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An international survey of sleeping problems in the general population

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Obesity Without Sleep Apnea Is Associated With Daytime Sleepiness

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What Keeps Us Awake: the Neuropharmacology of Stimulants and Wakefulness Promoting Medications

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Sleep and Sleep Regulation in Normal and Prion Protein-Deficient Mice

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Serotonin and sleep

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Depression and insomnia: questions of cause and effect

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A Genetic Variation in the Adenosine A2A Receptor Gene (ADORA2A) Contributes to Individual Sensitivity to Caffeine Effects on Sleep

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Interrelations Between Sleep and the Somatotropic Axis

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PHYSIOLOGICAL REVIEW ARTICLE: Brain structures and mechanisms involved in the control of cortical activation and wakefulness, with emphasis on the posterior hypothalamus and histaminergic neurons

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Sleep: Changes in Threshold to Electroconvulsive Shock in Rats after Deprivation of "Paradoxical" Phase

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Caffeine Use as a Model of Acute and Chronic Insomnia

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Neural Circuitry of Stress-Induced Insomnia in Rats

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1983 • 218 citations

Sleep and Serotonin An Unfinished Story

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Chapter 5: The organization of central cholinergic systems and their functional importance in sleep-waking states

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Prostaglandins and adenosine in the regulation of sleep and wakefulness

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Immobilisation stress induces a paradoxical sleep rebound in rat

1991 • 216 citations

Selectively bred Wistar–Kyoto rats: an animal model of depression and hyper-responsiveness to antidepressants

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Emerging views of dopamine in modulating sleep/wake state from an unlikely source: PD

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Hypoglycemia Activates Orexin Neurons and Selectively Increases Hypothalamic Orexin-B Levels

2001 • 211 citations

Caffeine Attenuates Waking and Sleep Electroencephalographic Markers of Sleep Homeostasis in Humans

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Paradoxical (REM) sleep genesis: The switch from an aminergic–cholinergic to a GABAergic–glutamatergic hypothesis

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A new animal model of endogenous depression: A summary of present findings

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Altered sleep regulation in leptin-deficient mice

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Comments on Posttraumatic Stress Disorder

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Caffeine Reduces Low-Frequency Delta Activity in the Human Sleep EEG

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Analysis of sleep-wakefulness rhythms in male rats after suprachiasmatic nucleus lesions and ocular enucleation

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Mice lacking the TNF 55 kDa receptor fail to sleep more after TNFalpha treatment.

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Neuropeptide S Stimulates the Hypothalamo-Pituitary-Adrenal Axis and Inhibits Food Intake

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NPAS2 as a transcriptional regulator of non-rapid eye movement sleep: Genotype and sex interactions

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Sleep-Related Hypoglycemia-Associated Autonomic Failure in Type 1 Diabetes

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Selective REM sleep deprivation and compensation phenomena in the rat

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The effect of sleep deprivation on sleep in rats with suprachiasmatic lesions

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Prostaglandin D2 induces sleep when microinjected into the preoptic area of conscious rats

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Changes in sleep architecture following chronic mild stress

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Ramelteon (TAK-375), A Selective MT1/MT2-Receptor Agonist, Reduces Latency to Persistent Sleep in a Model of Transient Insomnia Related to a Novel Sleep Environment

2005 • 167 citations

Nocturnal sleep in huntington's disease

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Sleep deprivation in the rat: an animal model of mania

1995 • 164 citations

The brain H3-receptor as a novel therapeutic target for vigilance and sleep–wake disorders

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Sleep and circadian abnormalities in a transgenic mouse model of Alzheimer’s disease: A role for cholinergic transmission

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Stress-induced changes in sleep in rodents: Models and mechanisms

2007 • 157 citations

High Corticosterone Levels in Prenatally Stressed Rats Predict Persistent Paradoxical Sleep Alterations

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Mice Lacking the TNF 55 kDa Receptor Fail to Sleep More After TNFα Treatment

1997 • 157 citations

Dependence of sleep on nutrients' availability

1979 • 156 citations

Humoral Links between Sleep and the Immune System

2003 • 156 citations

Social stress induces high intensity sleep in rats

1997 • 155 citations

GHRH and sleep

2004 • 155 citations

Prostaglandin D2, a cerebral sleep-inducing substance in rats.

1983 • 154 citations

Chronic mild stress affects sucrose intake and sleep in rats

2003 • 151 citations

Interactions between sleep and sensory physiology

1997 • 150 citations

Microinjection of glutamate into the pedunculopontine tegmentum induces REM sleep and wakefulness in the rat

2001 • 146 citations

Lipocalin-type prostaglandin D synthase produces prostaglandin D ₂ involved in regulation of physiological sleep

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Chronic mild stress-induced anhedonia model of depression

1995 • 144 citations

Home cage activity and behavioral performance in inbred and hybrid mice

2002 • 143 citations

Sleep induction by an adrenal steroid in the rat

1987 • 142 citations

Prostaglandin D2-sensitive, sleep-promoting zone defined in the ventral surface of the rostral basal forebrain.

1994 • 142 citations

Hypothalamo‐preoptic Histaminergic Projections in Sleep‐Wake Control in the Cat

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Cytokines and normal sleep

2005 • 140 citations

Interleukin-10 (cytokine synthesis inhibitory factor) acts in the central nervous system of rats to reduce sleep

1995 • 139 citations

Functional role of 5-HT2 receptors in the regulation of sleep and wakefulness in the rat

1989 • 139 citations

Effects of glutamate agonist versus procaine microinjections into the basal forebrain cholinergic cell area upon gamma and theta EEG activity and sleep–wake state

2000 • 138 citations

Neurological syndromes of organophosphorus compounds.

