Bimodal regulation of adenylate cyclase

The role of hormone receptors and GTP-regulatory proteins in membrane transduction

1980 • 1,750 citations

Biochemical Properties of Hormone-Sensitive Adenylate Cyclase

1980 • 1,016 citations

Dual regulation of adenylate cyclase accounts for narcotic dependence and tolerance.

1975 • 663 citations

Adenyl Cyclase

1962 • 555 citations

Opiate Receptor Binding of Agonists and Antagonists Affected Differentially by Sodium

1974 • 554 citations

Morphine-like drugs inhibit the stimulation by E prostaglandins of cyclic AMP formation by rat brain homogenate

1974 • 373 citations

Activation and attenuation of adenylate cyclase. The role of GTP-binding proteins as macromolecular messengers in receptor–cyclase coupling

1981 • 322 citations

Effects of Adenosine Nucleosides on Adenylate Cyclase, Phosphodiesterase, Cyclic Adenosine Monophosphate Accumulation, and Lipolysis in Fat Cells

1972 • 321 citations

Regulation of adenylate cyclase of neuroblastoma x glioma hybrid cells by alpha-adrenergic receptors. I. Inhibition of adenylate cyclase mediated by alpha receptors.

1979 • 288 citations

Adenosine analogs inhibit adipocyte adenylate cyclase by a GTP-dependent process: basis for actions of adenosine and methylxanthines on cyclic AMP production and lipolysis.

1978 • 253 citations

Coupling of catecholamine receptor from one cell with adenylate cyclase from another cell by cell fusion.

1976 • 240 citations

Opiates inhibit adenylate cyclase by stimulating GTP hydrolysis.

1981 • 234 citations

Muscarinic cholinergic receptor modulation of beta-adrenergic receptor affinity for catecholamines.

1978 • 224 citations

Progesterone inhibits membrane-bound adenylate cyclase in Xenopus laevis oocytes

1981 • 218 citations

Progesterone inhibits adenylate cyclase in Xenopus oocytes. Action on the guanine nucleotide regulatory protein.

1981 • 217 citations

Interaction of ligands with the opiate receptors of brain membranes: Regulation by ions and nucleotides

1978 • 216 citations

Coupling of opiate receptors to adenylate cyclase: requirement for Na+ and GTP.

1979 • 200 citations

Solubilization of active opiate receptors.

1980 • 199 citations

Stimulatory and Inhibitory Effects of Guanyl Nucleotides on Fat Cell Adenylate Cyclase

1973 • 198 citations

Inhibition of adenylate cyclase by hormones and neurotransmitters

1979 • 187 citations

Angiotensin II and alpha-adrenergic agonists inhibit rat liver adenylate cyclase.

1981 • 183 citations

GTP-dependent inhibition of cardiac adenylate cyclase by muscarinic cholinergic agonists

1979 • 178 citations

The fat cell adenylate cyclase system. Characterization and manipulation of its bimodal regulation by GTP.

1979 • 171 citations

Agonist-specific effects of guanine nucleotides on alpha-adrenergic receptors in human platelets.

1979 • 155 citations

Insulin stimulation of (Na+,K+)-adenosine triphosphatase-dependent 86Rb+ uptake in rat adipocytes.

1980 • 153 citations

Demonstration and Characterization of Opiate Inhibition of the Striatal Adenylate Cyclase

1981 • 149 citations

Angiotensin II Receptors in Bovine Adrenal Cortex

1974 • 147 citations

Adenosine receptor-mediated inhibition of rat cerebral cortical adenylate cyclase by a GTP-dependent process.

1980 • 141 citations

Solubilization of human platelet alpha-adrenergic receptors: evidence that agonist occupancy of the receptor stabilizes receptor--effector interactions.

1981 • 124 citations

Inhibition of platelet adenylate cyclase by epinephrine requires GTP

1978 • 123 citations

GTP stimulates and inhibits adenylate cyclase in fat cell membranes through distinct regulatory processes.

1977 • 120 citations

Differential regulation of the α2-adrenergic receptor by Na+ and guanine nucleotides

1980 • 119 citations

Epinephrine inhibits adenylate cyclase and stimulates a GTPase in human platelet membranes vis α‐adrenoceptors

1981 • 113 citations

ADP is a potent inhibitor of human platelet plasma membrane adenylate cyclase

1979 • 107 citations

Interactions of Divalent Cations and Guanine Nucleotides at α₂‐Noradrenergic Receptor Binding Sites in Bovine Brain Mechanisms

1980 • 99 citations

Opiate (Enkephalin) Receptors of Neuroblastoma Cells: Occurrence in Clusters on the Cell Surface

1979 • 96 citations

Stimulation of a D-2 Dopamine Receptor in the Intermediate Lobe of the Rat Pituitary Gland Decreases the Responsiveness of the β-Adrenoceptor: Biochemical Mechanism

1981 • 88 citations

α-Noradrenergic receptors in the brain: differential effects of sodium on binding of [3H]agonists and [3H]antagonists

1978 • 83 citations

Formation of ACh receptor clusters induced by positively charged latex beads

1981 • 80 citations

Stimulus-Response Coupling at α-Adrenergic Receptors

1978 • 78 citations

Nucleotide inhibition of adenyl cyclase activity in fat cell membranes

1969 • 75 citations

Horizons in Biochemistry and Biophysics

1978 • 73 citations

Characterization and partial purification of solubilized active opiate receptors from toad brain.

1981 • 64 citations

Yeast mating pheromone alpha factor inhibits adenylate cyclase.

1980 • 62 citations

Nicotinic acid inhibits adipocyte adenylate cyclase in a hormone—like manner

1980 • 53 citations

The interaction of norepinephrine and prostaglandin E1 on the adenyl cyclase system of human and rabbit blood platelets

1971 • 52 citations

The Stimulation of the Mitochondrial Uncoupler-Dependent ATPase in Isolated Hepatocytes by Catecholamines and Glucagon and Its Relationship to Gluconeogenesis

1979 • 49 citations

Characterization and solubilization of the alpha-adrenoreceptor of rat liver plasma membranes labeled with [3H]phenoxybenzamine.

1979 • 47 citations

Inhibition and activation of fat cell adenylate cyclase by GTP is mediated by structures of different size

1980 • 44 citations

Different inhibitory effect of adrenaline on platelet adenylate cyclase in the presence of GTP plus cholera toxin and of stable GTP analogues

1979 • 44 citations

Cholera toxin modifies diverse GTP-modulated regulatory proteins

1981 • 42 citations

Opioids, Noradrenaline and GTP Analogs Inhibit Cholera Toxin Activated Adenylate Cyclase in Neuroblastoma × Glioma Hybrid Cells

1981 • 31 citations

Interactions between alpha-adrenergic agents, prostaglandin E1, nicotinic acid, and adenosine in regulation of lipolysis in hamsters epididymal adipocytes.

1981 • 26 citations

Catecholamine-sensitive adenylate cyclase of caudate nucleus and cerebral cortex. Effects of guanine nucleotides

1977 • 26 citations

Biphasic effect of 5?-guanylylimidodiphosphate on fat cell adenylate cyclase

1974 • 23 citations

Inhibitory effect of guanyl nucleotides toward adenylate cyclase activity of Chinese hamster ovary cell membranes activated in vitro by cholera toxin.

1979 • 22 citations