Control of Sleep and Wakefulness

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Posttraumatic Stress Disorder in the National Comorbidity Survey

1995 • 10,182 citations

The Occurrence of Sleep-Disordered Breathing among Middle-Aged Adults

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Copper-Zinc Superoxide Dismutase (SOD1) Is Released by Microglial Cells and Confers Neuroprotection against 6-OHDA Neurotoxicity

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Aviat space environ med

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AChE-stained horizontal sections of the rat brain in stereotaxic coordinates

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Two-Process Model of Sleep Regulation

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The hypocretins: Hypothalamus-specific peptides with neuroexcitatory activity

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Interplay between Cortical Spreading Depolarization and Seizures

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Thalamocortical Oscillations in the Sleeping and Aroused Brain

1993 • 3,483 citations

Neurons Containing Hypocretin (Orexin) Project to Multiple Neuronal Systems

1998 • 3,381 citations

The memory function of sleep

2010 • 3,289 citations

Theta Oscillations in the Hippocampus

2002 • 3,216 citations

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An Energy Budget for Signaling in the Grey Matter of the Brain

2001 • 3,148 citations

Narcolepsy in orexin Knockout Mice

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Reactivation of Hippocampal Ensemble Memories During Sleep

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Modulation of Oscillatory Neuronal Synchronization by Selective Visual Attention

2001 • 2,820 citations

The Sleep Disorder Canine Narcolepsy Is Caused by a Mutation in the Hypocretin (Orexin) Receptor 2 Gene

1999 • 2,583 citations

High Gamma Power Is Phase-Locked to Theta Oscillations in Human Neocortex

2006 • 2,551 citations

Functional-Anatomic Fractionation of the Brain's Default Network

2010 • 2,536 citations

Structure and function of the brain serotonin system

1992 • 2,507 citations

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Parvalbumin neurons and gamma rhythms enhance cortical circuit performance

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Actions of caffeine in the brain with special reference to factors that contribute to its widespread use.

1999 • 2,431 citations

Regularly Occurring Periods of Eye Motility, and Concomitant Phenomena, During Sleep

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2005 • 2,323 citations

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Neurocognitive Consequences of Sleep Deprivation

2009 • 2,001 citations

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Pathophysiology of Sleep Apnea

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2004 • 1,822 citations

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Boosting slow oscillations during sleep potentiates memory

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Glutamate-mediated astrocyte–neuron signalling

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1993 • 1,683 citations

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Coordinated memory replay in the visual cortex and hippocampus during sleep

2006 • 1,644 citations

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1995 • 1,636 citations

The sleep switch: hypothalamic control of sleep and wakefulness

2001 • 1,609 citations

The Role and Regulation of Adenosine in the Central Nervous System

2001 • 1,595 citations

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2001 • 1,593 citations

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2006 • 1,593 citations

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1995 • 1,550 citations

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2000 • 1,533 citations

Ontogenetic Development of the Human Sleep-Dream Cycle

1966 • 1,531 citations

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1993 • 1,500 citations

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2008 • 1,495 citations

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2005 • 1,475 citations

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2001 • 1,421 citations

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2001 • 1,387 citations

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1983 • 1,379 citations

HIPPOCAMPAL ELECTRICAL ACTIVITY IN AROUSAL

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1984 • 1,316 citations

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2003 • 1,312 citations

Neurocognitive Consequences of Sleep Deprivation

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Natural Waking and Sleep States: A View From Inside Neocortical Neurons

2001 • 1,295 citations

Biogenic Amines and the States of Sleep

1969 • 1,274 citations

Mushroom body memoir: from maps to models

2003 • 1,266 citations

New vistas for α-frequency band oscillations

2007 • 1,264 citations

Neural substrates of awakening probed with optogenetic control of hypocretin neurons

2007 • 1,253 citations

Practice with Sleep Makes Perfect

2002 • 1,249 citations

GABA-containing neurons in the septum control inhibitory interneurons in the hippocampus

1988 • 1,247 citations

Correlates of Sleep and Waking in Drosophila melanogaster

2000 • 1,244 citations

Astrocytic Purinergic Signaling Coordinates Synaptic Networks

2005 • 1,243 citations

SLEEP AND AROUSAL: Thalamocortical Mechanisms

1997 • 1,239 citations

Grouping of brain rhythms in corticothalamic systems

2005 • 1,233 citations

Sleep Cycle Oscillation: Reciprocal Discharge by Two Brainstem Neuronal Groups

1975 • 1,216 citations

High-frequency network oscillation in the hippocampus

1992 • 1,200 citations

Adenosine: A Mediator of the Sleep-Inducing Effects of Prolonged Wakefulness

1997 • 1,198 citations

Brainstem Control of Wakefulness and Sleep

1990 • 1,188 citations

Orexin A activates locus coeruleus cell firing and increases arousal in the rat

1999 • 1,182 citations

General Anesthesia, Sleep, and Coma

2010 • 1,168 citations

Principles and practice of sleep medicine

2001 • 1,163 citations

Obstructive Sleep Apnea

2003 • 1,155 citations

Properties of a hyperpolarization‐activated cation current and its role in rhythmic oscillation in thalamic relay neurones.

1990 • 1,150 citations

Cellular localization of brain monoamines.

1962 • 1,141 citations

Replay of Neuronal Firing Sequences in Rat Hippocampus During Sleep Following Spatial Experience

1996 • 1,140 citations

A putative flip–flop switch for control of REM sleep

2006 • 1,140 citations

Mice lacking melanin-concentrating hormone are hypophagic and lean

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Histamine in the Nervous System

2008 • 1,133 citations

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1974 • 1,130 citations

Functional neuroanatomy of human rapid-eye-movement sleep and dreaming

1996 • 1,128 citations

Neurotransmitter actions in the thalamus and cerebral cortex and their role in neuromodulation of thalamocortical activity

1992 • 1,126 citations

Temporally Structured Replay of Awake Hippocampal Ensemble Activity during Rapid Eye Movement Sleep

2001 • 1,123 citations

Sleep and synaptic homeostasis: a hypothesis

2003 • 1,120 citations

Molecular Diversity of K⁺ Channels

1999 • 1,117 citations

The Sleep Slow Oscillation as a Traveling Wave

2004 • 1,113 citations

Effects of sleep deprivation on cognition

2010 • 1,105 citations

Chronic Behavioral Disorders of Human REM Sleep: A New Category of Parasomnia

1986 • 1,098 citations

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1984 • 1,084 citations

Sharp wave-associated high-frequency oscillation (200 Hz) in the intact hippocampus: network and intracellular mechanisms

1995 • 1,082 citations

Activation of Ventrolateral Preoptic Neurons During Sleep

1996 • 1,077 citations

Gamma rhythms and beta rhythms have different synchronization properties

2000 • 1,067 citations

Delayed emergence of a parkinsonian disorder in 38% of 29 older men initially diagnosed with idiopathic rapid eye movement sleep behavior disorder

1996 • 1,063 citations

EEG Alpha Activity Reflects Attentional Demands, and Beta Activity Reflects Emotional and Cognitive Processes

1985 • 1,061 citations

The gamma cycle

2007 • 1,041 citations

Nucleus basalis and thalamic control of neocortical activity in the freely moving rat

1988 • 1,035 citations

Orexins, orexigenic hypothalamic peptides, interact with autonomic, neuroendocrine and neuroregulatory systems

1999 • 1,028 citations

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2000 • 1,022 citations

Regulation of Clock and NPAS2 DNA Binding by the Redox State of NAD Cofactors

2001 • 1,013 citations

Entrainment of Neocortical Neurons and Gamma Oscillations by the Hippocampal Theta Rhythm

2008 • 1,011 citations

Rest in Drosophila Is a Sleep-like State

2000 • 1,007 citations

Sleep deprivation: Effect on sleep stages and EEG power density in man

1981 • 1,001 citations

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2007 • 1,001 citations

Dependence on REM Sleep of Overnight Improvement of a Perceptual Skill

1994 • 993 citations

Sleep, Memory, and Plasticity

2005 • 990 citations

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1998 • 982 citations

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2001 • 979 citations

Distribution of cholinergic neurons in rat brain: Demonstrated by the immunocytochemical localization of choline acetyltransferase

1983 • 964 citations

Coherent 40-Hz oscillation characterizes dream state in humans.

1993 • 961 citations

Electrophysiology of mammalian inferior olivary neurones in vitro. Different types of voltage‐dependent ionic conductances.

1981 • 960 citations

Hippocampal synaptic transmission enhanced by low concentrations of nicotine

1996 • 955 citations

Clues to the functions of mammalian sleep

2005 • 954 citations

The intralaminar and midline nuclei of the thalamus. Anatomical and functional evidence for participation in processes of arousal and awareness

2002 • 927 citations

Rapid-eye-movement sleep behaviour disorder as an early marker for a neurodegenerative disorder: a descriptive study

2006 • 926 citations

The thalamus as a neuronal oscillator

1984 • 917 citations

The brain as a dream state generator: an activation-synthesis hypothesis of the dream process

1977 • 913 citations

[Research on the neural structures and responsible mechanisms in different phases of physiological sleep].

1962 • 908 citations

Hippocampal sharp waves: Their origin and significance

1986 • 908 citations

Dorsal raphe neurons: depression of firing during sleep in cats

1976 • 902 citations

The relation of eye movements during sleep to dream activity: An objective method for the study of dreaming.

1957 • 900 citations

Intracellular analysis of relations between the slow (&lt; 1 Hz) neocortical oscillation and other sleep rhythms of the electroencephalogram

1993 • 893 citations

Hypothalamic Orexin Neurons Regulate Arousal According to Energy Balance in Mice

2003 • 892 citations

Tuning arousal with optogenetic modulation of locus coeruleus neurons

2010 • 889 citations

Cholinergic induction of network oscillations at 40 Hz in the hippocampus in vitro

1998 • 889 citations

Systematic Interindividual Differences in Neurobehavioral Impairment from Sleep Loss: Evidence of Trait-Like Differential Vulnerability

2004 • 880 citations

Obstructive sleep apnea and the prefrontal cortex: towards a comprehensive model linking nocturnal upper airway obstruction to daytime cognitive and behavioral deficits

2002 • 877 citations

Regional Slow Waves and Spindles in Human Sleep

2011 • 875 citations

Retrograde axonal transport and the demonstration of non‐specific projections to the cerebral cortex and striatum from thalamic intralaminar nuclei in the rat, cat and monkey

1974 • 873 citations

Functional comparison of neurotransmitter receptor subtypes in mammalian central nervous system

1990 • 872 citations

Discharge of Identified Orexin/Hypocretin Neurons across the Sleep-Waking Cycle

2005 • 840 citations

Vascular Syndromes of the Thalamus

2003 • 833 citations

Behavioral Correlates of Activity in Identified Hypocretin/Orexin Neurons

2005 • 830 citations

Segregation of Different GABA_AReceptors to Synaptic and Extrasynaptic Membranes of Cerebellar Granule Cells

1998 • 829 citations

Functional consequences of a CKIδ mutation causing familial advanced sleep phase syndrome

2005 • 828 citations

The Role of Sleep in Cognition and Emotion

2009 • 827 citations

Astrocytic Modulation of Sleep Homeostasis and Cognitive Consequences of Sleep Loss

