Nicotinic receptors: allosteric transitions and therapeutic targets in the nervous system

On the nature of allosteric transitions: A plausible model

1965 • 8,699 citations

Crystal structure of an ACh-binding protein reveals the ligand-binding domain of nicotinic receptors

2001 • 1,736 citations

Refined Structure of the Nicotinic Acetylcholine Receptor at 4Å Resolution

2004 • 1,626 citations

A variant associated with nicotine dependence, lung cancer and peripheral arterial disease

2008 • 1,497 citations

A study of the ‘desensitization’ produced by acetylcholine at the motor end‐plate

1957 • 1,457 citations

Acetylcholine receptors containing the β2 subunit are involved in the reinforcing properties of nicotine

1998 • 1,304 citations

Genome-wide association scan of tag SNPs identifies a susceptibility locus for lung cancer at 15q25.1

2008 • 1,287 citations

A double‐blind, placebo‐controlled trial

1986 • 1,281 citations

A susceptibility locus for lung cancer maps to nicotinic acetylcholine receptor subunit genes on 15q25

2008 • 1,264 citations

Structure and gating mechanism of the acetylcholine receptor pore

2003 • 1,261 citations

Linkage of a neurophysiological deficit in schizophrenia to a chromosome 15 locus

1997 • 1,142 citations

Nicotinic Acetylcholine Receptors and Nicotinic Cholinergic Mechanisms of the Central Nervous System

2006 • 1,130 citations

A CHOLINERGIC-ADRENERGIC HYPOTHESIS OF MANIA AND DEPRESSION

1972 • 1,077 citations

Recognition Dynamics Up to Microseconds Revealed from an RDC-Derived Ubiquitin Ensemble in Solution

2008 • 1,025 citations

Brain nicotinic acetylcholine receptors: native subtypes and their relevance

2006 • 838 citations

THE HEMOGLOBIN SYSTEM

1925 • 813 citations

Rings of negatively charged amino acids determine the acetylcholine receptor channel conductance

1988 • 798 citations

Nicotinic Receptors at the Amino Acid Level

2000 • 795 citations

Nicotine and Carbamylcholine Binding to Nicotinic Acetylcholine Receptors as Studied in AChBP Crystal Structures

2004 • 778 citations

Coarse-grained normal mode analysis in structural biology

2005 • 718 citations

Allosteric Mechanisms of Signal Transduction

2005 • 710 citations

Role of dopamine in the behavioural actions of nicotine related to addiction

2000 • 677 citations

Evidence in postmortem brain tissue for decreased numbers of hippocampal nicotinic receptors in schizophrenia

1995 • 676 citations

X-ray structure of a pentameric ligand-gated ion channel in an apparently open conformation

2008 • 667 citations

X-ray structure of a prokaryotic pentameric ligand-gated ion channel

2008 • 657 citations

A COMPARATIVE STUDY OF VISUOSPATIAL MEMORY AND LEARNING IN ALZHEIMER-TYPE DEMENTIA AND PARKINSON'S DISEASE

1988 • 654 citations

Allostery and cooperativity revisited

2008 • 653 citations

Structures of Aplysia AChBP complexes with nicotinic agonists and antagonists reveal distinctive binding interfaces and conformations

2005 • 617 citations

Reduced antinociception in mice lacking neuronal nicotinic receptor subunits

1999 • 546 citations

From ab initio quantum mechanics to molecular neurobiology: A cation–π binding site in the nicotinic receptor

1998 • 544 citations

Nicotine reinforcement and cognition restored by targeted expression of nicotinic receptors

2005 • 544 citations

Proof-of-Concept Trial of an α7 Nicotinic Agonist in Schizophrenia

2006 • 529 citations

Structure of a potentially open state of a proton-activated pentameric ligand-gated ion channel

2008 • 520 citations

Beta-amyloid activates the mitogen-activated protein kinase cascade via hippocampal alpha7 nicotinic acetylcholine receptors: In vitro and in vivo mechanisms related to Alzheimer's disease.

2001 • 516 citations

Recent advances in Cys-loop receptor structure and function

2006 • 505 citations

Nicotinic acetylcholine binding sites in Alzheimer's disease

1986 • 485 citations

β-Amyloid Activates the Mitogen-Activated Protein Kinase Cascade via Hippocampal α7 Nicotinic Acetylcholine Receptors:In VitroandIn VivoMechanisms Related to Alzheimer's Disease

2001 • 446 citations

Amyloid Peptide Aβ_1‐42 Binds Selectively and with Picomolar Affinity to α7 Nicotinic Acetylcholine Receptors

2000 • 421 citations

Mutations in the channel domain of a neuronal nicotinic receptor convert ion selectivity from cationic to anionic

1992 • 420 citations

Normalization by nicotine of deficient auditory sensory gating in the relatives of schizophrenics

1992 • 417 citations

Initial Phase 2 Trial of a Nicotinic Agonist in Schizophrenia

2008 • 414 citations

α7 Nicotinic Receptor Transduces Signals to Phosphatidylinositol 3-Kinase to Block A β-Amyloid-induced Neurotoxicity

2001 • 414 citations

Alternate Stoichiometries of α4β2 Nicotinic Acetylcholine Receptors

2003 • 406 citations

The diversity of subunit composition in nAChRs: Evolutionary origins, physiologic and pharmacologic consequences

2002 • 401 citations

The cholinergic system in Alzheimer's disease

1997 • 399 citations

Crystal structure of the extracellular domain of nAChR α1 bound to α-bungarotoxin at 1.94 Å resolution

2007 • 395 citations

Rationale, pharmacology and clinical efficacy of partial agonists of α4β2 nACh receptors for smoking cessation

2007 • 393 citations

Mutations at two distinct sites within the channel domain M2 alter calcium permeability of neuronal alpha 7 nicotinic receptor.

