Effects of hypocretin2‐saporin and antidopamine‐β‐hydroxylase‐saporin neurotoxic lesions of the dorsolateral pons on sleep and muscle tone
Data up to Jan 2025
Total Citations Per Year
Abstract
References (68)
The Rat Brain in Stereotaxic Coordinates
1982 • 53,055 citations
Brain stem reticular formation and activation of the EEG
1949 • 4,188 citations
The hypocretins: Hypothalamus-specific peptides with neuroexcitatory activity
1998 • 3,711 citations
Unresponsiveness to Cannabinoids and Reduced Addictive Effects of Opiates in CB 1 Receptor Knockout Mice
1999 • 3,597 citations
Neurons Containing Hypocretin (Orexin) Project to Multiple Neuronal Systems
1998 • 3,381 citations
Narcolepsy in orexin Knockout Mice
1999 • 3,014 citations
The Sleep Disorder Canine Narcolepsy Is Caused by a Mutation in the Hypocretin (Orexin) Receptor 2 Gene
1999 • 2,583 citations
A mutation in a case of early onset narcolepsy and a generalized absence of hypocretin peptides in human narcoleptic brains
2000 • 2,065 citations
Reduced Number of Hypocretin Neurons in Human Narcolepsy
2000 • 2,004 citations
Differential expression of orexin receptors 1 and 2 in the rat brain
2001 • 1,593 citations
Genetic Ablation of Orexin Neurons in Mice Results in Narcolepsy, Hypophagia, and Obesity
2001 • 1,387 citations
Sleep Cycle Oscillation: Reciprocal Discharge by Two Brainstem Neuronal Groups
1975 • 1,216 citations
Orexin A activates locus coeruleus cell firing and increases arousal in the rat
1999 • 1,182 citations
[Research on the neural structures and responsible mechanisms in different phases of physiological sleep].
1962 • 908 citations
Dorsal raphe neurons: depression of firing during sleep in cats
1976 • 902 citations
Neuronal activities in brain-stem cholinergic nuclei related to tonic activation processes in thalamocortical systems
1990 • 779 citations
SLEEP AS A PROBLEM OF LOCALIZATION
1930 • 661 citations
HYPOTHALAMIC REGULATION OF SLEEP IN RATS. AN EXPERIMENTAL STUDY
1946 • 655 citations
Distinct Narcolepsy Syndromes in Orexin Receptor-2 and Orexin Null Mice
2003 • 629 citations
A neural circuit for circadian regulation of arousal
2001 • 600 citations
Hypocretin (orexin) activation and synaptic innervation of the locus coeruleus noradrenergic system
1999 • 587 citations
Hypocretin-1 Modulates Rapid Eye Movement Sleep through Activation of Locus Coeruleus Neurons
2000 • 506 citations
Anatomical, Physiological, and Pharmacological Characteristics of Histidine Decarboxylase Knock-Out Mice: Evidence for the Role of Brain Histamine in Behavioral and Sleep–Wake Control
2002 • 472 citations
Fluctuation of extracellular hypocretin‐1 (orexin A) levels in the rat in relation to the light–dark cycle and sleep–wake activities
2001 • 441 citations
Different behaviors during paradoxical sleep without atonia depend on pontine lesion site
1982 • 374 citations
Unitary characteristics of presumptive cholinergic tegmental neurons during the sleep-waking cycle in freely moving cats
1989 • 358 citations
Neurotoxic lesions of the dorsolateral pontomesencephalic tegmentum-cholinergic cell area in the cat. II. Effects upon sleep-waking states
1988 • 346 citations
SOMNOLENCE CAUSED BY HYPOTHALAMIC LESIONS IN THE MONKEY
1939 • 343 citations
Release of Hypocretin (Orexin) during Waking and Sleep States
2002 • 335 citations
REM sleep behaviour disorder: an update on a series of 96 patients and a review of the world literature
1993 • 317 citations
Effects of locus coeruleus lesions upon cerebral monoamine content, sleep-wakefulness states and the response to amphetamine in the cat
1977 • 280 citations
Hypocretin-2-Saporin Lesions of the Lateral Hypothalamus Produce Narcoleptic-Like Sleep Behavior in the Rat
2001 • 273 citations
Circadian and Homeostatic Regulation of Hypocretin in a Primate Model: Implications for the Consolidation of Wakefulness
2003 • 270 citations
Changes in CSF hypocretin-1 (orexin A) levels in rats across 24 hours and in response to food deprivation
2001 • 220 citations
Cholinergic brainstem mechanisms of REM sleep in the rat
1986 • 163 citations
Central noradrenergic lesioning using anti-DBH-saporin: anatomical findings
1996 • 159 citations
Induction of rapid eye movement sleep by carbachol infusion into the pontine reticular formation in the rat
1995 • 157 citations
Evidence That Wakefulness and REM Sleep Are Controlled by a GABAergic Pontine Mechanism
1999 • 155 citations
Hypocretin receptor protein and mRNA expression in the dorsolateral pons of rats
2001 • 148 citations
Pontine structures and mechanisms involved in the generation of paradoxical (REM) sleep.