2009 • 815 citations

Restoration of brain energy metabolism as the function of sleep

1995 • 811 citations

Raphe unit activity in freely moving cats: Correlation with level of behavioral arousal

1979 • 809 citations

Animal sleep: A review of sleep duration across phylogeny

1984 • 804 citations

Hyperarousal and insomnia: State of the science

2009 • 794 citations

Effects of poor and short sleep on glucose metabolism and obesity risk

2009 • 787 citations

The cognitive neuroscience of sleep: neuronal systems, consciousness and learning

2002 • 780 citations

Neuronal activities in brain-stem cholinergic nuclei related to tonic activation processes in thalamocortical systems

1990 • 779 citations

Differential Distribution of Three Members of a Gene Family Encoding Low Voltage-Activated (T-Type) Calcium Channels

1999 • 779 citations

Local sleep in awake rats

2011 • 771 citations

Cross-Frequency Phase–Phase Coupling between Theta and Gamma Oscillations in the Hippocampus

2012 • 769 citations

Two types of hippocampal rhythmical slow activity in both the rabbit and the rat: Relations to behavior and effects of atropine, diethyl ether, urethane, and pentobarbital

1975 • 765 citations

Kv3 channels: voltage-gated K+ channels designed for high-frequency repetitive firing

2001 • 764 citations

Dopaminergic Role in Stimulant-Induced Wakefulness

2001 • 763 citations

Nicotine activates and desensitizes midbrain dopamine neurons

1997 • 762 citations

REM Sleep Behavior Disorder: Clinical, Developmental, and Neuroscience Perspectives 16 Years After its Formal Identification in SLEEP

2002 • 758 citations

Chronic stress impairs rat spatial memory on the Y maze, and this effect is blocked by tianeptine pretreatment.

1996 • 756 citations

The significance of the rabbit's septum as a relay station between the midbrain and the hippocampus I. The control of hippocampus arousal activity by the septum cells

1962 • 756 citations

To Eat or to Sleep? Orexin in the Regulation of Feeding and Wakefulness

2001 • 754 citations

Acetylcholine in mind: a neurotransmitter correlate of consciousness?

1999 • 750 citations

Cellular mechanisms of brain energy metabolism and their relevance to functional brain imaging

1999 • 745 citations

AN INHIBITORY MECHANISM IN THE BULBAR RETICULAR FORMATION

1946 • 736 citations

Metabolic consequences of sleep and sleep loss

2008 • 730 citations

Innervation of Histaminergic Tuberomammillary Neurons by GABAergic and Galaninergic Neurons in the Ventrolateral Preoptic Nucleus of the Rat

1998 • 720 citations

Discussion

1997 • 717 citations

Prevalence of restless legs syndrome and periodic limb movement disorder in the general population

2002 • 713 citations

High-frequency oscillations in human brain

1999 • 709 citations

Organization of cerebral cortical afferent systems in the rat. II. Magnocellular basal nucleus

1984 • 707 citations

Functional Neuroimaging Evidence for Hyperarousal in Insomnia

2004 • 707 citations

Adenosine receptors and behavioral actions of methylxanthines.

1981 • 705 citations

Potassium leak channels and the KCNK family of two-p-domain subunits

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Cortical Firing and Sleep Homeostasis

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Regulation of Dendritic Spine Morphology and Synaptic Function by Shank and Homer

2001 • 685 citations

Influences of hippocampal place cell firing in the awake state on the activity of these cells during subsequent sleep episodes

1989 • 682 citations

Optogenetic interrogation of neural circuits: technology for probing mammalian brain structures

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Genome-wide association study of restless legs syndrome identifies common variants in three genomic regions

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Inverted‐U relationship between the level of peripheral corticosterone and the magnitude of hippocampal primed burst potentiation

1992 • 671 citations

Decoupling of the brain's default mode network during deep sleep

2009 • 670 citations

Synchronization of fast (30-40 Hz) spontaneous cortical rhythms during brain activation

1996 • 661 citations

SLEEP AS A PROBLEM OF LOCALIZATION

1930 • 661 citations

Cholinergic systems in the rat brain: III. Projections from the pontomesencephalic tegmentum to the thalamus, tectum, basal ganglia, and basal forebrain

1986 • 659 citations

A STUDY OF THALAMO-CORTICAL RELATIONS

1941 • 658 citations

HYPOTHALAMIC REGULATION OF SLEEP IN RATS. AN EXPERIMENTAL STUDY

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Fos Expression in Orexin Neurons Varies with Behavioral State

2001 • 647 citations

Molecular and physiological diversity of nicotinic acetylcholine receptors in the midbrain dopaminergic nuclei.

2001 • 640 citations

Pathogenesis of Obstructive and Central Sleep Apnea

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Neuronal excitability modulation over the sleep cycle: a structural and mathematical model

1975 • 636 citations

Effect of Lesions of the Ventrolateral Preoptic Nucleus on NREM and REM Sleep

2000 • 631 citations

Distinct Narcolepsy Syndromes in Orexin Receptor-2 and Orexin Null Mice

2003 • 629 citations

A Third Vesicular Glutamate Transporter Expressed by Cholinergic and Serotoninergic Neurons

2002 • 626 citations

The deafferented reticular thalamic nucleus generates spindle rhythmicity

1987 • 624 citations

How (and why) the immune system makes us sleep

2009 • 623 citations

Chronic Insomnia as a Risk Factor for Developing Anxiety and Depression

2007 • 619 citations

ATP Released by Astrocytes Mediates Glutamatergic Activity-Dependent Heterosynaptic Suppression

2003 • 615 citations

Recovery of consciousness after brain injury: a mesocircuit hypothesis

2009 • 613 citations

Extensive and Divergent Effects of Sleep and Wakefulness on Brain Gene Expression

2004 • 611 citations

Abolition of spindle oscillations in thalamic neurons disconnected from nucleus reticularis thalami

1985 • 610 citations

A Genetic Risk Factor for Periodic Limb Movements in Sleep

2007 • 609 citations

Adenosine A2A, but not A1, receptors mediate the arousal effect of caffeine

2005 • 606 citations

Impact, diagnosis and treatment of restless legs syndrome (RLS) in a primary care population: the REST (RLS epidemiology, symptoms, and treatment) primary care study

2004 • 604 citations

A neural circuit for circadian regulation of arousal

2001 • 600 citations

5-Hydroxytryptamine2 and 5-hydroxytryptamine1A receptors mediate opposing responses on membrane excitability in rat association cortex

1991 • 599 citations

Abnormalities in CSF concentrations of ferritin and transferrin in restless legs syndrome

2000 • 598 citations

Reduction of Nightmares and Other PTSD Symptoms in Combat Veterans by Prazosin: A Placebo-Controlled Study

2003 • 597 citations

REM sleep behavior disorder and REM sleep without atonia in Parkinson’s disease

2002 • 593 citations

Hypocretin (orexin) activation and synaptic innervation of the locus coeruleus noradrenergic system

1999 • 587 citations

The origins of cholinergic and other subcortical afferents to the thalamus in the rat

1987 • 587 citations

Emotional Memory Formation Is Enhanced across Sleep Intervals with High Amounts of Rapid Eye Movement Sleep

2001 • 577 citations

High-Frequency Oscillations in the Output Networks of the Hippocampal–Entorhinal Axis of the Freely Behaving Rat

1996 • 575 citations

Molecular and Physiological Diversity of Nicotinic Acetylcholine Receptors in the Midbrain Dopaminergic Nuclei

2001 • 574 citations

Heightened synaptic plasticity of hippocampal CA1 neurons during a Cholinergically induced rhythmic state

1993 • 571 citations

REM sleep and dreaming: towards a theory of protoconsciousness

2009 • 571 citations

Excitation of Ventral Tegmental Area Dopaminergic and Nondopaminergic Neurons by Orexins/Hypocretins

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Diffuse projection systems: The integrative action of the thalamic reticular system

1949 • 569 citations

From waking to sleeping: neuronal and chemical substrates

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The functional neuroanatomy of PTSD: a critical review

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Ontogenesis of the states of sleep in rat, cat, and guinea pig during the first postnatal month

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Afferents to the orexin neurons of the rat brain

2005 • 565 citations

Pedunculopontine Nucleus Region Deep Brain Stimulation in Parkinson Disease: Surgical Anatomy and Terminology

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Sleep as a fundamental property of neuronal assemblies

2008 • 559 citations

The REM Sleep-Memory Consolidation Hypothesis

2001 • 559 citations

Promotion of sleep by targeting the orexin system in rats, dogs and humans

2007 • 557 citations

Visual Discrimination Task Improvement: A Multi-Step Process Occurring During Sleep

2000 • 555 citations

Epidemiology of Insomnia: a Longitudinal Study in a UK Population

2007 • 555 citations

Resting GABA concentration predicts peak gamma frequency and fMRI amplitude in response to visual stimulation in humans

2009 • 554 citations

Dreaming and REM sleep are controlled by different brain mechanisms

2000 • 549 citations

Adenosine and sleep–wake regulation

2004 • 548 citations

Melanin-concentrating hormone 1 receptor-deficient mice are lean, hyperactive, and hyperphagic and have altered metabolism

2002 • 547 citations

Astrocyte-Derived ATP Induces Vesicle Shedding and IL-1β Release from Microglia

2005 • 546 citations

Critical Role of Dorsomedial Hypothalamic Nucleus in a Wide Range of Behavioral Circadian Rhythms

2003 • 546 citations

Behavioral and Anatomical Correlates of Chronic Episodic Hypoxia during Sleep in the Rat

2001 • 544 citations

Brain Morphology Associated with Obstructive Sleep Apnea

2002 • 543 citations

Dopamine Is a Regulator of Arousal in the Fruit Fly

2005 • 542 citations

Arousal effect of orexin A depends on activation of the histaminergic system

2001 • 540 citations

Role and regulation of the ER chaperone BiP

1999 • 539 citations

Afferent connections of the laterodorsal and the pedunculopontine tegmental nuclei in the rat: A retro‐ and antero‐grade transport and immunohistochemical study

1992 • 535 citations

The Homeostatic Regulation of Sleep Need Is under Genetic Control

2001 • 535 citations

Cellular and Network Mechanisms of Slow Oscillatory Activity (&lt;1 Hz) and Wave Propagations in a Cortical Network Model

2003 • 534 citations

The prefrontal cortex in sleep

2002 • 534 citations

Enduring effects of chronic corticosterone treatment on spatial learning, synaptic plasticity, and hippocampal neuropathology in young and mid-aged rats

1995 • 527 citations

Lethargus is a Caenorhabditis elegans sleep-like state

2008 • 520 citations

Injections of drugs into the lateral ventricle of the cat

1954 • 514 citations

Hypocretin-1 Modulates Rapid Eye Movement Sleep through Activation of Locus Coeruleus Neurons

2000 • 506 citations

Hippocampal theta activity following selective lesion of the septal cholinergic systeM

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Thalamic Mechanisms of EEG Alpha Rhythms and Their Pathological Implications

2005 • 503 citations

A radioautographic study of the efferent pathways of the nucleus locus coeruleus

1974 • 500 citations

Role of Reticular Activation in the Modulation of Intracortical Synchronization

1996 • 500 citations

Functional Imaging of Working Memory after 24 Hr of Total Sleep Deprivation

2004 • 498 citations

Electrophysiological and pharmacological characterization of serotonergic dorsal raphe neurons recorded extracellularly and intracellularly in rat brain slices

1983 • 497 citations

Orexin/Hypocretin Excites the Histaminergic Neurons of the Tuberomammillary Nucleus

2001 • 495 citations

Frontal-midline theta from the perspective of hippocampal “theta”

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Serotonin Induces Excitatory Postsynaptic Potentials in Apical Dendrites of Neocortical Pyramidal Cells

1997 • 487 citations

Identification of sleep-promoting neurons in vitro

2000 • 485 citations

Neuropeptide S

2004 • 484 citations

Afferents to the Ventrolateral Preoptic Nucleus

2002 • 484 citations

Polysomnographic features of REM sleep behavior disorder

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Arousal systems

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The Sudden Infant Death Syndrome

2009 • 481 citations

Network modulation of a slow intrinsic oscillation of cat thalamocortical neurons implicated in sleep delta waves: cortically induced synchronization and brainstem cholinergic suppression

1991 • 479 citations

Hypocretin/Orexin Overexpression Induces An Insomnia-Like Phenotype in Zebrafish

2006 • 475 citations

A targeted mutation of the D3 dopamine receptor gene is associated with hyperactivity in mice.

