Orexin Gene Transfer into Zona Incerta Neurons Suppresses Muscle Paralysis in Narcoleptic Mice

The hypocretins: Hypothalamus-specific peptides with neuroexcitatory activity

1998 • 3,711 citations

Neurons Containing Hypocretin (Orexin) Project to Multiple Neuronal Systems

1998 • 3,381 citations

Narcolepsy in orexin Knockout Mice

1999 • 3,014 citations

The Sleep Disorder Canine Narcolepsy Is Caused by a Mutation in the Hypocretin (Orexin) Receptor 2 Gene

1999 • 2,583 citations

A mutation in a case of early onset narcolepsy and a generalized absence of hypocretin peptides in human narcoleptic brains

2000 • 2,065 citations

Reduced Number of Hypocretin Neurons in Human Narcolepsy

2000 • 2,004 citations

Expression of c- fos Protein in Brain: Metabolic Mapping at the Cellular Level

1988 • 1,916 citations

Differential expression of orexin receptors 1 and 2 in the rat brain

2001 • 1,593 citations

Genetic Ablation of Orexin Neurons in Mice Results in Narcolepsy, Hypophagia, and Obesity

2001 • 1,387 citations

The melanin‐concentrating hormone system of the rat brain: An immuno‐ and hybridization histochemical characterization

1992 • 1,052 citations

Safety and tolerability of gene therapy with an adeno-associated virus (AAV) borne GAD gene for Parkinson's disease: an open label, phase I trial

2007 • 1,028 citations

Tuning arousal with optogenetic modulation of locus coeruleus neurons

2010 • 889 citations

Distinct Narcolepsy Syndromes in Orexin Receptor-2 and Orexin Null Mice

2003 • 629 citations

Genetic and familial aspects of narcolepsy

1998 • 587 citations

Gene Therapy for Leber's Congenital Amaurosis is Safe and Effective Through 1.5 Years After Vector Administration

2009 • 540 citations

Stimulation of the caudal zona incerta is superior to stimulation of the subthalamic nucleus in improving contralateral parkinsonism

2006 • 492 citations

Melanin-concentrating hormone neurons discharge in a reciprocal manner to orexin neurons across the sleep–wake cycle

2009 • 420 citations

Expression of the melanin‐concentrating hormone (MCH) receptor mRNA in the rat brain

2001 • 378 citations

Protein Splicing of Inteins and Hedgehog Autoproteolysis: Structure, Function, and Evolution

1998 • 368 citations

Orexin peptides prevent cataplexy and improve wakefulness in an orexin neuron-ablated model of narcolepsy in mice

2004 • 334 citations

Clinical gene therapy using recombinant adeno-associated virus vectors

2008 • 312 citations

Concomitant loss of dynorphin, NARP, and orexin in narcolepsy

2005 • 295 citations

Bilateral stimulation of the caudal zona incerta nucleus for tremor control

2007 • 260 citations

Systemic and Nasal Delivery of Orexin-A (Hypocretin-1) Reduces the Effects of Sleep Deprivation on Cognitive Performance in Nonhuman Primates

2007 • 249 citations

Physiological Properties of Hypothalamic MCH Neurons Identified with Selective Expression of Reporter Gene after Recombinant Virus Infection

2004 • 228 citations

Locus coeruleus neurons: cessation of activity during cataplexy

1999 • 225 citations

Cataplexy-Active Neurons in the Hypothalamus

2004 • 223 citations

Neuronal Activity in Narcolepsy: Identification of Cataplexy-Related Cells in the Medial Medulla

1991 • 162 citations

Narp immunostaining of human hypocretin (orexin) neurons

2005 • 160 citations

A Consensus Definition of Cataplexy in Mouse Models of Narcolepsy

2009 • 145 citations

Sleep rhythmicity and homeostasis in mice with targeted disruption of mPeriod genes

2004 • 142 citations

A consensus definition of cataplexy in mouse models of narcolepsy.

2009 • 136 citations

State-dependent activity of neurons in the perifornical hypothalamic area during sleep and waking

2003 • 101 citations

Cataplexy-related neurons in the amygdala of the narcoleptic dog

2002 • 98 citations

Narcolepsy and the hypocretin system—where motion meets emotion

2006 • 82 citations

Orexin (hypocretin) gene transfer diminishes narcoleptic sleep behavior in mice

2008 • 70 citations

The neurobiology of narcolepsy-cataplexy

1993 • 58 citations

Sleep in host defense

2003 • 58 citations

Activity of Pontine Neurons during Sleep and Cataplexy in Hypocretin Knock-Out Mice

2009 • 22 citations

Alzheimer-associated APP+1 transgenic mice: Frameshift β-amyloid precursor protein is secreted in cerebrospinal fluid without inducing neuropathology

2005 • 7 citations