Dual actions of phorbol esters on cytosolic free Ca2+ concentrations and reconstitution with ionomycin of acute thyrotropin-releasing hormone responses.

A Rapid and Sensitive Method for the Quantitation of Microgram Quantities of Protein Utilizing the Principle of Protein-Dye Binding

1976 • 225,752 citations

A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

1976 • 200,127 citations

The role of protein kinase C in cell surface signal transduction and tumour promotion

1984 • 7,521 citations

Inositol trisphosphate, a novel second messenger in cellular signal transduction

1984 • 6,088 citations

Direct activation of calcium-activated, phospholipid-dependent protein kinase by tumor-promoting phorbol esters.

1982 • 4,786 citations

Calcium homeostasis in intact lymphocytes: cytoplasmic free calcium monitored with a new, intracellularly trapped fluorescent indicator.

1982 • 2,255 citations

Calcium channel modulation by neurotransmitters, enzymes and drugs

1983 • 1,267 citations

METHODS IN CANCER RESEARCH

1969 • 1,197 citations

Phorbol diester receptor copurifies with protein kinase C.

1983 • 1,185 citations

T-cell mitogens cause early changes in cytoplasmic free Ca2+ and membrane potential in lymphocytes

1982 • 1,026 citations

Calcium messenger system: an integrated view.

1984 • 916 citations

Autophosphorylation sites on the epidermal growth factor receptor

1984 • 730 citations

Synergistic functions of protein phosphorylation and calcium mobilization in platelet activation.

1983 • 705 citations

Establishment of Clonal Strains of Rat Pituitary Tumor Cells That Secrete Growth Hormone^1,2

1968 • 683 citations

Diacylglycerol and phorbol ester stimulate secretion without raising cytoplasmic free calcium in human platelets

1983 • 589 citations

In vitro studies on the mode of action of the phorbol esters, potent tumor promoters: Part 1

1980 • 477 citations

Enhancement of calcium current in Aplysia neurones by phorbol ester and protein kinase C

1985 • 476 citations

Phorbol ester and diacylglycerol mimic growth factors in raising cytoplasmic pH

1984 • 447 citations

Growth factors immediately raise cytoplasmic free Ca2+ in human fibroblasts.

1984 • 394 citations

Studies on the mechanism of skin tumor promotion: Evidence for several stages in promotion

1980 • 336 citations

Protein kinase C activation of physiological processes in human neutrophils at vanishingly small cytosolic Ca2+ levels

1984 • 334 citations

The temporal integration of the aldosterone secretory response to angiotensin occurs via two intracellular pathways.

1984 • 332 citations

Competitive inhibition by diacylglycerol of specific phorbol ester binding.

1984 • 306 citations

[46] Clonal strains of hormone-producing pituitary cells

1979 • 296 citations

Thyrotropin-releasing hormone rapidly activates the phosphodiester hydrolysis of polyphosphoinositides in GH3 pituitary cells. Evidence for the role of a polyphosphoinositide-specific phospholipase C in hormone action.

1983 • 292 citations

Diacylglycerol stimulates DNA synthesis and cell division in mouse 3T3 cells: role of Ca2+-sensitive phospholipid-dependent protein kinase.

1984 • 266 citations

Phosphorylation of phospholamban by calcium-activated, phospholipid-dependent protein kinase. Stimulation of cardiac sarcoplasmic reticulum calcium uptake.

1984 • 255 citations

Insulin secretion: Combined effects of phorbol ester and A23187

1983 • 250 citations

Phorbol ester induces desensitization of adenylate cyclase and phosphorylation of the beta-adrenergic receptor in turkey erythrocytes.

1984 • 233 citations

Epidermal growth factor and thyrotropin-releasing hormone act similarly on a clonal pituitary cell strain. Modulation of hormone production and inhibition of cell proliferation

1980 • 226 citations

Relationship of thyrotropin-releasing hormone-induced spike and plateau phases in cytosolic free Ca2+ concentrations to hormone secretion. Selective blockade using ionomycin and nifedipine.