1996 • 473 citations

Anatomical, Physiological, and Pharmacological Characteristics of Histidine Decarboxylase Knock-Out Mice: Evidence for the Role of Brain Histamine in Behavioral and Sleep–Wake Control

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Narcolepsy is strongly associated with the T-cell receptor alpha locus

2009 • 470 citations

Sleep states and memory processes

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Input of Orexin/Hypocretin Neurons Revealed by a Genetically Encoded Tracer in Mice

2005 • 463 citations

Reassessment of the structural basis of the ascending arousal system

2010 • 461 citations

Sleep–waking discharge patterns of ventrolateral preoptic/anterior hypothalamic neurons in rats

1998 • 460 citations

Reduced sleep in Drosophila Shaker mutants

2005 • 460 citations

Hypocretin/Orexin Excites Hypocretin Neurons via a Local Glutamate Neuron—A Potential Mechanism for Orchestrating the Hypothalamic Arousal System

2002 • 459 citations

Human Sleep, Sleep Loss and Behaviour

1993 • 458 citations

Gene expression and protein distribution of the orexin-1 receptor in the rat brain and spinal cord

2001 • 457 citations

Sleep in Drosophila is regulated by adult mushroom bodies

2006 • 452 citations

PHARMACOLOGICAL ASPECTS OF HUMAN AND CANINE NARCOLEPSY

1997 • 452 citations

Brain site-specificity of extracellular adenosine concentration changes during sleep deprivation and spontaneous sleep: an in vivo microdialysis study

2000 • 451 citations

Fast oscillations (20-40 Hz) in thalamocortical systems and their potentiation by mesopontine cholinergic nuclei in the cat.

1991 • 449 citations

Sleep Deprivation Selectively Impairs Memory Consolidation for Contextual Fear Conditioning

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The theta/gamma discrete phase code occuring during the hippocampal phase precession may be a more general brain coding scheme

2005 • 448 citations

The Role of Cytokines in Sleep Regulation

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The slow (&lt;1 Hz) rhythm of non-REM sleep: a dialogue between three cardinal oscillators

2009 • 441 citations

Measurement of Immediate‐Early Gene Activation‐ c‐fos and Beyond

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Sleep Deprivation Amplifies Reactivity of Brain Reward Networks, Biasing the Appraisal of Positive Emotional Experiences

2011 • 438 citations

Restless legs syndrome

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Locus coeruleus et sommeil paradoxal

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Identification of Wake-Active Dopaminergic Neurons in the Ventral Periaqueductal Gray Matter

2006 • 435 citations

Suppression of firing activity of 5-HT neurons in the dorsal raphe by alpha-adrenoceptor antagonists

1980 • 435 citations

Noradrenaline and serotonin selectively modulate thalamic burst firing by enhancing a hyperpolarization-activated cation current

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Cholinergic Basal Forebrain Neurons Burst with Theta during Waking and Paradoxical Sleep

2005 • 432 citations

Acetylcholine released from cerebral cortex in relation to state of activation

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Relative contributions of intracortical and thalamo-cortical processes in the generation of alpha rhythms, revealed by partial coherence analysis

1980 • 432 citations

Effect upon the EEG of acute injury to the brain stem activating system

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Sleep Suppression after Basal Forebrain Lesions in the Cat

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Arousal systems and attentional processes

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Acetylcholine Liberation from Cerebral Cortex during Paradoxical (REM) Sleep

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Orexin (Hypocretin) Neurons Contain Dynorphin

2001 • 424 citations

Noradrenergic and serotonergic modulation of a hyperpolarization‐activated cation current in thalamic relay neurones.

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Melanin-concentrating hormone neurons discharge in a reciprocal manner to orexin neurons across the sleep–wake cycle

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Cortical cholinergic inputs mediating arousal, attentional processing and dreaming: differential afferent regulation of the basal forebrain by telencephalic and brainstem afferents

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A role of melanin-concentrating hormone producing neurons in the central regulation of paradoxical sleep.

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A cortical neuropeptide with neuronal depressant and sleep-modulating properties

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Disfacilitation and active inhibition in the neocortex during the natural sleep-wake cycle: An intracellular study

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The comparative neuroanatomy and neurochemistry of zebrafish CNS systems of relevance to human neuropsychiatric diseases

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Histamine and noradrenaline decrease calcium-activated potassium conductance in hippocampal pyramidal cells

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Dual electroencephalogram markers of human sleep homeostasis: correlation between theta activity in waking and slow-wave activity in sleep

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Modeling Sleep and Wakefulness in the Thalamocortical System

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Anatomy and physiology of saccadic burst neurons in the alert squirrel monkey. I. Excitatory burst neurons

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Low acetylcholine during slow-wave sleep is critical for declarative memory consolidation

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Sleep Homeostasis and Cortical Synchronization: III. A High-Density EEG Study of Sleep Slow Waves in Humans

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A cholinergic mechanism in the brainstem reticular formation: Induction of paradoxical sleep

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A key role for orexin in panic anxiety

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Electrophysiological Characterization of GABAergic Neurons in the Ventral Tegmental Area

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REM sleep behavior disorder and degenerative dementia

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Genetics of Sleep and Sleep Disorders

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PDF Cells Are a GABA-Responsive Wake-Promoting Component of the Drosophila Sleep Circuit

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Mapping of cholinoceptive brainstem structures responsible for the generation of paradoxical sleep in the cat.

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Hypocretins (Orexins) Regulate Serotonin Neurons in the Dorsal Raphe Nucleus by Excitatory Direct and Inhibitory Indirect Actions

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Synucleinopathy pathology and REM sleep behavior disorder plus dementia or parkinsonism

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The genetic and molecular regulation of sleep: from fruit flies to humans

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mPer1 and mPer2 Are Essential for Normal Resetting of the Circadian Clock

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Characterization of Sleep in Zebrafish and Insomnia in Hypocretin Receptor Mutants

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Different behaviors during paradoxical sleep without atonia depend on pontine lesion site

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Differential Expression of Plasticity-Related Genes in Waking and Sleep and Their Regulation by the Noradrenergic System

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Sleep deprivation reduces perceived emotional intelligence and constructive thinking skills

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Macromolecule biosynthesis: a key function of sleep

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The Human K-Complex Represents an Isolated Cortical Down-State

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Neuroanatomical correlates of brainstem coma

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Unitary characteristics of presumptive cholinergic tegmental neurons during the sleep-waking cycle in freely moving cats

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Neuronal Activity of Histaminergic Tuberomammillary Neurons During Wake–Sleep States in the Mouse

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Homer1a is a core brain molecular correlate of sleep loss

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Behavioral and electroencephalographic effects of atropine and related compounds.

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Theta and Gamma Coordination of Hippocampal Networks during Waking and Rapid Eye Movement Sleep

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The Role of Hypocretins (Orexins) in Sleep Regulation and Narcolepsy

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Low-frequency rhythms in the thalamus of intact-cortex and decorticated cats

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Cholinergic activation and tonic excitation induce persistent gamma oscillations in mouse somatosensory cortex in vitro

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Sleep and Synaptic Homeostasis: Structural Evidence in Drosophila

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Widespread Changes in Synaptic Markers as a Function of Sleep and Wakefulness in Drosophila

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Convergent Excitation of Dorsal Raphe Serotonin Neurons by Multiple Arousal Systems (Orexin/Hypocretin, Histamine and Noradrenaline)

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Adenosine Inhibition of Mesopontine Cholinergic Neurons: Implications for EEG Arousal

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The novel brain neuropeptide, orexin‐A, modulates the sleep–wake cycle of rats

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Orientation Discrimination Performance Is Predicted by GABA Concentration and Gamma Oscillation Frequency in Human Primary Visual Cortex

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Elevated Anti-Streptococcal Antibodies in Patients with Recent Narcolepsy Onset

2009 • 335 citations

Release of Hypocretin (Orexin) during Waking and Sleep States

2002 • 335 citations

Orexin peptides prevent cataplexy and improve wakefulness in an orexin neuron-ablated model of narcolepsy in mice

2004 • 334 citations

The laterodorsal tegmentum is essential for burst firing of ventral tegmental area dopamine neurons

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Mathematical models of sleep regulation

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The Transcriptional Repressor DEC2 Regulates Sleep Length in Mammals

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Evidence for histaminergic arousal mechanisms in the hypothalamus of cat

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The development of neural synchrony reflects late maturation and restructuring of functional networks in humans

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Familial and sporadic fatal insomnia

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Release of Adenosine by Activation of NMDA Receptors in the Hippocampus

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The K-complex: Its slow (&lt;1-Hz) rhythmicity and relation to delta waves

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A dynamic role for the mushroom bodies in promoting sleep in Drosophila

2006 • 328 citations

Sleep Deprivation Elevates Expectation of Gains and Attenuates Response to Losses Following Risky Decisions

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A Novel Network of Multipolar Bursting Interneurons Generates Theta Frequency Oscillations in Neocortex

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Identification of SLEEPLESS, a Sleep-Promoting Factor

2008 • 323 citations

Differential expression of Shaw-related K+ channels in the rat central nervous system

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Marked Decrease in Sleepiness in Patients with Sleep Apnea by Etanercept, a Tumor Necrosis Factor-α Antagonist

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Single unit activity of locus coeruleus neurons in the freely moving cat

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Memory and Emotion

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Insights from studying human sleep disorders

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GABAergic and other noncholinergic basal forebrain neurons, together with cholinergic neurons, project to the mesocortex and isocortex in the rat

1997 • 319 citations

Biochemical regulation of non-rapid-eye-movement sleep

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Hippocampal theta rhythm: A tag for short‐term memory

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A critical role of the posterior hypothalamus in the mechanisms of wakefulness determined by microinjection of muscimol in freely moving cats

1989 • 317 citations

Neocortical and caudate projections of intralaminar thalamic neurons and their synaptic excitation from midbrain reticular core

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Mechanisms of oscillatory activity in guinea‐pig nucleus reticularis thalami in vitro: a mammalian pacemaker.

