide regulatory component of adenylate cyclase

1984 • 567 citations

Light- and GTP-regulated interaction of GTPase and other proteins with bovine photoreceptor membranes

1980 • 561 citations

Effects of Lipolytic and Antilipolytic Substances on Adenosine 3′,5′-Monophosphate Levels in Isolated Fat Cells

1968 • 555 citations

Adenyl Cyclase

1962 • 555 citations

A G Protein Directly Regulates Mammalian Cardiac Calcium Channels

1987 • 551 citations

A quantitative analysis of beta-adrenergic receptor interactions: resolution of high and low affinity states of the receptor by computer modeling of ligand binding data.

1980 • 545 citations

Distinct Subunits for the Regulation and Catalytic Activity of Aspartate Transcarbamylase^*

1965 • 541 citations

The protein cofactor necessary for ADP-ribosylation of Gs by cholera toxin is itself a GTP binding protein.

1986 • 533 citations

Growth factor-like action of phosphatidic acid

1986 • 531 citations

Uncoupling of cardiac muscarinic and β-adrenergic receptors from ion channels by a guanine nucleotide analogue

1985 • 527 citations

Inositol trisphosphate formation and calcium mobilization in Swiss 3T3 cells in response to platelet-derived growth factor

1984 • 520 citations

On the mechanism of activation of muscarinic K+ channels by adenosine in isolated atrial cells: involvement of GTP-binding proteins

1986 • 510 citations

Primary Structure and Biochemical Properties of an M ₂ Muscarinic Receptor

1987 • 510 citations

Simultaneous inhibitions of inositol phospholipid breakdown, arachidonic acid release, and histamine secretion in mast cells by islet-activating protein, pertussis toxin. A possible involvement of the toxin-specific substrate in the Ca2+-mobilizing receptor-mediated biosignaling system.

1985 • 509 citations

Purification and properties of the inhibitory guanine nucleotide-binding regulatory component of adenylate cyclase.

1984 • 498 citations

Characterization of transducin from bovine retinal rod outer segments. I. Separation and reconstitution of the subunits.

1983 • 492 citations

The STE4 and STE18 genes of yeast encode potential β and γ subunits of the mating factor receptor-coupled G protein

1989 • 491 citations

Site of G Protein Binding to Rhodopsin Mapped with Synthetic Peptides from the α Subunit

1988 • 491 citations

The Glucagon-sensitive Adenyl Cyclase System in Plasma Membranes of Rat Liver

1971 • 487 citations

Isolation and structure of a rhodopsin gene from D. melanogaster

1985 • 481 citations

Involvement of guanine nucleotide-binding protein in the gating of Ca2+ by receptors

1983 • 473 citations

Phosphatidate accumulation in hormone-treated hepatocytes via a phospholipase D mechanism.

1987 • 472 citations

Pertussis toxin-catalyzed ADP-ribosylation of transducin. Cysteine 347 is the ADP-ribose acceptor site.

1985 • 457 citations

Isolation and characterization of cGMP phosphodiesterase from bovine rod outer segments.

1979 • 448 citations

Direct Activation of Mammalian Atrial Muscarinic Potassium Channels by GTP Regulatory Protein G _k

1987 • 441 citations

G-protein βγ-subunits activate the cardiac muscarinic K+-channel via phospholipase A2

1989 • 438 citations

Adenyl Cyclase in Fat Cells

1969 • 437 citations

Mode of regulation of the ACh-sensitive K-channel by the muscarinic receptor in rabbit atrial cells

1984 • 436 citations

Pharmacological inhibition of the M‐current

1982 • 434 citations

The yeast SCG1 gene: A Gα-like protein implicated in the a- and α-factor response pathway

1987 • 431 citations

5-Hydroxytryptamine stimulates inositol phosphate production in a cell-free system from blowfly salivary glands. Evidence for a role of GTP in coupling receptor activation to phosphoinositide breakdown.

1985 • 429 citations

Origin and blockade of the synaptic responses of curarized sympathetic ganglia

1961 • 427 citations

Inhibition of receptor-mediated release of arachidonic acid by pertussis toxin

1984 • 418 citations

Adenyl Cyclase

1962 • 415 citations

Interleukin-1 stimulates diacylglycerol production in T lymphocytes by a novel mechanism

1988 • 413 citations

The inhibitory guanine nucleotide-binding regulatory component of adenylate cyclase. Properties and function of the purified protein.

1984 • 411 citations

Purification of a protein cofactor required for ADP-ribosylation of the stimulatory regulatory component of adenylate cyclase by cholera toxin.

1984 • 410 citations

Neurotransmitters decrease the calcium component of sensory neurone action potentials

1978 • 409 citations

Normal p21N-ras couples bombesin and other growth factor receptors to inositol phosphate production

1986 • 406 citations

Renal Adenyl Cyclase: Anatomically Separate Sites for Parathyroid Hormone and Vasopressin

1968 • 403 citations

Escherichia coli thioredoxin confers processivity on the DNA polymerase activity of the gene 5 protein of bacteriophage T7.

1987 • 399 citations

An M2 Muscarinic Receptor Subtype Coupled to Both Adenylyl Cyclase and Phosphoinositide Turnover

1987 • 398 citations

ADP-ribosylation of the specific membrane protein by islet-activating protein, pertussis toxin, associated with inhibition of a chemotactic peptide-induced arachidonate release in neutrophils. A possible role of the toxin substrate in Ca2+-mobilizing biosignaling.

1984 • 389 citations

Activation of two signal-transduction systems in hepatocytes by glucagon

1986 • 383 citations

The subunits of the stimulatory regulatory component of adenylate cyclase. Resolution of the activated 45,000-dalton (alpha) subunit.

1983 • 380 citations

Hormone-stimulated polyphosphoinositide breakdown in rat liver plasma membranes. Roles of guanine nucleotides and calcium.

1986 • 378 citations

Effects of Mg2+ and the beta gamma-subunit complex on the interactions of guanine nucleotides with G proteins.

1987 • 359 citations

Chemoattractant receptor-induced hydrolysis of phosphatidylinositol 4,5-bisphosphate in human polymorphonuclear leukocyte membranes. Requirement for a guanine nucleotide regulatory protein.

