A role for Gi in control of thrombin receptor-phospholipase C coupling in human platelets.

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

The role of protein kinase C in cell surface signal transduction and tumour promotion

1984 • 7,521 citations

Direct activation of calcium-activated, phospholipid-dependent protein kinase by tumor-promoting phorbol esters.

1982 • 4,786 citations

Inositol trisphosphate and diacylglycerol as second messengers

1984 • 3,535 citations

Inositol phospholipids and cell surface receptor function

1975 • 2,458 citations

Role of guanine nucleotide binding protein in the activation of polyphosphoinositide phosphodiesterase

1985 • 960 citations

Direct modification of the membrane adenylate cyclase system by islet-activating protein due to ADP-ribosylation of a membrane protein.

1982 • 808 citations

ADP ribosylation of the specific membrane protein of C6 cells by islet-activating protein associated with modification of adenylate cyclase activity.

1982 • 600 citations

Chemoattractant receptor-induced hydrolysis of phosphatidylinositol 4,5-bisphosphate in human polymorphonuclear leukocyte membranes. Requirement for a guanine nucleotide regulatory protein.

1985 • 358 citations

Antibodies directed against synthetic peptides distinguish between GTP-binding proteins in neutrophil and brain.

1987 • 356 citations

The rapid formation of inositol phosphates in human platelets by thrombin is inhibited by prostacyclin.

1984 • 319 citations

Two guanine nucleotide-binding proteins in rat brain serving as the specific substrate of islet-activating protein, pertussis toxin. Interaction of the alpha-subunits with beta gamma-subunits in development of their biological activities.

1986 • 315 citations

Mass changes in myoinositol trisphosphate in human platelets stimulated by thrombin. Inhibitory effects of phorbol ester.

1985 • 292 citations

Pertussis toxin does not inhibit muscarinic-receptor-mediated phosphoinositide hydrolysis or calcium mobilization

1985 • 284 citations

Regulation of the phosphoinositide hydrolysis pathway in thrombin-stimulated platelets by a pertussis toxin-sensitive guanine nucleotide-binding protein. Evaluation of its contribution to platelet activation and comparisons with the adenylate cyclase inhibitory protein, Gi.

1986 • 235 citations

1,2-Diacylglycerol and phorbol ester inhibit agonist-induced formation of inositol phosphates in human platelets: possible implications for negative feedback regulation of inositol phospholipid hydrolysis.

1985 • 222 citations

Evidence that Na+/H+ exchange regulates receptor-mediated phospholipase A2 activation in human platelets.

1986 • 196 citations

Phorbol myristate acetate inhibits thrombin-stimulated Ca2+ mobilization and phosphatidylinositol 4,5-bisphosphate hydrolysis in human platelets.

1985 • 179 citations

Evidence suggesting that a novel guanine nucleotide regulatory protein couples receptors to phospholipase C in exocrine pancreas

1986 • 177 citations

Thyrotropin-releasing hormone and GTP activate inositol trisphosphate formation in membranes isolated from rat pituitary cells.

1986 • 169 citations

Characterization of α2-adrenergic receptors on human platelets using [3H]yohimbine

1980 • 166 citations

Inhibitors of Na+/H+ exchange block epinephrine- and ADP-induced stimulation of human platelet phospholipase C by blockade of arachidonic acid release at a prior step.

1986 • 158 citations

Guanine nucleotides stimulate production of inositol trisphosphate in rat cortical membranes

1985 • 125 citations

Guanine nucleotides stimulate soluble phosphoinositide-specific phospholipase C in the absence of membranes.

1986 • 116 citations

The effects of alpha adrenergic agents on human platelet aggregation.

1979 • 112 citations

Counteraction of Calcium-Activated, Phospholipid-Dependent Protein Kinase Activation by Adenosine 3′,5′-Monophosphate and Guanosine 3′,5′-Monophosphate in Platelets1

1982 • 110 citations

Demonstration of cGMP‐dependent protein kinase and cGMP‐dependent phosphorylation in cell‐free extracts of platelets

1986 • 102 citations

Platelet activating factor raises intracellular calcium ion concentration in macrophages.

1986 • 101 citations

Regulation of membrane-associated and cytosolic phospholipase C activities in human platelets by guanosine triphosphate.

1986 • 98 citations

Islet‐activating protein, pertussis toxin, inhibits Ca²⁺‐induced and guanine nucleotide‐dependent releases of histamine and arachidonic acid from rat mast cells

1984 • 96 citations

A guanine nucleotide-dependent regulatory protein couples substance P receptors to phospholipase C in rat parotid gland

1986 • 95 citations

Modified platelet responses to thrombin. Evidence for two types of receptors or coupling mechanisms.

1986 • 94 citations

Ni-mediated inhibition of human platelet adenylate cyclase by thrombin

1984 • 94 citations

Positive Interaction between Agonists in the Aggregation Response of Human Blood Platelets: Interaction between ADP, Adrenaline and Vasopressin

1980 • 75 citations

Conformations of the alpha 39, alpha 41, and beta.gamma components of brain guanine nucleotide-binding proteins. Analysis by limited proteolysis.

1986 • 55 citations

Evidence for two GTPases activated by thrombin in membranes of human platelets

1986 • 52 citations

Leukotriene B₄ stimulation of phosphatidylinositol turnover in macrophages and inhibition by pertussis toxin

1986 • 50 citations

Islet-activating protein impairs ? 2-adrenoceptor-mediated inhibitory regulation of human platelet adenylate cyclase

1983 • 47 citations

Guanine nucleotide binding protein involved in muscarinic responses in the pig coronary artery is insensitive to islet-activating protein

1986 • 46 citations

Treatment of human platelets with trypsin, thrombin, or collagen inhibits the pertussis toxin-induced ADP-ribosylation of a 41-kDa protein.

1986 • 43 citations

Effect of pertussis toxin on the phosphodiesteratic cleavage of the polyphosphoinositides by guanosine 5′-O-thiotriphosphate and thrombin in permeabilized human platelets

1986 • 41 citations

Synergistic potentiation of 5-hydroxytryptamine secretion by platelet agonists and phorbol myristate acetate despite inhibition of agonist-induced arachidonate/thromboxane and β-thromboglobulin release and Ca2+ mobilization by phorbol myristate acetate

1986 • 40 citations

GTP and cytosol stimulate phosphoinositide hydrolysis in isolated platelet membranes

1986 • 37 citations

Phosphorylation of the 47 KDa protein in gamma-thrombin-stimulated human platelets does not activate phospholipase A2: Evidence against lipocortin

1986 • 24 citations