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Depletion of norepinephrine, but not serotonin, reduces long-term potentiation in the dentate gyrus of rat hippocampal slices

1985 • 314 citations

Selective Activation of the Extended Ventrolateral Preoptic Nucleus during Rapid Eye Movement Sleep

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Serotonin and the sleep/wake cycle: special emphasis on microdialysis studies

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Nightmares and trauma: a comparison of nightmares after combat with lifelong nightmares in veterans

1984 • 311 citations

Neuroimaging findings in post-traumatic stress disorder. Systematic review.

2002 • 310 citations

Temporal Framing of Thalamic Relay-Mode Firing by Phasic Inhibition during the Alpha Rhythm

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Variations in extracellular levels of dopamine, noradrenaline, glutamate, and aspartate across the sleep–wake cycle in the medial prefrontal cortex and nucleus accumbens of freely moving rats

2005 • 309 citations

Sleep EEG in the rat as a function of prior waking

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Sleep Homeostasis and Cortical Synchronization: I. Modeling the Effects of Synaptic Strength on Sleep Slow Waves

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Limbic cholinergic pathways involved in sleep and emotional behavior

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Cell Type-Specific Tuning of Hippocampal Interneuron Firing during Gamma OscillationsIn Vivo

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Orexins/hypocretins excite basal forebrain cholinergic neurones

2001 • 307 citations

The influence of learning on sleep slow oscillations and associated spindles and ripples in humans and rats

2009 • 305 citations

Projections of cholinergic and non-cholinergic neurons of the brainstem core to relay and associational thalamic nuclei in the cat and macaque monkey

1988 • 305 citations

The Cognitive Correlates of Human Brain Oscillations

2006 • 305 citations

Linkage disequilibrium between the beta frequency of the human EEG and a GABA _A receptor gene locus

2002 • 303 citations

Subthreshold Sodium Current from Rapidly Inactivating Sodium Channels Drives Spontaneous Firing of Tuberomammillary Neurons

2002 • 302 citations

Wake-promoting and sleep-suppressing actions of hypocretin (orexin): basal forebrain sites of action

2001 • 302 citations

What Keeps Us Awake: the Neuropharmacology of Stimulants and Wakefulness Promoting Medications

2004 • 302 citations

The emotional brain and sleep: An intimate relationship

2010 • 301 citations

Decreased Muscarinic Receptor Binding in the Arcuate Nucleus in Sudden Infant Death Syndrome

1995 • 301 citations

Brainstem Serotonergic Deficiency in Sudden Infant Death Syndrome

2010 • 298 citations

Sleep Deprivation Impairs the Accurate Recognition of Human Emotions

2010 • 298 citations

The stimulant effects of caffeine on locomotor behaviour in mice are mediated through its blockade of adenosine A_2A receptors

2000 • 297 citations

Sleep and Sleep Regulation in Normal and Prion Protein-Deficient Mice

1997 • 296 citations

A Sleep-Promoting Role for the Drosophila Serotonin Receptor 1A

2006 • 295 citations

Neuropeptide S-Mediated Control of Fear Expression and Extinction: Role of Intercalated GABAergic Neurons in the Amygdala

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Vglut2 afferents to the medial prefrontal and primary somatosensory cortices: A combined retrograde tracing in situ hybridization

2005 • 293 citations

Tandem-Pore K+ Channels Mediate Inhibition of Orexin Neurons by Glucose

2006 • 293 citations

Cholinergic projections from the midbrain and pons to the thalamus in the rat, identified by combined retrograde tracing and choline acetyltransferase immunohistochemistry

1985 • 293 citations

A Review of the Evidence for the Efficacy and Safety of Trazodone in Insomnia

2005 • 293 citations

gamma-Aminobutyric acid-containing basal forebrain neurons innervate inhibitory interneurons in the neocortex.

1992 • 293 citations

Cognitive dysfunction in sleep disorders

2001 • 293 citations

Orexins Activate Histaminergic Neurons via the Orexin 2 Receptor

2002 • 292 citations

Sleep-Dependent θ Oscillations in the Human Hippocampus and Neocortex

2003 • 292 citations

Sleep deprivation lowers inhibition and enhances impulsivity to negative stimuli

2010 • 291 citations

The Nucleus Basalis Magnocellularis Cholinergic System: One Hundred Years of Progress

1997 • 291 citations

The Brainstem and Serotonin in the Sudden Infant Death Syndrome

2009 • 291 citations

Elevated Tribbles homolog 2–specific antibody levels in narcolepsy patients

2010 • 290 citations

Projections of brainstem core cholinergic and non-cholinergic neurons of cat to intralaminar and reticular thalamic nuclei

1988 • 289 citations

Precise Long-Range Synchronization of Activity and Silence in Neocortical Neurons during Slow-Wave Sleep

2006 • 289 citations

Chemistry of the mind: Neurochemical modulation of prefrontal cortical function

2005 • 289 citations

State-Dependent Spike-Timing Relationships between Hippocampal and Prefrontal Circuits during Sleep

2009 • 288 citations

Cholinergic and noradrenergic modulation of the slow (approximately 0.3 Hz) oscillation in neocortical cells

1993 • 288 citations

PHA‐L analysis of projections from the supramammillary nucleus in the rat

1992 • 287 citations

A model of gamma‐frequency network oscillations induced in the rat CA3 region by carbachol in vitro

2000 • 287 citations

Incidental Lewy body disease in a patient with REM sleep behavior disorder

1995 • 286 citations

A re-evaluation of the effects of lesions of the pontine tegmentum and locus coeruleus on phenomena of paradoxical sleep in the cat.

1974 • 286 citations

Low‐frequency oscillatory activities intrinsic to rat and cat thalamocortical cells.

1991 • 286 citations

Genetic Determinants of Sleep Regulation in Inbred Mice

1999 • 286 citations

Direct and Indirect Excitation of Laterodorsal Tegmental Neurons by Hypocretin/Orexin Peptides: Implications for Wakefulness and Narcolepsy

2002 • 285 citations

Arousal Effect of Caffeine Depends on Adenosine A2A Receptors in the Shell of the Nucleus Accumbens

2011 • 285 citations

Role and Origin of the GABAergic Innervation of Dorsal Raphe Serotonergic Neurons

2000 • 285 citations

Wake and sleep EEG provide biomarkers in depression

2009 • 282 citations

Genetic variation in EEG activity during sleep in inbred mice

1998 • 282 citations

A role for cryptochromes in sleep regulation.

2002 • 282 citations

Afferent and efferent connections of the laterodorsal tegmental nucleus in the rat

1990 • 281 citations

Effects of locus coeruleus lesions upon cerebral monoamine content, sleep-wakefulness states and the response to amphetamine in the cat

1977 • 280 citations

Serotonin and noradrenaline excite GABAergic neurones of the guinea‐pig and cat nucleus reticularis thalami.

1991 • 280 citations

Prominent Burst Firing of Dopaminergic Neurons in the Ventral Tegmental Area during Paradoxical Sleep

2006 • 280 citations

Sleep Characteristics of Infants

1953 • 280 citations

Brain stem gigantocellular neurons: patterns of activity during behavior and sleep in the freely moving rat

1979 • 279 citations

Light-arousal and circadian photoreception circuits intersect at the large PDF cells of the Drosophila brain

2008 • 279 citations

Ventrolateral preoptic nucleus contains sleep-active, galaninergic neurons in multiple mammalian species

2002 • 279 citations

Circadian clock genes and sleep homeostasis

2009 • 278 citations

Sleep-disordered Breathing and Neuropsychological Deficits

1997 • 277 citations

Differential c-Fos Expression in Cholinergic, Monoaminergic, and GABAergic Cell Groups of the Pontomesencephalic Tegmentum after Paradoxical Sleep Deprivation and Recovery

1999 • 277 citations

Two inward currents and the transformation of low‐frequency oscillations of rat and cat thalamocortical cells.

1991 • 276 citations

Clinical correlates of 6-hydroxydopamine injections into A11 dopaminergic neurons in rats: A possible model for restless legs syndrome?

2000 • 275 citations

Synchronized Oscillations at α and θ Frequencies in the Lateral Geniculate Nucleus

2004 • 273 citations

Functional nicotinic ACh receptors on interneurones in the rat hippocampus

1997 • 273 citations

Hypocretin-2-Saporin Lesions of the Lateral Hypothalamus Produce Narcoleptic-Like Sleep Behavior in the Rat

2001 • 273 citations

A Causal Role for Brain-Derived Neurotrophic Factor in the Homeostatic Regulation of Sleep

2008 • 272 citations

Sleep homeostasis: A role for adenosine in humans?

2008 • 272 citations

Avoidance Task Training Potentiates Phasic Pontine-Wave Density in the Rat: A Mechanism for Sleep-Dependent Plasticity

2000 • 271 citations

Lapsing during Sleep Deprivation Is Associated with Distributed Changes in Brain Activation

2008 • 271 citations

Serotonergic and cholinergic inhibition of mesopontine cholinergic neurons controlling rem sleep: An in vitro electrophysiological study

1994 • 271 citations

CSF iron, ferritin and transferrin levels in restless legs syndrome

2005 • 271 citations

Circadian and Homeostatic Regulation of Hypocretin in a Primate Model: Implications for the Consolidation of Wakefulness

2003 • 270 citations

An analysis of ascending brain stem systems involved in hippocampal synchronization and desynchronization.

1981 • 270 citations

Laterodorsal tegmental stimulation elicits dopamine efflux in the rat nucleus accumbens by activation of acetylcholine and glutamate receptors in the ventral tegmental area

2000 • 268 citations

The roles of dopamine and serotonin, and of their receptors, in regulating sleep and waking

2008 • 267 citations

Orexin A excites serotonergic neurons in the dorsal raphe nucleus of the rat

2001 • 267 citations

Extraction of sleep-promoting factor S from cerebrospinal fluid and from brains of sleep-deprived animals

1975 • 266 citations

Activity of brain serotonergic neurons in the behaving animal.