1985 • 358 citations

Molecular mechanisms of transmembrane signalling

1985 • 352 citations

Adenyl Cyclase in Fat Cells

1969 • 352 citations

Mode of coupling between the β-adrenergic receptor and adenylate cyclase in turkey erythrocytes

1978 • 347 citations

Direct hyperpolarizing action of baclofen on hippocampal pyramidal cells

1984 • 342 citations

Characterization of transducin from bovine retinal rod outer segments. II. Evidence for distinct binding sites and conformational changes revealed by limited proteolysis with trypsin.

1983 • 331 citations

Receptor-Coupled Activation of Phosphoinositide-Specific Phospholipase C by an N Protein

1986 • 324 citations

Rapid decrease of phosphatidylinositol 4,5-bisphosphate in thrombin-stimulated platelets.

1982 • 323 citations

The rapid formation of inositol phosphates in human platelets by thrombin is inhibited by prostacyclin.

1984 • 319 citations

Molecular basis for two forms of the G protein that stimulates adenylate cyclase.

1986 • 319 citations

An agonist-specific effect of guanine nucleotides on binding to the beta adrenergic receptor.

1976 • 318 citations

The α Subunit of the GTP Binding Protein G _k Opens Atrial Potassium Channels

1987 • 317 citations

Reconstitution of Excitable Cell Membrane Structure in Vitro

1962 • 315 citations

Reconstitution of resolved muscarinic cholinergic receptors with purified GTP-binding proteins.

1985 • 314 citations

Regulation of beta-adrenergic receptors by guanyl-5'-yl imidodiphosphate and other purine nucleotides.

1976 • 314 citations

Stimulation and inhibition of adenylyl cyclases mediated by distinct regulatory proteins

1983 • 309 citations

The G protein-gated atrial K+ channel is stimulated by three distinct GIα-subunits

1988 • 306 citations

The regulatory components of adenylate cyclase and transducin. A family of structurally homologous guanine nucleotide-binding proteins.

1983 • 304 citations

Arachidonic acid metabolites as intracellular modulators of the G protein-gated cardiac K+ channel

1989 • 299 citations

Thyrotropin-releasing hormone rapidly activates the phosphodiester hydrolysis of polyphosphoinositides in GH3 pituitary cells. Evidence for the role of a polyphosphoinositide-specific phospholipase C in hormone action.

1983 • 292 citations

Primary structure of the α-subunit of transducin and its relationship to ras proteins

1985 • 291 citations

Resolution of some components of adenylate cyclase necessary for catalytic activity.

1977 • 283 citations

Coupling of the guanine nucleotide regulatory protein to chemotactic peptide receptors in neutrophil membranes and its uncoupling by islet-activating protein, pertussis toxin. A possible role of the toxin substrate in Ca2+-mobilizing receptor-mediated signal transduction.

1985 • 281 citations

Direct evidence for involvement of a guanine nucleotide-binding protein in chemotactic peptide-stimulated formation of inositol bisphosphate and trisphosphate in differentiated human leukemic (HL-60) cells. Reconstitution with Gi or Go of the plasma membranes ADP-ribosylated by pertussis toxin.

1986 • 276 citations

Selection of a Variant Lymphoma Cell Deficient in Adenylate Cyclase

1975 • 276 citations

Sequence of the Alpha Subunit of Photoreceptor G Protein: Homologies Between Transducin, ras , and Elongation Factors

1985 • 276 citations

Presence of three distinct molecular species of Gi protein alpha subunit. Structure of rat cDNAs and human genomic DNAs.

1988 • 275 citations

The stimulatory G protein of adenylyl cyclase, Gs, also stimulates dihydropyridine-sensitive Ca2+ channels. Evidence for direct regulation independent of phosphorylation by cAMP-dependent protein kinase or stimulation by a dihydropyridine agonist.

1988 • 273 citations

Identification of Specific Transducin α Subunits in Retinal Rod and Cone Photoreceptors

1986 • 272 citations

Dopamine inhibits adenylate cyclase in human prolactin-secreting pituitary adenomas

1979 • 271 citations

Two polyphosphatidylinositide metabolites control two K+ currents in a neuronal cell

1986 • 268 citations

The inhibitory guanine nucleotide-binding regulatory component of adenylate cyclase. Subunit dissociation and the inhibition of adenylate cyclase in S49 lymphoma cyc- and wild type membranes.

1984 • 265 citations

Enkephalin opens potassium channels on mammalian central neurones

1982 • 264 citations

Expression of Gsα in Escherichia coli

1989 • 262 citations

The influence of bound GDP on the kinetics of guanine nucleotide binding to G proteins.

1986 • 261 citations

Complex formation between metarhodopsin II and GTP‐binding protein in bovine protoreceptor membranes leads to a shift of the photoproduct equilibrium

1982 • 259 citations

Purification of the catalyst of adenylate cyclase.

1986 • 259 citations

Changes in membrane currents in bullfrog atrium produced by acetylcholine.

1976 • 259 citations

Islet-activating protein. A modifier of receptor-mediated regulation of rat islet adenylate cyclase.

1981 • 257 citations

Phosphatidylcholine breakdown in rat liver plasma membranes. Roles of guanine nucleotides and P2-purinergic agonists.

1987 • 253 citations

Mammalian .beta.2-adrenergic receptor: reconstitution of functional interactions between pure receptor and pure stimulatory nucleotide binding protein of the adenylate cyclase system

1984 • 249 citations

Identification of receptor contact site involved in receptor–G protein coupling

1987 • 249 citations

Zum Mechanismus der Membranwirkung des Acetylcholin an der Herzmuskelfaser

1958 • 247 citations

Receptor-mediated inhibition of adenylate cyclase and stimulation of arachidonic acid release in 3T3 fibroblasts. Selective susceptibility to islet-activating protein, pertussis toxin.

1985 • 245 citations

Angiotensin II and dopamine modulate both cAMP and inositol phosphate productions in anterior pituitary cells. Involvement in prolactin secretion.

