A ternary complex model explains the agonist-specific binding properties of the adenylate cyclase-coupled beta-adrenergic receptor.

Applied Regression Analysis

2005 • 18,630 citations

Applied Regression Analysis.

1967 • 1,561 citations

A study of the ‘desensitization’ produced by acetylcholine at the motor end‐plate

1957 • 1,457 citations

Statistical Quality Control and Routine Data Processing for Radioimmunoassays and Immunoradiometric Assays

1974 • 1,063 citations

Mathematical theory of complex ligand-binding systems at equilibrium: Some methods for parameter fitting

1972 • 615 citations

A quantitative analysis of beta-adrenergic receptor interactions: resolution of high and low affinity states of the receptor by computer modeling of ligand binding data.

1980 • 545 citations

The Glucagon-sensitive Adenyl Cyclase System in Plasma Membranes of Rat Liver

1971 • 487 citations

On the application of “a plausible model” of allosteric proteins to the receptor for acetylcholine

1967 • 425 citations

Mode of coupling between the β-adrenergic receptor and adenylate cyclase in turkey erythrocytes

1978 • 347 citations

An agonist-specific effect of guanine nucleotides on binding to the beta adrenergic receptor.

1976 • 318 citations

Regulation of beta-adrenergic receptors by guanyl-5'-yl imidodiphosphate and other purine nucleotides.

1976 • 314 citations

Resolution of some components of adenylate cyclase necessary for catalytic activity.

1977 • 283 citations

Alpha-adrenergic receptor subtypes: Quantitative assessment by ligand binding

1979 • 264 citations

The mobile receptor hypothesis and “cooperativity” of hormone binding. Application to insulin

1976 • 258 citations

On the mechanism of desensitization at cholinergic receptors.

1970 • 247 citations

Statistical characterization of the random errors in the radioimmunoassay dose--response variable.

1976 • 244 citations

5′-Guanylylimidodiphosphate, A Potent Activator of Adenylate Cyclase Systems in Eukaryotic Cells

1974 • 244 citations

Guanine nucleotides modulate muscarinic receptor binding in the heart

1979 • 236 citations

Agonist-promoted coupling of the beta-adrenergic receptor with the guanine nucleotide regulatory protein of the adenylate cyclase system.

1980 • 229 citations

Slowly reversible binding of catecholamine to a nucleotide-sensitive state of the beta-adrenergic receptor.

1977 • 228 citations

Quantitative resolution of beta-adrenergic receptor subtypes by selective ligand binding: application of a computerized model fitting technique.

1979 • 220 citations

Effect of guanine nucleotides on striatal dopamine receptors

1978 • 186 citations

Analysis of macromolecule-ligand binding by determination of stepwise equilibrium constants

1970 • 159 citations

Agonist-specific effects of guanine nucleotides on alpha-adrenergic receptors in human platelets.

1979 • 155 citations

A high affinity agonist . beta-adrenergic receptor complex is an intermediate for catecholamine stimulation of adenylate cyclase in turkey and frog erythrocyte membranes.

1980 • 152 citations

Guanine nucleotide‐controlled interactions between components of adenylate cyclase

1979 • 144 citations

Agonist-induced increase in apparent β-adrenergic receptor size

1978 • 138 citations

Unique uncoupling of the frog erythrocyte adenylate cyclase system by manganese. Loss of hormone and guanine nucleotide-sensitive enzyme activities without loss of nucleotide-sensitive, high affinity agonist binding.

1979 • 122 citations

Negative cooperativity among beta-adrenergic receptors in frog erythrocyte membranes.

1976 • 120 citations

Data Analysis in Biochemistry and Biophysics

1972 • 110 citations

Loss of beta-adrenergic receptor-guanine nucleotide regulatory protein interactions accompanies decline in catecholamine responsiveness of adenylate cyclase in maturing rat erythrocytes.

1980 • 110 citations

The non-stoichiometric floating receptor model for hormone sensitive adenylyl cyclase

1976 • 106 citations

Structure-activity relationships of adenylate cyclase-coupled beta adrenergic receptors: determination by direct binding studies.

1976 • 100 citations

Interaction of divalent antibody with cell surface antigens

1979 • 91 citations

Ligand specificity of state transitions in the cholinergic receptor: behavior of agonists and antagonists.

1979 • 89 citations

Multiple reactive sulfhydryl groups modulate the function of adenylate cyclase coupled beta-adrenergic receptors.

1979 • 83 citations

Use of (-)-[3H]dihydroalprenolol to study beta adrenergic receptor-adenylate cyclase coupling in C6 glioma cells: role of 5'-guanylylimidodiphosphate.

1977 • 69 citations

Multiple effects of guanosine triphosphate on beta adrenergic receptors and adenylate cyclase activity in rat heart, lung and brain.

1979 • 64 citations

Multi-subsite receptors for multivalent ligands. Application to drugs, hormones, and neurotransmitters.

1979 • 63 citations

Efficiency of coupling between the beta adrenergic receptor and adenylate cyclase.

1978 • 53 citations

Neurohypophyseal hormone-responsive renal adenylate cyclase. IV. A random-hit matrix model for coupline in a hormone-sensitive adenylate cyclase system.

1978 • 41 citations