Prolonged wakefulness induces experience-dependent synaptic plasticity in mouse hypocretin/orexin neurons

LTP and LTD

2004 • 3,754 citations

Narcolepsy in orexin Knockout Mice

1999 • 3,014 citations

The Sleep Disorder Canine Narcolepsy Is Caused by a Mutation in the Hypocretin (Orexin) Receptor 2 Gene

1999 • 2,583 citations

Neurocognitive Consequences of Sleep Deprivation

2009 • 2,001 citations

Sleep function and synaptic homeostasis

2005 • 1,972 citations

Activity of norepinephrine-containing locus coeruleus neurons in behaving rats anticipates fluctuations in the sleep-waking cycle

1981 • 1,903 citations

Learning Induces Long-Term Potentiation in the Hippocampus

2006 • 1,841 citations

Neurocognitive Consequences of Sleep Deprivation

2005 • 1,297 citations

Effects of cAMP Simulate a Late Stage of LTP in Hippocampal CA1 Neurons

1993 • 1,212 citations

The neural circuit of orexin (hypocretin): maintaining sleep and wakefulness

2007 • 1,177 citations

Drugs of Abuse and Stress Trigger a Common Synaptic Adaptation in Dopamine Neurons

2003 • 1,133 citations

Single cocaine exposure in vivo induces long-term potentiation in dopamine neurons

2001 • 1,084 citations

Rapid Rewiring of Arcuate Nucleus Feeding Circuits by Leptin

2004 • 975 citations

Clues to the functions of mammalian sleep

2005 • 954 citations

Discharge of Identified Orexin/Hypocretin Neurons across the Sleep-Waking Cycle

2005 • 840 citations

Behavioral Correlates of Activity in Identified Hypocretin/Orexin Neurons

2005 • 830 citations

Dopaminergic Role in Stimulant-Induced Wakefulness

2001 • 763 citations

Orexin A in the VTA Is Critical for the Induction of Synaptic Plasticity and Behavioral Sensitization to Cocaine

2006 • 704 citations

SLEEP AS A PROBLEM OF LOCALIZATION

1930 • 661 citations

Fos Expression in Orexin Neurons Varies with Behavioral State

2001 • 647 citations

Extensive and Divergent Effects of Sleep and Wakefulness on Brain Gene Expression

2004 • 611 citations

Mediation of Hippocampal Mossy Fiber Long-Term Potentiation by Cyclic AMP

1994 • 600 citations

Hypocretin (orexin) activation and synaptic innervation of the locus coeruleus noradrenergic system

1999 • 587 citations

Afferents to the orexin neurons of the rat brain

2005 • 565 citations

cAMP contributes to mossy fiber LTP by initiating both a covalently mediated early phase and macromolecular synthesis-dependent late phase

1994 • 501 citations

Hypothalamic Arousal Regions Are Activated during Modafinil-Induced Wakefulness

2000 • 484 citations

Hypocretin/Orexin Excites Hypocretin Neurons via a Local Glutamate Neuron—A Potential Mechanism for Orchestrating the Hypothalamic Arousal System

2002 • 459 citations

Interaction between the Corticotropin-Releasing Factor System and Hypocretins (Orexins): A Novel Circuit Mediating Stress Response

2004 • 445 citations

Fluctuation of extracellular hypocretin‐1 (orexin A) levels in the rat in relation to the light–dark cycle and sleep–wake activities

2001 • 441 citations

Sleep Deprivation in the Rat: X. Integration and Discussion of the Findings

1989 • 421 citations

Clinical effects of sleep fragmentation versus sleep deprivation

2003 • 402 citations

Sleep Deprivation in the Rat

1966 • 356 citations

A Systematic Review of Modafinil

2006 • 343 citations

Modafinil Occupies Dopamine and Norepinephrine Transporters in Vivo and Modulates the Transporters and Trace Amine Activity in Vitro

2006 • 318 citations

Circadian and Homeostatic Regulation of Hypocretin in a Primate Model: Implications for the Consolidation of Wakefulness

2003 • 270 citations

Neuronal Gene Expression in the Waking State: A Role for the Locus Coeruleus

1996 • 265 citations

Forskolin-Induced LTP in the CA1 Hippocampal Region Is NMDA Receptor Dependent

2004 • 243 citations

Changes in CSF hypocretin-1 (orexin A) levels in rats across 24 hours and in response to food deprivation

2001 • 220 citations

Orexin and MCH neurons express c‐Fos differently after sleep deprivation vs. recovery and bear different adrenergic receptors

2005 • 195 citations

Input organization and plasticity of hypocretin neurons

2005 • 195 citations

Adenosine Inhibits Activity of Hypocretin/Orexin Neurons by the A1 Receptor in the Lateral Hypothalamus: A Possible Sleep-Promoting Effect

2006 • 186 citations

Modafinil induces wakefulness without intensifying motor activity or subsequent rebound hypersomnolence in the rat.

1997 • 170 citations

Cocaine-induced potentiation of synaptic strength in dopamine neurons: Behavioral correlates in GluRA(–/–) mice

2004 • 160 citations

Sleep Deprivation in the Rat: I. Conceptual Issues

1989 • 152 citations

Gene expression in the rat brain during sleep deprivation and recovery sleep: an Affymetrix GeneChip® study

2005 • 141 citations

Modafinil: Preclinical, Clinical, and Post-Marketing Surveillance—A Review of Abuse Liability Issues

2004 • 139 citations

The nicotinic antagonist mecamylamine has antidepressant-like effects in wild-type but not β2- or α7-nicotinic acetylcholine receptor subunit knockout mice

2006 • 123 citations

Innervation of orexin/hypocretin neurons by GABAergic, glutamatergic or cholinergic basal forebrain terminals evidenced by immunostaining for presynaptic vesicular transporter and postsynaptic scaffolding proteins

2006 • 116 citations

The hypocretins and sleep

2005 • 105 citations

Neurobiological similarities in antidepressant sleep deprivation and psychostimulant use: a psychostimulant theory of antidepressant sleep deprivation

1998 • 99 citations

Modafinil more effectively induces wakefulness in orexin-null mice than in wild-type littermates

2004 • 93 citations

Dopaminergic regulation of orexin neurons

2005 • 90 citations

The stimulant effect of modafinil on wakefulness is not associated with an increase in anxiety in mice

1994 • 80 citations

Bidirectional Dopaminergic Modulation of Excitatory Synaptic Transmission in Orexin Neurons

2006 • 58 citations

Increased spontaneous eye blink rate following prolonged wakefulness

2006 • 49 citations

Modafinil [2-[(Diphenylmethyl)sulfinyl]acetamide] and Circadian Rhythms in Syrian Hamsters: Assessment of the Chronobiotic Potential of a Novel Alerting Compound

2006 • 18 citations