1984 • 226 citations

The cytoplasmic concentration of free calcium in platelets is controlled by stimulators of cyclic AMP production (PGD2, PGE1, forskolin)

1983 • 217 citations

Vinculin, a cytoskeletal substrate of protein kinase C.

1983 • 215 citations

Evidence for the platelet-derived growth factor-stimulated tyrosine phosphorylation of the platelet-derived growth factor receptor in vivo. Immunopurification using a monoclonal antibody to phosphotyrosine.

1984 • 209 citations

Thyroliberin stimulates rapid hydrolysis of phosphatidylinositol 4,5-bisphosphate by a phosphodiesterase in rat mammotropic pituitary cells. Evidence for an early Ca2+-independent action

1983 • 203 citations

Phorbol myristate acetate stimulates ATP-dependent calcium transport by the plasma membrane of neutrophils.

1984 • 193 citations

Evidence for the role of phosphorylase kinase, protein kinase C, and other Ca2+-sensitive protein kinases in the response of hepatocytes to angiotensin II and vasopressin.

1984 • 192 citations

Thyrotropin-releasing hormone-induced spike and plateau in cytosolic free Ca2+ concentrations in pituitary cells. Relation to prolactin release.

1984 • 192 citations

Thyrotropin-releasing hormone stimulates rapid loss of phosphatidylinositol and its conversion to 1,2-diacylglycerol and phosphatidic acid in rat mammotropic pituitary cells. Association with calcium mobilization and prolactin secretion.

1983 • 181 citations

Ca2+-dependent and -independent release of neurotransmitters from PC12 cells: a role for protein kinase C activation?

1984 • 180 citations

Distinct patterns of cytoplasmic protein phosphorylation related to regulation of synthesis and release of prolactin by GH cells.

1983 • 172 citations

Diacylglycerol modulates binding and phosphorylation of the epidermal growth factor receptor.

1984 • 168 citations

Inositol trisphosphate mediates thyrotropin-releasing hormone mobilization of nonmitochondrial calcium in rat mammotropic pituitary cells.

1984 • 168 citations

Vasoactive intestinal peptide (VIP) stimulates prolactin (PRL) release and cAMP production in a rat pituitary cell line (GH3/B6). Additive effects of VIP and TRH on PRL release

1979 • 160 citations

Inhibition by calmodulin of calcium/phospholipid-dependent protein phosphorylation.

1984 • 151 citations

Cyclic nucleotides control a system which regulates Ca2+ sensitivity of platelet secretion

1984 • 147 citations

Thyrotropin-Releasing Hormone (TRH) Stimulates Biphasic Elevation of Cytoplasmic Free Calcium in GH₃Cells. Further Evidence that TRH Mobilizes Cellular and Extracellular Ca²⁺*

1985 • 143 citations

Serotonin secretion from human platelets may be modified by Ca2+-activated, phospholipid-dependent myosin phosphorylation.

1984 • 143 citations

Characterization of phorbol ester receptors and their down-modulation in GH4C1 rat pituitary cells.

1981 • 142 citations

Thyrotropin-releasing hormone induces redistribution of protein kinase C in GH4C1 rat pituitary cells.

1985 • 140 citations

Activation of protein kinase C by non-phorbol tumor promoter, mezerein

1984 • 135 citations

Evidence for the Role of Calcium and Diacylglycerol as Dual Second Messengers in Thyrotropin-Releasing Hormone Action: Involvement of Diacylglycerol*

1984 • 132 citations

Thyrotropin-releasing hormone rapidly activates protein phosphorylation in GH3 pituitary cells by a lipid-linked, protein kinase C-mediated pathway.

1984 • 115 citations

Receptor-mediated release of plasma membrane-associated calcium and stimulation of calcium uptake by thyrotropin-releasing hormone in pituitary cells in culture.