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Pharmacology of neuropeptide S in mice: therapeutic relevance to anxiety disorders

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A non-circadian role for clock-genes in sleep homeostasis:a strain comparison

2007 • 135 citations

Sleep-wakefulness patterns in the helpless rat

1991 • 134 citations

Insomnia following parachlorophenylalanin in the rat

1968 • 133 citations

Effects of N6-cyclopentyladenosine and caffeine on sleep regulation in the rat

1996 • 131 citations

Effect of Age on the Circadian Pattern of Sleep and Wakefulness in the Mouse

1986 • 128 citations

Sleep homeostasis in suprachiasmatic nuclei-lesioned rats: effects of sleep deprivation and triazolam administration

1992 • 127 citations

A model of sleep-disordered breathing in the C57BL/6J mouse

2001 • 126 citations

Genetic Studies of Sleep in Mice

1972 • 126 citations

Sleep in mice with nonfunctional growth hormone-releasing hormone receptors

2003 • 125 citations

Sleep abnormalities in mentally retarded autistic subjects: Down's syndrome with mental retardation and normal subjects

1999 • 122 citations

5-HT2 receptors could be primarily involved in the regulation of slow-wabe sleep in the rat

1987 • 121 citations

Pattern Recognition of Sleep in Rodents Using Piezoelectric Signals Generated by Gross Body Movements

2007 • 121 citations

Modifications of sleep structure induced by increasing levels of acoustic perturbation in normal subjects

1990 • 121 citations

Sleep research in depressive illness: Clinical implications —a tasting menu

1995 • 121 citations

Sleep in the rat during food deprivation and subsequent restitution of food

1977 • 119 citations

Influence of environmental temperature on the sleep-wakefulness cycle in the rat

1972 • 117 citations

Evolution of insomnia: current status and future direction

2004 • 117 citations

EEG sleep studies in “pure” primary alcoholism during subacute withdrawal: Relationships to normal controls, age, and other clinical variables

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β2-Containing Nicotinic Receptors Contribute to the Organization of Sleep and Regulate Putative Micro-Arousals in Mice

2004 • 116 citations

Brain and core temperatures and peripheral vasomotion during sleep and wakefulness at various ambient temperatures in the rat

1990 • 115 citations

An Automated System for Recording and Analysis of Sleep in Mice

2000 • 115 citations

Facteurs génétiques dans le déterminisme du cycle veille-sommeil chez la souris

1974 • 112 citations

Effects of seganserin, a 5-HT2 antagonist, and temazepam on human sleepsstages and EEG power spectra

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Age-independent and age-related deficits in visuospatial learning, sleep–wake states, thermoregulation and motor activity in PDAPP mice

2002 • 111 citations

Acetylcholine and the Regulation of REM Sleep: Basic Mechanisms and Clinical Implications for Affective Illness and Narcolepsy

1987 • 110 citations

Strain differences in sleep and other pathophysiological sequelae of influenza virus infection in naive and immunized mice

1995 • 109 citations

Performance During Frequent Sleep Disruption

1987 • 109 citations

Effects of light on sleep and activity rhythms

1978 • 109 citations

Emerging anti-insomnia drugs: tackling sleeplessness and the quality of wake time

2008 • 108 citations

A social conflict increases EEG slow-wave activity during subsequent sleep

2001 • 107 citations

Histamine-induced arousal in the conscious and pentobarbital-pretreated rat.

1982 • 107 citations

The two faces of Eve

2004 • 107 citations

Sleep disorders in the elderly

2001 • 106 citations

Sleep is increased in mice with obesity induced by high-fat food

2005 • 106 citations

Effects of centrally administered orexin-B and orexin-A: a role for orexin-1 receptors in orexin-B-induced hyperactivity

2001 • 104 citations

A rodent model of sleep disturbances in posttraumatic stress disorder: The role of context after fear conditioning

2005 • 104 citations

The hypothalamic-pituitary-adrenocortical system and sleep in man

1995 • 103 citations

Rat Strain Differences Suggest a Role for Corticotropin-Releasing Hormone in Modulating Sleep

1997 • 103 citations

Effects of H1- and H2-histamine receptor agonists and antagonists on sleep and wakefulness in the rat

1986 • 102 citations

Influence of shock training and explicit fear-conditioned cues on sleep architecture in mice: strain comparison.

2003 • 101 citations

Sleep in the Wistar-Kyoto rat, a putative genetic animal model for depression

2000 • 100 citations

Sleep Stages and EEG Power Spectrum in Relation to Acoustical Stimulus Arousal Threshold in the Rat

1993 • 100 citations

Differential sleep-promoting effects of five sleep substances nocturnally infused in unrestrained rats.

1984 • 100 citations

Restraint increases prolactin and REM sleep in C57BL/6J mice but not in BALB/cJ mice

2001 • 100 citations

Circadian control of the sleep–wake cycle

2006 • 98 citations

Corticotropin-releasing hormone involvement in stressor-induced alterations in sleep and in the regulation of waking

1995 • 98 citations

Age-related changes in the sleep pattern of male adult rats

1983 • 98 citations

Fatal familial insomnia: a model disease in sleep physiopathology

2005 • 96 citations

Role of adenosine in sleep in rats.