1986 • 245 citations

Evidence for Interdependent Action of Glucagon and Nucleotides on the Hepatic Adenylate Cyclase System

1974 • 244 citations

Stimulation of Adenosine 3′,5′-Monophosphate Production by Growth Hormone-Releasing Factor and Its Inhibition by Somatostatin in Anterior Pituitary Cellsin Vitro*

1983 • 244 citations

Ns and Ni, the stimulatory and inhibitory regulatory components of adenylyl cyclases. Purification of the human erythrocyte proteins without the use of activating regulatory ligands.

1984 • 242 citations

Angiotensin increases inositol trisphosphate and calcium in vascular smooth muscle.

1985 • 241 citations

The subunits of the stimulatory regulatory component of adenylate cyclase. Resolution, activity, and properties of the 35,000-dalton (beta) subunit.

1983 • 237 citations

Newly Identified Brain Potassium Channels Gated by the Guanine Nucleotide Binding Protein G _o

1988 • 236 citations

Amino acid sequence of retinal transducin at the site ADP-ribosylated by cholera toxin.

1984 • 235 citations

Adenyl Cyclase in Fat Cells

1970 • 235 citations

Synaptic excitation and inhibition resulting from direct action of acetylcholine on two types of chemoreceptors on individual amphibian parasympathetic neurones

1977 • 233 citations

Stimulation of inositol trisphosphate and diacylglycerol production in renal tubular cells by parathyroid hormone.

1987 • 232 citations

β-Adrenergic Inhibition of Cardiac Sodium Channels by Dual G-Protein Pathways

1989 • 232 citations

The effect of GTP and Mg2+ on the GTPase activity and the fluorescent properties of Go.

1987 • 231 citations

Somatogenic Receptors of Rat Liver: Regulation by Insulin*

1980 • 230 citations

Catecholamine-stimulated GTPase cycle. Multiple sites of regulation by beta-adrenergic receptor and Mg2+ studied in reconstituted receptor-Gs vesicles.

1986 • 225 citations

Bradykinin stimulation of inositol polyphosphate production in porcine aortic endothelial cells.

1986 • 225 citations

Modulation of adenylate cyclase of human platelets by phorbol ester

1985 • 225 citations

Splice Variants of the α Subunit of the G Protein G _s Activate Both Adenylyl Cyclase and Calcium Channels

1989 • 225 citations

Rapid accumulation of inositol phosphates in isolated rat superior cervical sympathetic ganglia exposed to V1-vasopressin and muscarinic cholinergic stimuli

1984 • 224 citations

Guanine nucleotides modulate the binding affinity of the oligopeptide chemoattractant receptor on human polymorphonuclear leukocytes.

1983 • 223 citations

Functional homology between signal-coupling proteins. Cholera toxin inactivates the GTPase activity of transducin.

1982 • 221 citations

Elementary currents through Ca2+ channels in Guinea pig myocytes

1983 • 220 citations

Hormone-sensitive adenylyl cyclases useful models for studying hormone receptor functions in cell-free systems

1973 • 219 citations

THE RELATIONSHIP OF EPINEPHRINE AND GLUCAGON TO LIVER PHOSPHORYLASE

1956 • 218 citations

Histamine-sensitive adenylate cyclase in mammalian brain

1976 • 218 citations

The calcium signal and phosphatidylinositol breakdown in 2H3 cells.

1984 • 214 citations

Identification of a gamma subunit associated with the adenylyl cyclase regulatory proteins Ns and Ni.

1984 • 214 citations

Specificity of the functional interactions of the beta-adrenergic receptor and rhodopsin with guanine nucleotide regulatory proteins reconstituted in phospholipid vesicles.

1985 • 213 citations

Molecular Cloning of Complementary DNA for the Alpha Subunit of the G Protein that Stimulates Adenylate Cyclase

1985 • 209 citations

Mechanism of action of gonadotropin-releasing hormone. Involvement of phospholipid turnover in luteinizing hormone release.

1981 • 208 citations

Calcitonin gene-related peptide elevates cyclic AMP levels in chick skeletal muscle: possible neurotrophic role for a coexisting neuronal messenger.

1987 • 207 citations

Mammalian .beta.2-adrenergic receptor: purification and characterization

1984 • 207 citations

Kinetics of Activation of Phospholipase C by P2Y Purinergic Receptor Agonists and Guanine Nucleotides

1989 • 206 citations

Reconstitution of catecholamine-stimulated adenylate cyclase activity using three purified proteins.

1985 • 206 citations

Thyroliberin stimulates rapid hydrolysis of phosphatidylinositol 4,5-bisphosphate by a phosphodiesterase in rat mammotropic pituitary cells. Evidence for an early Ca2+-independent action

1983 • 203 citations

Solubilization and characterization of the beta-adrenergic receptor binding sites of frog erythrocytes.

1976 • 203 citations

gamma-aminobutyric acid B receptors are negatively coupled to adenylate cyclase in brain, and in the cerebellum these receptors may be associated with granule cells.

1984 • 202 citations

Mode of coupling between hormone receptors and adenylate cyclase elucidated by modulation of membrane fluidity

1978 • 202 citations

Interaction of porcine vasoactive intestinal peptide with dispersed pancreatic acinar cells from the guinea pig. Structural requirements for effects of vasoactive intestinal peptide and secretin on cellular adenosine 3':5'-monophosphate.

1976 • 200 citations

A nucleotide regulatory site for somatostatin inhibition of adenylate cyclase in S49 lymphoma cells

1983 • 200 citations

Human alveolar macrophage arachidonic acid metabolism

1988 • 199 citations

Functional reconstitution of the alpha 2-adrenergic receptor with guanine nucleotide regulatory proteins in phospholipid vesicles.

1986 • 199 citations

Thyrotropin-releasing hormone activates a Ca2+-dependent polyphosphoinositide phosphodiesterase in permeable GH3 cells. GTP gamma S potentiation by a cholera and pertussis toxin-insensitive mechanism.

1986 • 197 citations

Family of G protein α chains: amphipathic analysis and predicted structure of functional domains

1986 • 197 citations

Acetylcholine hyperpolarizes central neurones by acting on an M2 muscarinic receptor

1986 • 196 citations

Trigger and Amplification Mechanisms in Visual Phototransduction

1985 • 196 citations

Luteinizing hormone increases inositol trisphosphate and cytosolic free Ca2+ in isolated bovine luteal cells.