1993 • 389 citations

Structural changes involved in protein binding correlate with intrinsic motions of proteins in the unbound state

2005 • 371 citations

Cognitive function in schizophrenia

2003 • 368 citations

Broad-Spectrum, Non-Opioid Analgesic Activity by Selective Modulation of Neuronal Nicotinic Acetylcholine Receptors

1998 • 365 citations

Chronic Exposure to Nicotine Upregulates the Human α4β2 Nicotinic Acetylcholine Receptor Function

2001 • 355 citations

Nicotine binding to brain receptors requires a strong cation–π interaction

2009 • 353 citations

Distribution and Pharmacology of α6-Containing Nicotinic Acetylcholine Receptors Analyzed with Mutant Mice

2002 • 342 citations

On the nature of allosteric transitions: Implications of non-exclusive ligand binding

1966 • 336 citations

On the nature of partial agonism in the nicotinic receptor superfamily

2008 • 335 citations

Is cancer triggered by altered signalling of nicotinic acetylcholine receptors?

2009 • 335 citations

Comparative Alterations of Nicotinic and Muscarinic Binding Sites in Alzheimer's and Parkinson's Diseases

1992 • 324 citations

Nicotinic receptor stimulation protects neurons against β‐amyloid toxicity

1997 • 320 citations

Muscle and neuronal nicotinic acetylcholine receptors

2007 • 316 citations

Amino acids of the Torpedo marmorata acetylcholine receptor .alpha. subunit labeled by a photoaffinity ligand for the acetylcholine binding site

1988 • 314 citations

The ion channel of the nicotinic acetylcholine receptor is formed by the homologous helices M II of the receptor subunits

1986 • 313 citations

Intravenous nicotine in Alzheimer's disease: a pilot study

1988 • 312 citations

Crystal structure of nicotinic acetylcholine receptor homolog AChBP in complex with an α-conotoxin PnIA variant

2005 • 311 citations

Crucial Role of α4 and α6 Nicotinic Acetylcholine Receptor Subunits from Ventral Tegmental Area in Systemic Nicotine Self-Administration

2008 • 309 citations

Crystal structure of a Cbtx–AChBP complex reveals essential interactions between snake α-neurotoxins and nicotinic receptors

2005 • 304 citations

A prokaryotic proton-gated ion channel from the nicotinic acetylcholine receptor family

2006 • 302 citations

Nicotinic receptor function: new perspectives from knockout mice

2000 • 297 citations

Structure of the high-affinity binding site for noncompetitive blockers of the acetylcholine receptor: serine-262 of the delta subunit is labeled by [3H]chlorpromazine.

1986 • 296 citations

Nicotinic Receptors in the Habenulo-Interpeduncular System Are Necessary for Nicotine Withdrawal in Mice

2009 • 291 citations

Novel pharmacological targets for the treatment of Parkinson's disease

2006 • 290 citations

New Roles for β-Arrestins in Cell Signaling: Not Just for Seven-Transmembrane Receptors

2006 • 289 citations

Characterization of <scp>l</scp>‐[³H]Nicotine Binding in Human Cerebral Cortex: Comparison Between Alzheimer's Disease and the Normal

1986 • 288 citations

Nicotinic Acetylcholine Receptor Signalling: Roles in Alzheimer's Disease and Amyloid Neuroprotection

2009 • 285 citations

β-Amyloid_1–42Peptide Directly Modulates Nicotinic Receptors in the Rat Hippocampal Slice

2001 • 284 citations

Identification of a GABA_AReceptor Anesthetic Binding Site at Subunit Interfaces by Photolabeling with an Etomidate Analog

2006 • 284 citations

Decreased Protein Levels of Nicotinic Receptor Subunits in the Hippocampus and Temporal Cortex of Patients with Alzheimer’s Disease

2000 • 283 citations

Selective dopamine antagonists reduce nicotine self-administration

1991 • 279 citations

Heterogeneity and complexity of native brain nicotinic receptors

2007 • 277 citations

Hierarchical Control of Dopamine Neuron-Firing Patterns by Nicotinic Receptors

2006 • 277 citations

Nicotinic acetylcholine receptors as targets for antidepressants

2002 • 270 citations

Normal mode analysis of macromolecular motions in a database framework: Developing mode concentration as a useful classifying statistic

2002 • 267 citations

Models of the extracellular domain of the nicotinic receptors and of agonist- and Ca ²⁺ -binding sites

2002 • 262 citations

Potentiation of α7 nicotinic acetylcholine receptors via an allosteric transmembrane site

2008 • 258 citations

Nicotine Upregulates Its Own Receptors through Enhanced Intracellular Maturation

2005 • 255 citations

The subtypes of nicotinic acetylcholine receptors on dopaminergic terminals of mouse striatum

2007 • 251 citations

Identification of a novel amino acid alpha-tyrosine 93 within the cholinergic ligands-binding sites of the acetylcholine receptor by photoaffinity labeling. Additional evidence for a three-loop model of the cholinergic ligands-binding sites.