1985 • 95 citations

REM sleep abnormalities in a new animal model of endogenous depression

1990 • 95 citations

Sleep Abnormalities During Abstinence in Alcohol-Dependent Patients

2001 • 95 citations

Corticotropin-releasing hormone (CRH) as a regulator of waking

2001 • 93 citations

Sleep in Young and Old Rats

1979 • 93 citations

Sleep, sleep deprivation and infectious disease: Studies in animals

1995 • 92 citations

Catecholamines and the sleep-wake cycle II. REM sleep

1983 • 92 citations

Are there distinctive sleep problems in Angelman syndrome?

2007 • 91 citations

Sleep disorders in psychiatry

2006 • 91 citations

Effects of chronic stress on sleep in rats

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Differential effects of acute cold and footshock on the sleep of rats

2000 • 90 citations

Neural-immune interactions in the regulation of sleep

2003 • 90 citations

Paradoxical sleep deprivation and locomotor activity in rats

1981 • 90 citations

Increased REM sleep in rats selectively bred for cholinergic hyperactivity

1988 • 89 citations

Perchance to dream: Solving the mystery of sleep through genetic analysis

2002 • 89 citations

Effects of social stimuli on sleep in mice: non-rapid-eye-movement (NREM) sleep is promoted by aggressive interaction but not by sexual interaction

2001 • 88 citations

Evidence That REM Sleep Is Controlled by the Activation of Brain Stem Pedunculopontine Tegmental Kainate Receptor

2002 • 87 citations

Platform sleep deprivation affects deep slow wave sleep in addition to REM sleep

1985 • 87 citations

Influence of Contextual Fear on Sleep in Mice: A Strain Comparison

2003 • 86 citations

Inhibition of sleep in rats by inorganic selenium compounds, inhibitors of prostaglandin D synthase.

1991 • 85 citations

Sleep features in Tourette's syndrome, neuroacanthocytosis and Huntington's chorea

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Sommeil et température cérébrale du rat au cours de l'exposition chronique en ambiance chaude

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Drugs for sleep disorders: mechanisms and therapeutic prospects

2006 • 84 citations

Excitation of the pedunculopontine tegmental NMDA receptors induces wakefulness and cortical activation in the rat

2001 • 84 citations

Effects of α-fluoromethylhistidine on sleep-waking parameters in rats

1985 • 83 citations

Impaired Rapid Eye Movement Sleep in the Tg2576 APP Murine Model of Alzheimer's Disease with Injury to Pedunculopontine Cholinergic Neurons

2005 • 82 citations

The Sedative Effects and Mechanism of Action of Cedrol Inhalation with Behavioral Pharmacological Evaluation

2003 • 82 citations

Control of sleep states in the rat by short light-dark cycles

1975 • 81 citations

Sleep disturbance induced by substance P in mice

2005 • 80 citations

Influence of fear conditioning on elicited ponto-geniculo-occipital waves and rapid eye movement sleep.

2001 • 80 citations

Brain mechanisms that control sleep and waking

2004 • 80 citations

Intravenous infusions of nutrients and sleep in the rat: an ischymetric sleep regulation hypothesis

1980 • 80 citations

REM sleep: a sensitive index of fear conditioning in rats

2005 • 80 citations

Sleep disturbances in Ube3a maternal-deficient mice modeling Angelman syndrome

2005 • 80 citations

Altered Circadian and Homeostatic Sleep Regulation in Prokineticin 2-Deficient Mice

2007 • 80 citations

Effects of chronic ethanol exposure on sleep in rats

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Daily pattern of sleep, motor activity and feeding in the rat: Effects of regular and gradually extended photoperiods

1978 • 79 citations

Mechanisms of sleep induction by GABA(A) receptor agonists.

2007 • 79 citations

Mild electrical stimulation of pontine tegmentum around locus coeruleus reduces rapid eye movement sleep in rats

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Effect of p-chlorophenylalanine and tryptophan on sleep, EEG and motor activity in the rat

1981 • 78 citations

Fatal familial insomnia: clinical features and molecular genetics

1999 • 78 citations

Different types of norepinephrinergic receptors are involved in preoptic area mediated independent modulation of sleep-wakefulness and body temperature

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Chronic Prenatal Stress Affects Development and Behavioral Depression in Rats

1998 • 78 citations

Age-related Changes in Sleep in the Rat

1999 • 77 citations

Human physiological models of insomnia

2007 • 74 citations

Sleep disturbances and excessive daytime sleepiness in Parkinson disease: an overview

2006 • 73 citations

Sleep after differing amounts of conditioned fear training in BALB/cJ mice

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Catecholamines and the sleep-wake cycle I. EEG and behavioral arousal

1982 • 73 citations

Further definition of the effect of corticosterone on the sleep–wake pattern in the male rat

2001 • 72 citations

An anti-tumor necrosis factor antibody suppresses sleep in rats and rabbits

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Effect of ambient temperature on the sleep-waking cycle in two strains of mice

1984 • 71 citations

Effects of the Neuropeptide Substance P on Sleep, Mood, and Neuroendocrine Measures in Healthy Young Men

2002 • 70 citations

Sleep changes in fasting rats

1989 • 69 citations

Alpha-adrenoceptive influences on the control of the sleep-waking cycle in the cat

1980 • 69 citations

Effect of electric foot shocks, immobilization, and corticosterone administration on the sleep–wake pattern in the rat

2000 • 69 citations

Awakening properties of modafinil without paradoxical sleep rebound: comparative study with amphetamine in the rat

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Differential effects of two types of environmental novelty on activity and sleep in BALB/cJ and C57BL/6J mice

2005 • 68 citations

The organization of sleep and wakefulness after maternal separation in young rats

1976 • 68 citations

Sundown Syndrome in Severely Demented Patients with Probable Alzheimer's Disease

1995 • 68 citations

Interleukin-10 Inhibits Spontaneous Sleep in Rabbits

1999 • 68 citations

Diurnal Rhythms of Sleep In The Rat: Augmentation of Paradoxical Sleep Following Alterations of The Feeding Schedule

1971 • 67 citations

A diallel analysis of the genetic underpinnings of mouse sleep

1974 • 67 citations

Centrally Administered Neuropeptide S Activates Orexin-Containing Neurons in the Hypothalamus and Stimulates Feeding in Rats

2006 • 67 citations

Additive wake-promoting actions of medial basal forebrain noradrenergic α1- and β-receptor stimulation.

