PERIOD3, circadian phenotypes, and sleep homeostasis

Principles and Practice of Sleep Medicine

2011 • 5,079 citations

Two-Process Model of Sleep Regulation

2008 • 3,914 citations

Hypothalamic regulation of sleep and circadian rhythms

2005 • 2,613 citations

Cumulative Sleepiness, Mood Disturbance, and Psychomotor Vigilance Performance Decrements During a Week of Sleep Restricted to 4–5 Hours per Night

1997 • 2,032 citations

Sleep function and synaptic homeostasis

2005 • 1,972 citations

The genetics of mammalian circadian order and disorder: implications for physiology and disease

2008 • 1,495 citations

Sleep Homeostasis and Models of Sleep Regulation

1999 • 1,429 citations

An h Per2 Phosphorylation Site Mutation in Familial Advanced Sleep Phase Syndrome

2001 • 1,421 citations

Timing of human sleep: recovery process gated by a circadian pacemaker

1984 • 1,378 citations

Leptin Levels Are Dependent on Sleep Duration: Relationships with Sympathovagal Balance, Carbohydrate Regulation, Cortisol, and Thyrotropin

2004 • 967 citations

Differential Functions of mPer1, mPer2, and mPer3 in the SCN Circadian Clock

2001 • 876 citations

Three period Homologs in Mammals: Differential Light Responses in the Suprachiasmatic Circadian Clock and Oscillating Transcripts Outside of Brain

1998 • 867 citations

Functional consequences of a CKIδ mutation causing familial advanced sleep phase syndrome

2005 • 828 citations

A Length Polymorphism in the Circadian Clock Gene Per3 is Linked to Delayed Sleep Phase Syndrome and Extreme Diurnal Preference

2003 • 712 citations

Practice Parameters for the Clinical Evaluation and Treatment of Circadian Rhythm Sleep Disorders

2007 • 582 citations

Circadian and sleep/wake dependent aspects of subjective alertness and cognitive performance

1992 • 580 citations

Sleep as a fundamental property of neuronal assemblies

2008 • 559 citations

Familial advanced sleep-phase syndrome: A short-period circadian rhythm variant in humans

1999 • 558 citations

Principles and Practice of Sleep Medicine

1990 • 544 citations

Association of structural polymorphisms in the human period3 gene with delayed sleep phase syndrome

2001 • 516 citations

PER3 Polymorphism Predicts Sleep Structure and Waking Performance

2007 • 508 citations

Circadian Rhythm Sleep Disorders: Part II, Advanced Sleep Phase Disorder, Delayed Sleep Phase Disorder, Free-Running Disorder, and Irregular Sleep-Wake Rhythm

2007 • 507 citations

Association of intrinsic circadian period with morningness–eveningness, usual wake time, and circadian phase.

2001 • 461 citations

Association of intrinsic circadian period with morningness-eveningness, usual wake time, and circadian phase.

2001 • 436 citations

Modeling of a Human Circadian Mutation Yields Insights into Clock Regulation by PER2

2007 • 386 citations

Invited Review: Integration of human sleep-wake regulation and circadian rhythmicity

2002 • 368 citations

EEG Power Density during Nap Sleep: Reflection of an Hourglass Measuring the Duration of Prior Wakefulness

1987 • 352 citations

An American Academy of Sleep Medicine Review

2000 • 334 citations

Mathematical models of sleep regulation

2003 • 333 citations

Sleep states alter activity of suprachiasmatic nucleus neurons

2003 • 311 citations

Circadian regulation of sleep in mammals: Role of the suprachiasmatic nucleus

2005 • 305 citations

Individual differences in human circadian rhythms

1977 • 283 citations

Circadian clock genes and sleep homeostasis

2009 • 278 citations

Sleep homeostasis: A role for adenosine in humans?

2008 • 272 citations

A functional genetic variation of adenosine deaminase affects the duration and intensity of deep sleep in humans

2005 • 255 citations

The electroencephalographic fingerprint of sleep is genetically determined: A twin study

2008 • 255 citations

Variation of electroencephalographic activity during non‐rapid eye movement and rapid eye movement sleep with phase of circadian melatonin rhythm in humans

1997 • 245 citations

The circadian and homeostatic modulation of sleep pressure during wakefulness differs between morning and evening chronotypes

2003 • 240 citations

Phase Relationships between Sleep-Wake Cycle and Underlying Circadian Rhythms in Morningness-Eveningness

2004 • 238 citations

Timing and Consolidation of Human Sleep, Wakefulness, and Performance by a Symphony of Oscillators

2005 • 238 citations

A light-independent oscillatory gene mPer3 in mouse SCN and OVLT

1998 • 234 citations

Banking Sleep: Realization of Benefits During Subsequent Sleep Restriction and Recovery

2009 • 234 citations

Repeated Partial Sleep Deprivation Progressively Changes the EEG During Sleep and Wakefulness

1993 • 233 citations

Age-related change in the relationship between circadian period, circadian phase, and diurnal preference in humans

2002 • 222 citations

Heritability of diurnal type: a nationwide study of 8753 adult twin pairs

2007 • 219 citations

Association of the Length Polymorphism in the Human Per3 Gene with the Delayed Sleep-Phase Syndrome: Does Latitude Have an Influence Upon It?

