GTP hydrolysis by pure Ni, the inhibitory regulatory component of adenylyl cyclases.

Mechanism of cholera toxin action: Covalent modification of the guanyl nucleotide-binding protein of the adenylate cyclase system

1978 • 902 citations

Direct modification of the membrane adenylate cyclase system by islet-activating protein due to ADP-ribosylation of a membrane protein.

1982 • 808 citations

ADP-ribosylation of membrane proteins catalyzed by cholera toxin: basis of the activation of adenylate cyclase.

1978 • 732 citations

Mechanism of adenylate cyclase activation by cholera toxin: Inhibition of GTP hydrolysis at the regulatory site

1977 • 726 citations

Catecholamine-stimulated GTPase activity in turkey erythrocyte membranes

1976 • 623 citations

Aluminum: a requirement for activation of the regulatory component of adenylate cyclase by fluoride.

1982 • 618 citations

Identification of the predominant substrate for ADP-ribosylation by islet activating protein.

1983 • 583 citations

The enzymatic preparation of [α-32P]nucleoside triphosphates, cyclic [32P]AMP, and cyclic [32P]GMP

1979 • 574 citations

The guanine nucleotide activating site of the regulatory component of adenylate cyclase. Identification by ligand binding.

1982 • 542 citations

Purification of the regulatory component of adenylate cyclase.

1980 • 497 citations

Loss of the inhibitory function of the guanine nucleotide regulatory component of adenylate cyclase due to its ADP ribosylation by islet-activating protein, pertussis toxin, in adipocyte membranes.

1983 • 406 citations

Stimulation and inhibition of adenylyl cyclases mediated by distinct regulatory proteins

1983 • 309 citations

Islet-activating protein. A modifier of receptor-mediated regulation of rat islet adenylate cyclase.

1981 • 257 citations

Mammalian .beta.2-adrenergic receptor: reconstitution of functional interactions between pure receptor and pure stimulatory nucleotide binding protein of the adenylate cyclase system

1984 • 249 citations

5′-Guanylylimidodiphosphate, A Potent Activator of Adenylate Cyclase Systems in Eukaryotic Cells

1974 • 244 citations

Ns and Ni, the stimulatory and inhibitory regulatory components of adenylyl cyclases. Purification of the human erythrocyte proteins without the use of activating regulatory ligands.

1984 • 242 citations

Pertussis toxin substrate, the putative Ni component of adenylyl cyclases, is an alpha beta heterodimer regulated by guanine nucleotide and magnesium.

1983 • 237 citations

Identification of a gamma subunit associated with the adenylyl cyclase regulatory proteins Ns and Ni.

1984 • 214 citations

A nucleotide regulatory site for somatostatin inhibition of adenylate cyclase in S49 lymphoma cells

1983 • 200 citations

Pertussis toxin inhibits enkephalin stimulation of GTPase of NG108-15 cells.

1983 • 187 citations

Rhodopsin-enhanced GTPase activity of the inhibitory GTP-binding protein of adenylate cyclase.

1984 • 166 citations

Guanine nucleotide inhibition of cyc- S49 mouse lymphoma cell membrane adenylyl cyclase.

1982 • 151 citations

Effects of guanine nucleotides and Mg on human erythrocyte Ni and Ns, the regulatory components of adenylyl cyclase.

1984 • 144 citations

Modulation of sodium-sensitive GTPase by partial opiate agonists. An explanation for the dual requirement for Na+ and GTP in inhibitory regulation of adenylate cyclase.

1982 • 125 citations

Epinephrine inhibits adenylate cyclase and stimulates a GTPase in human platelet membranes vis α‐adrenoceptors

1981 • 113 citations

On the mechanism of activation of fat cell adenylate cyclase by guanine nucleotides. An explanation for the biphasic inhibitory and stimulatory effects of the nucleotides and the role of hormones.

1975 • 106 citations

Functional reconstitution of beta-adrenergic receptors and the stimulatory GTP-binding protein of adenylate cyclase.

1982 • 100 citations

Transient and steady state kinetics of the interaction of guanyl nucleotides with the adenylyl cyclase system from rat liver plasma membranes. Interpretation in terms of a simple two-state model.

1980 • 92 citations

Hormone receptor-mediated stimulation of adenylyl cyclase systems. Nucleotide effects and analysis in terms of a simple two-state model for the basic receptor-affected enzyme.

1980 • 72 citations

Occurrence of an Inhibitory Guanine Nucleotide‐Binding Regulatory Component of the Adenylate Cyclase System in cyc⁻ Variants of S49 Lymphoma Cells

1983 • 69 citations

Inhibitory regulation of adenylyl cyclase in the absence of stimulatory regulation. Requirements and kinetics of guanine nucleotide-induced inhibition of the cyc- S49 adenylyl cyclase.

1983 • 65 citations

Activation and desensitization of beta-adrenergic receptor-coupled GTPase and adenylate cyclase of frog and turkey erythrocyte membranes.

1980 • 60 citations

Islet‐activating protein prevents nicotinic acid‐induced GTPase stimulation and GTP but not GTPγS‐induced adenylate cyclase inhibition in rat adipocytes

1983 • 56 citations

Forskolin regulation of liver membrane adenylyl cyclase

1983 • 45 citations

Hormone‐stimulated GTPase activity in rat pancreatic plasma membranes

1979 • 37 citations

Cholera toxin inhibits prostaglandin E₁ but not adrenaline‐induced stimulation of GTP hydrolysis in human platelet membranes

1982 • 34 citations

A two-state model of an enzyme with an allosteric regulatory site capable of metabolizing the regulatory ligand. Simplified mathematical treatments of transient and steady state kinetics of an activator and its competitive inhibition as applied to adenylyl cyclases.

1980 • 33 citations