Cholinergic Regulation of Orexin/Hypocretin Neurons Through M3 Muscarinic Receptor in Mice

Neurons Containing Hypocretin (Orexin) Project to Multiple Neuronal Systems

1998 • 3,381 citations

Narcolepsy in orexin Knockout Mice

1999 • 3,014 citations

Hypothalamic regulation of sleep and circadian rhythms

2005 • 2,613 citations

A mutation in a case of early onset narcolepsy and a generalized absence of hypocretin peptides in human narcoleptic brains

2000 • 2,065 citations

Genetic Ablation of Orexin Neurons in Mice Results in Narcolepsy, Hypophagia, and Obesity

2001 • 1,387 citations

The neural circuit of orexin (hypocretin): maintaining sleep and wakefulness

2007 • 1,177 citations

Distribution of orexin neurons in the adult rat brain

1999 • 1,052 citations

Orexins, orexigenic hypothalamic peptides, interact with autonomic, neuroendocrine and neuroregulatory systems

1999 • 1,028 citations

The Neurobiology of Sleep: Genetics, cellular physiology and subcortical networks

2002 • 902 citations

Hypothalamic Orexin Neurons Regulate Arousal According to Energy Balance in Mice

2003 • 892 citations

Behavioral Correlates of Activity in Identified Hypocretin/Orexin Neurons

2005 • 830 citations

Neuronal activities in brain-stem cholinergic nuclei related to tonic activation processes in thalamocortical systems

1990 • 779 citations

SK&F 96365, a novel inhibitor of receptor-mediated calcium entry

1990 • 762 citations

Input of Orexin/Hypocretin Neurons Revealed by a Genetically Encoded Tracer in Mice

2005 • 463 citations

Hypocretin/Orexin Excites Hypocretin Neurons via a Local Glutamate Neuron—A Potential Mechanism for Orchestrating the Hypothalamic Arousal System

2002 • 459 citations

Mice lacking the M3 muscarinic acetylcholine receptor are hypophagic and lean

2001 • 373 citations

Orexin-induced hyperlocomotion and stereotypy are mediated by the dopaminergic system11Published on the World Wide Web on 27 June 2000.

2000 • 350 citations

Orexins/hypocretins excite basal forebrain cholinergic neurones

2001 • 307 citations

Direct and Indirect Excitation of Laterodorsal Tegmental Neurons by Hypocretin/Orexin Peptides: Implications for Wakefulness and Narcolepsy

2002 • 285 citations

Pontine regulation of REM sleep components in cats: integrity of the pedunculopontine tegmentum (PPT) is important for phasic events but unnecessary for atonia during REM sleep

1992 • 241 citations

Regulation of orexin neurons by the monoaminergic and cholinergic systems

2003 • 222 citations

Serotonergic Regulation of the Orexin/Hypocretin Neurons through the 5-HT_1AReceptor

2004 • 190 citations

Hypocretins (orexins) and sleep–wake disorders

2005 • 154 citations

Localization of muscarinic M3 receptor protein and M3 receptor binding in rat brain

1994 • 148 citations

Cholecystokinin Activates Orexin/Hypocretin Neurons through the Cholecystokinin A Receptor

2005 • 141 citations

Orexin Neurons Are Directly and Indirectly Regulated by Catecholamines in a Complex Manner

2006 • 120 citations

Innervation of orexin/hypocretin neurons by GABAergic, glutamatergic or cholinergic basal forebrain terminals evidenced by immunostaining for presynaptic vesicular transporter and postsynaptic scaffolding proteins

2006 • 116 citations

Discharge patterns of neurons in cholinergic regions of the basal forebrain during waking and sleep

2000 • 98 citations

Beneficial metabolic effects of M3 muscarinic acetylcholine receptor deficiency

2006 • 84 citations

Autoradiographic mapping of M3 muscarinic receptors in the rat brain.

1993 • 67 citations

Presynaptic muscarinic (M3) receptors reduce excitatory transmission in dopamine neurons of the rat mesencephalon

1999 • 45 citations

Selective inactivation of muscarinic receptor subtypes

1994 • 42 citations

Paradoxical Sleep in Mice Lacking M<sub>3</sub> and M<sub>2</sub>/M<sub>4</sub> Muscarinic Receptors

2005 • 40 citations

M3 muscarinic receptors mediate cholinergic excitation of the spontaneous activity of subthalamic neurons in the rat

1996 • 28 citations

The m3 muscarinic acetylcholine receptor differentially regulates calcium influx and release through modulation of monovalent cation channels

1998 • 24 citations