1981 • 113 citations

Thyrotropin-Releasing Hormone (TRH) Selectively and Rapidly Stimulates Phosphatidylinositol Turnover in GH Pituitary Cells: A Possible Second Step of TRH Action*

1982 • 105 citations

Thyrotropin-releasing hormone rapidly and transiently stimulates cytosolic calcium-dependent protein phosphorylation in GH3 pituitary cells.

1982 • 102 citations

Thyrotropin-releasing hormone increases cytosolic free Ca2+ in clonal pituitary cells (GH3 cells): direct evidence for the mobilization of cellular calcium.

1984 • 101 citations

Tumor-Promoting Phorbol Esters Affect Production of Prolactin and Growth Hormone by Rat Pituitary Cells*

1981 • 98 citations

Voltage-dependent calcium channels in pituitary cells in culture. II. Participation in thyrotropin-releasing hormone action on prolactin release.

1984 • 97 citations

Calcium movement and membrane potential changes in the early phase of neutrophil activation by phorbol myristate acetate: a study with ion-selective electrodes.

1982 • 97 citations

Somatostatin Inhibits Vasoactive Intestinal Peptide-Stimulated Cyclic Adenosine Monophosphate Accumulation in GH Pituitary Cells^*

1983 • 93 citations

Thyrotropin-releasing hormone-induced changes in intracellular [Ca2+] measured by microspectrofluorometry on individual quin2-loaded cells.

1984 • 92 citations

Monitoring of cytosolic free Ca2+ in C5a-stimulated neutrophils: loss of receptor-modulated Ca2+ stores and Ca2+ uptake in granule-free cytoplasts.

1984 • 81 citations

Synergistic stimulation of prolactin release by phorbol ester, A23187 and forskolin

1984 • 80 citations

Rapid phosphorylation-dephosphorylation of specific proteins induced by phorbol ester in HL-60 cells. Further characterization of the phosphorylation of 17-kilodalton and 27-kilodalton proteins in myeloid leukemic cells and human monocytes.

1984 • 78 citations

Thyrotropin-releasing hormone stimulates rapid breakdown of phosphatidylinositol 4,5-bisphosphate and phosphatidylinositol 4-phosphate in GH3 pituitary tumor cells.

1984 • 78 citations

Phorbol ester-induced protein secretion in rat parotid gland. Relationship to the role of inositol lipid breakdown and protein kinase C activation in stimulus-secretion coupling.

1984 • 77 citations

Evidence for the Role of Calcium and Diacylglycerol as Dual Second Messengers in Thyrotropin-Releasing Hormone Action: Involvement of Ca⁺²*

1984 • 76 citations

Thyrotropin-Releasing Hormone Rapidly Stimulates a Biphasic Secretion of Prolactin and Growth Hormone in GH₄C₁Rat Pituitary Tumor Cells*

1985 • 76 citations

Insulin and 17β-Estradiol Increase the Intracellular Prolactin Content of GH₄C₁Cells*

1981 • 72 citations

Ca2+ ionophores affect phosphoinositide metabolism differently than thyrotropin-releasing hormone in GH3 pituitary cells.

1984 • 72 citations

Differential Effects of Thyrotropin-Releasing Hormone,Vasoactive Intestinal Peptide, Phorbol Ester, and Depolarization in GH₄C₁Rat Pituitary Cells*

1985 • 64 citations

Difference in Calcium Requirements for Forskolin-Induced Release of Prolactin from Normal Pituitary Cells and GH₄C₁Cells in Culture^*

1984 • 38 citations

The insulin receptor and tyrosine protein kinase activity

1984 • 32 citations

Vasoactive intestinal peptide causes a calcium-dependent stimulation of prolactin secretion in GH4C1 cells

1984 • 29 citations

Studies on the control and dynamics of thyrotropin secretion from isolated adenohypophyseal cells

1977 • 28 citations

Association of phorbol ester receptor down modulation with a cryptic receptor state.

1983 • 23 citations

Platelet-Derived Growth Factor Selectively Decreases Prolactin Production in Pituitary Cells in Culture*

1983 • 20 citations