Islet-activating protein. A modifier of receptor-mediated regulation of rat islet adenylate cyclase.

PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT

1951 • 319,299 citations

Method for the Isolation of Intact Islets of Langerhans from the Rat Pancreas

1967 • 2,783 citations

The role of hormone receptors and GTP-regulatory proteins in membrane transduction

1980 • 1,750 citations

An ultrasensitive method for the simultaneous determination of cyclic AMP and cyclic GMP in small-volume samples from blood and tissue

1977 • 679 citations

Two distinct adenosine-sensitive sites on adenylate cyclase.

1977 • 574 citations

Mechanism of adenylate cyclase activation through the beta-adrenergic receptor: catecholamine-induced displacement of bound GDP by GTP.

1978 • 372 citations

Modification by islet-activating protein of receptor-mediated regulation of cyclic AMP accumulation in isolated rat heart cells.

1981 • 326 citations

Regulation of adenylate cyclase of neuroblastoma x glioma hybrid cells by alpha-adrenergic receptors. I. Inhibition of adenylate cyclase mediated by alpha receptors.

1979 • 288 citations

Adenosine analogs inhibit adipocyte adenylate cyclase by a GTP-dependent process: basis for actions of adenosine and methylxanthines on cyclic AMP production and lipolysis.

1978 • 253 citations

Coupling of opiate receptors to adenylate cyclase: requirement for Na+ and GTP.

1979 • 200 citations

Islet-activating protein. Enhanced insulin secretion and cyclic AMP accumulation in pancreatic islets due to activation of native calcium ionophores.

1979 • 193 citations

Adenylate Cyclase in Islets of Langerhans

1973 • 178 citations

GTP-dependent inhibition of cardiac adenylate cyclase by muscarinic cholinergic agonists

1979 • 178 citations

Islets-Activating Protein (IAP) in Bordetella pertussis that Potentiates Insulin Secretory Responses of Rats

1978 • 178 citations

The fat cell adenylate cyclase system. Characterization and manipulation of its bimodal regulation by GTP.

1979 • 171 citations

Reconstitution of catecholamine-sensitive adenylate cyclase. Reconstitution of the uncoupled variant of the S40 lymphoma cell.

1979 • 171 citations

Glucagon Receptors in β-Cells

1972 • 145 citations

Slow interaction of islet-activating protein with pancreatic islets during primary culture to cause reversal of alpha-adrenergic inhibition of insulin secretion.

1980 • 143 citations

Inhibition of platelet adenylate cyclase by epinephrine requires GTP

1978 • 123 citations

Biological Properties of Islets-Activating Protein (IAP) Purified from the Culture Medium of Bordetella pertussis

1978 • 117 citations

Regulation of human platelet adenylate cyclase by epinephrine, prostaglandin E1, and guanine nucleotides. Evidence for separate guanine nucleotide sites mediating stimulation and inhibition.

1979 • 108 citations

Regulation of adenylate cyclase activity in hamster adipocytes

1980 • 101 citations

Determination of the turn-off reaction for the hormone-activated adenylate cyclase.

1979 • 98 citations

Inhibition of hamster fat cell adenylate cyclase by prostaglandin E₁ and epinephrine: Requirement for GTP and sodium ions

1979 • 97 citations

Transient and steady state kinetics of the interaction of guanyl nucleotides with the adenylyl cyclase system from rat liver plasma membranes. Interpretation in terms of a simple two-state model.

1980 • 92 citations

Adenylate cyclase activity in isolated rat islets of Langerhans Effects of agents which alter rates of insulin secretion

1973 • 86 citations

Adenosine and the regulation of insulin secretion by isolated rat islets of Langerhans

1977 • 59 citations

Guanyl nucleotide regulation of hormonally-responsive adenylyl cyclases

1979 • 59 citations

Nicotinic acid inhibits adipocyte adenylate cyclase in a hormone—like manner

1980 • 53 citations

Effect of in Vivo Pretreatment of Rats with a New Protein Purified fromBordetellapertussis onin VitroSecretion of Insulin: Role of Calcium

1979 • 45 citations

Different inhibitory effect of adrenaline on platelet adenylate cyclase in the presence of GTP plus cholera toxin and of stable GTP analogues

1979 • 44 citations

Regulation of platelet adenylate cyclase by adenosine

1979 • 43 citations

Specific Mg2+ and adenosine sites involved in a bireactant mechanism for adenylate cyclase inhibition and their probable localization on this enzyme's catalytic component

1979 • 41 citations

Insulin release from mouse islets. Effect of glucose and hormones on adenylate cyclase

1972 • 41 citations

A two-state model of an enzyme with an allosteric regulatory site capable of metabolizing the regulatory ligand. Simplified mathematical treatments of transient and steady state kinetics of an activator and its competitive inhibition as applied to adenylyl cyclases.

1980 • 33 citations

Regulation of adenylyl cyclase from isolated pancreatic islets by prostaglandins and guanosine 5'-triphosphate

1974 • 33 citations

Effects of cholera toxin on adenylate cyclase. Studies with guanylylimidodiphosphate.

1975 • 26 citations

Inhibitory effect of guanyl nucleotides toward adenylate cyclase activity of Chinese hamster ovary cell membranes activated in vitro by cholera toxin.

1979 • 22 citations

[5] Isolation of cyclic AMP by inorganic salt coprecipitation

1974 • 13 citations

Effects of guanosine on insulin secretion and adenylyl and guanylyl cyclase activities of isolated rat islets of Langerhans

1977 • 10 citations