1990 • 247 citations

Allosteric modulation of nicotinic acetylcholine receptors

2007 • 243 citations

Activation of the Nicotinic Acetylcholine Receptor Involves a Switch in Conformation of the α Subunits

2002 • 243 citations

Identification of the prokaryotic ligand-gated ion channels and their implications for the mechanisms and origins of animal Cys-loop ion channels.

2004 • 237 citations

Nicotinic receptor abnormalities in Alzheimer’s disease

2001 • 237 citations

Safety, Pharmacokinetics, and Effects on Cognitive Function of Multiple Doses of GTS-21 in Healthy, Male Volunteers

2002 • 236 citations

Blockade of Nicotine Self-Administration with Nicotinic Antagonists in Rats

1999 • 235 citations

α6-Containing Nicotinic Acetylcholine Receptors Dominate the Nicotine Control of Dopamine Neurotransmission in Nucleus Accumbens

2007 • 235 citations

Impaired attention is central to the cognitive deficits observed in alpha 7 deficient mice

2006 • 229 citations

A Pilot Controlled Clinical Trial of ABT-418, a Cholinergic Agonist, in the Treatment of Adults With Attention Deficit Hyperactivity Disorder

1999 • 229 citations

Molecular mechanism for analgesia involving specific antagonism of α9α10 nicotinic acetylcholine receptors

2006 • 225 citations

Mapping of the Benzodiazepine Recognition Site on GABA-A Receptors

2002 • 225 citations

Correlation of Structure and Function in Enzyme Action

1963 • 222 citations

Decreased Signs of Nicotine Withdrawal in Mice Null for the β4 Nicotinic Acetylcholine Receptor Subunit

2004 • 221 citations

Detection and trapping of intermediate states priming nicotinic receptor channel opening

2009 • 216 citations

Schizophrenia and the α7 Nicotinic Acetylcholine Receptor

2007 • 212 citations

Rodent Habenulo–Interpeduncular Pathway Expresses a Large Variety of Uncommon nAChR Subtypes, But Only the α3β4 and α3β3β4 Subtypes Mediate Acetylcholine Release

2009 • 212 citations

Presence of a lattice structure in membrane fragments rich in nicotinic receptor protein from the electric organ of Torpedo marmorata

1973 • 212 citations

Nicotinic receptors in aging and dementia

2002 • 209 citations

Neuronal nicotinic receptors: A perspective on two decades of drug discovery research

2007 • 203 citations

Genetic Correlation of Inhibitory Gating of Hippocampal Auditory Evoked Response and α-Bungarotoxin-Binding Nicotinic Cholinergic Receptors in Inbred Mouse Strains

1996 • 202 citations

Identifying the Lipid-Protein Interface of the Torpedo Nicotinic Acetylcholine Receptor: Secondary Structure Implications

1994 • 200 citations

Differential Role of Nicotinic Acetylcholine Receptor Subunits in Physical and Affective Nicotine Withdrawal Signs

2008 • 197 citations

Ligand-gated ion channels: mechanisms underlying ion selectivity

2003 • 196 citations

Deletion of the 7 Nicotinic Acetylcholine Receptor Gene Improves Cognitive Deficits and Synaptic Pathology in a Mouse Model of Alzheimer's Disease

2009 • 190 citations

Structural determinants of selective α-conotoxin binding to a nicotinic acetylcholine receptor homolog AChBP

2006 • 189 citations

Normal Mode Analysis Suggests a Quaternary Twist Model for the Nicotinic Receptor Gating Mechanism

2005 • 187 citations

In Vivo Activation of Midbrain Dopamine Neurons via Sensitized, High-Affinity α6∗ Nicotinic Acetylcholine Receptors

2008 • 187 citations

Crystal Structure of Acetylcholine-binding Protein from Bulinus truncatus Reveals the Conserved Structural Scaffold and Sites of Variation in Nicotinic Acetylcholine Receptors

2005 • 182 citations

SSR180711, a Novel Selective α7 Nicotinic Receptor Partial Agonist: (1) Binding and Functional Profile

2006 • 181 citations

Alpha-conotoxin Vc1.1 alleviates neuropathic pain and accelerates functional recovery of injured neurones

2005 • 178 citations

Nicotine and Behavioral Markers of Risk for Schizophrenia A Double-Blind, Placebo-Controlled, Cross-Over Study

2002 • 176 citations

Quantitative assessment of nicotinic acetylcholine receptor proteins in the cerebral cortex of Alzheimer patients

2000 • 176 citations

Identification of calcium binding sites that regulate potentiation of a neuronal nicotinic acetylcholine receptor.