1987 • 194 citations

Pertussis toxin blocks both cyclic AMP-mediated and cyclic AMP-independent actions of somatostatin. Evidence for coupling of Ni to decreases in intracellular free calcium.

1985 • 190 citations

The effect of activating ligands on the intrinsic fluorescence of guanine nucleotide-binding regulatory proteins.

1987 • 190 citations

A new GTP‐binding protein in brain tissues serving as the specific substrate of islet‐activating protein, pertussis toxin

1987 • 189 citations

Stimulation by vasopressin and alpha-catecholamines of phosphatidylinositol formation in isolated rat liver parenchymal cells.

1980 • 188 citations

Reconstitution of Somatostatin and Muscarinic Receptor Mediated Stimulation of K⁺Channels by Isolated G_KProtein in Clonal Rat Anterior Pituitary Cell Membranes *

1987 • 188 citations

Chemotactic factor causes rapid decreases in phosphatidylinositol,4,5-bisphosphate and phosphatidylinositol 4-monophosphate in rabbit neutrophils

1983 • 188 citations

Pertussis toxin inhibits enkephalin stimulation of GTPase of NG108-15 cells.

1983 • 187 citations

Angiotensin II and alpha-adrenergic agonists inhibit rat liver adenylate cyclase.

1981 • 183 citations

Membrane-dependent guanine nucleotide binding and GTPase activities of soluble protein from bovine rod cell outer segments.

1979 • 183 citations

Molecular cloning and expression of a fifth muscarinic acetylcholine receptor

1989 • 182 citations

Activation of phospholipases A2 and C in pig aortic endothelial cells synthesizing prostacyclin.

1982 • 182 citations

The Stimulatory Effect of Luteinizing Hormone on Adenosine 3‘,5‘-Monophosphate Accumulation in Corpus Luteum Slices

1966 • 181 citations

Substance P induced hydrolysis of inositol phospholipids in guinea-pig ileum and rat hypothalamus

1983 • 181 citations

Mechanisms of muscarinic receptor action on Go in reconstituted phospholipid vesicles

1989 • 180 citations

A mutation that prevents GTP-dependent activation of the α chain of Gs

1988 • 176 citations

Role of Ni in coupling angiotensin receptors to inhibition of adenylate cyclase in hepatocytes.

1985 • 175 citations

Carboxyl Rerminal Domain of G _sα Specifies Coupling of Receptors to Stimulation of Adenylyl Cyclase

1988 • 174 citations

Role of calcium and cAMP in the action of adrenocorticotropin on aldosterone secretion.

1985 • 173 citations

Stimulatory Effects of LH, FSH and Prostaglandins upon Cyclic 3′,5′-AMP Levels in Porcine Granulosa Cells1

1972 • 171 citations

Hormonal regulation of testicular luteinizing hormone receptors. Effects on cyclic AMP and testosterone responses in isolated Leydig cells.

1977 • 171 citations

Thyrotropin-releasing hormone and GTP activate inositol trisphosphate formation in membranes isolated from rat pituitary cells.

1986 • 169 citations

Identification of the GTP-binding protein encoded by Gi3 complementary DNA.

1988 • 169 citations

Similar effects of substance P and related peptides on salivation and on phosphatidylinositol turnover in rat salivary glands.

1980 • 168 citations

Rhodopsin-enhanced GTPase activity of the inhibitory GTP-binding protein of adenylate cyclase.

1984 • 166 citations

Pertussis toxin attenuates atrial natriuretic factor-mediated inhibition of adenylate cyclase. Involvement of inhibitory guanine nucleotide regulatory protein.

1987 • 165 citations

The effect of intracellular cyclic nucleotides and calcium on the action potential and acetylcholine response of isolated cardiac cells

1982 • 164 citations

Purification of the beta-adrenergic receptor. Identification of the hormone binding subunit.

1981 • 162 citations

A single GTP-binding protein regulates K+-channels coupled with dopamine, histamine and acetylcholine receptors

1987 • 161 citations

Bimodal regulation of adenylate cyclase

1982 • 161 citations

Relationships within the family of GTP-binding proteins isolated from bovine central nervous system.

1985 • 160 citations

Carbachol and oxytocin stimulate the generation of inositol phosphates in the guinea pig myometrium

1986 • 159 citations

Primary structure of the β‐subunit of bovine transducin deduced from the cDNA sequence

1985 • 155 citations

Agonist-specific effects of guanine nucleotides on alpha-adrenergic receptors in human platelets.

1979 • 155 citations

Purification of heterotrimeric GTP-binding proteins from brain: identification of a novel form of Go

1988 • 153 citations

Activation of Adenyl Cyclase by Glucagon in Cat and Human Heart

1969 • 152 citations

Guanine nucleotide inhibition of cyc- S49 mouse lymphoma cell membrane adenylyl cyclase.

1982 • 151 citations

Hepatic alpha 1-adrenergic receptors show agonist-specific regulation by guanine nucleotides. Loss of nucleotide effect after adrenalectomy.

1982 • 149 citations

Use of Liver Adenyl Cyclase for Assay of Glucagon in Human Gastro-intestinal Tract and Pancreas1

1964 • 149 citations

Glucagon Receptors in β-Cells

1972 • 145 citations

Effects of guanine nucleotides and Mg on human erythrocyte Ni and Ns, the regulatory components of adenylyl cyclase.

1984 • 144 citations

Chromatographic resolution and immunologic identification of the alpha 40 and alpha 41 subunits of guanine nucleotide-binding regulatory proteins from bovine brain.

1988 • 144 citations

Purification of the muscarinic acetylcholine receptor from porcine brain.

1985 • 142 citations

Primary structure of the α‐subunit of bovine adenylate cyclase‐stimulating G‐protein deduced from the cDNA sequence

1986 • 142 citations

Adenosine receptor-mediated inhibition of rat cerebral cortical adenylate cyclase by a GTP-dependent process.

1980 • 141 citations

Stimulation of choleragen enzymatic activities by GTP and two soluble proteins purified from bovine brain.