1991 • 265 citations

The Orexin/Hypocretin System in Zebrafish Is Connected to the Aminergic and Cholinergic Systems

2004 • 265 citations

Neuronal Gene Expression in the Waking State: A Role for the Locus Coeruleus

1996 • 265 citations

Activity of mesencephalic dopamine and non-dopamine neurons across stages of sleep and waking in the rat

1983 • 265 citations

Distribution of neuropeptide S receptor mRNA and neurochemical characteristics of neuropeptide S‐expressing neurons in the rat brain

2006 • 264 citations

Behavioral correlates of dopaminergic unit activity in freely moving cats

1983 • 264 citations

Protein distribution of the orexin-2 receptor in the rat central nervous system

2002 • 263 citations

An adenosine A2a agonist increases sleep and induces Fos in ventrolateral preoptic neurons

2001 • 263 citations

Induction of sharp wave–ripple complexes in vitro and reorganization of hippocampal networks

2005 • 261 citations

Projections from basal forebrain to prefrontal cortex comprise cholinergic, GABAergic and glutamatergic inputs to pyramidal cells or interneurons

2008 • 261 citations

An inverse agonist of the histamine H3 receptor improves wakefulness in narcolepsy: Studies in orexin−/− mice and patients

2007 • 261 citations

A Genetic Variation in the Adenosine A2A Receptor Gene (ADORA2A) Contributes to Individual Sensitivity to Caffeine Effects on Sleep

2007 • 261 citations

Temporal binding via cortical coincidence detection of specific and nonspecific thalamocortical inputs: A voltage-dependent dye-imaging study in mouse brain slices

2002 • 260 citations

GABA release in the locus coeruleus as a function of sleep/wake state

1997 • 259 citations

ORGANIZATION OF THE DIFFUSE THALAMIC PROJECTION SYSTEM

1951 • 259 citations

Frequency-Dependent Noradrenergic Modulation of Long-Term Potentiation in the Hippocampus

1984 • 257 citations

Behavioral, biochemical, histological, and electrophysiological effects of 192 IgG-saporin injections into the basal forebrain of rats

1994 • 256 citations

Emotional enhancement of memory: how norepinephrine enables synaptic plasticity

2010 • 256 citations

The reticular nucleus revisited: Intrinsic and network properties of a thalamic pacemaker

2005 • 256 citations

Sleep-Related Hippocampo-Cortical Interplay during Emotional Memory Recollection

2007 • 256 citations

Multiple output pathways of the basal forebrain: organization, chemical heterogeneity, and roles in vigilance

2000 • 255 citations

A functional genetic variation of adenosine deaminase affects the duration and intensity of deep sleep in humans

2005 • 255 citations

The electroencephalographic fingerprint of sleep is genetically determined: A twin study

2008 • 255 citations

Origin of Active States in Local Neocortical Networks during Slow Sleep Oscillation

2010 • 254 citations

Sustained increase in hippocampal sharp-wave ripple activity during slow-wave sleep after learning

2008 • 253 citations

The cognitive cost of sleep lost

2011 • 253 citations

The process of awakening: a PET study of regional brain activity patterns mediating the re-establishment of alertness and consciousness

2002 • 253 citations

The neurobiology, diagnosis, and treatment of narcolepsy

2003 • 251 citations

Nicotinic Receptor Activation in Human Cerebral Cortical Interneurons: a Mechanism for Inhibition and Disinhibition of Neuronal Networks

2000 • 251 citations

The neuronal network responsible for paradoxical sleep and its dysfunctions causing narcolepsy and rapid eye movement (REM) behavior disorder

2010 • 250 citations

Epidemiological evidence for the links between sleep, circadian rhythms and metabolism

2009 • 250 citations

Multiple origins of the cortical gamma rhythm

2010 • 250 citations

A Role for REM Sleep in Recalibrating the Sensitivity of the Human Brain to Specific Emotions

2010 • 249 citations

Electrophysiology of a slow (0.5‐4 Hz) intrinsic oscillation of cat thalamocortical neurones in vivo.

1992 • 248 citations

Elevated Sleep Spindle Density after Learning or after Retrieval in Rats

2006 • 247 citations

Precisely Synchronized Oscillatory Firing Patterns Require Electroencephalographic Activation

1999 • 246 citations

Cholinergic projections from the laterodorsal and pedunculopontine tegmental nuclei to the pontine gigantocellular tegmental field in the cat

1988 • 245 citations

PERIOD3, circadian phenotypes, and sleep homeostasis

2009 • 245 citations

Different cellular types in mesopontine cholinergic nuclei related to ponto-geniculo-occipital waves

1990 • 243 citations

Common scale-invariant patterns of sleep–wake transitions across mammalian species

2004 • 243 citations

Hypothalamic orexin (hypocretin) neurons express vesicular glutamate transporters VGLUT1 or VGLUT2

2003 • 242 citations

MRI-determined regional brain iron concentrations in early- and late-onset restless legs syndrome

2006 • 242 citations

PHYSIOLOGICAL REVIEW ARTICLE: Brain structures and mechanisms involved in the control of cortical activation and wakefulness, with emphasis on the posterior hypothalamus and histaminergic neurons

2000 • 242 citations

Firing of ‘possibly’ cholinergic neurons in the rat laterodorsal tegmental nucleus during sleep and wakefulness

1992 • 242 citations

Cellular Mechanisms of the Slow (&lt;1 Hz) Oscillation in Thalamocortical Neurons In Vitro

2002 • 242 citations

Characterization of neurons of the supramammillary nucleus and mammillary body that discharge rhythmically with the hippocampal theta rhythm in the rat

1994 • 241 citations

Serotonergic Antidepressants are Associated with REM Sleep Without Atonia

2004 • 240 citations

Restless legs syndrome

2009 • 240 citations

Sleep and Brain Energy Levels: ATP Changes during Sleep

2010 • 240 citations

Adenosine analogs and sleep in rats.

1984 • 239 citations

Growth hormone-deficient dwarfism in the rat: a new mutation

1988 • 239 citations

Differential Roles of Orexin Receptor-1 and -2 in the Regulation of Non-REM and REM Sleep

2011 • 238 citations

The electrophysiology of adenosine in the mammalian central nervous system

1991 • 238 citations

Sleep Homeostasis Modulates Hypocretin-Mediated Sleep-to-Wake Transitions

2009 • 237 citations

Localized Loss of Hypocretin (Orexin) Cells in Narcolepsy Without Cataplexy

2009 • 237 citations

Bulbo-thalamic neurons related to thalamocortical activation processes during paradoxical sleep

1984 • 237 citations

BRAIN STEM ELECTRICAL ACTIVITY DURING DEEP SLEEP.

1963 • 236 citations

Mechanisms of Sleep-Dependent Consolidation of Cortical Plasticity

2009 • 236 citations

Sleep Restriction Alters the Hypothalamic‐Pituitary‐Adrenal Response to Stress

2002 • 235 citations

The potassium channel subunit KV3.1b is localized to somatic and axonal membranes of specific populations of CNS neurons

1995 • 235 citations

Supramammillary cell firing and hippocampal rhythmical slow activity

1991 • 234 citations

Processing of learned information in paradoxical sleep: relevance for memory

1995 • 234 citations

The effects of one night of sleep deprivation on known‐risk and ambiguous‐risk decisions

2007 • 233 citations

The relationship of interleukin-1 and immune functions to sleep in humans.

1986 • 232 citations

Central serotonin neurons are required for arousal to CO ₂

2010 • 232 citations

Localization of the Brainstem GABAergic Neurons Controlling Paradoxical (REM) Sleep

2009 • 231 citations

Subregional organization of preoptic area /anterior hypothalamic projections to arousal-related monoaminergic cell groups

2000 • 231 citations

REM Sleep Induction by Physostigmine Infusion During Sleep

1976 • 230 citations

Long-lasting insomnia induced by preoptic neuron lesions and its transient reversal by muscimol injection into the posterior hypothalamus in the cat

1989 • 230 citations

GABA release in the dorsal raphe nucleus: role in the control of REM sleep

1997 • 229 citations

Physiological Properties of Hypothalamic MCH Neurons Identified with Selective Expression of Reporter Gene after Recombinant Virus Infection

2004 • 228 citations

Nitric oxide controls oscillatory activity in thalamocortical neurons

1992 • 227 citations

Diazepam-induced changes in sleep: Role of the α1 GABA_Areceptor subtype

2001 • 227 citations

Direct Evidence for Wake-Related Increases and Sleep-Related Decreases in Synaptic Strength in Rodent Cortex

2010 • 226 citations

Locus coeruleus neurons: cessation of activity during cataplexy

1999 • 225 citations

Prostaglandin D2, a cerebral sleep-inducing substance in monkeys.

1988 • 225 citations

Serotonin hyperpolarizes cholinergic low-threshold burst neurons in the rat laterodorsal tegmental nucleus in vitro.

1992 • 224 citations

A non-circadian role for cAMP signaling and CREB activity in Drosophila rest homeostasis

2001 • 224 citations

Cataplexy-Active Neurons in the Hypothalamus

2004 • 223 citations

Neuronal activity of orexin and non-orexin waking-active neurons during wake–sleep states in the mouse

2008 • 223 citations

Involvement of GABAergic and cholinergic medial septal neurons in hippocampal theta rhythm

2005 • 223 citations

Regulation of orexin neurons by the monoaminergic and cholinergic systems

2003 • 222 citations

Endogenous nonneuronal modulators of synaptic transmission control cortical slow oscillations in vivo

2009 • 221 citations

Neural Circuitry of Stress-Induced Insomnia in Rats

2008 • 221 citations

Cataplectic-like behavior in cats after micro-injections of carbachol in pontine reticular formation

1974 • 221 citations

Spontaneous muscle twitches during sleep guide spinal self-organization

2003 • 220 citations

Acetylcholine systems and rhythmic activities during the waking–sleep cycle

2004 • 220 citations

Parvalbumin-Deficiency Facilitates Repetitive IPSCs and Gamma Oscillations in the Hippocampus

2003 • 218 citations

Intracortical and corticothalamic coherency of fast spontaneous oscillations.

1996 • 218 citations

Effects of sleep deprivation on Color-Word, Emotional, and Specific Stroop interference and on self-reported anxiety

2005 • 218 citations

Recovery Sleep Following Sleep Deprivation in Intact and Suprachiasmatic Nuclei-Lesioned Rats

1983 • 218 citations

Involvement of histaminergic neurons in arousal mechanisms demonstrated with H3-receptor ligands in the cat

1990 • 217 citations

Chapter 5: The organization of central cholinergic systems and their functional importance in sleep-waking states

1993 • 217 citations

Rapid eye movement sleep disturbance in posttraumatic stress disorder

1994 • 216 citations

Sleep Homeostasis and Cortical Synchronization: II. A Local Field Potential Study of Sleep Slow Waves in the Rat

2007 • 216 citations

Prostaglandins and adenosine in the regulation of sleep and wakefulness

2006 • 216 citations

A neuroanatomical gradient in the pontine tegmentum for the cholinoceptive induction of desynchronized sleep signs

1987 • 215 citations

Sleep Restriction Suppresses Neurogenesis Induced by Hippocampus-Dependent Learning

2005 • 214 citations

Sleep Promotes the Neural Reorganization of Remote Emotional Memory

2009 • 214 citations

Does REM Sleep Deprivation Induce a Supersensitivity of Dopaminergic Receptors in the Rat Brain?