1996 • 173 citations

Brain Neuronal Nicotinic Receptors as New Targets for Drug Discovery

2006 • 173 citations

Structural basis for lipid modulation of nicotinic acetylcholine receptor function

2004 • 173 citations

Acute effects of the selective cholinergic channel activator (nicotinic agonist) ABT-418 in Alzheimer's disease

1999 • 169 citations

Nicotinic receptors in wonderland

2001 • 166 citations

α-RgIA: A Novel Conotoxin That Specifically and Potently Blocks the α9α10 nAChR^,

2006 • 164 citations

Mutational Analysis of the Charge Selectivity Filter of the α7 Nicotinic Acetylcholine Receptor

1999 • 161 citations

Central Nicotinic Receptors: Structure, Function, Ligands, and Therapeutic Potential

2007 • 161 citations

Analgesic α-Conotoxins Vc1.1 and Rg1A Inhibit N-Type Calcium Channels in Rat Sensory Neurons via GABA_BReceptor Activation

2008 • 160 citations

Executive and social behaviors under nicotinic receptor regulation

2003 • 160 citations

The nicotinic receptor ligand binding domain

2002 • 159 citations

Localization of nAChR subunit mRNAs in the brain of Macaca mulatta

2000 • 157 citations

Acute nicotinic blockade produces cognitive impairment in normal humans

1992 • 155 citations

A cog in cognition: How the α7 nicotinic acetylcholine receptor is geared towards improving cognitive deficits

2009 • 155 citations

Nicotine is a Selective Pharmacological Chaperone of Acetylcholine Receptor Number and Stoichiometry. Implications for Drug Discovery

2009 • 155 citations

The Prototoxin lynx1 Acts on Nicotinic Acetylcholine Receptors to Balance Neuronal Activity and Survival In Vivo

2006 • 153 citations

Blockage of muscle and neuronal nicotinic acetylcholine receptors by fluoxetine (Prozac)

1997 • 150 citations

Identification of a New Component of the Agonist Binding Site of the Nicotinic α7 Homooligomeric Receptor

1995 • 147 citations

Agonist-induced changes in the structure of the acetylcholine receptor M2 regions revealed by photoincorporation of an uncharged nicotinic noncompetitive antagonist.

1992 • 145 citations

Crystal structures of Lymnaea stagnalis AChBP in complex with neonicotinoid insecticides imidacloprid and clothianidin

2008 • 145 citations

Targeting the Alpha 7 Nicotinic Acetylcholine Receptor to Reduce Amyloid Accumulation in Alzheimers Disease Pyramidal Neurons

2006 • 143 citations

Brain choline in depression: In vivo detection of potential pharmacodynamic effects of antidepressant therapy using hydrogen localized spectroscopy

1994 • 142 citations

Desensitization of Nicotinic Acetylcholine Receptors as a Strategy for Drug Development

2008 • 141 citations

TC-5619: An alpha7 neuronal nicotinic receptor-selective agonist that demonstrates efficacy in animal models of the positive and negative symptoms and cognitive dysfunction of schizophrenia

2009 • 140 citations

Increased orbitofrontal cortex levels of choline in depressed adolescents as detected by in vivo proton magnetic resonance spectroscopy

2000 • 139 citations

Acetylcholine receptor channel structure in the resting, open, and desensitized states probed with the substituted-cysteine-accessibility method

2001 • 137 citations

Antidepressants Noncompetitively Inhibit Nicotinic Acetylcholine Receptor Function

1999 • 137 citations

Characterisation of the effects of nicotine in the five-choice serial reaction time task in rats: antagonist studies

2000 • 135 citations

Age-Related Effects of the Nicotinic Antagonist Mecamylamine on Cognition and Behavior

1994 • 135 citations

Differential responsivity of mood, behavior, and cognition to cholinergic agents in elderly neuropsychiatric populations

1988 • 134 citations

Molecular mechanisms and binding site locations for noncompetitive antagonists of nicotinic acetylcholine receptors

2006 • 133 citations

Cytisine, a partial agonist of high-affinity nicotinic acetylcholine receptors, has antidepressant-like properties in male C57BL/6J mice

2007 • 131 citations

The Synthesis, Structural Characterization, and Receptor Specificity of the α-Conotoxin Vc1.1

2006 • 130 citations

Nicotine and Nicotinic Receptors; Relevance to Parkinson’s Disease

2002 • 129 citations

Tropisetron improves deficits in auditory P50 suppression in schizophrenia

2005 • 129 citations

Normalizing Effects of Nicotine and a Novel Nicotinic Agonist on Hippocampal Auditory Gating in Two Animal Models

1997 • 129 citations

Conversion of the Ion Selectivity of the 5-HT3AReceptor from Cationic to Anionic Reveals a Conserved Feature of the Ligand-gated Ion Channel Superfamily

2001 • 127 citations

α7 and non‐α7 nicotinic acetylcholine receptors modulate dopamine release in vitro and in vivo in the rat prefrontal cortex