2003 • 66 citations

Effects of adrenalectomy and subsequent corticosterone replacement on rat sleep state and EEG power spectra

1998 • 66 citations

The dose-response effects of caffeine on sleep in rats

1987 • 66 citations

Effect of environmental temperature on sleep, locomotor activity, core body temperature and immune responses of C57BL/6J mice

2007 • 66 citations

Depriving Rats of REM Sleep: The Identification of a Methodological Problem

1977 • 65 citations

The GABAA agonist gaboxadol improves the quality of post-nap sleep

2001 • 64 citations

Behavioral despair in mice after prenatal stress

2000 • 63 citations

Sleep rebound in animals deprived of paradoxical sleep by the modified multiple platform method

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Sleep patterns over 21-day period in rats with chronic constriction of sciatic nerve

2003 • 63 citations

Deficiency of Growth Hormone-Releasing Hormone Signaling Is Associated with Sleep Alterations in the Dwarf Rat

2001 • 63 citations

An interleukin-1 receptor fragment inhibits spontaneous sleep and muramyl dipeptide-induced sleep in rabbits

1996 • 62 citations

Effects of 12-h sleep deprivation and of 12-h cold exposure on sleep regulation and cortical temperature in the rat

1993 • 62 citations

"Rebound" Recovery from Deprivation of Paradoxical Sleep in the Rabbit.

1963 • 62 citations

Effects of short-acting hypnotics on sleep latency in rats placed on grid suspended over water

2003 • 61 citations

Brief skin temperature changes towards thermoneutrality trigger REM sleep in rats

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A tryptophan-rich protein diet efficiently restores sleep after food deprivation in the rat

2004 • 61 citations

Changes in Sleep Patterns in Spontaneously Hypertensive Rats

2004 • 61 citations

Prostaglandin E₂Activates the Histaminergic System via the EP₄Receptor to Induce Wakefulness in Rats

2003 • 60 citations

Vigilance states in a parkinsonian model, the MPTP mouse

2004 • 60 citations

Study of a GABA c receptor antagonist on sleep-waking behavior in rats

2001 • 60 citations

Inhibition of tumor necrosis factor in the brain suppresses rabbit sleep

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Aging and sleep in the albino rat

1972 • 59 citations

Organophosphate neurotoxicity: chronic effects of sarin on the electroencephalogram of monkey and man.

1982 • 59 citations

Functional Magnetic Resonance Imaging in Conscious Animals: A New Tool in Behavioural Neuroscience Research

2006 • 58 citations

Awaking effect of prostaglandin E2 in freely moving rats

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A novel role of pedunculopontine tegmental kainate receptors: a mechanism of rapid eye movement sleep generation in the rat

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Cold Exposure and Sleep in the Rat: Effects on Sleep Architecture and the Electroencephalogram

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The sequential hypothesis on sleep function. I. Evidence that the structure of sleep depends on the nature of the previous waking experience

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Interleukin-4 inhibits spontaneous sleep in rabbits

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Selective increases in non-rapid eye movement sleep following whole body heating in rats

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Fear conditioning increases NREM sleep.

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Twenty-four hour rhythms of selected ambient temperature in rat and hamster

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Interleukin-1β Mediates Sleep Alteration in Rats With Rotenone-Induced Parkinsonism

2007 • 56 citations

Excitation and Prolonged Waking Produced by Catecholamines Injected into the Ventricular System of Cats

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Modafinil for Excessive Sleepiness Associated With Chronic Shift Work Sleep Disorder

2007 • 55 citations

Effects of Methoxamine and a-Adrenoceptor Antagonists, Prazosin and Yohimbine, on the Sleep-Wake Cycle of the Rat

1984 • 55 citations

Effects of the serotonin 5-HT2A/2C receptor agonist DOI and of the selective 5-HT2A or 5-HT2C receptor antagonists EMD 281014 and SB-243213, respectively, on sleep and waking in the rat

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Sleep fragmentation in the arthritic rat

1988 • 55 citations

Comparison of the sleep pattern throughout a protocol of chronic sleep restriction induced by two methods of paradoxical sleep deprivation

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A translational, caffeine-induced model of onset insomnia in rats and healthy volunteers

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Pattern of desynchronized sleep during deprivation and recovery induced in the rat by changes in ambient temperature*

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Sleep pattern in rats under different stress modalities

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Glutamatergic stimulation of the basal forebrain elevates extracellular adenosine and increases the subsequent sleep

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Prion protein: a role in sleep regulation?

