Suppression of Insulin Release by Galanin and Somatostatin Is Meditated by a G-protein

Calcium homeostasis in intact lymphocytes: cytoplasmic free calcium monitored with a new, intracellularly trapped fluorescent indicator.

1982 • 2,255 citations

Intracellular ATP directly blocks K+ channels in pancreatic B-cells

1984 • 1,199 citations

Glucose induces closure of single potassium channels in isolated rat pancreatic β-cells

1984 • 1,099 citations

Regulation of insulin release by calcium.

1981 • 866 citations

Roles of G protein subunits in transmembrane signalling

1988 • 794 citations

Ca2+, cAMP, and phospholipid-derived messengers in coupling mechanisms of insulin secretion

1987 • 773 citations

Opposite effects of tolbutamide and diazoxide on the ATP-dependent K+ channel in mouse pancreatic ?-cells

1986 • 572 citations

Neurotransmitters decrease the calcium conductance activated by depolarization of embryonic chick sensory neurones.

1981 • 555 citations

Glucose dependent K+-channels in pancreatic?-cells are regulated by intracellular ATP

1985 • 388 citations

STUDIES IN OBESE‐HYPERGLYCEMIC MICE*

1965 • 373 citations

The mechanism of the calcium signal and correlation with histamine release in 2H3 cells.

1984 • 351 citations

Galanin inhibits acetylcholine release in the ventral hippocampus of the rat: histochemical, autoradiographic, in vivo, and in vitro studies.

1987 • 347 citations

Two roles for guanine nucleotides in the stimulus-secretion sequence of neutrophils

1986 • 339 citations

Lymphocyte membrane potential assessed with fluorescent probes

1980 • 336 citations

Interrelationship of islet metabolism, adenosine triphosphate content and insulin release

1973 • 307 citations

Neuropeptidergic versus cholinergic and adrenergic regulation of islet hormone secretion

1986 • 265 citations

Guanine nucleotides induce Ca2+-independent insulin secretion from permeabilized RINm5F cells.

1987 • 244 citations

A guanine nucleotide-binding protein mediates the inhibition of voltage-dependent calcium current by somatostatin in a pituitary cell line.

1986 • 243 citations

The ATP‐sensitivity of K⁺ channels in rat pancreatic B‐cells is modulated by ADP

1986 • 242 citations

ATP-Sensitive K+ Channels in Pancreatic β-Cells: Spare-Channel Hypothesis

1988 • 220 citations

Block of calcium channels by enkephalin and somatostatin in neuroblastoma-glioma hybrid NG108-15 cells.

1986 • 218 citations

Human alveolar macrophage arachidonic acid metabolism

1988 • 199 citations

The Significance of Calcium for Glucose Stimulation of Insulin Release

1975 • 197 citations

ATP-sensitive K+ channels that are blocked by hypoglycemia-inducing sulfonylureas in insulin-secreting cells are activated by galanin, a hyperglycemia-inducing hormone.

1988 • 193 citations

Islet-activating protein. Enhanced insulin secretion and cyclic AMP accumulation in pancreatic islets due to activation of native calcium ionophores.

1979 • 193 citations

Opposite effects of tolbutamide and diazoxide on 86Rb+ fluxes and membrane potential in pancreatic B cells

1982 • 179 citations

Inhibition of ATP-regulated K+ channels precedes depolarization-induced increase in cytoplasmic free Ca2+ concentration in pancreatic beta-cells.

1987 • 173 citations

Ca2+-mediated generation of inositol 1,4,5-triphosphate and inositol 1,3,4,5-tetrakisphosphate in pancreatic islets. Studies with K+, glucose, and carbamylcholine.

1987 • 157 citations

Glucose-induced oscillations of cytoplasmic Ca2+ in the pancreatic β-cell

1988 • 152 citations

Somatostatin, an inhibitor of ACTH secretion, decreases cytosolic free calcium and voltage-dependent calcium current in a pituitary cell line

1986 • 110 citations

Islet cyclic AMP levels are not lowered during alpha 2-adrenergic inhibition of insulin release.

1984 • 105 citations

Diazoxide and D600 Inhibition of Insulin Release: Distinct Mechanisms Explain the Specificity for Different Stimuli

1982 • 99 citations

Signal Transduction in Insulin Secretion:.

1986 • 96 citations

Block in Insulin Release from Column-Perifused Pancreatic β-Cells Induced by Islet Cell Surface Antibodies and Complement

1981 • 96 citations

The role of cyclic AMP in insulin release

1984 • 93 citations

Characterization of the inositol 1,4,5-trisphosphate-induced Ca2+ release in pancreatic β-cells

1987 • 86 citations

Regulation of insulin secretion from islets of Langerhans rendered permeable by electric discharge

1982 • 86 citations

Somatostatin lowers the cytosolic free Ca2+ concentration in clonal rat pituitary cells (GH3 cells)

1984 • 81 citations

Galanin inhibits glucose-stimulated insulin release by a mechanism involving hyperpolarization and lowering of cytoplasmic free Ca2+ concentration

1986 • 75 citations

Inhibition of glucose-stimulated insulin release by alpha 2-adrenoceptor activation is parallelled by both a repolarization and a reduction in cytoplasmic free Ca2+ concentration.

1988 • 70 citations

Potassium dependence of the membrane potential of pancreatic B‐cells

1978 • 69 citations

Galanin and the endocrine pancreas

1988 • 58 citations

Inhibition by somatostatin of glucose induced 3′: 5′‐monophosphate (Cyclic AMP) accumulation and insulin release in isolated pancreatic islets of the rat

1975 • 56 citations

Glyceraldehyde, but not cyclic AMP‐stimulated insulin release is preceded by a rise in cytosolic free Ca²⁺

1984 • 55 citations

Mode of Action of Clonidine Upon Islet Function: Dissociated Effects Upon the Time Course and Magnitude of Insulin Release

1980 • 52 citations

Cyclic AMP potentiates glucose‐induced insulin release from mouse pancreatic islets without increasing cytosolic free Ca2

1985 • 45 citations

Islet Electrical Pacemaker Response to Alpha-Adrenergic Stimulation

1982 • 43 citations

Cytosolic Free-Calcium Concentrations in Normal Pancreatic Islet Cells: Effect of Secretagogues and Somatostatin

1987 • 41 citations

Stimulation of insulin release by the phorbol ester 12-O-tetradecanoylphorbol 13-acetate in the clonal cell line RINm5F despite a lowering of the free cytoplasmic Ca2+ concentration

1986 • 33 citations

<b>Catecholamines inhibit insulin release independently of changes in cytosolic free </b><b>Ca<sup>2+</sup></b>

1985 • 29 citations

Direct evidence for opposite effects of D-glucose and D-glyceraldehyde on cytoplasmic pH of mouse pancreatic β-cells

1986 • 27 citations

Calcium and diacylglycerol control of secretion

1987 • 26 citations

α₂‐Adrenergic inhibition of pancreatic islet glucose utilization is mediated by an inhibitory guanine nucleotide regulatory protein

1987 • 25 citations

Somatostatin inhibition of glucose-induced electrical activity in cultured rat islet cells

1977 • 25 citations