2001 • 124 citations
Are the gigantocellular tegmental field neurons responsible for paradoxical sleep?
1981 • 124 citations
Effects of lateral hypothalamic lesion with the neurotoxin hypocretin-2–saporin on sleep in Long–Evans rats
2003 • 118 citations
Continuous pontine cholinergic microinfusion via mini-pump induces sustained alterations in rapid eye movement (REM) sleep
1986 • 111 citations
A study of pontine lesions suppressing deep sleep in the cat.
1965 • 105 citations
Effects of hypocretin–saporin injections into the medial septum on sleep and hippocampal theta
2001 • 100 citations
Somnolence, recovery and hyposomnia following ventro-medial diencephalic lesions in the rat
1969 • 99 citations
Norepinephrine-Deficient Mice Exhibit Normal Sleep-Wake States but have Shorter Sleep Latency after Mild Stress and Low Doses of Amphetamine
2003 • 95 citations
Elimination of paradoxical sleep by lesions of the pontine gigantocellular tegmental field in the cat
1979 • 93 citations
Neurotoxic lesion of the mesencephalic reticular formation and/or the posterior hypothalamus does not alter waking in the cat
1991 • 85 citations
Cholinergically induced REM sleep triggers Fos-like immunoreactivity in dorsolateral pontine regions associated with REM sleep
1992 • 76 citations
The effects of posterior hypothalamic lesions on behavioral and electrographic manifestations of sleep and waking in cats.
1968 • 75 citations
Rapid Eye Movement Sleep induction by microinjection of the GABA-A antagonist bicuculline into the dorsal subcoeruleus area of the rat
2003 • 73 citations
Narcolepsy in the Older Adult
2003 • 71 citations
Mechanisms of Sleep Control
1990 • 69 citations
Long‐term effects of decreased noradrenergic central nervous system innervation on pain behavior and opioid antinociception
2003 • 68 citations
Relation of pontine choline acetyltransferase immunoreactive neurons with cells which increase discharge during REM sleep
1987 • 61 citations
Sleep patterning and behaviour in cats with pontine lesions creating REM without atonia
1994 • 49 citations
[Effects of lesions in the pontine tegmentum on the sleep stages in the rat].
1976 • 48 citations
Cortical activity and sleep in the rat lateral hypothalamic syndrome
1980 • 46 citations
Subcortical waking and sleep during lateral hypothalamic “somnolence” in rats
1982 • 44 citations
Increase of paradoxical sleep induced by microinjections of ibotenic acid into the ventrolateral part of the posterior hypothalamus in the cat.
1988 • 44 citations
Microinjections of muscimol and bicuculline into the pontine reticular formation modify the sleep-waking cycle in the rat
1991 • 42 citations
Retrograde degeneration and colchicine protection of basal forebrain cholinergic neurons following hippocampal injections of an immunotoxin against the p75 nerve growth factor receptor
1997 • 40 citations
Destruction of locus coeruleus neuronal perikarya after injection of anti-dopamine-B-hydroxylase immunotoxin into the olfactory bulb of the rat
1998 • 36 citations
Noradrenaline neurotoxin DSP-4 effects on sleep and brain temperature in the rat
1998 • 35 citations
Retrogradely transported CTB–saporin kills sympathetic preganglionic neurons
1999 • 33 citations
Narcoleptic canines display periodic leg movements during sleep
2001 • 31 citations
Daily pattern of EEG activity in rats with lateral hypothalamic lesions.
1994 • 13 citations