An adenosine A2A receptor agonist induces sleep by increasing GABA release in the tuberomammillary nucleus to inhibit histaminergic systems in rats

High performance liquid chromatographic determination of subpicomole amounts of amino acids by precolumn fluorescence derivatization with o-phthaldialdehyde

1979 • 1,842 citations

Activation of Ventrolateral Preoptic Neurons During Sleep

1996 • 1,077 citations

The role of histamine and the tuberomamillary nucleus in the nervous system

2003 • 890 citations

Innervation of Histaminergic Tuberomammillary Neurons by GABAergic and Galaninergic Neurons in the Ventrolateral Preoptic Nucleus of the Rat

1998 • 720 citations

Molecular cloning of the rat A2 adenosine receptor: selective co-expression with D2 dopamine receptors in rat striatum

1992 • 646 citations

Comparative localization of two forms of glutamic acid decarboxylase and their mRNAs in rat brain supports the concept of functional differences between the forms

1994 • 610 citations

The sedative component of anesthesia is mediated by GABAA receptors in an endogenous sleep pathway

2002 • 554 citations

Arousal effect of orexin A depends on activation of the histaminergic system

2001 • 540 citations

Afferents to the Ventrolateral Preoptic Nucleus

2002 • 484 citations

Anatomical, Physiological, and Pharmacological Characteristics of Histidine Decarboxylase Knock-Out Mice: Evidence for the Role of Brain Histamine in Behavioral and Sleep–Wake Control

2002 • 472 citations

High-performance liquid chromatographic determination of plasma and brain histamine without previous purification of biological samples: Cation-exchange chromatography coupled with post-column derivatization fluorometry

1985 • 400 citations

Immunohistochemical localization of adenosine A2A receptors in the rat central nervous system

1998 • 374 citations

GABAergic neurons in the rat pontomesencephalic tegmentum: Codistribution with cholinergic and other tegmental neurons projecting to the posterior lateral hypothalamus

1995 • 342 citations

A critical role of the posterior hypothalamus in the mechanisms of wakefulness determined by microinjection of muscimol in freely moving cats

1989 • 317 citations

An adenosine A2a agonist increases sleep and induces Fos in ventrolateral preoptic neurons

2001 • 263 citations

PHYSIOLOGICAL REVIEW ARTICLE: Brain structures and mechanisms involved in the control of cortical activation and wakefulness, with emphasis on the posterior hypothalamus and histaminergic neurons

2000 • 242 citations

Histaminergic descending inputs to the mesopontine tegmentum and their role in the control of cortical activation and wakefulness in the cat

1996 • 233 citations

Involvement of histaminergic neurons in arousal mechanisms demonstrated with H3-receptor ligands in the cat

1990 • 217 citations

Hypothalamic regulation of sleep and arousal

2003 • 173 citations

Involvement of histamine in the control of the waking state

1993 • 164 citations

Promotion of sleep mediated by the A2a-adenosine receptor and possible involvement of this receptor in the sleep induced by prostaglandin D2 in rats.

1996 • 162 citations

Activation of ventrolateral preoptic neurons by the somnogen prostaglandin D ₂

1998 • 161 citations

Coexistence of adenosine deaminase, histidine decarboxylase, and glutamate decarboxylase in hypothalamic neurons of the rat

1985 • 152 citations

Origin of neuronal inputs to the region of the tuberomammillary nucleus of the rat brain

1991 • 144 citations

GABA release in posterior hypothalamus across sleep-wake cycle

1996 • 143 citations

Hypothalamo‐preoptic Histaminergic Projections in Sleep‐Wake Control in the Cat

1994 • 141 citations

A2a adenosine receptor gene expression in developing rat brain

1993 • 138 citations

Minireview: Sleep regulation in adenosine A _2A receptor-deficient mice

2003 • 134 citations

Multiple neurotransmitters in the tuberomammillary nucleus: Comparison of rat, mouse, and guinea pig

1992 • 128 citations

Region‐dependent difference in the sleep‐promoting potency of an adenosine A_2A receptor agonist

1999 • 116 citations

Orexin (hypocretin)/dynorphin neurons control GABAergic inputs to tuberomammillary neurons

2004 • 108 citations

Prostaglandin D2 in Sleep-Wake Regulation: Recent Progress and Perspectives

2002 • 107 citations

Involvement of adenosine A2A receptor in sleep promotion

1998 • 105 citations

Electrophysiology of excitatory and inhibitory afferents to rat histaminergic tuberomammillary nucleus neurons from hypothalamic and forebrain sites

1997 • 105 citations

Extracellular histamine levels in the feline preoptic/anterior hypothalamic area during natural sleep–wakefulness and prolonged wakefulness: An in vivo microdialysis study

2002 • 92 citations

Histaminergic systems and sleep

1985 • 89 citations

Changes in motoric, exploratory and emotional behaviours and neuronal acetylcholine content and 5‐HT turnover in histidine decarboxylase‐KO mice

2004 • 88 citations

Effects of α-fluoromethylhistidine on sleep-waking parameters in rats

1985 • 83 citations

Extracellular histamine level in the frontal cortex is positively correlated with the amount of wakefulness in rats

2004 • 78 citations

Prostaglandin E₂Activates the Histaminergic System via the EP₄Receptor to Induce Wakefulness in Rats

2003 • 60 citations

Excitatory effect of histamine on the arousal system and its inhibition by H1 blockers

1989 • 54 citations

Effect of histamine depletion on the circadian amplitude of the sleep-wakefulness cycle

1991 • 32 citations

Strong rebound of wakefulness follows prostaglandin D₂‐ or adenosine A_2a receptor agonist‐induced sleep

2000 • 31 citations

Role of orexin and prostaglandin E2 in activating histaminergic neurotransmission

2004 • 17 citations

Activation of sensory nerves participates in stress-induced histamine release from mast cells in rats

1999 • 14 citations

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