2009 • 127 citations

Crystal structure of a Cbtx-AChBP complex reveals essential interactions between snake alpha-neurotoxins and nicotinic receptors,

2005 • 127 citations

Nicotinic Antagonist Augmentation of Selective Serotonin Reuptake Inhibitor-Refractory Major Depressive Disorder

2008 • 126 citations

Nicotinic interactions with antipsychotic drugs, models of schizophrenia and impacts on cognitive function

2007 • 125 citations

The nicotinic antagonist mecamylamine has antidepressant-like effects in wild-type but not β2- or α7-nicotinic acetylcholine receptor subunit knockout mice

2006 • 123 citations

Clozapine improves deficient inhibitory auditory processing in DBA/2 mice, via a nicotinic cholinergic mechanism

2003 • 123 citations

ABT-089, A Neuronal Nicotinic Receptor Partial Agonist, for the Treatment of Attention-Deficit/Hyperactivity Disorder in Adults: Results of a Pilot Study

2006 • 122 citations

The Interface between Extracellular and Transmembrane Domains of Homomeric Cys-Loop Receptors Governs Open-Channel Lifetime and Rate of Desensitization

2008 • 120 citations

Experimentally based model of a complex between a snake toxin and the α7 nicotinic receptor

2002 • 119 citations

Targeted Molecular Dynamics Study of C-Loop Closure and Channel Gating in Nicotinic Receptors

2006 • 118 citations

SSR591813, a Novel Selective and Partial α₄β₂ Nicotinic Receptor Agonist with Potential as an Aid to Smoking Cessation

2003 • 116 citations

A Lipid-dependent Uncoupled Conformation of the Acetylcholine Receptor

2009 • 113 citations

Modular Design of Cys-loop Ligand-gated Ion Channels: Functional 5-HT3 and GABA ρ1 Receptors Lacking the Large Cytoplasmic M3M4 Loop

2008 • 113 citations

Galanthamine and Non-competitive Inhibitor Binding to ACh-binding Protein: Evidence for a Binding Site on Non-α-subunit Interfaces of Heteromeric Neuronal Nicotinic Receptors

2007 • 113 citations

In Vitro Characterization

1993 • 112 citations

Interaction of the Acetylcholine (Nicotinic) Receptor Protein from Torpedo marmorata Electric Organ with Monolayers of Pure Lipids

1978 • 109 citations

Role of neuronal nicotinic receptors in the effects of nicotine and ethanol on contextual fear conditioning

2004 • 107 citations

Nicotinic receptors, allosteric proteins and medicine

2008 • 106 citations

Role of the Nucleus Raphe Magnus in Antinociception Produced by ABT-594: Immediate Early Gene Responses Possibly Linked to Neuronal Nicotinic Acetylcholine Receptors on Serotonergic Neurons

1998 • 105 citations

Therapeutic potential of neuronal nicotinic acetylcholine receptor agonists as novel analgesics

1999 • 105 citations

Critical Elements Determining Diversity in Agonist Binding and Desensitization of Neuronal Nicotinic Acetylcholine Receptors

1998 • 104 citations

The Calcium Sensor Protein Visinin-like Protein-1 Modulates the Surface Expression and Agonist Sensitivity of the α4β2 Nicotinic Acetylcholine Receptor

2002 • 104 citations

Long-term effects of chronic nicotine exposure on brain nicotinic receptors

2007 • 102 citations

Imaging of Nicotinic and Muscarinic Receptors in Alzheimer's Disease: Effect of Tacrine Treatment

1997 • 101 citations

Transdermal nicotine attenuates depression symptoms in nonsmokers: a double-blind, placebo-controlled trial

2006 • 101 citations

Localization of [³H]nicotine, [³H]cytisine, [³H]epibatidine, and [¹²⁵I]α‐bungarotoxin binding sites in the brain of Macaca mulatta

2003 • 100 citations

Are α9α10 Nicotinic Acetylcholine Receptors a Pain Target for α-Conotoxins?

2007 • 100 citations

Positive Allosteric Modulation of the α7 Nicotinic Acetylcholine Receptor: Ligand Interactions with Distinct Binding Sites and Evidence for a Prominent Role of the M2-M3 Segment

2008 • 100 citations

α-RgIA, a Novel Conotoxin That Blocks the α9α10 nAChR: Structure and Identification of Key Receptor-Binding Residues

2008 • 98 citations

Nicotinic Acetylcholine Receptors: From Molecular Biology to Cognition

2005 • 97 citations

Performance deficit of α7 nicotinic receptor knockout mice in a delayed matching‐to‐place task suggests a mild impairment of working/episodic‐like memory

2005 • 97 citations

The Neuronal Pathways Mediating the Behavioral and Addictive Properties of Nicotine

2009 • 96 citations

THE HEMOGLOBIN SYSTEM

1925 • 96 citations

Identification of Nicotinic Acetylcholine Receptor Amino Acids Photolabeled by the Volatile Anesthetic Halothane

2003 • 96 citations

Common Determinants of Single Channel Conductance within the Large Cytoplasmic Loop of 5-Hydroxytryptamine Type 3 and α4β2 Nicotinic Acetylcholine Receptors

2006 • 95 citations

Antidepressant-like effects of nicotinic acetylcholine receptor antagonists, but not agonists, in the mouse forced swim and mouse tail suspension tests

2008 • 94 citations

Selective α7 nicotinic receptor activation by AZD0328 enhances cortical dopamine release and improves learning and attentional processes

2009 • 94 citations

Implications of the quaternary twist allosteric model for the physiology and pathology of nicotinic acetylcholine receptors

2006 • 94 citations

ABT-594 [(R)-5-(2-azetidinylmethoxy)-2-chloropyridine]: a novel, orally effective analgesic acting via neuronal nicotinic acetylcholine receptors: I. In vitro characterization.