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Stress-induced insomnia: opioid-dopamine interactions

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Effects of Lighting Conditions on Sleep and Wakefulness in Albino Lewis and Pigmented Brown Norway Rats

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Neuropeptide S and Its Receptor: A Newly Deorphanized G Protein–Coupled Receptor System

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Cafeteria diet-induced sleep is blocked by subdiaphragmatic vagotomy in rats

1998 • 52 citations

Effects of Buspirone on Sleep and Respiration

1990 • 52 citations

Wakefulness-inducing effects of histamine in the basal forebrain of freely moving rats

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Changes in sleep after acute and repeated administration of nicotine in the rat

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Sleep-wakefulness rhythms in mice after suprachiasmatic nucleus lesions.

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The hypothalamic peptidergic system, hypocretin/orexin and vigilance control

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Electrophysiological evaluation of three paradoxical sleep deprivation techniques in rats

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Models of sleep regulation in mammals

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Auditory deprivation modifies sleep in the guinea-pig

1997 • 50 citations

Fear-conditioned suppression of REM sleep: relationship to Fos expression patterns in limbic and brainstem regions in BALB/cJ mice

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Role of noradrenergic and GABA-ergic inputs in pedunculopontine tegmentum for regulation of rapid eye movement sleep in rats

2006 • 50 citations

REM sleep inhibition by light in the albino rat

1972 • 49 citations

Role of corticotropin-releasing hormone in stressor-induced alterations of sleep in rat

2002 • 49 citations

Influence of a 1 h immobilization stress on sleep states and corticotropin-like intermediate lobe peptide (CLIP or ACTH18–39, Ph-ACTH18–39) brain contents in the rat

1997 • 49 citations

An ether stressor increases REM sleep in rats: possible role of prolactin

2000 • 48 citations

Awaking effect of PGE2 microinjected into the preoptic area of rats

1988 • 48 citations

Decreased Slow-Wave and Paradoxical Sleep in a Rat Chronic Pain Model

1989 • 48 citations

Diurnal Effects of Acute and Chronic Administration of Ethanol on Sleep in Rats

2002 • 48 citations

Homeostatic Regulation of Sleep in a Genetic Model of Depression in the Mouse: Effects of Muscarinic and 5-HT1A Receptor Activation

2005 • 47 citations

Is insomnia best categorized as a symptom or a disease?

2004 • 47 citations

Stimulation of NMDA and AMPA receptors in the rat nucleus basalis of Meynert affects sleep

1999 • 47 citations

Chronic exposure of rats to noise: Relationship between long-term memory deficits and slow wave sleep disturbances

2006 • 47 citations

The pharmacology of wakefulness

2006 • 47 citations

Hypoglycemia Counterregulation During Sleep

2003 • 47 citations

Sleep during chronic ethanol administration and withdrawal in rats.

1978 • 46 citations

Role of serotonin in sleep mechanisms.

2001 • 46 citations

Shortening of the photoperiod affects sleep distribution, EEG and cortical temperature in the Djungarian hamster

1996 • 46 citations

Effect of ambient temperature on the 24-hour sleep-wake cycle in normal and capsaicin-treated rats

1983 • 46 citations

Evidence that brain prostaglandin E2 is involved in physiological sleep-wake regulation in rats.

1989 • 45 citations

Varying photoperiod in the laboratory rat: profound effect on 24-h sleep pattern but no effect on sleep homeostasis

1995 • 45 citations

Rat Strain Differences in Freezing and Sleep Alterations Associated with Contextual Fear

2005 • 45 citations

Rat strain differences in sleep after acute mild stressors and short-term sleep loss

2004 • 45 citations

Increased Basal REM Sleep But No Difference in Dark Induction or Light Suppression of REM Sleep in Flinders Rats with Cholinergic Supersensitivity

1996 • 45 citations

Prostaglandin E2 exerts an awaking effect in the posterior hypothalamus at a site distinct from that mediating its febrile action in the anterior hypothalamus

1992 • 44 citations

Model insomnia by methylphenidate and caffeine and use in the evaluation of temazepam

1982 • 44 citations

Electroencephalographic Changes with Age in Male Mice

1975 • 44 citations

Food Restriction Alters the Diurnal Distribution of Sleep in Rats

1999 • 44 citations

Cafeteria diet promotes sleep in rats

1987 • 43 citations

Strain differences in the influence of open field exposure on sleep in mice

2004 • 43 citations

Changes in EEG power spectra and behavioral states in rats exposed to the acetylcholinesterase inhibitor chlorpyrifos and muscarinic agonist oxotremorine

2001 • 43 citations

Sleep fragmentation, and changes in locomotor activity and body temperature in trypanosome-infected rats

1995 • 43 citations

Short light–dark cycles affect sleep in mice

2007 • 43 citations

Influence of some biologically meaningful odorants on the vigilance states of the rat

1979 • 42 citations

Changes in the sleep–wake cycle architecture and cortical nitric oxide release during ageing in the rat

2003 • 42 citations

Deleterious effects of an environmental noise on sleep and contribution of its physical components in a rat model

2004 • 42 citations

Disruptions in Sleep Time and Sleep Architecture in a Mouse Model of Repeated Ethanol Withdrawal

2006 • 42 citations

Sleep wake profile and EEG spectral power in young or old senescence accelerated mice

2004 • 42 citations

Role of alpha and beta adrenoceptors in locus coeruleus stimulation-induced reduction in rapid eye movement sleep in freely moving rats

2004 • 42 citations

Altered sleep and behavioral patterns of arthritic rats.