1988 • 141 citations

The regulatory component of adenylate cyclase. Purification and properties of the turkey erythrocyte protein.

1981 • 141 citations

A role for Gi in control of thrombin receptor-phospholipase C coupling in human platelets.

1988 • 138 citations

Reconstitution of catecholamine-stimulated binding of guanosine 5'-O-(3-thiotriphosphate) to the stimulatory GTP-binding protein of adenylate cyclase

1984 • 136 citations

Angiotensin II-induced stimulation of voltage-dependent Ca2+ currents in an adrenal cortical cell line.

1988 • 134 citations

Primary structure of the α‐subunit of bovine adenylate cyclase‐inhibiting G‐protein deduced from the cDNA sequence

1986 • 134 citations

Characterization of transducin from bovine retinal rod outer segments. Participation of the amino-terminal region of T alpha in subunit interaction.

1987 • 131 citations

Neuropeptide Y inhibits cardiac adenylate cyclase through a pertussis toxin-sensitive G protein.

1987 • 130 citations

Regulation of calcium currents by a GTP analogue: Potentiation of (−)-baclofen-mediated inhibition

1986 • 130 citations

DNA replication.

1988 • 130 citations

The Somatostatin Receptor Is Directly Coupled to Adenylate Cyclase in GH4Ci Pituitary Cell Membranes*

1984 • 130 citations

Suppression of Insulin Release by Galanin and Somatostatin Is Meditated by a G-protein

1989 • 130 citations

Acetylglyceryl ether phosphorylcholine. A potent activator of hepatic phosphoinositide metabolism and glycogenolysis.

1983 • 129 citations

Odorant‐ and Guanine Nucleotide‐Stimulated Phosphoinositide Turnover in Olfactory Cilia^a

1987 • 128 citations

Adenosine 3′,5′-Monophosphate (Cyclic AMP) as the Mediator of the Actions of Melanocyte Stimulating Hormone (MSH) and Norepinephrine on the Frog Skin¹

1969 • 127 citations

Two different adenylyl cyclases in brain distinguished by monoclonal antibodies

1988 • 126 citations

The role of the guanine nucleotide exchange reaction in the regulation of the beta-adrenergic receptor and in the actions of catecholamines and cholera toxin on adenylate cyclase in turkey erythrocyte membranes.

1980 • 126 citations

Mechanisms of slow postsynaptic potentials

1981 • 124 citations

Effects of Ca++ and Prostaglandin E1 on Vasopressin Activation of Renal Adenyl Cyclase

1971 • 121 citations

Chapter 5 First Stage of Amplification in the Cyclic-Nucleotide Cascade of Vision

1981 • 121 citations

Reconstitution of a hormone-sensitive adenylate cyclase system. The pure beta-adrenergic receptor and guanine nucleotide regulatory protein confer hormone responsiveness on the resolved catalytic unit.

1984 • 120 citations

β‐Subunits of the human liver G_s/G_i signal‐transducing proteins and those of bovine retinal rod cell transducin are identical

1986 • 119 citations

Neurotensin stimulates inositol phospholipid hydrolysis in rat brain slices

1984 • 118 citations

Activation mechanism of rod outer segment cyclic GMP phosphodiesterase. Release of inhibitor by the GTP/GTP-binding protein.

1983 • 117 citations

Characterization of VIP‐sensitive adenylate cyclase in guinea pig brain

1977 • 116 citations

[3H]GDP release from rat and hamster adipocyte membranes independently linked to receptors involved in activation or inhibition of adenylate cyclase. Differential susceptibility to two bacterial toxins.

1984 • 116 citations

Histamine Stimulation of Inositol 1‐Phosphate Accumulation in Lithium‐Treated Slices from Regions of Guinea Pig Brain

1984 • 116 citations

G-protein distribution in canine cardiac sarcoplasmic reticulum and sarcolemma: Comparison to rabbit skeletal muscle membranes and to brain and erythrocyte G-proteins

1987 • 115 citations

Characterization by two-dimensional peptide mapping of the gamma subunits of Ns and Ni, the regulatory proteins of adenylyl cyclase, and of transducin, the guanine nucleotide-binding protein of rod outer segments of the eye.

1985 • 114 citations

Adenylate cyclase assembled in vitro: cholera toxin substrates determine different patterns of regulation by isoproterenol and guanosine 5'-triphosphate.

1979 • 114 citations

Guanine nucleotide regulation of a mammalian myocardial muscarinic receptor system. Evidence for homo- and heterotropic cooperativity in ligand binding analyzed by computer-assisted curve fitting.

1985 • 113 citations

Epinephrine inhibits adenylate cyclase and stimulates a GTPase in human platelet membranes vis α‐adrenoceptors

1981 • 113 citations

The agonist-specific effect of magnesium ion on binding by beta-adrenergic receptors in S49 lymphoma cells. Interaction of GTP and magnesium in adenylate cyclase activation.

1978 • 111 citations

Expression of cDNAs for G proteins in Escherichia coli. Two forms of Gs alpha stimulate adenylate cyclase.

1987 • 111 citations

Potentiation by thrombin of the secretion of serotonin from permeabilized platelets equilibrated with Ca2+ buffers. Relationship to protein phosphorylation and diacylglycerol formation

1984 • 110 citations

Phospholipid methylation affects immunoglobulin E-mediated histamine and arachidonic acid release in rat leukemic basophils

1980 • 106 citations

Characterization of a calcium-mediated activation of arachidonic acid turnover in adrenal phospholipids by corticotropin.

1979 • 106 citations

Synaptic delay in the heart: an ionophoretic study.

1978 • 105 citations

κOpiate Agonists Inhibit Ca2+ Influx in Rat Spinal Cord-Dorsal Root Ganglion Cocultures

1989 • 104 citations

Alpha i-3 cDNA encodes the alpha subunit of Gk, the stimulatory G protein of receptor-regulated K+ channels.

1988 • 104 citations

Activation of myocardial adenyl cyclase by histamine in guinea pig, cat, and human heart

1971 • 104 citations

Neurotensin-mediated inhibition of cyclic AMP formation in neuroblastoma N1E115 cells: involvement of the inhibitory GTP-binding component of adenylate cyclase.