1998 • 94 citations

Nicotinic treatment for degenerative neuropsychiatric disorders such as Alzheimer’s disease and Parkinson’s disease

2000 • 92 citations

Effect of R3487/MEM3454, a novel nicotinic α7 receptor partial agonist and 5-HT3 antagonist on sustained attention in rats

2008 • 92 citations

Integrating smoking cessation treatment into primary care: an effectiveness study

2004 • 89 citations

The β‐amyloid protein of Alzheimer’s disease binds to membrane lipids but does not bind to the α7 nicotinic acetylcholine receptor

2007 • 88 citations

Neuroprotective and memory-related actions of novel alpha-7 nicotinic agents with different mixed agonist/antagonist properties.

1998 • 85 citations

α-Conotoxins ImI and ImII Target Distinct Regions of the Human α7 Nicotinic Acetylcholine Receptor and Distinguish Human Nicotinic Receptor Subtypes

2004 • 84 citations

Allosteric Modulators of the α7 Nicotinic Acetylcholine Receptor

2008 • 83 citations

Nicotinic Receptors and Neurodegenerative Dementing Diseases

1995 • 79 citations

Non-Agonist-Binding Subunit Interfaces Confer Distinct Functional Signatures to the Alternate Stoichiometries of the 4 2 Nicotinic Receptor: An 4- 4 Interface Is Required for Zn2+ Potentiation

2008 • 79 citations

Cholesterol Interacts with Transmembrane α-Helices M1, M3, and M4 of the Torpedo Nicotinic Acetylcholine Receptor: Photolabeling Studies Using [³H]Azicholesterol

2005 • 77 citations

Tonic nicotinic modulation of serotoninergic transmission in the spinal cord

2001 • 77 citations

Differential nicotinic regulation of the nigrostriatal and mesolimbic dopaminergic pathways: Implications for drug development

2006 • 77 citations

TC‐5214 (S‐(+)‐Mecamylamine): A Neuronal Nicotinic Receptor Modulator with Antidepressant Activity

2008 • 77 citations

ABT-089 [2-methyl-3-(2-(S)-pyrrolidinylmethoxy)pyridine]: I. A potent and selective cholinergic channel modulator with neuroprotective properties.

1997 • 77 citations

Neuronal nicotinic receptor inhibition for treating mood disorders preliminary controlled evidence with mecamylamine

2002 • 74 citations

Nicotine and nicotinic receptor antagonists potentiate the antidepressant‐like effects of imipramine and citalopram

2003 • 74 citations

Adjuvant Galantamine Administration Improves Negative Symptoms in a Patient With Treatment-Refractory Schizophrenia

2002 • 74 citations

Nicotinic Acetylcholine Receptor Antagonistic Activity of Monoamine Uptake Blockers in Rat Hippocampal Slices

1999 • 73 citations

Inhibition of Neuronal Nicotinic Acetylcholine Receptor Channels Expressed in &lt;I&gt;Xenopus&lt;/I&gt; Oocytes by β-Amyloid&lt;SUB&gt;1–42&lt;/SUB&gt; Peptide

2005 • 72 citations

Kinetic, Mechanistic, and Structural Aspects of Unliganded Gating of Acetylcholine Receptor Channels

2000 • 72 citations

Involvement of the prefrontal cortex but not the dorsal hippocampus in the attention-enhancing effects of nicotine in rats

2003 • 70 citations

Partial agonists as therapeutic agents at neuronal nicotinic acetylcholine receptors

2006 • 67 citations

From Muscle Endplate to Brain Synapses: A Short History of Synapses and Agonist-Activated Ion Channels

1998 • 67 citations

β2 Subunit Contribution to 4/7 α-Conotoxin Binding to the Nicotinic Acetylcholine Receptor

2005 • 66 citations

Intracellular complexes of the β2 subunit of the nicotinic acetylcholine receptor in brain identified by proteomics

2007 • 64 citations

Identification of Binding Sites in the Nicotinic Acetylcholine Receptor for TDBzl-etomidate, a Photoreactive Positive Allosteric Effector

2008 • 64 citations

Discovery of a novel class of conotoxin from Conus litteratus, lt14a, with a unique cysteine pattern

2006 • 64 citations

Antisense knockdown of the rat α7 nicotinic acetylcholine receptor produces spatial memory impairment

2006 • 63 citations

Defunctionalized Lobeline Analogues: Structure−Activity of Novel Ligands for the Vesicular Monoamine Transporter