2000 • 42 citations

Sleep and EEG features in genetic models of Down syndrome

2007 • 42 citations

The Prevalence, Morbidities, and Treatments of Insomnia

2007 • 42 citations

Sleep alterations in an experimental orofacial pain model in rats

2003 • 41 citations

Sleep during Experimental Trypanosomiasis in Rabbits

1994 • 41 citations

Room light impairs sleep in the albino rat

1994 • 41 citations

Effects of Maternal Separation on Baseline Sleep and Cold Stress-Induced Sleep Rebound in Adult Wistar Rats

2004 • 41 citations

Strain Differences in the Somnogenic Effects of Interferon Inducers in Mice

1996 • 41 citations

Manipulations during forced wakefulness have differential impact on sleep architecture, EEG power spectrum, and Fos induction

1998 • 40 citations

Sleep and EEG patterns in the chronic constriction injury model of neuropathic pain

2003 • 40 citations

Effects of Some H1-Antagonists on the Sleep-Wake Cycle in Sleep-Disturbed Rats

2007 • 40 citations

Prenatal protein malnourished rats show changes in sleep/wake behavior as adults

2000 • 40 citations

Caffeine treatment regulates neuropeptide S system expression in the rat brain

2006 • 40 citations

Effect of low dose ethanol on the EEG of alcohol-preferring and -nonpreferring rats

1988 • 40 citations

Effects of a-fluoromethylhistidine on sleep and wakefulness in the rat

1988 • 40 citations

Prenatal exposure to alcohol in adult rats: relationships between sleep and memory deficits, and effects of glucose administration on memory

1996 • 39 citations

Sleep-inducing function of noradrenergic fibers in the medial preoptic area

1993 • 39 citations

The role of alpha-2 receptors in the medial preoptic area in the regulation of sleep-wakefulness and body temperature

1998 • 39 citations

Prenatal stress is associated with depression-related electroencephalographic sleep changes in adult male rats: A preliminary report

1999 • 39 citations

Modulation of desynchronized sleep through microinjection of ?-adrenergic agonists and antagonists in the dorsal pontine tegmentum of the cat

1989 • 38 citations

The GABA A receptor antagonist picrotoxin attenuates most sleep changes induced by progesterone

1999 • 37 citations

Differences in Sleep-induced Hypoxia between A/J and DBA/2J Mouse Strains

2003 • 37 citations

Strain differences in sleep patterns of healthy and influenza-infected inbred mice.

2003 • 37 citations

Chronic exposure to an environmental noise permanently disturbs sleep in rats: Inter-individual vulnerability

2005 • 37 citations

Effects of three hypnotics on the sleep-wakefulness cycle in sleep-disturbed rats

2004 • 36 citations

A corticotropin-releasing hormone antisense oligodeoxynucleotide reduces spontaneous waking in the rat

2003 • 36 citations

Mechanism controlling sleep organization of the obese Zucker rats

1998 • 36 citations

Dose effects of temazepam in transient insomnia.

1990 • 35 citations

Sleep and Aging in Animals: Relationships with Circadian Rhythms and Memory

1989 • 35 citations

Slow Wave Sleep-inducing Effects of First Generation H1-Antagonists.

1999 • 35 citations

Rat strain differences in response to dark pulse triggering of paradoxical sleep

1991 • 35 citations

5-HT receptor agonists 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI) and 8-OH-DPAT increase wakefulness in the rat

1990 • 35 citations

Differential Effects of Flunitrazepam on Human Sleep in Combination with Flumazenil

1989 • 34 citations

Increased waking as well as increased synchronization following administration of selective 5-HT uptake inhibitors to rats

1989 • 34 citations

Changes in thermal preference, sleep–wakefulness, body temperature and locomotor activity of rats during continuous recording for 24 hours

2004 • 34 citations

Influence of long-term food restriction on sleep pattern in male rats

2005 • 34 citations

Substance P promotes sleep in the ventrolateral preoptic area of rats

2004 • 34 citations

The Temporal Sequence of Gut Peptide–CNS Interactions TrackedIn Vivoby Magnetic Resonance Imaging

2007 • 33 citations

Armodafinil, the R-enantiomer of modafinil: Wake-promoting effects and pharmacokinetic profile in the rat

2006 • 33 citations

Sleep deficits in diabetic rats: restoration following chronic intravenous or intracerebroventricular infusions of insulin

1984 • 33 citations

Twenty-Four—Hour Disruption of the Sleep-Wake Cycle and Sleep-Onset REM-Like Episodes in a Rat Model of African Trypanosomiasis

2004 • 33 citations

[Suppression of sleep with p-chloromethamphetamine and p-chlorophenylalanine].

1966 • 32 citations

Neural–immune interactions in disorders of sleep-wakefulness organization

2007 • 32 citations

Nicotine treatment regulates neuropeptide S system expression in the rat brain

2007 • 32 citations

Effects of Aging on Sleep in the Golden Hamster

1998 • 31 citations

The effects of buspirone on sleep in the rat

1986 • 31 citations

Sleep and wakefulness disturbances in Parkinson’s disease

2006 • 31 citations

Interactions between brief restraint, novelty and footshock stress on subsequent sleep and EEG power in rats

2007 • 31 citations

Effects of corticosterone replacement on the temporal patterning of activity and sleep in adrenalectomized rats

1980 • 31 citations

Suppression of sleep by prostaglandin synthesis inhibitors in unrestrained rats

1988 • 31 citations

Intravenous administration of inorganic selenium compounds, inhibitors of prostaglandin D synthase, inhibits sleep in freely moving rats

1993 • 31 citations

Strong rebound of wakefulness follows prostaglandin D₂‐ or adenosine A_2a receptor agonist‐induced sleep

