Interleukin‐1β enhances non‐rapid eye movement sleep when microinjected into the dorsal raphe nucleus and inhibits serotonergic neuronsin vitro

Unresponsiveness to Cannabinoids and Reduced Addictive Effects of Opiates in CB ₁ Receptor Knockout Mice

1999 • 3,597 citations

Structure and function of the brain serotonin system

1992 • 2,507 citations

The sleep switch: hypothalamic control of sleep and wakefulness

2001 • 1,609 citations

Brainstem Control of Wakefulness and Sleep

1990 • 1,188 citations

Dorsal raphe neurons: depression of firing during sleep in cats

1976 • 902 citations

The Neurobiology of Sleep: Genetics, cellular physiology and subcortical networks

2002 • 902 citations

Raphe unit activity in freely moving cats: Correlation with level of behavioral arousal

1979 • 809 citations

“Inflammatory” Cytokines

2000 • 499 citations

Electrophysiological and pharmacological characterization of serotonergic dorsal raphe neurons recorded extracellularly and intracellularly in rat brain slices

1983 • 497 citations

Principles and Practice of Sleep Medicine

2001 • 488 citations

Sleep-promoting effects of endogenous pyrogen (interleukin-1)

1984 • 450 citations

Keeping cool: a hypothesis about the mechanisms and functions of slow-wave sleep

1990 • 387 citations

Mechanisms of oscillatory activity in guinea‐pig nucleus reticularis thalami in vitro: a mammalian pacemaker.

1993 • 316 citations

Interleukin-1 beta augments release of norepinephrine, dopamine, and serotonin in the rat anterior hypothalamus

1993 • 293 citations

Gene expression and function of interleukin I, interleukin 6 and tumor necrosis factor in the brain

1994 • 288 citations

Distinct roles for CD4 and CD8 as co-receptors in antigen receptor signalling

1993 • 274 citations

Serotonergic and cholinergic inhibition of mesopontine cholinergic neurons controlling rem sleep: An in vitro electrophysiological study

1994 • 271 citations

Voltage- and ligand-activated inwardly rectifying currents in dorsal raphe neurons in vitro

1988 • 248 citations

The relationship of interleukin-1 and immune functions to sleep in humans.

1986 • 232 citations

Interleukin 1 receptors in the brain and endocrine tissues

1993 • 228 citations

Interleukin 1 alters rat sleep: temporal and dose-related effects

1991 • 223 citations

Sleep and Serotonin An Unfinished Story

1999 • 218 citations

Handbook of Behavioral State Control: Cellular and Molecular Mechanisms

2000 • 174 citations

Interleukin-1 augments gamma-aminobutyric acidA receptor function in brain.

1991 • 165 citations

Sleep Disorders: Basic and Clinical Research

1983 • 164 citations

Single unit recordings in the nuclei raphe dorsalis and magnus during the sleep-waking cycle of semi-chronic prepared cats

1981 • 158 citations

Nocturnal plasma levels of cytokines in healthy men

1992 • 147 citations

Behavioral state-related changes of extracellular serotonin concentration in the dorsal raphe nucleus: a microdialysis study in the freely moving cat

1994 • 130 citations

Diurnal variations of interleukin-1β mRNA and β-actin mRNA in rat brain

1997 • 129 citations

Interleukin-1β decreases acetylcholine measured by microdialysis in the hippocampus of freely moving rats

1991 • 126 citations

Pharmacological and Immunohistochemical Evidence for Serotonergic Modulation of Cholinergic Nucleus Basalis Neurons

1993 • 118 citations

Sleep and Cerebrospinal Fluid Interleukin-1-Like Activity in the Cat

1988 • 113 citations

Extracellular serotonin levels change with behavioral state but not with pyrogen-induced hyperthermia

1991 • 111 citations

Anti-interleukin-1 beta reduces sleep and sleep rebound after sleep deprivation in rats

1994 • 108 citations

The sleep–wake switch: A neuronal alarm clock

2000 • 103 citations

Rat Strain Differences Suggest a Role for Corticotropin-Releasing Hormone in Modulating Sleep

1997 • 103 citations

Differential Oscillatory Properties of Cholinergic and Non‐cholinergic Nucleus Basalis Neurons in Guinea Pig Brain Slice

1996 • 100 citations

Intrahypothalamic infusion of interleukin-1β increases the release of corticotropin-releasing hormone (CRH 41) and adrenocorticotropic hormone (ACTH) in free-moving rats bearing a push-pull cannula in the median eminence

1990 • 94 citations

Corticotropin-releasing hormone (CRH) as a regulator of waking

2001 • 93 citations

Interleukin-1 is involved in responses to sleep deprivation in the rabbit

1994 • 90 citations

Modulation of IL-1β gene expression in the rat CNS during sleep deprivation

1996 • 89 citations

Reserpine suppression of dorsal raphe neuronal firing: mediation by adrenergic system