2005 • 219 citations

Molecular analysis of avian circadian clock genes

2000 • 208 citations

A Quantitative Model of Sleep-Wake Dynamics Based on the Physiology of the Brainstem Ascending Arousal System

2007 • 197 citations

Homeostatic Sleep Pressure and Responses to Sustained Attention in the Suprachiasmatic Area

2009 • 193 citations

Separation of circadian and wake duration-dependent modulation of EEG activation during wakefulness

2002 • 186 citations

An Inherited Functional Circadian Clock in Zebrafish Embryos

2000 • 176 citations

Circadian and homeostatic sleep regulation in morningness–eveningness

2006 • 175 citations

Suprachiasmatic nucleus in sleep–wake regulation

2007 • 175 citations

Simulation of daytime vigilance by the additive interaction of a homeostatic and a circadian process

1994 • 172 citations

Period3 Structural Variation: A Circadian Biomarker Associated with Breast Cancer in Young Women

2005 • 172 citations

Early morning executive functioning during sleep deprivation is compromised by a PERIOD3 polymorphism.

2008 • 155 citations

PER3 Polymorphism Predicts Cumulative Sleep Homeostatic but Not Neurobehavioral Changes to Chronic Partial Sleep Deprivation

2009 • 150 citations

Familial Advanced Sleep Phase Syndrome

2001 • 146 citations

Inter-Individual Differences In Habitual Sleep Timing and Entrained Phase of Endogenous Circadian Rhythms of BMAL1, PER2 and PER3 mRNA in Human Leukocytes

2008 • 146 citations

Functional Magnetic Resonance Imaging-Assessed Brain Responses during an Executive Task Depend on Interaction of Sleep Homeostasis, Circadian Phase, and PER3 Genotype

2009 • 144 citations

Delayed Sleep Phase Syndrome: Pathophysiology and Treatment Options

2004 • 140 citations

Long Term Effects of Sleep Deprivation on The Mammalian Circadian Pacemaker

2007 • 136 citations

Characteristics of Insomniacs with Self-Reported Morning and Evening Chronotypes

2007 • 127 citations

Age‐related change in the association between a polymorphism in the PER3 gene and preferred timing of sleep and waking activities

2007 • 123 citations

Genetic Differences in Human Circadian Clock Genes among Worldwide Populations

2008 • 120 citations

Circadian rhythm sleep disorders: Characteristics and entrainment pathology in delayed sleep phase and non-24 sleep–wake syndrome

2007 • 110 citations

Daily Light Exposure in Morning-Type and Evening-Type Individuals

2007 • 105 citations

A mathematical model of the sleep/wake cycle

2009 • 104 citations

Circadian Phase Resetting in Older People by Ocular Bright Light Exposure

2001 • 94 citations

Circadian Phase in Delayed Sleep Phase Syndrome: Predictors and Temporal Stability Across Multiple Assessments

2006 • 78 citations

Difference in sleep regulation between morning and evening circadian types as indexed by antero-posterior analyses of the sleep EEG

2006 • 78 citations

Evolution of a Length Polymorphism in the Human PER3 Gene, a Component of the Circadian System

2005 • 78 citations

Season of Birth, Gender, and Social-Cultural Effects on Sleep Timing Preferences in Humans

2009 • 76 citations

PER3 polymorphism and cardiac autonomic control: effects of sleep debt and circadian phase

2008 • 68 citations

How do genes exert their role? Period 3 gene variants and possible influences on mood disorder phenotypes

2007 • 62 citations

Human Circadian Physiology and Sleep-Wake Regulation

2001 • 59 citations

EEG Slow Wave Activity, REM Sleep, and Rectal Temperature During Night and Day Sleep in Morning‐Type and Evening‐Type Subjects

1991 • 51 citations

Differences between morning-types and evening-types in the dynamics of EEG slow wave activity during night sleep

1991 • 49 citations

Alpha activity in the human REM sleep EEG: topography and effect of REM sleep deprivation

1999 • 43 citations

Circadian and Homeostatic Regulation of Human Sleep and Cognitive Performance and Its Modulation by PERIOD3

2009 • 25 citations

Association of the 54‐nucleotide repeat polymorphism of hPer3 with heroin dependence in Han Chinese population

2007 • 21 citations

Refined anatomical isolation of functional sleep circuits exhibits distinctive regional and circadian gene transcriptional profiles

2009 • 18 citations