Cloning, Sequencing, and Expression of the Gene Coding for the Human Platelet α ₂ -Adrenergic Receptor

DNA sequencing with chain-terminating inhibitors

1977 • 69,181 citations

A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity

1983 • 26,063 citations

A simple method for displaying the hydropathic character of a protein

1982 • 22,471 citations

Efficientin vitrosynthesis of biologically active RNA and RNA hybridization probes from plasmids containing a bacteriophage SP6 promoter

1984 • 6,459 citations

G PROTEINS: TRANSDUCERS OF RECEPTOR-GENERATED SIGNALS

1987 • 6,374 citations

The pUC plasmids, an M13mp7-derived system for insertion mutagenesis and sequencing with synthetic universal primers

1982 • 6,153 citations

Cloning of the gene and cDNA for mammalian β-adrenergic receptor and homology with rhodopsin

1986 • 1,264 citations

Enzyme changes in neonatal skeletal muscle: effect of thyroid deficiency

1978 • 1,103 citations

Cloning, sequencing and expression of complementary DNA encoding the muscarinic acetylcholine receptor

1986 • 917 citations

Synthetic oligonucleotide probes deduced from amino acid sequence data

1985 • 759 citations

cDNA for the human beta 2-adrenergic receptor: a protein with multiple membrane-spanning domains and encoded by a gene whose chromosomal location is shared with that of the receptor for platelet-derived growth factor.

1987 • 687 citations

Regulation of transmembrane signaling by receptor phosphorylation

1987 • 678 citations

A family of receptors coupled to guanine nucleotide regulatory proteins

1987 • 636 citations

Cloning of the cDNA for the human beta 1-adrenergic receptor.

1987 • 577 citations

Validation and statistical analysis of a computer modeling method for quantitative analysis of radioligand binding data for mixtures of pharmacological receptor subtypes.

1982 • 573 citations

Primary Structure and Biochemical Properties of an M ₂ Muscarinic Receptor

1987 • 510 citations

An intronless gene encoding a potential member of the family of receptors coupled to guanine nucleotide regulatory proteins

1987 • 509 citations

Isolation and nucleotide sequence of the gene encoding human rhodopsin.

1984 • 495 citations

Light-dependent phosphorylation of rhodopsin: number of phosphorylation sites

1982 • 441 citations

Rhodopsin and bacteriorhodopsin: structure—function relationships

1982 • 430 citations

Primary structure of porcine cardiac muscarinic acetylcholine receptor deduced from the cDNA sequence

1986 • 344 citations

Ligand binding to the β-adrenergic receptor involves its rhodopsin-like core

1987 • 318 citations

Heterogeneity of alpha-2 adrenergic receptors

1985 • 297 citations

Pre- and postsynaptic effects of yohimbine stereoisomers on noradrenergic transmission in the pulmonary artery of the rabbit

1979 • 273 citations

The avian beta-adrenergic receptor: primary structure and membrane topology.

1986 • 252 citations

Delineation of the intronless nature of the genes for the human and hamster beta 2-adrenergic receptor and their putative promoter regions.

1987 • 248 citations

Characterization of α-adrenoceptors participating in the central hypotensive and sedative effects of clonidine using yohimbine, rauwolscine and corynanthine

1981 • 215 citations

Light-dependent phosphorylation of rhodopsin by β-adrenergic receptor kinase

1986 • 205 citations

Anatomical evidence for alpha-2 adrenoceptor heterogeneity: differential autoradiographic distributions of [3H]rauwolscine and [3H]idazoxan in rat brain.

1987 • 185 citations

[3H]rauwolscine and [3H]yohimbine binding to rat cerebral and human platelet membranes: Possible heterogeneity of α2-adrenoceptors

1982 • 184 citations

Characterization of α2-adrenergic receptors on human platelets using [3H]yohimbine

1980 • 166 citations

Agonist-dependent phosphorylation of the alpha 2-adrenergic receptor by the beta-adrenergic receptor kinase.

1987 • 156 citations

The carboxyl terminus of the hamster β-adrenergic receptor expressed in mouse L cells is not required for receptor sequestration

1987 • 142 citations

Functional activity and regulation of human beta 2-adrenergic receptors expressed in Xenopus oocytes.

1987 • 137 citations

Chapter 1 Rhodopsin chemistry, structure and topography

1982 • 115 citations

The pronatriodilatin gene is located on the distal short arm of human chromosome 1 and on mouse chromosome 4.

1985 • 111 citations

The partial primary structure of bovine rhodopsin and its topography in the retinal rod cell disc membrane

1980 • 106 citations

Purification and characterization of the human platelet alpha 2-adrenergic receptor.

1986 • 94 citations

[³H]‐rauwolscine binding to α₂‐adrenoceptors in the mammalian kidney: apparent receptor heterogeneity between species

1985 • 73 citations

Effects of α₂‐adrenoceptor agonists and of related compounds on aggregation of, and on adenylate cyclase activity in, human platelets

1984 • 62 citations

Comparison of potency of α₂‐adrenoceptor antagonists in vitro: evidence for heterogeneity of α₂‐adrenoceptors

1986 • 49 citations

Heterogeneity of mammalian α2-adrenoceptors delineated by [3H]yohimbine binding

1986 • 45 citations

Purification of the alpha 2-adrenergic receptor from porcine brain using a yohimbine-agarose affinity matrix.

1987 • 34 citations

Arylazide photoaffinity probe for α2-adrenoceptors

1985 • 6 citations