2005 • 62 citations

Nicotinic receptors and Alzheimer's disease

2003 • 62 citations

Nicotinic Acetylcholine receptors: from molecular biology to cognition

2006 • 62 citations

The Steroid Promegestone Is a Noncompetitive Antagonist of theTorpedoNicotinic Acetylcholine Receptor that Interacts with the Lipid-Protein Interface

1999 • 60 citations

Toxin insights into nicotinic acetylcholine receptors

2006 • 60 citations

Interaction of Noncompetitive Inhibitors with an Immobilized α3β4 Nicotinic Acetylcholine Receptor Investigated by Affinity Chromatography, Quantitative−Structure Activity Relationship Analysis, and Molecular Docking

2004 • 58 citations

Phosphorylation of the Nicotinic Acetylcholine Receptor by Protein Tyrosine Kinases^a

1995 • 58 citations

Nicotinic acetylcholine receptor antagonist effect of fluoxetine in rat hippocampal slices

1997 • 57 citations

Performance of α7 nicotinic receptor null mutants is impaired in appetitive learning measured in a signaled nose poke task

2005 • 57 citations

A structural model of agonist binding to the α3β4 neuronal nicotinic receptor

2003 • 54 citations

The conformation of acetylcholine at its target site in the membrane-embedded nicotinic acetylcholine receptor

2007 • 51 citations

Effects of fluoxetine on wild and mutant neuronal α7 nicotinic receptors

1998 • 51 citations

Novel α7 nicotinic receptor isoforms and deficient cholinergic transcription in schizophrenia

2007 • 49 citations

Computational approaches to understand α‐conotoxin interactions at neuronal nicotinic receptors

2004 • 49 citations

Spontaneous conformational change and toxin binding in α7 acetylcholine receptor: Insight into channel activation and inhibition

2008 • 48 citations

Attention-deficit/hyperactivity disorder: A plausible mouse model?

2006 • 46 citations

Determinants of Zinc Potentiation on the α4 Subunit of Neuronal Nicotinic Receptors

2005 • 45 citations

In SilicoModels for the Human α4β2 Nicotinic Acetylcholine Receptor

2008 • 45 citations

Modeling Multiple Species of Nicotine and Deschloroepibatidine Interacting with α4β2 Nicotinic Acetylcholine Receptor: From Microscopic Binding to Phenomenological Binding Affinity

2005 • 44 citations

Structure-guided drug design: Conferring selectivity among neuronal nicotinic receptor and acetylcholine-binding protein subtypes

2007 • 43 citations

Modeling Subtype-Selective Agonists Binding with α4β2 and α7 Nicotinic Acetylcholine Receptors: Effects of Local Binding and Long-Range Electrostatic Interactions

2006 • 42 citations

The actions of suxamethonium (succinyldicholine) as an agonist and channel blocker at the nicotinic receptor of frog muscle.

1990 • 42 citations

Comorbid bipolar disorder in Tourette’s syndrome responds to the nicotinic receptor antagonist mecamylamine (Inversine)

2000 • 42 citations

A-366833: A novel nicotinonitrile-substituted 3,6-diazabicyclo[3.2.0]-heptane α4β2 nicotinic acetylcholine receptor selective agonist: Synthesis, analgesic efficacy and tolerability profile in animal models

2007 • 42 citations

Probing the Structure of the Nicotinic Acetylcholine Receptor with the Hydrophobic Photoreactive Probes [¹²⁵I]TID-BE and [¹²⁵I]TIDPC/16

1998 • 41 citations

Nicotinic receptors as targets for therapeutic discovery

2007 • 41 citations

Determination of α‐conotoxin binding modes on neuronal nicotinic acetylcholine receptors

2004 • 41 citations

The α7 nicotinic acetylcholine receptor-selective antagonist, methyllycaconitine, partially protects against β-amyloid1–42 toxicity in primary neuron-enriched cultures

2004 • 38 citations

A chimera encoding the fusion of an acetylcholine-binding protein to an ion channel is stabilized in a state close to the desensitized form of ligand-gated ion channels

2005 • 37 citations

A model for short α-neurotoxin bound to nicotinic acetylcholine receptor from Torpedo californica: Comparison with long-chain α-neurotoxins and α-conotoxins

2005 • 37 citations

The role of neuronal nicotinic acetylcholine receptors in antinociception: Effects of ABT-594

1998 • 36 citations

Partial agonist and neuromodulatory activity of S 24795 for alpha7 nAChR responses of hippocampal interneurons

2007 • 35 citations

The 2.7 Å Structure of AChBP, Homologue of the Ligand‐Binding Domain of the Nicotinic Acetylcholine Receptor

2002 • 35 citations

Inhibition Mechanism of the Acetylcholine Receptor by α-Neurotoxins as Revealed by Normal-Mode Dynamics

2008 • 33 citations

Transgenic mice over-expressing human β-amyloid have functional nicotinic alpha 7 receptors

2005 • 33 citations

Bacterial Expression, NMR, and Electrophysiology Analysis of Chimeric Short/Long-chain α-Neurotoxins Acting on Neuronal Nicotinic Receptors