1978 • 213 citations

Sleep imaging and the neuro-psychological assessment of dreams

2002 • 213 citations

The Effects of 53 Hours of Sleep Deprivation on Moral Judgment

2007 • 213 citations

Further Observations on the Effect of Anoxia on Histamine Release from Guinea-Pig and Rat Lung Tissue in Vitro

1962 • 212 citations

Role of adenosine in behavioral state modulation: a microdialysis study in the freely moving cat

1997 • 212 citations

Organization of diencephalic dopamine neurones projecting to the spinal cord in the rat

1985 • 211 citations

THE ORIGIN OF THE BERGER RHYTHM

1935 • 211 citations

Adenine derivatives as neurohumoral agents in the brain. The quantities liberated on excitation of superfused cerebral tissues

1972 • 211 citations

Functional microstates within human REM sleep: first evidence from fMRI of a thalamocortical network specific for phasic REM periods

2007 • 209 citations

Orexin/Hypocretin and Histamine: Distinct Roles in the Control of Wakefulness Demonstrated Using Knock-Out Mouse Models

2009 • 209 citations

T-type Ca2+ channels, SK2 channels and SERCAs gate sleep-related oscillations in thalamic dendrites

2008 • 209 citations

Brainstem afferents to the basal forebrain in the rat

1988 • 208 citations

The Atonia and Myoclonia of Active (REM) Sleep

1990 • 207 citations

Activation of c‐fos in GABAergic neurones in the preoptic area during sleep and in response to sleep deprivation

2004 • 207 citations

Fast track:Unilateral vibrissae stimulation during waking induces interhemispheric EEG asymmetry during subsequent sleep in the rat

2000 • 206 citations

Adenosine and Sleep Homeostasis in the Basal Forebrain

2006 • 205 citations

PHYSIOLOGY OF THE NERVOUS SYSTEM

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Nitric Oxide Acutely Inhibits Neuronal Energy Production

1999 • 203 citations

Electroencephalogram Power Density and Slow Wave Sleep as a Function of Prior Waking and Circadian Phase

1990 • 203 citations

Brain Control of Wakefulness and Sleep

2005 • 203 citations

Mapping the differential effects of procaine on frequency and amplitude of reticularly elicited hippocampal rhythmical slow activity

1993 • 202 citations

Hippocampal synaptic plasticity and spatial learning are impaired in a rat model of sleep fragmentation

2006 • 202 citations

Functional imaging of working memory in obstructive sleep-disordered breathing

2005 • 202 citations

Localization of the GABAergic and non‐GABAergic neurons projecting to the sublaterodorsal nucleus and potentially gating paradoxical sleep onset

2003 • 201 citations

Lateral geniculate nucleus unitary discharge in sleep and waking: state- and rate-specific aspects

1983 • 200 citations

Sleep deprivation induces the unfolded protein response in mouse cerebral cortex

2005 • 200 citations

The EEG in metabolic encephalopathy and coma.

2004 • 199 citations

Lack of sleep affects the evaluation of emotional stimuli

2010 • 199 citations

Criteria for the diagnosis of the narcoleptic syndrome.

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Electrophysiological evidence that noradrenergic neurons of the rat locus coeruleus are tonically inhibited by GABA during sleep

1998 • 199 citations

Cholinergic projections from the basal forebrain to the frontal cortex: a combined fluorescent tracer and immunohistochemical analysis in the rat

1983 • 198 citations

The Effect of Sleep Deprivation on Cerebral Glucose Metabolic Rate in Normal Humans Assessed with Positron Emission Tomography

1991 • 197 citations

Discharge Profiles of Identified GABAergic in Comparison to Cholinergic and Putative Glutamatergic Basal Forebrain Neurons across the Sleep–Wake Cycle

2009 • 197 citations

Decreased transferrin receptor expression by neuromelanin cells in restless legs syndrome

2004 • 197 citations

Thalamic Ca _v 3.1 T-type Ca ² + channel plays a crucial role in stabilizing sleep

2005 • 197 citations

Sleep‐waking discharge patterns of median preoptic nucleus neurons in rats

2002 • 197 citations

Orexins (hypocretins) directly excite tuberomammillary neurons

2001 • 197 citations

Control and Function of the Homeostatic Sleep Response by Adenosine A₁Receptors

2009 • 197 citations

Acetylcholine hyperpolarizes central neurones by acting on an M2 muscarinic receptor

1986 • 196 citations

Evidence for a paradoxical sleep window for place learning in the Morris water maze

1996 • 196 citations

Orexin and MCH neurons express c‐Fos differently after sleep deprivation vs. recovery and bear different adrenergic receptors

2005 • 195 citations

Intracellular potential of medullary reticular neurons during sleep and wakefulness

1981 • 195 citations

REM Sleep–like Atonia of Hypoglossal (XII) Motoneurons Is Caused by Loss of Noradrenergic and Serotonergic Inputs

2005 • 195 citations

Distribution of glycine-immunoreactive cell bodies and fibers in the rat brain

1996 • 195 citations

State-dependent release of acetylcholine in rat thalamus measured by in vivo microdialysis

1994 • 194 citations

Phase Segregation of Medial Septal GABAergic Neurons during Hippocampal Theta Activity

2004 • 194 citations

Changes in brain gene expression after long‐term sleep deprivation

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Impairment of Attentional Networks after 1 Night of Sleep Deprivation

2008 • 193 citations

Behavioral State Control through Differential Serotonergic Inhibition in the Mesopontine Cholinergic Nuclei: A Simultaneous Unit Recording and Microdialysis Study

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Update on the pharmacology of REM sleep behavior disorder

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Memory Consolidation in Sleep

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Optogenetic disruption of sleep continuity impairs memory consolidation

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Genome-wide association study identifies new HLA class II haplotypes strongly protective against narcolepsy

2010 • 192 citations

The endogenous somnogen adenosine excites a subset of sleep-promoting neurons via A2A receptors in the ventrolateral preoptic nucleus

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FUNCTIONAL CONNECTIONS BETWEEN PONTINE RETICULAR FORMATION AND LATERAL GENICULATE NUCLEUS DURING DEEP SLEEP.

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Sleep Deprivation Reduces Proliferation of Cells in the Dentate Gyrus of the Hippocampus in Rats

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Effects on sleep and wakefulness of the injection of hypocretin-1 (orexin-A) into the laterodorsal tegmental nucleus of the cat

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Brainstem control of the events of rem sleep

1984 • 190 citations

Dominant localization of prostaglandin D receptors on arachnoid trabecular cells in mouse basal forebrain and their involvement in the regulation of non-rapid eye movement sleep

2001 • 190 citations

Serotonergic Regulation of the Orexin/Hypocretin Neurons through the 5-HT_1AReceptor

2004 • 190 citations

The treatment of restless legs syndrome with intravenous iron dextran

2004 • 188 citations

Cellular substrates and laminar profile of sleep K-complex

1997 • 188 citations

Expression of a Poly-Glutamine-Ataxin-3 Transgene in Orexin Neurons Induces Narcolepsy–Cataplexy in the Rat

2004 • 188 citations

Lack of delta waves and sleep disturbances during non-rapid eye movement sleep in mice lacking α1 _G -subunit of T-type calcium channels

2004 • 188 citations

Insufficient Sleep Reversibly Alters Bidirectional Synaptic Plasticity and NMDA Receptor Function

2006 • 187 citations

Evidence for Differential Control of Posterior Hypothalamic, Supramammillary, and Medial Mammillary Theta-Related Cellular Discharge by Ascending and Descending Pathways

1996 • 186 citations

Adenosine Inhibits Activity of Hypocretin/Orexin Neurons by the A1 Receptor in the Lateral Hypothalamus: A Possible Sleep-Promoting Effect

2006 • 186 citations

Reduction of high‐frequency network oscillations (ripples) and pathological network discharges in hippocampal slices from connexin 36‐deficient mice

2002 • 185 citations

Microdialysis perfusion of 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH- DPAT) in the dorsal raphe nucleus decreases serotonin release and increases rapid eye movement sleep in the freely moving cat

1996 • 185 citations

Astrocyte-Derived Adenosine and A₁Receptor Activity Contribute to Sleep Loss-Induced Deficits in Hippocampal Synaptic Plasticity and Memory in Mice

2011 • 185 citations

Distinct Patterns of Striatal Medium Spiny Neuron Activity during the Natural Sleep–Wake Cycle

2006 • 185 citations

Light deprivation damages monoamine neurons and produces a depressive behavioral phenotype in rats

2008 • 185 citations

Mice lacking the TNF 55 kDa receptor fail to sleep more after TNFalpha treatment.

1997 • 185 citations

The energy hypothesis of sleep revisited

2008 • 185 citations

NPAS2 as a transcriptional regulator of non-rapid eye movement sleep: Genotype and sex interactions

2006 • 184 citations

D1 Receptor Activation in the Mushroom Bodies Rescues Sleep-Loss-Induced Learning Impairments in Drosophila

2008 • 184 citations

Sleep deprivation suppresses neurogenesis in the adult hippocampus of rats

2005 • 184 citations

Sleep‐waking discharge patterns of neurons recorded in the rat perifornical lateral hypothalamic area

2002 • 184 citations

De la narcolepsie

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Firing rates and patterns of midbrain reticular neurons during steady and transitional states of the sleep-waking cycle

1982 • 184 citations

Parvalbumin, calbindin, or calretinin in cortically projecting and GABAergic, cholinergic, or glutamatergic basal forebrain neurons of the rat

2003 • 183 citations

Identification of a population of sleep-active cerebral cortex neurons

2008 • 183 citations

Theta activity in the waking EEG is a marker of sleep propensity in the rat

2005 • 183 citations

Genetics of the human electroencephalogram (EEG) and event-related brain potentials (ERPs): a review

1994 • 182 citations

Projections of GABAergic and cholinergic basal forebrain and GABAergic preoptic‐anterior hypothalamic neurons to the posterior lateral hypothalamus of the rat

1994 • 182 citations

Extracellular adenosine levels in neostriatum and hippocampus during rest and activity periods of rats

1996 • 182 citations

EEG Correlation of the Discharge Properties of Identified Neurons in the Basal Forebrain

2000 • 181 citations

Galanin induces a hyperpolarization of norepinephrine-containing locus coeruleus neurons in the brainstem slice

1995 • 181 citations

Basal ganglia control of sleep–wake behavior and cortical activation

2010 • 180 citations

Essential Role of Dopamine D₂Receptor in the Maintenance of Wakefulness, But Not in Homeostatic Regulation of Sleep, in Mice

2010 • 180 citations

Modulation of a transient outward current in serotonergic neurones by α1-adrenoceptors

1985 • 180 citations

The effect of sleep onset on upper airway muscle activity in patients with sleep apnoea versus controls

2005 • 179 citations

Hypothalamic γ-Aminobutyric Acid Neurons Project to the Neocortex

1983 • 179 citations

Astrogliosis in epilepsy leads to overexpression of adenosine kinase, resulting in seizure aggravation

2005 • 179 citations

Altered sleep–wake characteristics and lack of arousal response to H ₃ receptor antagonist in histamine H ₁ receptor knockout mice

2006 • 179 citations

Discharge patterns of the nucleus parabrachialis lateralis neurons of the cat during sleep and waking

1977 • 179 citations

Basal forebrain cholinergic and noncholinergic projections to the thalamus and brainstem in cats and monkeys

1988 • 179 citations

Loss of hypocretin (orexin) neurons with traumatic brain injury

2009 • 178 citations

Metabolic Regulation of Neuronal Plasticity by the Energy Sensor AMPK

2010 • 178 citations

The role of a raphe serotonin system in the control of septal unit activity and hippocampal desynchronization

1978 • 178 citations

Sleep–wake regulation and hypocretin–melatonin interaction in zebrafish

2009 • 177 citations

Sleep function(s) and cerebral metabolism

1995 • 177 citations

Sleep Deprivation Increases A₁Adenosine Receptor Binding in the Human Brain: A Positron Emission Tomography Study

2007 • 177 citations

The brainstem projection to the lateral geniculate nucleus in the cat: Identification of cholinergic and monoaminergic elements

1987 • 176 citations

Neuronal metabolism governs cortical network response state

2006 • 176 citations

Neuropeptide Y Inhibits Hypocretin/Orexin Neurons by Multiple Presynaptic and Postsynaptic Mechanisms: Tonic Depression of the Hypothalamic Arousal System

2004 • 175 citations

Corticotropin Releasing Hormone Type 2 Receptors in the Dorsal Raphe Nucleus Mediate the Behavioral Consequences of Uncontrollable Stress

2003 • 175 citations

Presynaptic Nicotinic Receptors Facilitate Monoaminergic Transmission

1998 • 174 citations

Sleep deprivation‐induced alterations in excitatory synaptic transmission in the CA1 region of the rat hippocampus

2005 • 174 citations

Effects of IV and ICV Hypocretin-1 (Orexin A) in Hypocretin Receptor-2 Gene Mutated Narcoleptic Dogs and IV Hypocretin-1 Replacement Therapy in a Hypocretin-ligand-deficient Narcoleptic Dog

2003 • 174 citations

The effect of sleep deprivation on sleep in rats with suprachiasmatic lesions

1983 • 174 citations

Electrophysiological and pharmacological properties of interneurons in the cat dorsal lateral geniculate nucleus

1995 • 173 citations

Executive mechanisms of paradoxical sleep.

