The βγ subunits of GTP-binding proteins activate the muscarinic K+ channel in heart

Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches

1981 • 18,584 citations

Single-Channel Recording

1995 • 2,565 citations

Isolation of two proteins with high affinity for guanine nucleotides from membranes of bovine brain.

1984 • 1,300 citations

Fitting and Statistical Analysis of Single-Channel Records

1983 • 1,098 citations

GTP-binding proteins couple cardiac muscarinic receptors to a K channel

1985 • 868 citations

Direct modification of the membrane adenylate cyclase system by islet-activating protein due to ADP-ribosylation of a membrane protein.

1982 • 808 citations

Purification and properties of the inhibitory guanine nucleotide regulatory unit of brain adenylate cyclase.

1984 • 585 citations

Identification of the predominant substrate for ADP-ribosylation by islet activating protein.

1983 • 583 citations

The guanine nucleotide activating site of the regulatory component of adenylate cyclase. Identification by ligand binding.

1982 • 542 citations

Uncoupling of cardiac muscarinic and β-adrenergic receptors from ion channels by a guanine nucleotide analogue

1985 • 527 citations

On the mechanism of activation of muscarinic K+ channels by adenosine in isolated atrial cells: involvement of GTP-binding proteins

1986 • 510 citations

Acetylcholine activation of single muscarinic K+ channels in isolated pacemaker cells of the mammalian heart

1983 • 471 citations

Mode of regulation of the ACh-sensitive K-channel by the muscarinic receptor in rabbit atrial cells

1984 • 436 citations

Über humorale Übertragbarkeit der Herznervenwirkung

1926 • 253 citations

The purified alpha subunits of Go and Gi from bovine brain require beta gamma for association with phospholipid vesicles.

1986 • 253 citations

Zum Mechanismus der Membranwirkung des Acetylcholin an der Herzmuskelfaser

1958 • 247 citations

Physical and immunological characterization of a guanine nucleotide-binding protein purified from bovine cerebral cortex.

1985 • 205 citations

GTP-binding proteins: One molecular machine can transduce diverse signals

1986 • 157 citations

Effects of guanine nucleotides and Mg on human erythrocyte Ni and Ns, the regulatory components of adenylyl cyclase.

1984 • 144 citations

Atriopeptin II decreases cytosolic free Ca in cultured vascular smooth muscle cells

1986 • 135 citations

Subunit interactions of native and ADP-ribosylated alpha 39 and alpha 41, two guanine nucleotide-binding proteins from bovine cerebral cortex.

1986 • 116 citations

Characterization by two-dimensional peptide mapping of the gamma subunits of Ns and Ni, the regulatory proteins of adenylyl cyclase, and of transducin, the guanine nucleotide-binding protein of rod outer segments of the eye.

1985 • 114 citations

Altered activity of the inhibitory guanyl nucleotide-binding component (Ni) induced by pertussis toxin. Uncoupling of Ni from receptor with continued coupling of Ni to the catalytic unit.

1984 • 100 citations

Role of intracellular Mg2+ in the activation of muscarinic K+ channel in cardiac atrial cell membrane

1986 • 77 citations

Hormonal inhibition of adenylate cyclase. alpha 2 Adrenergic receptors promote release of [3H]guanylylimidodiphosphate from platelet membranes.

1982 • 71 citations

Development of muscarinic cholinergic inhibition of adenylate cyclase in embryonic chick heart. Its relationship to changes in the inhibitory guanine nucleotide regulatory protein.

1986 • 68 citations

ISLET-ACTIVATING PROTEIN, PERTUSSIS TOXIN: SUBUNIT STRUCTURE AND MECHANISM FOR ITS MULTIPLE BIOLOGICAL ACTIONS

1985 • 24 citations

[1] A buffer system for amino acid analyzers with automatic integrators

1983 • 15 citations

STRUCTURAL AND FUNCTIONAL PROPERTIES OF NS AND Ni, THE REGULATORY COMPONENTS OF ADENYLYL CYCLASES

1985 • 4 citations

Resolution of Agonists and Gpp(NH)p Mediated Adenylate Cyclase Inhibition with Pertussis Toxin

1985 • 2 citations