1986 • 104 citations

Cyclic AMP-independent, dual regulation of voltage-dependent Ca2+ currents by LHRH and somatostatin in a pituitary cell line.

1988 • 101 citations

A role for Ni in the hormonal stimulation of adenylate cyclase

1985 • 99 citations

Pertussis Toxin Blocks the Somatostatin-Induced Inhibition of Growth Hormone Release and Adenosine 3′,5′ -Monophosphate Accumulation^*

1983 • 98 citations

Mouse neuroblastoma adenylate cyclase. Adenosine and adenosine analogues as potent effectors of adenylate cyclase activity.

1975 • 98 citations

Postsynaptic serotonin-sensitive adenylate cyclase in the central nervous system. I. Development and distribution of serotonin and dopamine-sensitive adenylate cyclases in rat and guinea pig brain.

1978 • 97 citations

Inhibition of hamster fat cell adenylate cyclase by prostaglandin E₁ and epinephrine: Requirement for GTP and sodium ions

1979 • 97 citations

The human genome encodes at least three non-allellic G proteins with α_i-type subunits

1987 • 97 citations

ADP-ribosylation of transducin by pertussis toxin.

1985 • 96 citations

Effect of lhrh on incorporation of [32p]-orthophosphate into phosphatidylinositol by dispersed anterior pituitary cells

1982 • 96 citations

Multiple Roles of Erythrocyte Supernatant in the Activation of Adenylate Cyclase by Vibrio cholerae Toxin in Vitro

1976 • 96 citations

Identification by molecular cloning of two forms of the α‐subunit of the human liver stimulatory (G_s) regulatory component of adenylyl cyclase

1986 • 96 citations

Effects of Vasoactive Intestinal Peptide, Secretin, and Related Peptides on Rat Colonic Transport and Adenylate Cyclase Activity

1977 • 96 citations

The effect of gonadotropins on testicular adenyl cyclase

1969 • 94 citations

Purification and characterization of the human platelet alpha 2-adrenergic receptor.

1986 • 94 citations

Activation of phospholipase C and prostaglandin synthesis by [arginine]vasopressin in cultures

1984 • 94 citations

A new GTP-binding protein in differentiated human leukemic (HL-60) cells serving as the specific substrate of islet-activating protein, pertussis toxin.

1987 • 93 citations

Bradykinin and angiotensin II activation of arachidonic acid deacylation and prostaglandin E2 formation in rabbit kidney. Hormone-sensitive versus hormone-insensitive lipid pools of arachidonic acid.

1981 • 92 citations

Transient and steady state kinetics of the interaction of guanyl nucleotides with the adenylyl cyclase system from rat liver plasma membranes. Interpretation in terms of a simple two-state model.

1980 • 92 citations

Serotonin 5-HT1 receptors mediate inhibition of cyclic AMP production in neurons

1986 • 91 citations

Association of a solubilized prostaglandin E2 receptor from renal medulla with a pertussis toxin-reactive guanine nucleotide regulatory protein.

1986 • 91 citations

Glucagon and epinephrine stimulation of adenyl cyclase in isolated rat liver plasma membranes

1969 • 91 citations

7‐O‐hemisuccinyl‐deacetyl forskolin—sepharose: a novel affinity support for purification of adenylate cyclase

1982 • 91 citations

Dual actions of phorbol esters on cytosolic free Ca2+ concentrations and reconstitution with ionomycin of acute thyrotropin-releasing hormone responses.

1985 • 89 citations

GTP hydrolysis by pure Ni, the inhibitory regulatory component of adenylyl cyclases.

1984 • 89 citations

Effect of glucagon on rat heart adenyl cyclase

1969 • 89 citations

The distribution of the components of the cyclic GMP cycle in retina.

1980 • 87 citations

Chapter 14 Cyclic-Nucleotide Metabolism in Vertebrate Photoreceptors: A Remarkable Analogy and an Unraveling Enigma

1981 • 87 citations

A Drosophila melanogaster G protein alpha subunit gene is expressed primarily in embryos and pupae.

1988 • 85 citations

A Monoclonal Antibody to the α Subunit of G _k Blocks Muscarinic Activation of Atrial K ⁺ Channels

1988 • 85 citations

Human G_i protein α‐subunit: deduction of amino acid structure from a cloned cDNA

1987 • 85 citations

Turkey erythrocyte membranes as a model for regulation of phospholipase C by guanine nucleotides.

1987 • 85 citations

Control of Aldosterone Production by Angiotensin II Is Mediated by Two Guanine Nucleotide Regulatory Proteins*

1987 • 85 citations

Regulation of hormone-receptor coupling to adenylyl cyclase. Effects of GTP and GDP.

1980 • 85 citations

Inhibition of Adenylate Cyclase by Angiotensin II in Rat Renal Cortex*

1982 • 84 citations

Inhibition of platelet adenylate cyclase by 1-O-alkyl-2-O-acetyl-sn-glyceryl-3-phosphorylcholine (platelet-activating factor).

1982 • 83 citations

Studies on the hepatic alpha 1-adrenergic receptor. Modulation of guanine nucleotide effects by calcium, temperature, and age.

1985 • 82 citations

The kyotorphin (Tyrosine-Arginine) Receptor and a Selective Reconstitution with Purified Gi, Measured with GTPase and Phospholipase C Assays

1989 • 82 citations

Mammalian alpha 1-adrenergic receptor. Purification and characterization of the native receptor ligand binding subunit.

1986 • 81 citations

Hydrodynamic properties of the regulatory component of adenylate cyclase.

1980 • 81 citations

Purification of a beta 35 form of the beta gamma complex common to G-proteins from human placental membranes.

1987 • 81 citations

Neuroblastoma adenylate cyclase. Role of 2-chloroadenosine, prostaglandin E1, and guanine nucleotides in regulation of activity.

1976 • 80 citations

Characterization of transducin from bovine retinal rod outer segments. Mechanism and effects of cholera toxin-catalyzed ADP-ribosylation.

1984 • 79 citations

Recombinant αi-3 Subunit of G Protein Activates Gk-gated K+ Channels

1989 • 79 citations

Vasoactive intestinal polypeptide increases inositol phospholipid breakdown in the rat superior cervical ganglion

1986 • 79 citations

Angiotensin II receptors and inhibitory actions in Leydig cells.