2007 • 32 citations

Mechanism of Cl- Selection by a Glutamate-gated Chloride (GluCl) Receptor Revealed through Mutations in the Selectivity Filter

2006 • 31 citations

Reversal of Agonist Selectivity by Mutations of Conserved Amino Acids in the Binding Site of Nicotinic Acetylcholine Receptors

2006 • 31 citations

The three‐dimensional structure of the analgesic α‐conotoxin, RgIA

2008 • 30 citations

Molecular Engineering of Conotoxins: The Importance of Loop Size to α-Conotoxin Structure and Function

2008 • 29 citations

Modeling Binding Modes of α7 Nicotinic Acetylcholine Receptor with Ligands: The Roles of Gln117 and Other Residues of the Receptor in Agonist Binding

2008 • 29 citations

Effect of intraventricular injections of dihydro-beta-erythroidine (DH,β E) on spatial memory in the rat

1996 • 28 citations

ALLOSTERIC INTERACTIONS INTERPRETED IN TERMS OF QUATERNARY STRUCTURE.

1964 • 27 citations

Rapsyn carboxyl terminal domains mediate muscle specific kinase–induced phosphorylation of the muscle acetylcholine receptor

2008 • 25 citations

Conformation-Sensitive Steroid and Fatty Acid Sites in the Transmembrane Domain of the Nicotinic Acetylcholine Receptor

2007 • 25 citations

Molecular Basis of the Charge Selectivity of Nicotinic Acetylcholine Receptor and Related Ligand‐Gated Ion Channels

2007 • 24 citations

Dynamic Structural Investigations on the Torpedo Nicotinic Acetylcholine Receptor by Time‐Resolved Photoaffinity Labeling

2006 • 23 citations

Effect of β-Amyloid Peptide 1-42 on the Cytoprotective Action Mediated by α7 Nicotinic Acetylcholine Receptors in Growth Factor-Deprived Differentiated PC-12 Cells

2003 • 23 citations

Computer modeling of binding of diverse weak toxins to nicotinic acetylcholine receptors

2007 • 22 citations

Congenital myasthenic syndromes: A diverse array of molecular targets

2003 • 22 citations

Ligand Selectivity for the Acetylcholine Binding Site of the Rat α4β2 and α3β4 Nicotinic Subtypes Investigated by Molecular Docking

2005 • 21 citations

Structural Determinates for Apolipoprotein E-Derived Peptide Interaction with the α7 Nicotinic Acetylcholine Receptor

2007 • 21 citations

Computational evidence for the ligand selectivity to the α4β2 and α3β4 nicotinic acetylcholine receptors

2006 • 21 citations

Role of the Outer β-Sheet in Divalent Cation Modulation of α7 Nicotinic Receptors

2006 • 21 citations

Pharmacokinetics and Safety Profile of Ispronicline (TC‐1734), a New Brain Nicotinic Receptor Partial Agonist, in Young Healthy Male Volunteers

2006 • 20 citations

Charge Scan Reveals an Extended Region at the Intracellular End of the GABA Receptor Pore that Can Influence Ion Selectivity

2007 • 19 citations

Structural Characterization of Agonist and Antagonist-Bound Acetylcholine-Binding Protein From Aplysia californica

2006 • 18 citations

Homology modelling of theApis melliferanicotinic acetylcholine receptor (nAChR) and docking of imidacloprid and fipronil insecticides and their metabolites

2008 • 17 citations

Neuroprotection in alzheimer’s disease — new strategies for treatment

2000 • 17 citations

Nicotinic Regulation of Calcium/Calmodulin-Dependent Protein Kinase II Activation in the Spinal Cord

2006 • 16 citations

Docking of α-cobratoxin suggests a basal conformation of the nicotinic receptor

2007 • 15 citations

Behavioral effects of acute hexamethonium in rats chronically intoxicated with nicotine

1988 • 14 citations

Replacement of asparagine with arginine at the extracellular end of the second transmembrane (M2) region of insect GABA receptors increases sensitivity to penicillin G

2006 • 14 citations

Opened by a twist: a gating mechanism for the nicotinic acetylcholine receptor

2007 • 13 citations

Nicotinic acetylcholine receptor antagonistic property of the selective dopamine uptake inhibitor, GBR-12909 in rat hippocampal slices

2007 • 11 citations

Docking of 6-chloropyridazin-3-yl derivatives active on nicotinic acetylcholine receptors into molluscan Acetylcholine Binding Protein (AChBP)

2005 • 10 citations

Gates and filters: unveiling the physiological roles of nicotinic acetylcholine receptors in dopaminergic transmission

2008 • 9 citations

Model of the extracellular domain of the human α7 nAChR based on the crystal structure of the mouse α1 nAChR extracellular domain

2008 • 9 citations

Mapping the acetylcholine-binding sites of Torpedo nicotinic receptor using photoaffinity labeling

2004 • 2 citations

Docking of 6-chloropyridazin-3-yl derivatives active on nicotinic acetylcholine receptors into molluscan Acetylcholine Binding Protein

2003 • 2 citations

Deleted Work

1955 • 0 citations