2000 • 31 citations

Effects of Prenatal Alcohol Exposure on Neonatal Sleep‐wake Behaviour and Adult Alcohol Consumption in Rats

1986 • 30 citations

Caffeine Reduces Low-Frequency Delta Activity in the Human Sleep EEG

1995 • 30 citations

Effects of the acute administration of ethanol on the sleep of the rat: A dose-response study

1978 • 30 citations

Pharmacology of ethanol and glutamate antagonists on rodent sleep: A comparative study

1994 • 30 citations

Sleep patterns in the genetically obese Zucker rat: effect of acarbose treatment

1989 • 30 citations

Hypotension Reduces Sleep Apneas in Zucker Lean and Zucker Obese Rats

1996 • 29 citations

Sleep variations in C57BL and BALBc mice from 3 weeks to 14 weeks of age

1983 • 29 citations

Mouse strain differences in the effects of corticotropin releasing hormone (CRH) on sleep and wakefulness

2007 • 29 citations

Time-related changes in the sleep-wake cycle of rats infected with Trypanosoma brucei brucei

1994 • 28 citations

Functional MRI shows activation of the medial preoptic area during sleep

2005 • 28 citations

Combined modulating effects of the general arousal and the specific hunger arousal on the olfactory bulb responses in the rat

1979 • 28 citations

Influence of ambient temperature on the sleep-wakefulness cycle in the golden hamster

1984 • 28 citations

Instrumental REM Sleep Deprivation in Neonates Leads to Adult Depression-like Behaviors in Rats

2003 • 28 citations

Changes in sleep on chronic exposure to warm and cold ambient temperatures

2005 • 28 citations

Caffeine-induced sleep disruption: effects on waking the following day and its reversal with an hypnotic

1996 • 28 citations

Sublingual zolpidem is more effective than oral zolpidem in initiating early onset of sleep in the post-nap model of transient insomnia: A polysomnographic study

2008 • 27 citations

Sleep deficits in rats after NMDA receptor blockade

1992 • 27 citations

Technologies of sleep research

2007 • 26 citations

The role of 5-hydroxytryptophan (5-HTP) in the regulation of the sleep/wake cycle in parachlorophenylalanine (p-CPA) pretreated rat: a multiple approach study

1991 • 26 citations

Habituation of insulin-induced hypoglycemic transcription activation of lateral hypothalamic orexin-A-containing neurons to recurring exposure

2006 • 26 citations

Long lasting alteration in REM sleep of female rats submitted to long maternal separation

2007 • 25 citations

Sleep disturbance due to transportation noise: ear plugs vs oral drugs

1984 • 25 citations

The selective histamine H1-receptor agonist 2-(3-trifluoromethylphenyl)histamine increases waking in the rat

1994 • 24 citations

The Effect of a 3-Day Increase of Ambient Temperature Toward the Thermoneutral Zone on Rapid Eye Movement Sleep in the Rat

1993 • 24 citations

Changes in REM sleep occurrence due to rhythmical auditory stimulation in the rat

2000 • 24 citations

Chapter 22 Sleep regulation: relation to photoperiod, sleep duration, waking activity, and torpor

1996 • 24 citations

EFFECT OF PRENATAL ALCOHOL EXPOSURE ON NEONATAL SLEEP-WAKE BEHAVIOUR AND ADULT ALCOHOL CONSUMPTION IN THE AA AND ANA RAT LINES

1987 • 24 citations

Sleep–wake architecture in mouse models for Down syndrome

2004 • 24 citations

[STUDY OF SELECTIVE DEPRIVATION OF THE PARADOXAL PHASE OF SLEEP IN THE CAT].

1964 • 24 citations

Hypoglycemia activates arousal-related neurons and increases wake time in adult rats

2007 • 23 citations

Strain Differences in the Sleep of Rats

1987 • 23 citations

The Effects of Sensory Stimulation on REM Sleep Duration

1998 • 22 citations

Hypnotics: Clinical Value of Pharmaco-EEG Methods

1986 • 22 citations

Adrenal Steroids and the Maintenance of a Circadian Distribution of Paradoxical Sleep in Rats

1971 • 22 citations

Caffeine During Sleep Deprivation

2000 • 22 citations

SOME EFFECTS OF HISTAMINE IN THE NORMAL AND HAEMOPHILUS PERTUSSIS VACCINATED RAT

1958 • 22 citations

Effects of early handling on basal and stress-induced sleep parameters in rats

2003 • 22 citations

Effects of Muscimol or Homotaurine on Sleep–Wake States in Alcohol-Dependent Rats During Withdrawal

1998 • 22 citations

Changes of Sleep Patterns in Rats with Chronic Constriction Injury under Aversive Conditions

2007 • 21 citations

Influence of Temporomandibular Joint Pain on Sleep Patterns: Role of Nitric Oxide

2004 • 21 citations

Pattern of REM sleep occurrence in continuous darkness following the exposure to low ambient temperature in the rat

2001 • 21 citations

Enhancement of REM sleep with auditory stimulation in young and old rats

1992 • 20 citations

Effects of auditory stimulation during rapid eye movement sleep in healthy volunteers and depressed patients

1991 • 20 citations

The effects of high intensity white noise on the sleep pattern of the rat

1966 • 20 citations

Effect of the Specific Benzodiazepine Antagonist Ro 15-1788 on Sleep

1986 • 20 citations

Sleep-inducing effects of three hypnotics in a new model of insomnia in rats

1981 • 20 citations

The Hypnotic, Electroencephalographic, and Antinociceptive Properties of Nonpeptide ORL1 Receptor Agonists After Intravenous Injection in Rodents

2006 • 20 citations

Effects of chronic and acute ethanol administration on sleep in laboratory rats.