1988 • 79 citations

D-2 Dopamine Receptor-Mediated Inhibition of Adenylate Cyclase Activity in the Intermediate Lobe of the Rat Pituitary Gland Requires Guanosine 5'-Triphosphate

1982 • 78 citations

Insulation of the conduction pathway of muscle transverse tubule calcium channels from the surface charge of bilayer phospholipid.

1986 • 77 citations

Calcitonin gene-related peptide and cyclic AMP stimulate phosphoinositide turnover in skeletal muscle cells

1989 • 76 citations

Hysteretic activation of adenylyl cyclases. II. Mg ion regulation of the activation of the regulatory component as analyzed by reconstitution.

1981 • 75 citations

Secretagogue-induced formation of inositol phosphates in rat exocrine pancreas. Implications for a messenger role for inositol trisphosphate

1984 • 74 citations

The 35- and 36-kDa beta subunits of GTP-binding regulatory proteins are products of separate genes.

1988 • 74 citations

Gonadotropin-Releasing Hormone Stimulates Phospholipid Labeling in Cultured Granulosa Cells*

1982 • 74 citations

Hysteretic activation of adenylyl cyclases. I. Effect of Mg ion on the rate of activation by guanine nucleotides and fluoride.

1981 • 74 citations

Solubilization of the vasopressin receptor from rat liver plasma membranes. Evidence for a receptor X GTP-binding protein complex.

1986 • 73 citations

Hormone receptor-mediated stimulation of adenylyl cyclase systems. Nucleotide effects and analysis in terms of a simple two-state model for the basic receptor-affected enzyme.

1980 • 72 citations

The Stimulation of Adenosine 3‘,5‘-Monophosphate Production by Antidiuretic Factors

1963 • 72 citations

Regulation of thyrotropin-releasing hormone binding by monovalent cations and guanyl nucleotides.

1984 • 72 citations

Serotonin increases the production of inositol phosphates and mobilises calcium via the 5-HT2 receptor in A7r5 smooth muscle cells

1986 • 71 citations

Hormonal inhibition of adenylate cyclase. alpha 2 Adrenergic receptors promote release of [3H]guanylylimidodiphosphate from platelet membranes.

1982 • 71 citations

Shift in the relation between flash‐induced metarhodopsin I and metarhodopsin II within the first 10% rhodopsin bleaching in bovine disc membranes

1981 • 70 citations

Molecular cloning of a new human G protein Evidence for two G_iα‐like protein families

1987 • 70 citations

Angiotensin II inhibits adenylate cyclase from adrenal cortex glomerulosa zone

1983 • 70 citations

Mechanism of guanine nucleotide regulatory protein-mediated inhibition of adenylate cyclase. Studies with isolated subunits of transducin in a reconstituted system.

1986 • 70 citations

Colony-stimulating factor 1-induced Na+ influx into human monocytes involves activation of a pertussis toxin-sensitive GTP-binding protein.

1988 • 69 citations

Mechanism of action of monoclonal antibodies that block the light activation of the guanyl nucleotide-binding protein, transducin.

1987 • 69 citations

Corticotropin-releasing factor stimulates adenylate cyclase activity in the anterior pituitary gland

1982 • 68 citations

H1-Histaminergic activation stimulates inositol-1-phosphate accumulation in chromaffin cells

1986 • 67 citations

Direct demonstration of adrenocorticotropin-induced changes in cytoplasmic free calcium with aequorin in adrenal glomerulosa cell.

1986 • 67 citations

Inhibition by glucagon of the calcium pump in liver plasma membranes.

1984 • 67 citations

Stimulation of Prostaglandin Accumulation by Luteinizing Hormone-Releasing Hormone (LHRH) and LHRH Analogs in Rat Granulosa Cells in Vitro*

1980 • 66 citations

Isolation of GTP-binding proteins from myeloid HL-60 cells. Identification of two pertussis toxin substrates.

1987 • 66 citations

Characterization of Peptide YY Receptors in the Brain

1989 • 65 citations

Effects of angiotensin II on phosphatidylinositol and polyphosphoinositide turnover in rat kidney. Mechanism of prostaglandin release.

1982 • 65 citations

Reconstitution of the purified porcine atrial muscarinic acetylcholine receptor with purified porcine atrial inhibitory guanine nucleotide binding protein

1987 • 63 citations

The α Subunit of the GTP Binding Protein Activates Muscarinic Potassium Channels of the Atrium

1988 • 62 citations

Bradykinin-induced changes in phosphatidyl inositol turnover in cultured rabbit papillary collecting tubule cells.

1985 • 59 citations

Studies on Receptor-mediated Activation of Adenylyl Cyclases

1974 • 58 citations

Molecular cloning and sequence determination of a cDNA coding for the α‐subunit of a G_o‐type protein of Xenopus laevis oocytes

1989 • 57 citations

Studies on Receptor-mediated Activation of Adenylyl Cyclases

1974 • 57 citations

Identification of a new GTP-binding protein. A Mr = 43,000 substrate for pertussis toxin.

1987 • 57 citations

Human Pancreatic Tumor Growth Hormone-Releasing Factor Stimulates Anterior Pituitary Adenylate Cyclase Activity, Adenosine 3′,5′-Monophosphate Accumulation, and Growth Hormone Release in a Calmodulin-Dependent Manner*

1984 • 55 citations

Hormonal regulation of pituitary GH₃ cell K⁺ channels by G_k is mediated by its α‐subunit

1987 • 55 citations

Stimulation of a low Km GTPase by inhibitors of adipocyte adenylate cyclase.

1982 • 53 citations

Characterization of the Dopamine-Responsive Adenylate Cyclase of Bovine Parathyroid Cells and Its Relationship to Parathyroid Hormone Secretion

1980 • 53 citations

Biphasic effects of prostaglandin E2 on the human fat cell adenylate cyclase.

1979 • 52 citations

The stimulatory effect of prostaglandin E₂ on adenyl cyclase in the bovine corpus luteum

1970 • 52 citations

Identification and characterization of leukotriene D4 receptors and signal transduction processes in rat basophilic leukemia cells.