1978 • 84 citations

Voltammetric detection of the release of 5-hydroxyindole compounds throughout the sleep-waking cycle of the rat

1990 • 82 citations

Substance P (Neurokinin 1) Receptor Antagonists Enhance Dorsal Raphe Neuronal Activity

2002 • 81 citations

Reversibility of Para-chlorophenylalanine-induced insomnia by intrahypothalamic microinjection of l-5-hydroxytryptophan

1989 • 77 citations

Sleep and Serotonin: An Unfinished Story

1999 • 74 citations

GHRH and IL1β increase cytoplasmic Ca2+ levels in cultured hypothalamic GABAergic neurons

2002 • 71 citations

Interleukin-1 induces slow-wave sleep at the prostaglandin D2-sensitive sleep-promoting zone in the rat brain.

1998 • 67 citations

Serotonin neurons and sleep. I. Long term recordings of dorsal raphe discharge frequency and PGO waves.

1987 • 63 citations

Microinjection of interleukin-1 into brain: Separation of sleep and fever responses

1989 • 62 citations

Bastadins relate ryanodine-sensitive and -insensitive Ca2+ efflux pathways in skeletal SR and BC3H1 cells

1997 • 62 citations

Cholinergic Mechanisms Regulating REM Sleep

1997 • 62 citations

Differential effects of cytokines on thermosensitive neurons in guinea pig preoptic area slices

1991 • 61 citations

Changes in the serotonergic system during the sleep-wake cycle: Simultaneous polygraphic and voltammetric recordings in hypothalamus using a telemetry system

1994 • 61 citations

Comparative, behavioural and electrocortical effects of tumor necrosis factor-α and interleukin-1 microinjected into the locus coeruleus of rat

1997 • 60 citations

Interleukin-1 Induces Slow-Wave Sleep at the Prostaglandin D₂-Sensitive Sleep-Promoting Zone in the Rat Brain

1998 • 59 citations

Flow cytometric identification and isolation of hypertrophic type II pneumocytes after partial pneumonectomy

1989 • 54 citations

5-Hydroxytryptamine mediates inhibitory postsynaptic potentials in rat dorsal raphe neurons

1985 • 52 citations

Interleukin-1 induces changes in sleep, brain temperature, and serotonergic metabolism

1997 • 52 citations

WAY-100635 and GR127935: Effects on 5-hydroxytryptamine-containing neurones

1994 • 51 citations

5-hydroxytryptophan, but not l-tryptophan, alters sleep and brain temperature in rats

1999 • 49 citations

Effect of interleukin-1 beta on EEG power density during sleep depends on circadian phase

1996 • 46 citations

Blockade of 5-hydroxytryptamine (serotonin)-2 receptors alters interleukin-1-induced changes in rat sleep

1999 • 45 citations

Effect of the putative 5-HT1A antagonists WAY100135 and SDZ 216—525 on 5-HT neuronal firing in the guinea-pig dorsal raphe nucleus

1994 • 44 citations

Blockade by interleukin-1 receptor antagonist of IL-1β-induced neuronal activity in guinea pig preoptic area slices

1992 • 43 citations

Single-unit responses of serotonergic dorsal raphe nucleus neurons to environmental heating and pyrogen administration in freely moving cats

1987 • 41 citations

GABAergic input to cholinergic nucleus basalis neurons

1998 • 35 citations

Reduction of cerebellar GABAA responses by interleukin-1 (IL-1) through an indomethacin insensitive mechanism

1996 • 34 citations

Muramyl peptide/serotonin receptors in brain-derived preparations.

1989 • 34 citations

Sleep as a behavioral model of neuro-immune interactions

1999 • 32 citations

Muramyl dipeptide and IL-1 effects on sleep and brain temperature after inhibition of serotonin synthesis

1997 • 30 citations

5-HT1A and 5-HT2 receptors differentially regulate the excitability of 5-HT-containing neurones of the guinea pig dorsal raphe nucleus in vitro

2001 • 27 citations

The Serotoninergic System and Sleep-Wakefulness Regulation

1995 • 27 citations

Serotonergic activation stimulates the pituitary-adrenal axis and alters interleukin-1 mRNA expression in rat brain

2003 • 21 citations

Interleukin-1β inhibits acetylcholine synthesis in the pituitary corticotropic cell line AtT20

1989 • 17 citations

Reduction of excitation by interleukin-1β in rat neocortical slices visualized using infrareddarkfield videomicroscopy

1997 • 17 citations

Effects of endogenous pyrogen and prostaglandin E2 on hypothalamic neurons in guinea pig brain slices

1987 • 17 citations

Interleukin-1β and calcitonin, but not corticotropin-releasing factor, alter sleep cycles when injected into the rat hypothalamic lateral paraventricular area

1999 • 13 citations