The CircadianClockMutation Alters Sleep Homeostasis in the Mouse

Two-Process Model of Sleep Regulation

2008 • 3,914 citations

Narcolepsy in orexin Knockout Mice

1999 • 3,014 citations

The Sleep Disorder Canine Narcolepsy Is Caused by a Mutation in the Hypocretin (Orexin) Receptor 2 Gene

1999 • 2,583 citations

Role of the CLOCK Protein in the Mammalian Circadian Mechanism

1998 • 1,915 citations

Mutagenesis and Mapping of a Mouse Gene, Clock , Essential for Circadian Behavior

1994 • 1,570 citations

Positional Cloning of the Mouse Circadian Gene

1997 • 1,335 citations

Human Sleep: Its Duration and Organization Depend on Its Circadian Phase

1980 • 899 citations

Functional Identification of the Mouse Circadian Clock Gene by Transgenic BAC Rescue

1997 • 664 citations

Altered circadian activity rhythms and sleep in mice devoid of prion protein

1996 • 655 citations

Effect of SCN lesions on sleep in squirrel monkeys: evidence for opponent processes in sleep-wake regulation

1993 • 655 citations

Molecular Cloning and Characterization of Bif-1

2001 • 637 citations

Paradoxical timing of the circadian rhythm of sleep propensity serves to consolidate sleep and wakefulness in humans

1994 • 606 citations

CLOCK, an essential pacemaker component, controls expression of the circadian transcription factor DBP

2000 • 418 citations

Clock controls circadian period in isolated suprachiasmatic nucleus neurons

1998 • 376 citations

The dependence of onset and duration of sleep on the circadian rhythm of rectal temperature

1981 • 371 citations

Sleep and Sleep Regulation in Normal and Prion Protein-Deficient Mice

1997 • 296 citations

The DBP gene is expressed according to a circadian rhythm in the suprachiasmatic nucleus and influences circadian behavior

1997 • 291 citations

Genetic Determinants of Sleep Regulation in Inbred Mice

1999 • 286 citations

Genetic variation in EEG activity during sleep in inbred mice

1998 • 282 citations

Requirement of Circadian Genes for Cocaine Sensitization in Drosophila

1999 • 259 citations

The Circadian Variation of Experimentally Displaced Sleep

1981 • 247 citations

Effects of Method, Duration, and Sleep Stage on Rebounds from Sleep Deprivation in the Rat

1999 • 219 citations

Recovery Sleep Following Sleep Deprivation in Intact and Suprachiasmatic Nuclei-Lesioned Rats

1983 • 218 citations

Suprachiasmatic nuclei lesions eliminate circadian temperature and sleep rhythms in the rat

1984 • 210 citations

Homeostatic sleep regulation in habitual short sleepers and long sleepers

1996 • 191 citations

Mice lacking the TNF 55 kDa receptor fail to sleep more after TNFalpha treatment.

1997 • 185 citations

The effect of sleep deprivation on sleep in rats with suprachiasmatic lesions

1983 • 174 citations

Scoring Transitions to REM Sleep in Rats Based on the EEG Phenomena of Pre-REM Sleep: An Improved Analysis of Sleep Structure

1994 • 173 citations

Key Role of 5-HT_1BReceptors in the Regulation of Paradoxical Sleep as Evidenced in 5-HT_1BKnock-Out Mice

1999 • 172 citations

Sleep Initiation and Initial Sleep Intensity: Interactions of Homeostatic and Circadian Mechanisms

1989 • 168 citations

Mice Lacking the TNF 55 kDa Receptor Fail to Sleep More After TNFα Treatment

1997 • 157 citations

The Transcription Factor DBP Affects Circadian Sleep Consolidation and Rhythmic EEG Activity

2000 • 149 citations

Effect of Age on the Circadian Pattern of Sleep and Wakefulness in the Mouse

1986 • 128 citations

Electroencephalogram analysis of non-rapid eye movement sleep in rats

1988 • 126 citations

REM-sleep timing is controlled homeostatically by accumulation of REM-sleep propensity in non-REM sleep

1994 • 123 citations

Molecular Cloning and Characterization of the HumanCLOCKGene: Expression in the Suprachiasmatic Nuclei

1999 • 119 citations

Suprachiasmatic nuclei Lessions in the rat: Alterations in sleep circadian rhythms

1978 • 82 citations

Localization of candidate genomic regions influencing paradoxical sleep in mice

1997 • 76 citations

Non-rapid eye movement sleep is suppressed in transgenic mice with a deficiency in the somatotropic system

1996 • 72 citations

Photic induction of Period gene expression is reduced in Clock mutant mice

1999 • 57 citations

Circadian rhythms of sleep and wakefulness in mice: analysis using long-term automated recording of sleep

1985 • 50 citations

Sleep-promoting effect of the sleep-promoting substance (SPS) and delta sleep-inducing peptide (DSIP) in the mouse

1980 • 44 citations

Strain Differences in the Somnogenic Effects of Interferon Inducers in Mice

1996 • 41 citations

Relationships Among Wake Episode Lengths, Contiguous Sleep Episode Lengths, and Electroencephalographic Delta Waves in Rats with Suprachiasmatic Nuclei Lesions

1987 • 38 citations

Effects of Aging on Sleep in the Golden Hamster

1998 • 31 citations

Circadian and Homeostatic Influences on Sleep in the Squirrel Monkey: Sleep after Sleep Deprivation

1999 • 31 citations

Human insulin gene insertion in mice. Effects on the sleep–wake cycle?

1999 • 14 citations