1987 • 50 citations

Effects of angiotensin-II and potassium on phospholipid metabolism in the adrenal zona glomerulosa.

1981 • 49 citations

Regulation of glucagon receptor binding. Lack of effect of Mg and preferential role for GDP.

1985 • 48 citations

Reticulocyte lysates synthesize an active alpha subunit of the stimulatory G protein Gs.

1988 • 48 citations

Detection of α-Transducin in Retinal Rods But Not Cones

1986 • 48 citations

Presence of both beta1- and beta2-adrenergic receptors in a single cell type.

1981 • 48 citations

The G protein beta 2 complementary DNA encodes the beta 35 subunit.

1987 • 47 citations

Acth stimulation of adenyl cyclase in adrenal homogenates

1967 • 43 citations

A monoclonal antibody to guanine nucleotide binding protein inhibits the light-activated cyclic GMP pathway in frog rod outer segments.

1984 • 43 citations

Choleragen-stimulated release of guanyl nucleotides from turkey erythrocyte membranes.

1982 • 43 citations

Treatment of rabbit neutrophils with phorbol esters results in increased ADP‐ribosylation catalyzed by pertussis toxin and inhibition of the GTPase stimulated by fMet‐Leu‐Phe

1986 • 42 citations

Thyrotropin (TSH)-Releasing Hormone Decreases Phosphatidylinositol and Increases Unesterified Arachidonic Acid in Thyrotropic Cells: Possible Early Events in Stimulation of TSH Secretion*

1984 • 42 citations

Effects of Cholecystokinin on Adenylate Cyclase Activity in Dispersed Pancreatic Acinar Cells

1977 • 40 citations

Novel S49 lymphoma variants with aberrant cyclic AMP metabolism.

1981 • 40 citations

The light-activated GTP-dependent cyclic GMP phosphodiesterase complex of bovine retinal rod outer segments. Dark resolution of the catalytic and regulatory proteins.

1981 • 39 citations

The interaction of nucleotides with pertussis toxin. Direct evidence for a nucleotide binding site on the toxin regulating the rate of ADP-ribosylation of Ni, the inhibitory regulatory component of adenylyl cyclase.

1986 • 39 citations

STIMULATION OF PHOSPHATIDIC ACID AND PHOSPHATIDYLINOSITOL LABELING IN LUTEAL CELLS BY LUTEINIZING HORMONE RELEASING HORMONE

1983 • 39 citations

On the relationship between formylmethionyl-leucyl-phenylalanine stimulation of arachidonyl phosphatidylinositol turnover and lysosomal enzyme secretion by rabbit neutrophils.

1981 • 38 citations

Sidedness of reconstituted calcium channels from muscle transverse tubules as determined by D600 and D890 blockade

1986 • 38 citations

Hormone‐stimulated GTPase activity in rat pancreatic plasma membranes

1979 • 37 citations

Effects of substance P on inositol triphosphate accumulation, on contractile responses and on arachidonic acid release and prostaglandin biosynthesis in rabbit iris sphincter muscle

1986 • 35 citations

Cholera toxin inhibits prostaglandin E₁ but not adrenaline‐induced stimulation of GTP hydrolysis in human platelet membranes

1982 • 34 citations

GONADOTROPIN-RELEASING HORMONE STIMULATES PHOSPHATIDYLINOSITOL LABELING AND PROSTAGLANDIN E PRODUCTION IN LEYDIG CELLS

1984 • 32 citations

STIMULATION OF RAT GASTRIC ADENYLATE CYCLASE BY HISTAMINE AND HISTAMINE ANALOGUES AND BLOCKADE BY BURIMAMIDE

1974 • 31 citations

Rapid binding of guanosine 5'-0-(3-thiotriphosphate) to an apparent complex of .beta.-adrenergic receptor and the GTP-binding regulatory protein Gs

1988 • 31 citations

The Impact of Streptozotocin-induced Diabetes Mellitus on Cyclic Nucleotide Regulation of Skeletal Muscle Amino Acid Metabolism in the Rat

1980 • 31 citations

Guanine nucleotides and monovalent cations increase agonist affinity of prostaglandin E2 receptors in hamster adipocytes.

1982 • 30 citations

Action of cholecystokinin and cholinergic agents on membrane-bound calcium in dispersed pancreatic acinar cells.

1976 • 30 citations

On the mode of action of catecholamines on the turkey erythrocyte adenylyl cyclase. Evaluation of basic activity states after removal of endogenous GDP and interpretation of nucleotide regulation and hormone activation in terms of a two-state model.

1980 • 30 citations

The relationship between alpha 1-adrenergic receptor occupation and the mobilization of intracellular calcium.

1984 • 28 citations

Prostaglandins increase GTP hydrolysis by membranes from human mononuclear cells.

1980 • 27 citations

Studies on the mechanism of inhibition of hepatic cAMP accumulation by vasopressin

1983 • 26 citations

Enkephalin-mediated inhibition of forskolin-stimulated rabbit luteal adenylyl cyclase activity

1983 • 25 citations

Prostacyclin Activation of Adenylyl Cyclase in Rabbit Corpus Luteum Membranes: Comparison with 6-Keto Prostaglandin F1α and Prostaglandin E11

1979 • 25 citations

Vasopressin and angiotensin induce inositol lipid breakdown in rat adenohypophysial cells in primary culture

1987 • 24 citations

Effects of Somatostatin on the Hepatic Adenylate Cyclase System in the Rat

1977 • 22 citations

Parallel inactivation of α₂‐adrenergic agonist binding and N_i by alkaline treatment

1985 • 22 citations

Molecular mechanisms of signal transduction

2000 • 22 citations

Modulation of Ovarian Adenylate Cyclase Response to Gonadotropins Following Luteinization of the Rat Ovary

1977 • 19 citations

Sucrose-gap recordings of nerve-evoked potentials in mammalian parasympathetic ganglia

1981 • 18 citations

Adenylate cyclase inhibition by hormones

1983 • 17 citations

Correction

1989 • 7 citations

POLYPEPTIDE AND PROTEIN HORMONES

1966 • 1 citations