Structure and gating mechanism of the acetylcholine receptor pore

PROCHECK: a program to check the stereochemical quality of protein structures

1993 • 23,689 citations

MOLSCRIPT: a program to produce both detailed and schematic plots of protein structures

1991 • 14,222 citations

Improved methods for building protein models in electron density maps and the location of errors in these models

1991 • 12,831 citations

Crystal structure of an ACh-binding protein reveals the ligand-binding domain of nicotinic receptors

2001 • 1,736 citations

SETOR: Hardware-lighted three-dimensional solid model representations of macromolecules

1993 • 1,295 citations

A rapid finite difference algorithm, utilizing successive over‐relaxation to solve the Poisson–Boltzmann equation

1991 • 1,257 citations

Acetylcholine receptor channel imaged in the open state

1995 • 1,002 citations

Emerging structure of the Nicotinic Acetylcholine receptors

2002 • 896 citations

Nicotinic Acetylcholine Receptor an 9 Å Resolution

1993 • 822 citations

Rings of negatively charged amino acids determine the acetylcholine receptor channel conductance

1988 • 798 citations

Nicotinic Receptors at the Amino Acid Level

2000 • 795 citations

Determination of the fold of the core protein of hepatitis B virus by electron cryomicroscopy

1997 • 791 citations

The pore dimensions of gramicidin A

1993 • 619 citations

Nicotinic acetylcholine receptor at 4.6 Å resolution: transverse tunnels in the channel 1 1Edited by J. Karn

1999 • 487 citations

Reconstruction of three-dimensional images from electron micrographs of structures with helical symmetry

1970 • 474 citations

Organization of acetylcholine receptors in quick-frozen, deep-etched, and rotary-replicated Torpedo postsynaptic membrane.

1979 • 429 citations

Diffraction by helical structures

1958 • 422 citations

Identification of acetylcholine receptor channel-lining residues in the entire M2 segment of the α subunit

1994 • 418 citations

Chimaeric nicotinic–serotonergic receptor combines distinct ligand binding and channel specificities

1993 • 401 citations

Similarity measures between images

1987 • 353 citations

Location of a δ-subunit region determining ion transport through the acetylcholine receptor channel

1986 • 315 citations

The ion channel of the nicotinic acetylcholine receptor is formed by the homologous helices M II of the receptor subunits

1986 • 313 citations

Channel gating governed symmetrically by conserved leucine residues in the M2 domain of nicotinic receptors

1995 • 304 citations

Structure of the high-affinity binding site for noncompetitive blockers of the acetylcholine receptor: serine-262 of the delta subunit is labeled by [3H]chlorpromazine.

1986 • 296 citations

A Hydrophobic Gating Mechanism for Nanopores

2001 • 295 citations

An open-channel blocker interacts with adjacent turns of α-helices in the nicotinic acetylcholine receptor

1990 • 275 citations

Specific binding sites for alcohols and anesthetics on ligand-gated ion channels

2000 • 266 citations

Congenital myasthenic syndrome caused by prolonged acetylcholine receptor channel openings due to a mutation in the M2 domain of the epsilon subunit.

1995 • 252 citations

Ion channel of acetylcholine receptor reconstructed from images of postsynaptic membranes

1988 • 247 citations

Activation of the Nicotinic Acetylcholine Receptor Involves a Switch in Conformation of the α Subunits

2002 • 243 citations

Mutations of γ-aminobutyric acid and glycine receptors change alcohol cutoff: Evidence for an alcohol receptor?

1998 • 216 citations

Identifying the Lipid-Protein Interface of the Torpedo Nicotinic Acetylcholine Receptor: Secondary Structure Implications

1994 • 200 citations

The Location of the Gate in the Acetylcholine Receptor Channel

1998 • 196 citations

Development of a superfluid helium stage for high-resolution electron microscopy

1991 • 188 citations

The role of conserved leucines in the M2 domain of the acetylcholine receptor in channel gating.

1995 • 174 citations

Mutations in Different Functional Domains of the Human Muscle Acetylcholine Receptor Subunit in Patients with the Slow-Channel congenital Myasthenic Syndrome

1997 • 148 citations

Location of a threonine residue in the α -subunit M2 transmembrane segment that determines the ion flow through the acetylcholine receptor channel

1991 • 148 citations

Image contrast in high-resolution electron microscopy of biological macromolecules: TMV in ice

1992 • 145 citations

Agonist-induced changes in the structure of the acetylcholine receptor M2 regions revealed by photoincorporation of an uncharged nicotinic noncompetitive antagonist.

1992 • 145 citations

The Extracellular Linker of Muscle Acetylcholine Receptor Channels Is a Gating Control Element

2000 • 121 citations

Acetylcholine receptor M3 domain: stereochemical and volume contributions to channel gating

1999 • 118 citations

Tubular crystals of acetylcholine receptor.

1984 • 110 citations

Correction of high-resolution data for curvature of the Ewald sphere

2000 • 97 citations

Distortion correction of tubular crystals: improvements in the acetylcholine receptor structure

1997 • 71 citations

Contribution of the β Subunit M2 Segment to the Ion-Conducting Pathway of the Acetylcholine Receptor

1998 • 65 citations

Probing the Structure of the Nicotinic Acetylcholine Receptor Ion Channel with the Uncharged Photoactivable Compound [3H]Diazofluorene

1998 • 60 citations