Identification and characterization of leukotriene D4 receptors and signal transduction processes in rat basophilic leukemia cells.

A Rapid and Sensitive Method for the Quantitation of Microgram Quantities of Protein Utilizing the Principle of Protein-Dye Binding

1976 • 225,752 citations

A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

1976 • 200,127 citations

THE ATTRACTIONS OF PROTEINS FOR SMALL MOLECULES AND IONS

1949 • 19,979 citations

Relationship between the inhibition constant (KI) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction

1973 • 12,522 citations

Inositol trisphosphate and diacylglycerol as second messengers

1984 • 3,535 citations

The role of hormone receptors and GTP-regulatory proteins in membrane transduction

1980 • 1,750 citations

A ternary complex model explains the agonist-specific binding properties of the adenylate cyclase-coupled beta-adrenergic receptor.

1980 • 1,579 citations

Leukotriene C: a slow-reacting substance from murine mastocytoma cells.

1979 • 992 citations

Leukotrienes are potent constrictors of human bronchi

1980 • 984 citations

The inositol tris/tetrakisphosphate pathway—demonstration of Ins(l,4,5)P3 3-kinase activity in animal tissues

1986 • 702 citations

Simultaneous inhibitions of inositol phospholipid breakdown, arachidonic acid release, and histamine secretion in mast cells by islet-activating protein, pertussis toxin. A possible involvement of the toxin-specific substrate in the Ca2+-mobilizing receptor-mediated biosignaling system.

1985 • 509 citations

Slow reacting substances of anaphylaxis: Identification of leukotrienes C-1 and D from human and rat sources

1980 • 433 citations

Rapid accumulation of inositol phosphates in isolated rat superior cervical sympathetic ganglia exposed to V1-vasopressin and muscarinic cholinergic stimuli

1984 • 224 citations

Calcium stimulation of a novel lipoxygenase

1980 • 179 citations

Isolation and characterization of the inositol cyclic phosphate products of polyphosphoinositide cleavage by phospholipase C. Physiological effects in permeabilized platelets and Limulus photoreceptor cells.

1985 • 167 citations

In vitro and in vivo mechanisms of leukotriene-mediated bronchoconstriction in the guinea pig.

1982 • 146 citations

Characterization of a leukotriene D4 receptor in guinea pig lung.

1983 • 105 citations

Leukotriene C4 binding to rat lung membranes.

1983 • 97 citations

Leukotriene D4 treatment of bovine aortic endothelial cells and murine smooth muscle cells in culture results in an increase in phospholipase A2 activity.

1986 • 90 citations

Purification of a mammalian 5-lipoxygenase from rat basophilic leukemia cells

1985 • 89 citations

Binding of leukotrienes C4 and D4 to membranes from guinea pig lung: Regulation by ions and gaunine nucleotides

1983 • 83 citations

THE EFFECT OF LEUKOTRIENE C₄ ON MUCIN RELEASE INTO THE CAT TRACHEA in vivo AND in vitro

1982 • 82 citations

Molecular heterogeneity of leukotriene receptors: correlation of smooth muscle contraction and radioligand binding in guinea-pig lung.

1985 • 69 citations

Characterization of the leukotriene D4 receptor in guinea-pig lung

1984 • 66 citations

Specific receptors for leukotriene C4 on a smooth muscle cell line.

1983 • 66 citations

Effects of leukotrienes on isolated guinea-pig pulmonary arteries

1981 • 65 citations

Tissue distribution and functional correlation of [3H]leukotriene C4 and [3H]leukotriene D4 binding sites in guinea-pig uterus and lung preparations.

1985 • 63 citations

Contraction of guinea pig uterus by synthetic leukotrienes

1982 • 61 citations

Identification and characterization of leukotriene D4 receptors in adult and fetal human lung

1985 • 56 citations

Islet-activating protein inhibits leukotriene D4- and leukotriene C4- but not bradykinin- or calcium ionophore-induced prostacyclin synthesis in bovine endothelial cells.

1986 • 49 citations

Leukotriene E4 binds specifically to LTD4 receptors in guinea pig lung membranes

1985 • 47 citations

Regulation of ligand binding to leukotriene D4 receptors: effects of cations and guanine nucleotides

1984 • 46 citations

Identification of leukotriene D4 receptor binding sites in guinea pig lung homogenates using [3H]leukotriene D4

1984 • 36 citations

Specific binding of leukotriene C4 to ileal segments and subcellular fractions of ileal smooth muscle cells.

1984 • 33 citations

Effect of the serine-borate complex on the relative ability of leukotriene C4, D4 and E4 to inhibit lung and brain [3H]leukotriene D4 and [3H]leukotriene C4 binding: Demonstration of the agonists' potency order for leukotriene D4 and leukotriene C4 receptors

1984 • 29 citations

Leukotriene C₄‐induced cyclic nucleotide changes and contractile response in guinea pig trachea

1982 • 29 citations

The binding of leukotriene C4 and leukotriene D4 to membranes of a smooth muscles cell line (BC3H1) and evidence that leukotriene induced contraction in these cells is mediated by thromboxane, protein and RNA syntheses

1985 • 26 citations

Evidence for a similar receptor site for binding of [3H]leukotriene E4 and [3H]leukotriene D4 to the guinea-pig crude lung membrane

1984 • 25 citations

Synthesis and pharmacological characterization of 5-(2-dodecylphenyl)-4,6-dithianonanedioic acid and 5-[2-(8-phenyloctyl)phenyl]-4,6-dithianonanedioic acid: prototypes of a novel class of leukotriene antagonists

1985 • 23 citations

Leukotriene C4 ([3H] - LTC4) binding to membranes isolated from a hamster smooth muscle cell line (DDTIMF2)

1984 • 22 citations

Characterization of [3H]leukotriene D4 binding sites in guinea-pig ventricular myocardium.

1985 • 20 citations

Characterization of specific receptors for leukotriene D4 on human alveolar macrophages

1984 • 20 citations

Solubilization of [3H]leukotriene D4 receptor complex from guinea pig lung membranes.

1986 • 16 citations

Differential effects of methacholine and leukotriene D4 on cyclic nucleotide content and isoproterenol-induced relaxation in the opossum trachea.

1986 • 14 citations