1988 • 173 citations

Prostaglandin D2 induces sleep when microinjected into the preoptic area of conscious rats

1982 • 173 citations

Conservation of sleep: insights from non-mammalian model systems

2008 • 172 citations

The Wake-Promoting Hypocretin–Orexin Neurons Are in an Intrinsic State of Membrane Depolarization

2003 • 171 citations

Sleep Deprivation Decreases Binding of [¹¹C]Raclopride to Dopamine D₂/D₃Receptors in the Human Brain

2008 • 170 citations

Adenosinergic modulation of rat basal forebrain neurons during sleep and waking: neuronal recording with microdialysis

1999 • 169 citations

Circadian disruption and metabolic disease: Findings from animal models

2010 • 169 citations

Rhythmicity of septal cell discharges at various levels of reticular excitation

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Pontine Nitric Oxide Modulates Acetylcholine Release, Rapid Eye Movement Sleep Generation, and Respiratory Rate

1997 • 168 citations

Sleep Deprivation by the “Flower Pot” Technique and Spatial Reference Memory

1997 • 168 citations

A test of the effects of acute sleep deprivation on general and specific self-reported anxiety and depressive symptoms: An experimental extension

2010 • 168 citations

Circadian and Homeostatic Regulation of Structural Synaptic Plasticity in Hypocretin Neurons

2010 • 167 citations

A₁Receptor and Adenosinergic Homeostatic Regulation of Sleep-Wakefulness: Effects of Antisense to the A₁Receptor in the Cholinergic Basal Forebrain

2003 • 167 citations

Hypocretin/orexin depolarizes and decreases potassium conductance in locus coeruleus neurons

2000 • 166 citations

Importance of the ventrolateral region of the periaqueductal gray and adjacent tegmentum in the control of paradoxical sleep as studied by muscimol microinjections in the cat

1996 • 166 citations

Hypocretin (orexin) enhances neuron activity and cell synchrony in developing mouse GFP‐expressing locus coeruleus

2002 • 166 citations

Sleep Deprivation Impairs Long-Term Potentiation in Rat Hippocampal Slices

2002 • 166 citations

Sleep-promoting effects of cerebrospinal fluid from sleep-deprived goats.

1967 • 166 citations

All-night spectral analysis of the sleep EEG in untreated depressives and normal controls

1984 • 165 citations

Anatomy and physiology of saccadic burst neurons in the alert squirrel monkey. II. Inhibitory burst neurons

1986 • 165 citations

Differential modulation of high-frequency gamma-electroencephalogram activity and sleep-wake state by noradrenaline and serotonin microinjections into the region of cholinergic basalis neurons.

1998 • 165 citations

Effects of arousal‐ and feeding‐related neuropeptides on dopaminergic and GABAergic neurons in the ventral tegmental area of the rat

2006 • 164 citations

A limit cycle mathematical model of the REM sleep oscillator system

1986 • 164 citations

Neurochemical afferents controlling the activity of serotonergic neurons in the dorsal raphe nucleus: microiontophoretic studies in the awake cat

1992 • 164 citations

Promotion of sleep mediated by the A2a-adenosine receptor and possible involvement of this receptor in the sleep induced by prostaglandin D2 in rats.

1996 • 162 citations

A pharmacological model of paradoxical sleep: The role of cholinergic and monoamine systems

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Ponto-Geniculo-Occipital (PGO) Burst Neurons: Correlative Evidence for Neuronal Generators of PGO Waves

1978 • 162 citations

Human brain activity time-locked to rapid eye movements during REM sleep

2008 • 162 citations

Neuronal Activity in Narcolepsy: Identification of Cataplexy-Related Cells in the Medial Medulla

1991 • 162 citations

CSF Histamine Contents in Narcolepsy, Idiopathic Hypersomnia and Obstructive Sleep Apnea Syndrome

2009 • 161 citations

Activation of ventrolateral preoptic neurons by the somnogen prostaglandin D ₂

1998 • 161 citations

Involvement of 5-HT_1A Receptors in Homeostatic and Stress-Induced Adaptive Regulations of Paradoxical Sleep: Studies in 5-HT_1A Knock-Out Mice

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Rapid eye movement sleep behavior disorder preceding Parkinson's disease with therapeutic response to levodopa

1996 • 160 citations

Characterization of inhibition mediated by adenosine in the hippocampus of the rat in vitro.

1989 • 160 citations

Contribution of 5-HT₂Receptor Subtypes to Sleep–Wakefulness and Respiratory Control, and Functional Adaptations in Knock-Out Mice Lacking 5-HT_2AReceptors

2005 • 160 citations

Activation of Phasic Pontine-Wave Generator Prevents Rapid Eye Movement Sleep Deprivation-Induced Learning Impairment in the Rat: A Mechanism for Sleep-Dependent Plasticity

2004 • 160 citations

Evidence that Neurons of the Sublaterodorsal Tegmental Nucleus Triggering Paradoxical (REM) Sleep Are Glutamatergic

2011 • 159 citations

Cognitive neuroscience of sleep

2010 • 158 citations

Neuroimaging Insights into the Pathophysiology of Sleep Disorders

2008 • 158 citations

Drosophila HyperkineticMutants Have Reduced Sleep and Impaired Memory

2007 • 158 citations

Heritability of Sleep Electroencephalogram

2008 • 158 citations

Stress-induced changes in sleep in rodents: Models and mechanisms

2007 • 157 citations

Mice Lacking the TNF 55 kDa Receptor Fail to Sleep More After TNFα Treatment

1997 • 157 citations

Preliminary data on the possible hypnogenic role of adenosine¹

1973 • 157 citations

Cellular basis of pontine ponto-geniculo-occipital wave generation and modulation.

1997 • 157 citations

Treating insomnia: Current and investigational pharmacological approaches

2006 • 156 citations

Effects of Saporin-Induced Lesions of Three Arousal Populations on Daily Levels of Sleep and Wake

2007 • 156 citations

Dynamics of sleep-wake cyclicity in developing rats

2005 • 156 citations

Muscarine depolarizes rat substantia nigra zona compacta and ventral tegmental neurons in vitro through M1-like receptors.

1990 • 156 citations

The role of basal forebrain neurons in tonic and phasic activation of the cerebral cortex

1999 • 155 citations

Evidence That Wakefulness and REM Sleep Are Controlled by a GABAergic Pontine Mechanism

1999 • 155 citations

Facilitation of Task Performance and Removal of the Effects of Sleep Deprivation by an Ampakine (CX717) in Nonhuman Primates

2005 • 154 citations

Prostaglandin D2, a cerebral sleep-inducing substance in rats.

1983 • 154 citations

Noradrenaline hyperpolarizes identified rat mesopontine cholinergic neurons in vitro

1993 • 154 citations

A Polysomnographic Comparison of Veterans With Combat-Related PTSD, Depressed Men, and Non-Ill Controls

1997 • 154 citations

Exclusive Postsynaptic Action of Hypocretin-Orexin on Sublayer 6b Cortical Neurons

2004 • 153 citations

Cerebral Structural Changes in Severe Obstructive Sleep Apnea

2005 • 153 citations

Restless Legs Syndrome and Periodic Leg Movements in Sleep: The Primary Role of Dopaminergic Mechanism

1991 • 153 citations

Deficiency in short-chain fatty acid β-oxidation affects theta oscillations during sleep

2003 • 152 citations

Dealing with inter-individual differences in the temporal dynamics of fatigue and performance: importance and techniques.

2004 • 152 citations

Two types of cerebral activation during active sleep: relations to behavior

1977 • 152 citations

Magnetic resonance findings in REM sleep behavior disorder

1989 • 151 citations

Firing Properties of Anatomically Identified Neurons in the Medial Septum of Anesthetized and Unanesthetized Restrained Rats

2006 • 151 citations

Sleep suppression following kainic acid-induced lesions of the basal forebrain

1986 • 151 citations

Brainstem sites for the carbachol elicitation of the hippocampal theta rhythm in the rat

1993 • 150 citations

Increased sleep pressure reduces resting state functional connectivity

2010 • 150 citations

Brain stem PGO-on cells projecting directly to the cat dorsal lateral geniculate nucleus

1980 • 150 citations

Cellular Dynamics of Cholinergically Induced α (8–13 Hz) Rhythms in Sensory Thalamic NucleiIn Vitro

2008 • 149 citations

Decreased CSF Histamine in Narcolepsy With and Without Low CSF Hypocretin-1 in Comparison to Healthy Controls

2009 • 149 citations

The presence of pacemaker HCN channels identifies theta rhythmic GABAergic neurons in the medial septum

2008 • 149 citations

Interleukin 1-receptor antagonist blocks interleukin 1-induced sleep and fever

1991 • 149 citations

Disinhibition of ventrolateral preoptic area sleep-active neurons by adenosine: a new mechanism for sleep promotion

2003 • 149 citations

The Transcription Factor DBP Affects Circadian Sleep Consolidation and Rhythmic EEG Activity

2000 • 149 citations

M5 Muscarinic Receptors Are Required for Prolonged Accumbal Dopamine Release after Electrical Stimulation of the Pons in Mice

2002 • 148 citations

Differential increase in the expression of heat shock protein family members during sleep deprivation and during sleep

2003 • 147 citations

Variant between CPT1B and CHKB associated with susceptibility to narcolepsy

2008 • 146 citations

Involvement of Direct and Indirect Pathways in Electrocorticographic Activation

1998 • 146 citations

Presynaptic depression of excitatory synaptic inputs to rat hypoglossal motoneurons by muscarinic M2 receptors

1996 • 146 citations

"Hypersexuality" and Behavioral Changes in Cats Caused by Administration of p -Chlorophenylalanine

1970 • 146 citations

Differential Target-Dependent Actions of Coexpressed Inhibitory Dynorphin and Excitatory Hypocretin/Orexin Neuropeptides

2006 • 145 citations

Differential Modulation of High-Frequency γ-Electroencephalogram Activity and Sleep–Wake State by Noradrenaline and Serotonin Microinjections into the Region of Cholinergic Basalis Neurons

