The stimulant effects of caffeine on locomotor behaviour in mice are mediated through its blockade of adenosine A_2A receptors

Actions of caffeine in the brain with special reference to factors that contribute to its widespread use.

1999 • 2,431 citations

ADENOSINE REGULATES VIA TWO DIFFERENT TYPES OF RECEPTORS, THE ACCUMULATION OF CYCLIC AMP IN CULTURED BRAIN CELLS

1979 • 1,370 citations

Differential Effect of Stress on In Vivo Dopamine Release in Striatum, Nucleus Accumbens, and Medial Frontal Cortex

1989 • 1,107 citations

Aggressiveness, hypoalgesia and high blood pressure in mice lacking the adenosine A2a receptor

1997 • 906 citations

Adenosine–dopamine receptor–receptor interactions as an integrative mechanism in the basal ganglia

1997 • 804 citations

Adenosine receptors and behavioral actions of methylxanthines.

1981 • 705 citations

Selective Amplification And Cloning Of Four New Members Of The G Protein-coupled Receptor Family

1989 • 647 citations

Interchangeability of Stress and Amphetamine in Sensitization

1980 • 565 citations

Adenosine, Adenosine Receptors and the Actions of Caffeine *

1995 • 563 citations

Increased Anxiogenic Effects of Caffeine in Panic Disorders

1985 • 427 citations

Are methylxanthine effects due to antagonism of endogenous adenosine?

1979 • 419 citations

Sedative and anticonvulsant effects of adenosine analogs in mouse and rat.

1982 • 393 citations

Pharmacology of adenosine A2A receptors

1996 • 321 citations

RDC8 codes for an adenosine A2 receptor with physiological constitutive activity

1990 • 270 citations

Adenosine-dopamine interactions in the ventral striatum

1997 • 247 citations

Purinergic approaches in experimental therapeutics

1997 • 238 citations

The orphan receptor cDNA RDC7 encodes an A1 adenosine receptor.

1991 • 191 citations

Increased Sensitivity to Caffeine in Patients With Panic Disorders

1984 • 190 citations

8‐(3‐Chlorostyryl)caffeine (CSC) is a selective A₂‐adenosine antagonist in vitro and in vivo

1993 • 174 citations

Antagonism of adenosine A2A receptors underlies the behavioural activating effect of caffeine and is associated with reduced expression of messenger RNA for NGFI-A and NGFI-B in caudate–putamen and nucleus accumbens

1997 • 170 citations

3,7-Dimethyl-1-propargylxanthine: A potent and selective in vivo antagonist of adenosine analogs

1988 • 141 citations

Effects of N6-cyclopentyladenosine and caffeine on sleep regulation in the rat

1996 • 131 citations

Biphasic changes in locomotor behavior and in expression of mRNA for NGFI-A and NGFI-B in rat striatum following acute caffeine administration

1995 • 129 citations

Interactions in the behavioral effects of methylxanthines and adenosine derivatives.

1983 • 128 citations

Anxiolytic activity of adenosine receptor activation in mice

1995 • 127 citations

Caffeine Intake, Tolerance, and Withdrawal in Women: A Population-Based Twin Study

1999 • 124 citations

Effects of isolation, handling and novelty on the pituitary-adrenal response in the mouse

1982 • 121 citations

Reinforcing effects of caffeine in humans.

1988 • 120 citations

[Action of caffeine on the spontaneous motility of the mouse].

1965 • 105 citations

Involvement of adenosine A2A receptor in sleep promotion

1998 • 105 citations

A1 and A2A adenosine receptors and A1 mRNA in mouse brain: effect of long-term caffeine treatment

1997 • 104 citations

Behavioral effects of A1- and A2-selective adenosine agonists and antagonists: evidence for synergism and antagonism.

1991 • 103 citations

Comparison of the behavioral effects of adenosine agonists and dopamine antagonists in mice

1989 • 101 citations

Locomotor activity in mice during chronic treatment with caffeine and withdrawal

1993 • 98 citations

Effects of Caffeine and Theophylline on Activity of Rats in Relation to Brain Xanthine Concentrations

1972 • 97 citations

Hypothalamic-Pituitary-Adrenocortical Responses to Psychological Stress and Caffeine in Men at High and Low Risk for Hypertension

1998 • 96 citations

Caffeine: relationship to human anxiety, plasma MHPG and cortisol.

1984 • 95 citations

Long‐term Treatment with some Methylxanthines Decreases the Susceptibility to Bicuculline‐ and Pentylenetetrazol‐induced Seizures in Mice. Relationship to c‐ios Expression and Receptor Binding

1996 • 73 citations

Comparison of the behavioural effects of an adenosine A1/A2-receptor antagonist, CGS 15943A, and an A1-selective antagonist, DPCPX

1991 • 70 citations

The dose-response effects of caffeine on sleep in rats

1987 • 66 citations

EFFECT OF CAFFEINE ON LOCOMOTOR ACTIVITY AND CENTRAL CATECHOLAMINE MECHANISMS: A STUDY WITH SPECIAL REFERENCE TO DRUG INTERACTION

1975 • 62 citations

Pharmacological characterization of a simple behavioral response mediated selectively by central adenosine A1 receptors, using in vivo and in vitro techniques.

1998 • 62 citations

Caffeine as an intensifier of stress-induced hormonal and pathophysiologic changes in mice

1980 • 61 citations

Inhibition of nigrostriatal release of dopamine in the rat by adenosine receptor agonists: A1 receptor mediation

1989 • 60 citations

Relationship of plasma and brain concentrations of caffeine and metabolites to benzodiazepine receptor binding and locomotor activity.

1989 • 59 citations

Caffeine-induced behavioral stimulation is dose-dependent and associated with A1 adenosine receptor occupancy.

1992 • 45 citations

Depletion of catecholamines in the brain of rats differentially affects stimulation of locomotor activity by caffeine, d-amphetamine, and methylphenidate

1990 • 44 citations

Neuroendocrine effects of caffeine. II. Effects on thyrotropin and corticosterone secretion.

1983 • 43 citations

The differential role of A1 and A2 adenosine receptor subtypes in locomotor activity and place conditioning in rats

1996 • 39 citations

SCH 58261: A selective A2A adenosine receptor antagonists

1997 • 36 citations

Inherent differences in sensitivity to methylxanthines among inbred mice

1986 • 35 citations

NECA-induced hypomotility in mice: Evidence for a predominantly central site of action

1989 • 35 citations

Differential Role of Nucleus Accumbens and Caudate-Putamen in Mediating the Effect of Nomifensine and Methamphetamine on Ambulation and Rearing of Rats in the Open-Field Test

1995 • 33 citations

Effects of selective agonists and antagonists for A1 or A2A adenosine receptors on sleep-waking patterns in rats

1996 • 33 citations

CGS 15943, a nonxanthine adenosine receptor antagonist: Effects on locomotor activity of nontolerant and caffeine-tolerant rats

1991 • 30 citations

Potential use of DPCPX as probe for in vivo localization of brain A1 adenosine receptors

1992 • 21 citations

Inhibitory and excitatory effects of adenosine antagonists on spontaneous locomotor activity in mice

1997 • 16 citations

Central effects of corticotropin releasing factor (CRF): evidence for similar interactions with environmental novelty and with caffeine

1990 • 16 citations

Knockouts anxious for new therapy

1997 • 12 citations

Deleted Work

1955 • 0 citations