Melanin-concentrating hormone neurons discharge in a reciprocal manner to orexin neurons across the sleep–wake cycle

Principles and Practice of Sleep Medicine

2011 • 5,079 citations

Neurons Containing Hypocretin (Orexin) Project to Multiple Neuronal Systems

1998 • 3,381 citations

Narcolepsy in orexin Knockout Mice

1999 • 3,014 citations

The Sleep Disorder Canine Narcolepsy Is Caused by a Mutation in the Hypocretin (Orexin) Receptor 2 Gene

1999 • 2,583 citations

A mutation in a case of early onset narcolepsy and a generalized absence of hypocretin peptides in human narcoleptic brains

2000 • 2,065 citations

Reduced Number of Hypocretin Neurons in Human Narcolepsy

2000 • 2,004 citations

Genetic Ablation of Orexin Neurons in Mice Results in Narcolepsy, Hypophagia, and Obesity

2001 • 1,387 citations

A role for melanin-concentrating hormone in the central regulation of feeding behaviour

1996 • 1,301 citations

Neural substrates of awakening probed with optogenetic control of hypocretin neurons

2007 • 1,253 citations

Mice lacking melanin-concentrating hormone are hypophagic and lean

1998 • 1,139 citations

Discharge of Identified Orexin/Hypocretin Neurons across the Sleep-Waking Cycle

2005 • 840 citations

Behavioral Correlates of Activity in Identified Hypocretin/Orexin Neurons

2005 • 830 citations

Hypocretin/Orexin- and melanin-concentrating hormone-expressing cells form distinct populations in the rodent lateral hypothalamus: Relationship to the neuropeptide Y and agouti gene-related protein systems

1998 • 687 citations

Promotion of sleep by targeting the orexin system in rats, dogs and humans

2007 • 557 citations

Hypocretin (orexin) cell loss in Parkinson's disease

2007 • 524 citations

Sympathetic and cardiovascular actions of orexins in conscious rats

1999 • 439 citations

A role of melanin-concentrating hormone producing neurons in the central regulation of paradoxical sleep.

2003 • 416 citations

Expression of the melanin‐concentrating hormone (MCH) receptor mRNA in the rat brain

2001 • 378 citations

The Hypothalamic Neuropeptide Melanin-Concentrating Hormone Acts in the Nucleus Accumbens to Modulate Feeding Behavior and Forced-Swim Performance

2005 • 339 citations

Physiological Changes in Glucose Differentially Modulate the Excitability of Hypothalamic Melanin-Concentrating Hormone and Orexin NeuronsIn Situ

2005 • 320 citations

Action Potential-Dependent Regulation of Gene Expression: Temporal Specificity in Ca²⁺, cAMP-Responsive Element Binding Proteins, and Mitogen-Activated Protein Kinase Signaling

1997 • 304 citations

Basic Mechanisms of Sleep-Wake States

2005 • 290 citations

Orexin Signaling Mediates the Antidepressant-Like Effect of Calorie Restriction

2008 • 227 citations

Sleep disorders in Parkinson's disease: An overview

2007 • 209 citations

Reductions in circulating anabolic hormones induced by sustained sleep deprivation in rats

2004 • 208 citations

Orexin and MCH neurons express c‐Fos differently after sleep deprivation vs. recovery and bear different adrenergic receptors

2005 • 195 citations

Melanin concentrating hormone depresses synaptic activity of glutamate and GABA neurons from rat lateral hypothalamus

2001 • 187 citations

Sleep‐waking discharge patterns of neurons recorded in the rat perifornical lateral hypothalamic area

2002 • 184 citations

Induction of c-fos expression in hypothalamic magnocellular neurons requires synaptic activation and not simply increased spike activity

1994 • 174 citations

The Wake-Promoting Hypocretin–Orexin Neurons Are in an Intrinsic State of Membrane Depolarization

2003 • 171 citations

Characterization of MCH-mediated obesity in mice

2003 • 171 citations

Chronic REM-sleep deprivation of rats elevates metabolic rate and increases UCP1 gene expression in brown adipose tissue

2005 • 149 citations

Abnormal response of melanin-concentrating hormone deficient mice to fasting: Hyperactivity and rapid eye movement sleep suppression

2008 • 133 citations

Opposite effects of noradrenaline and acetylcholine upon hypocretin/orexin versus melanin concentrating hormone neurons in rat hypothalamic slices

2004 • 110 citations

Blocking melanin-concentrating hormone MCH1 receptor affects rat sleep–wake architecture

2007 • 105 citations

Multi-Transcriptional Profiling of Melanin-Concentrating Hormone and Orexin-Containing Neurons

2005 • 104 citations

Mice lacking melanin-concentrating hormone receptor 1 demonstrate increased heart rate associated with altered autonomic activity

2004 • 94 citations

Hypothalamic gene expression in long-term fasted rats: relationship with body fat

2003 • 91 citations

PRINCIPLES AND PRACTICE OF SLEEP MEDICINE

1990 • 90 citations

Sleep architecture of the melanin‐concentrating hormone receptor 1‐knockout mice

2008 • 80 citations

Depression: relationships to sleep paralysis and other sleep disturbances in a community sample

2007 • 75 citations

MCH-containing neurons in the hypothalamus of the cat: Searching for a role in the control of sleep and wakefulness

2006 • 70 citations

Vigilance states and body temperature during the circadian cycle in fed and fasted pigeons (Columba livia)

1998 • 67 citations

Metabolic adjustments to increasing foraging costs of starlings in a closed economy

2005 • 61 citations

Is myosin light-chain phosphorylation a regulatory signal for the osmotic activation of the Na⁺-K⁺-2Cl⁻ cotransporter?

2005 • 49 citations

Parodoxical effect of orexin A: hypophagia induced by hyperthermia

2003 • 47 citations

Cardiovascular effects of melanin-concentrating hormone

2006 • 36 citations