1998 • 145 citations

Sleep and its homeostatic regulation in mice lacking the adenosine A₁ receptor

2003 • 145 citations

A discrete pontine ischemic lesion could cause REM sleep behavior disorder

2000 • 145 citations

Lipocalin-type prostaglandin D synthase produces prostaglandin D ₂ involved in regulation of physiological sleep

2006 • 144 citations

Localization of pontine PGO wave generation sites and their anatomical projections in the rat

1998 • 144 citations

Effects of interleukin-1β on sleep are mediated by the type I receptor

1998 • 144 citations

Increased ATP content/production in the hypothalamus may be a signal for energy-sensing of satiety: studies of the anorectic mechanism of a plant steroidal glycoside

2004 • 144 citations

Circadian and Homeostatic Control of Rapid Eye Movement (REM) Sleep: Promotion of REM Tendency by the Suprachiasmatic Nucleus

2000 • 144 citations

Prefrontal Cortex–Projecting Glutamatergic Thalamic Paraventricular Nucleus-Excited by Hypocretin: A Feedforward Circuit That May Enhance Cognitive Arousal

2006 • 143 citations

Calcium‐Dependent Regulation of Genetically Determined Spike and Waves by the Reticular Thalamic Nucleus of Rats

1993 • 143 citations

Selective Action of Orexin (Hypocretin) on Nonspecific Thalamocortical Projection Neurons

2002 • 143 citations

Immediate‐early genes in spontaneous wakefulness and sleep: expression of c‐fos and NGFI‐A mRNA and protein

1994 • 141 citations

Measures of Cortical Plasticity after Transcranial Paired Associative Stimulation Predict Changes in Electroencephalogram Slow-Wave Activity during Subsequent Sleep

2008 • 141 citations

Cytokines and normal sleep

2005 • 140 citations

Circadian Rhythm of Synaptic Excitability in Rat And Monkey Central Nervous System

1977 • 139 citations

Effects of glutamate agonist versus procaine microinjections into the basal forebrain cholinergic cell area upon gamma and theta EEG activity and sleep–wake state

2000 • 138 citations

Severe depression and antidepressants: focus on a pooled analysis of placebo-controlled studies on agomelatine

2007 • 138 citations

The effects of adenosine on the development of long-term potentiation

1990 • 137 citations

Adenosine A₁and A_2AReceptors in Mouse Prefrontal Cortex Modulate Acetylcholine Release and Behavioral Arousal

2009 • 137 citations

Norepinephrine and serotonin: Opposite effects on the activity of lateral geniculate neurons evoked by optic pathway stimulation

1980 • 137 citations

Decreased brain histamine content in hypocretin/orexin receptor-2 mutated narcoleptic dogs

2001 • 137 citations

Brainstem and Spinal Cord Circuitry Regulating REM Sleep and Muscle Atonia

2011 • 136 citations

The Unrested Resting Brain: Sleep Deprivation Alters Activity within the Default-mode Network

2009 • 136 citations

Single Neuron Activity in Cat Gigantocellular Tegmental Field: Selectivity of Discharge in Desynchronized Sleep

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Diurnal variation of TNFα in the rat brain

1997 • 135 citations

Microdialysis perfusion of orexin-A in the basal forebrain increases wakefulness in freely behaving rats.

2001 • 134 citations

Homer proteins in Ca2+ signaling by excitable and non-excitable cells

2007 • 134 citations

Sleep, memory and emotion

2010 • 134 citations

Minireview: Sleep regulation in adenosine A _2A receptor-deficient mice

2003 • 134 citations

Characterization and mapping of sleep–waking specific neurons in the basal forebrain and preoptic hypothalamus in mice

2009 • 134 citations

Localization of pontine PGO wave generation sites and their anatomical projections in the rat

1998 • 133 citations

Inhibition of nitric oxide synthesis inhibits rat sleep

1994 • 133 citations

On the Functional Significance of c-fos Induction During the Sleep-waking Cycle

2000 • 133 citations

Insomnia following parachlorophenylalanin in the rat

1968 • 133 citations

Neuronal discharge of preoptic/anterior hypothalamic thermosensitive neurons: relation to NREM sleep

1995 • 133 citations

Regulation of Synaptic Efficacy in Hypocretin/Orexin-Containing Neurons by Melanin Concentrating Hormone in the Lateral Hypothalamus

2008 • 132 citations

Sleep-wakefulness, EEG and behavioral studies of chronic cats without the thalamus: the 'athalamic' cat.

1972 • 132 citations

The Neural Substrates of Infant Sleep in Rats

2005 • 132 citations

ATP and its metabolite adenosine act synergistically to mobilize intracellular calcium via the formation of inositol 1,4,5-trisphosphate in a smooth muscle cell line.

1992 • 132 citations

Contribution of synapses in the medial supramammillary nucleus to the frequency of hippocampal theta rhythm in freely moving rats

1995 • 132 citations

Electroencephalographic sleep correlates of episode and vulnerability to recurrence in depression

1997 • 131 citations

Narcolepsy and low CSF orexin (hypocretin) concentration after a diencephalic stroke

2001 • 131 citations

Spontaneous High-Frequency (10–80 Hz) Oscillations during Up States in the Cerebral CortexIn Vitro

2008 • 130 citations

Homeostatic Regulation of Sleep: A Role for Preoptic Area Neurons

2006 • 130 citations

The Interpretation of the EEG in Stupor and Coma

2005 • 130 citations

Cholinergic nucleus basalis neurons are excited by histamine in vitro

1995 • 130 citations

Genetics of normal and pathological sleep in humans

2005 • 130 citations

Orexin receptor 2 expression in the posterior hypothalamus rescues sleepiness in narcoleptic mice

2011 • 130 citations

Modulation of rhythmic brain activity by diazepam: GABA _A receptor subtype and state specificity

2004 • 129 citations

Neuroimaging findings in post-traumatic stress disorder

2002 • 128 citations

Inhibition of nitric oxide synthesis suppresses sleep in rabbits

1994 • 128 citations

c-Fos Expression in GABAergic, Serotonergic, and Other Neurons of the Pontomedullary Reticular Formation and Raphe after Paradoxical Sleep Deprivation and Recovery

2000 • 128 citations

Mood changes after sleep deprivation in morningness–eveningness chronotypes in healthy individuals

2007 • 127 citations

Narcolepsy and the HLA region

2001 • 127 citations

Sleep homeostasis in suprachiasmatic nuclei-lesioned rats: effects of sleep deprivation and triazolam administration

1992 • 127 citations

Hippocampal neurogenesis is reduced by sleep fragmentation in the adult rat

2007 • 127 citations

Effects of Ibotenate and 192IgG-Saporin Lesions of the Nucleus Basalis Magnocellularis/Substantia Innominata on Spontaneous Sleep and Wake States and on Recovery Sleep after Sleep Deprivation in Rats

2008 • 127 citations

Genetic Evidence for a Role of CREB in Sustained Cortical Arousal

2003 • 126 citations

Frequency Modulation of Hippocampal Theta by the Supramammillary Nucleus, and Other Hypothalamo–Hippocampal Interactions: Mechanisms and Functional Implications

1998 • 126 citations

Anti-Tribbles Homolog 2 (TRIB2) Autoantibodies in Narcolepsy are Associated with Recent Onset of Cataplexy

2010 • 126 citations

Effects of adenosine on gabaergic synaptic inputs to identified ventrolateral preoptic neurons

2003 • 126 citations

The neurobiological origins of psychoanalytic dream theory

1977 • 126 citations

Genetic Studies of Sleep in Mice

1972 • 126 citations

Glycinergic and GABA_A-Mediated Inhibition of Somatic Motoneurons Does Not Mediate Rapid Eye Movement Sleep Motor Atonia

2008 • 126 citations

Sleep in mice with nonfunctional growth hormone-releasing hormone receptors

2003 • 125 citations

Discharge patterns of hippocampal theta-related cells in the caudal diencephalon of the urethan-anesthetized rat

1995 • 125 citations

Distribution of α1, α4, γ2, and δ subunits of GABAA receptors in hippocampal granule cells

2004 • 125 citations

Neurotensin-induced bursting of cholinergic basal forebrain neurons promotes gamma and theta cortical activity together with waking and paradoxical sleep.

2000 • 125 citations

Low body stores of iron and restless legs syndrome: a correctable cause of insomnia in adolescents and teenagers

2002 • 124 citations

Direct and Indirect Inhibition by Catecholamines of Hypocretin/Orexin Neurons

2005 • 124 citations

Are the gigantocellular tegmental field neurons responsible for paradoxical sleep?

1981 • 124 citations

Selective loss of GABA _B receptors in orexin-producing neurons results in disrupted sleep/wakefulness architecture

2009 • 123 citations

Impaired GABA and Glycine Transmission Triggers Cardinal Features of Rapid Eye Movement Sleep Behavior Disorder in Mice

2011 • 123 citations

The midline posterior hypothalamic region comprises a critical part of the ascending brainstem hippocampal synchronizing pathway

1994 • 123 citations

Cholinergic and noncholinergic brainstem neurons expressing Fos after paradoxical (REM) sleep deprivation and recovery

2005 • 123 citations

Subcellular localization of the K+ channel subunit Kv3.1b in selected rat CNS neurons

1997 • 123 citations

Origins and Distribution of Cholinergically Induced β Rhythms in Hippocampal Slices

2000 • 123 citations

Hebbian modification of a hippocampal population pattern in the rat

1999 • 122 citations

Serotonin Agonists and Antagonists in Obstructive Sleep Apnea

2003 • 122 citations

Intracellular recording of lumbar motoneuron membrane potential during sleep and wakefulness

1978 • 121 citations

Waking selective neurons in the posterior hypothalamus and their response to histamine H3-receptor ligands: an electrophysiological study in freely moving cats

2003 • 121 citations

Hypocretin (Orexin) Induces Calcium Transients in Single Spines Postsynaptic to Identified Thalamocortical Boutons in Prefrontal Slice

2003 • 121 citations

The roles of melatonin and light in the pathophysiology and treatment of circadian rhythm sleep disorders

2008 • 121 citations

Opioid and dopamine antagonist drug challenges in untreated restless legs syndrome patients

2001 • 121 citations

Activity of dorsal raphe cells across the sleep–waking cycle and during cataplexy in narcoleptic dogs

2003 • 120 citations

Orexin Neurons Are Directly and Indirectly Regulated by Catecholamines in a Complex Manner

2006 • 120 citations

Early Life Blockade of 5-Hydroxytryptamine 1A Receptors Normalizes Sleep and Depression-Like Behavior in Adult Knock-Out Mice Lacking the Serotonin Transporter

2006 • 120 citations

Importance of cholinergic, GABAergic, serotonergic and other neurons in the medial medullary reticular formation for sleep-wake states studied by cytotoxic lesions in the cat

1994 • 119 citations

Relaxation and sleep induced by warming of preoptic region and anterior hypothalamus in cats

1969 • 119 citations

Sleep fragmentation elevates behavioral, electrographic and neurochemical measures of sleepiness

2007 • 119 citations

Neuronal activity in the subcortically denervated hippocampus: A chronic model for epilepsy

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Localization of the neurons active during paradoxical (REM) sleep and projecting to the locus coeruleus noradrenergic neurons in the rat