A quantitative analysis of beta-adrenergic receptor interactions: resolution of high and low affinity states of the receptor by computer modeling of ligand binding data.

PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT

1951 • 319,299 citations

Comparison of Experimental Binding Data and Theoretical Models in Proteins Containing Subunits^*

1966 • 2,956 citations

Simultaneous analysis of families of sigmoidal curves: application to bioassay, radioligand assay, and physiological dose-response curves.

1978 • 2,400 citations

The binding of agonists to brain muscarinic receptors.

1978 • 656 citations

Mathematical theory of complex ligand-binding systems at equilibrium: Some methods for parameter fitting

1972 • 615 citations

Properties of [3H]haloperidol and [3H]dopamine binding associated with dopamine receptors in calf brain membranes.

1976 • 480 citations

On the application of “a plausible model” of allosteric proteins to the receptor for acetylcholine

1967 • 425 citations

An agonist-specific effect of guanine nucleotides on binding to the beta adrenergic receptor.

1976 • 318 citations

Regulation of beta-adrenergic receptors by guanyl-5'-yl imidodiphosphate and other purine nucleotides.

1976 • 314 citations

The mobile receptor hypothesis and “cooperativity” of hormone binding. Application to insulin

1976 • 258 citations

5′-Guanylylimidodiphosphate, A Potent Activator of Adenylate Cyclase Systems in Eukaryotic Cells

1974 • 244 citations

Slowly reversible binding of catecholamine to a nucleotide-sensitive state of the beta-adrenergic receptor.

1977 • 228 citations

Quantitative resolution of beta-adrenergic receptor subtypes by selective ligand binding: application of a computerized model fitting technique.

1979 • 220 citations

The Relation between Classical and Cooperative Models for Drug Action

1973 • 194 citations

Adenylate cyclase permanently uncoupled from hormone receptors in a novel variant of S49 mouse lymphoma cells.

1977 • 173 citations

Magnesium dependence of agonist binding to adenylate cyclase-coupled hormone receptors.

1978 • 158 citations

Regulation of adenylate cyclase-coupled beta adrenergic receptor binding sites by beta adrenergic catecholamines in vitro.

1976 • 119 citations

The agonist-specific effect of magnesium ion on binding by beta-adrenergic receptors in S49 lymphoma cells. Interaction of GTP and magnesium in adenylate cyclase activation.

1978 • 111 citations

Structure-activity relationships of adenylate cyclase-coupled beta adrenergic receptors: determination by direct binding studies.

1976 • 100 citations

On the analysis of pharmacological experiments in terms of an allosteric receptor model.

1973 • 99 citations

Effects of GTP on binding of (3H) glucagon to receptors in rat hepatic plasma membranes.

1977 • 91 citations

Differences between agonist and antagonist binding following beta-adrenergic receptor desensitization.

1978 • 84 citations

[1] Theory of protein-ligand interaction

1975 • 81 citations

Quantitative analysis of the binding of ligands to their receptors

1975 • 81 citations

Radioligand binding to beta adrenergic receptors of intact cultured S49 cells.

1978 • 75 citations

Regulation of beta adrenergic receptors in isolated frog erythrocyte plasma membranes.

1977 • 61 citations

Efficiency of coupling between the beta adrenergic receptor and adenylate cyclase.

1978 • 53 citations

Ligand binding to dopamine-receptors: Analysis & interpretation

1978 • 12 citations