Transient and steady state kinetics of the interaction of guanyl nucleotides with the adenylyl cyclase system from rat liver plasma membranes. Interpretation in terms of a simple two-state model.

PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT

1951 • 319,299 citations

A highly sensitive adenylate cyclase assay

1974 • 4,213 citations

Mechanism of cholera toxin action: Covalent modification of the guanyl nucleotide-binding protein of the adenylate cyclase system

1978 • 902 citations

Isolation of an organ specific protein antigen from cell-surface membrane rat liver

1968 • 883 citations

ADP-ribosylation of membrane proteins catalyzed by cholera toxin: basis of the activation of adenylate cyclase.

1978 • 732 citations

Mechanism of adenylate cyclase activation by cholera toxin: Inhibition of GTP hydrolysis at the regulatory site

1977 • 726 citations

Catecholamine-stimulated GTPase activity in turkey erythrocyte membranes

1976 • 623 citations

The enzymatic preparation of [α-32P]nucleoside triphosphates, cyclic [32P]AMP, and cyclic [32P]GMP

1979 • 574 citations

The Glucagon-sensitive Adenyl Cyclase System in Plasma Membranes of Rat Liver

1971 • 519 citations

Relationship between the beta-adrenergic receptor and adenylate cyclase.

1977 • 497 citations

Mechanism of adenylate cyclase activation through the beta-adrenergic receptor: catecholamine-induced displacement of bound GDP by GTP.

1978 • 372 citations

Hormone-stimulated desensitization of hormone-dependent adenylyl cyclase. Dual action of luteninizing hormone on pig graafian follicle membranes.

1976 • 244 citations

5′-Guanylylimidodiphosphate, A Potent Activator of Adenylate Cyclase Systems in Eukaryotic Cells

1974 • 244 citations

A persistent active state of the adenylate cyclase system produced by the combined actions of isoproterenol and guanylyl imidodiphosphate in frog erythrocyte membranes.

1975 • 221 citations

The hepatic adenylate cyclase system. I. Evidence for transition states and structural requirements for guanine nucloetide activiation

1975 • 171 citations

Evidence for distinct guanine nucleotide sites in the regulation of the glucagon receptor and of adenylate cyclase activity.

1977 • 168 citations

Detergent-dispersed Adenylate Cyclase from Rat Brain

1973 • 155 citations

Metal and metal-ATP interactions with brain and cardiac adenylate cyclases.

1975 • 145 citations

GTP stimulates and inhibits adenylate cyclase in fat cell membranes through distinct regulatory processes.

1977 • 120 citations

Activation of the hepatic adenylate cyclase system by divalent cations.

1977 • 120 citations

Solubilization and separation of the glucagon receptor and adenylate cyclase in guanine nucleotide-sensitive states.

1977 • 113 citations

On the mechanism of activation of fat cell adenylate cyclase by guanine nucleotides. An explanation for the biphasic inhibitory and stimulatory effects of the nucleotides and the role of hormones.

1975 • 106 citations

Altered guanine nucleotide hydrolysis as basis for increased adenylate cyclase activity after cholera toxin treatment.

1977 • 92 citations

Synergistic activation of adenylate cyclase by guanylyl imidophosphate and epinephrine

1976 • 91 citations

The hepatic adenylate cyclase system. III. A mathematical model for the steady state kinetics of catalysis and nucleotide regulation

1975 • 84 citations

Neuroblastoma adenylate cyclase. Role of 2-chloroadenosine, prostaglandin E1, and guanine nucleotides in regulation of activity.

1976 • 80 citations

The hepatic adenylate cyclase system. II. Substrate binding and utilization and the effects of magnesium ion and pH

1975 • 74 citations

Influence of cholera toxin on the regulation of adenylate cyclase by GTP

1977 • 71 citations

Coupling of glucagon receptor to adenylyl cyclase. Requirement of a receptor-related guanyl nucleotide binding site for coupling of receptor to the enzyme.

1979 • 57 citations

Activation of hepatic adenylate cyclase by guanyl nucleotides. Modeling of the transient kinetics suggests an “excited” state of GTPase is a control component of the system.

1977 • 45 citations

Coupling of the glucagon receptor to adenylyl cyclase by GDP: evidence for two levels of regulation of adenylyl cyclase.

1979 • 43 citations

Improved methods for determination of guanylyl cyclase activity and synthesis of [α-32P]GTP

1979 • 37 citations

A two-state model of an enzyme with an allosteric regulatory site capable of metabolizing the regulatory ligand. Simplified mathematical treatments of transient and steady state kinetics of an activator and its competitive inhibition as applied to adenylyl cyclases.

1980 • 33 citations

Adenylate cyclase from Fasciola hepatica. 2. Role of guanine nucleotides in coupling adenylate cyclase and serotonin receptors.

1978 • 26 citations

Prostacyclin Activation of Adenylyl Cyclase in Rabbit Corpus Luteum Membranes: Comparison with 6-Keto Prostaglandin F1α and Prostaglandin E11

1979 • 25 citations

Regulation of hepatic adenylate cyclase by glucagon, GTP, divalent cations, and adenosine

1976 • 25 citations

Studies on Receptor-mediated Activation of Adenylyl Cyclases

1974 • 23 citations

Reversible activation of hepatic adenylate cyclase by guanyl-5'-yl-(alpha,beta-methylene)diphosphonate and guanyl-5'-yl imidodiphosphate.

1977 • 22 citations