1978 • 20 citations

Functional changes in waking and sleeping rats after lesions in the olfactory pathways

1982 • 20 citations

On the role of brain alpha-adrenergic systems in the production of paradoxical sleep.

1982 • 19 citations

EEG spectra, behavioral states and motor activity in rats exposed to acetylcholinesterase inhibitor chlorpyrifos

2002 • 19 citations

RO 15-1788 decreases hypnotic effects of sleep deprivation

1987 • 18 citations

Reduction of rapid eye movement (REM) sleep by glucose alone or glucose and insulin in rats

1988 • 18 citations

Effects of temperature on sleep in the developing rat

1998 • 18 citations

Sleep suppressant action of quipazine: Relation to central serotonergic stimulation

1981 • 17 citations

Basic science of sleep

2004 • 17 citations

Role of orexin and prostaglandin E2 in activating histaminergic neurotransmission

2004 • 17 citations

A method for evaluating potential hypnotic compounds in rats

1978 • 16 citations

Sleep disorders: An overview

2004 • 16 citations

Effects of p-chlorophenylalanine on thermoregulation and sleep in rats

1992 • 16 citations

Activity of some benzodiazepine receptor ligands with reduced sedative and muscle relaxant properties on stress-induced electrocorticogram arousal in sleeping rats

1987 • 16 citations

Modulation of desynchronized sleep through microinjection of ?1-adrenergic agonists and antagonists in the dorsal pontine tegmentum of the cat

1992 • 16 citations

Tonic activity of α1 adrenergic receptors of the medial preoptic area contributes towards increased sleep in rats

2006 • 15 citations

Effects of Light and Circadian Rhythm on the Occurrence of REM Sleep in the Rat

1980 • 15 citations

Relationship of ethanol blood level to REM and non-REM sleep time and distribution in the rat

1978 • 15 citations

Cocaine effects on sleep parameters in the rat

1977 • 15 citations

[Effect of santalol on the sleep-wake cycle in sleep-disturbed rats].

2007 • 15 citations

Effects of chronic dietary administration of the cholinergic false precursor N-amino-N, N-dimethylaminoethanol on behavior and cholinergic parameters in rats

1986 • 14 citations

Model insomnia, noise, and methylphenidate, used for the evaluation of hypnotic drugs

1978 • 14 citations

Auditory deprivation modifies biological rhythms in the golden hamster.

2000 • 13 citations

Sleep–wake study in an animal model of acute and chronic heat stress

2006 • 13 citations

Circadian variations in vigilance states in the alcohol-dependent rat

1990 • 12 citations

The effect of GABAA antagonist bicuculline on dorsal raphe nucleus and frontal cortex extracellular serotonin: A window on SWS and REM sleep modulation

2006 • 11 citations

Sleep-wake disturbances in an animal model of chronic cholinergic insufficiency

1993 • 11 citations

Mild insomnia induced by environmental perturbations in the rat: a study of this new model and of its possible applications in pharmacological research.

1982 • 10 citations

Effects of ethanol inhalation on EEG in rats

1991 • 10 citations

In utero ethanol exposure decreases rapid eye movement sleep in female Sprague–Dawley rat offspring

2000 • 10 citations

[Inversion of insomnia produced by para-chlorophenylalanine in the rat. Intraperitoneal and intraventricular administration of 5-hydroxytryptophan].

1980 • 10 citations

The role of neuropeptides in sleep modulation

2004 • 9 citations

Sleep and timekeeping changes, and dysregulation of the biological clock in experimental trypanosomiasis.

1994 • 9 citations

Effects of temazepam 7.5 mg and temazepam 15 mg on sleep maintenance and sleep architecture in a model of transient insomnia

2005 • 9 citations

Sleep–wake effects of meta-chlorophenyl piperazine and mianserin in the behaviorally depressed rat

2002 • 9 citations

Promotion of sleep by prostaglandin D2 in rats made insomniac by pretreatment with para-chlorophenylalanine

1994 • 8 citations

Effect of Tandospirone on Sleep Latency in Rats Placed on a Grid Suspended Over Water

2007 • 8 citations

Neuropeptides as Possible Targets in Sleep Disorders: Special Emphasis on Hypocretin-Deficient Narcolepsy

2007 • 8 citations

Effectiveness of Yohimbine in Treating Narcolepsy

1994 • 8 citations

Neuropeptides as possible targets in sleep disorders

2006 • 7 citations

[Modulation of the multiunit responses of the olfactory bulb and respiratory activity as a function of the significance of odors in freely moving rats].

1977 • 7 citations

Neonatal REM sleep is regulated by corticotropin releasing factor

2007 • 7 citations

Sleep–wake effects of yohimbine and atropine in rats with a clomipramine-based model of depression

2002 • 7 citations

Effects of Kynurenic Acid and Ketamine on Neonatal Sleep in Rats

1989 • 7 citations

Muramyl dipeptide, amphetamine, and physostigmine: Effects on sleep of rabbits

1987 • 6 citations

Polysomnography in transgenic hSOD1 mice as Down syndrome model

2003 • 6 citations

Translational Models of Sleep and Sleep Disorders

2008 • 4 citations

Stress-induced partial insomnia: a model for the evaluation of potential hypnotic compounds [proceedings].

1977 • 4 citations