Crucial Role of α4 and α6 Nicotinic Acetylcholine Receptor Subunits from Ventral Tegmental Area in Systemic Nicotine Self-Administration

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Acetylcholine receptors containing the β2 subunit are involved in the reinforcing properties of nicotine

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Nicotinic Receptors at the Amino Acid Level

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Self-administered nicotine activates the mesolimbic dopamine system through the ventral tegmental area

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Long-Term Potentiation of Excitatory Inputs to Brain Reward Areas by Nicotine

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Nicotine Activation of α4* Receptors: Sufficient for Reward, Tolerance, and Sensitization

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Synaptic Mechanisms Underlie Nicotine-Induced Excitability of Brain Reward Areas

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Abnormal avoidance learning in mice lacking functional high-affinity nicotine receptor in the brain

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Mortality from smoking worldwide

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Molecular and physiological diversity of nicotinic acetylcholine receptors in the midbrain dopaminergic nuclei.

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Molecular and Physiological Diversity of Nicotinic Acetylcholine Receptors in the Midbrain Dopaminergic Nuclei

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Nicotine amplifies reward-related dopamine signals in striatum

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Nicotine reinforcement and cognition restored by targeted expression of nicotinic receptors

2005 • 544 citations

Subunit Composition of Functional Nicotinic Receptors in Dopaminergic Neurons Investigated with Knock-Out Mice

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The neurobiology of nicotine addiction: bridging the gap from molecules to behaviour

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The diversity of subunit composition in nAChRs: Evolutionary origins, physiologic and pharmacologic consequences

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Effects of nicotinic stimulation on cognitive performance

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The "two-headed" latent inhibition model of schizophrenia: modeling positive and negative symptoms and their treatment

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Identification of four classes of brain nicotinic receptors using beta2 mutant mice.

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Neuronal Nicotinic Receptor a6 Subunit mRNA is Selectively Concentrated in Catecholaminergic Nuclei of the Rat Brain

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Frequency-dependent modulation of dopamine release by nicotine

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Distribution and Pharmacology of α6-Containing Nicotinic Acetylcholine Receptors Analyzed with Mutant Mice

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Identification of Four Classes of Brain Nicotinic Receptors Using β2 Mutant Mice

1998 • 323 citations

Hierarchical Control of Dopamine Neuron-Firing Patterns by Nicotinic Receptors

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Cannabinoid CB1 receptor knockout mice fail to self-administer morphine but not other drugs of abuse

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Chronic Nicotine Cell Specifically Upregulates Functional α4* Nicotinic Receptors: Basis for Both Tolerance in Midbrain and Enhanced Long-Term Potentiation in Perforant Path

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α6-Containing Nicotinic Acetylcholine Receptors Dominate the Nicotine Control of Dopamine Neurotransmission in Nucleus Accumbens

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The mGluR5 antagonist MPEP decreased nicotine self-administration in rats and mice

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The β2 but not α7 subunit of the nicotinic acetylcholine receptor is required for nicotine-conditioned place preference in mice

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Self-administration of the cannabinoid receptor agonist WIN 55,212-2 in drug-naive mice

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The Cannabinoid CB1 Antagonist N-Piperidinyl-5-(4-chlorophenyl)-1-(2,4-dichlorophenyl) -4-methylpyrazole-3-carboxamide (SR-141716A) Differentially Alters the Reinforcing Effects of Heroin under Continuous Reinforcement, Fixed Ratio, and Progressive Ratio Schedules of Drug Self-Administration in Rats

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Assembly of α4β2 Nicotinic Acetylcholine Receptors Assessed with Functional Fluorescently Labeled Subunits: Effects of Localization, Trafficking, and Nicotine-Induced Upregulation in Clonal Mammalian Cells and in Cultured Midbrain Neurons

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Opposite Effects of Amphetamine Self-administration Experience on Dendritic Spines in the Medial and Orbital Prefrontal Cortex

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Effects of Combined Systemic Alcohol and Central Nicotine Administration into Ventral Tegmental Area on Dopamine Release in the Nucleus Accumbens

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125I-alpha-conotoxin MII identifies a novel nicotinic acetylcholine receptor population in mouse brain.

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Nicotine self-administration in animals as a dependence model

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Pharmacology of α-Conotoxin MII-Sensitive Subtypes of Nicotinic Acetylcholine Receptors Isolated by Breeding of Null Mutant Mice

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Primary Reinforcing Effects of Nicotine Are Triggered from Multiple Regions Both Inside and Outside the Ventral Tegmental Area

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Evidence that nicotinic alpha(7) receptors are not involved in the hyperlocomotor and rewarding effects of nicotine.

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κ-Opioid receptor agonist U50,488H modulates cocaine and morphine self-administration in drug-naive rats and mice

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CB1 cannabinoid receptor agonist WIN 55, 212-2 decreases intravenous cocaine self-administration in rats

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Subcellular Trafficking, Pentameric Assembly, and Subunit Stoichiometry of Neuronal Nicotinic Acetylcholine Receptors Containing Fluorescently Labeled α6 and β3 Subunits

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Discrimination and self-administration of nicotine by inbred strains of mice

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CB1 receptor agonist and heroin, but not cocaine, reinstate cannabinoid‐seeking behaviour in the rat

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Involvement of α6 nicotinic receptor subunit in nicotine-elicited locomotion, demonstrated by in vivo antisense oligonucleotide infusion

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Reinforcing effects of nicotine microinjections into the ventral tegmental area of mice: Dependence on cholinergic nicotinic and dopaminergic D1 receptors

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Effects of nicotinic and NMDA receptor channel blockers on intravenous cocaine and nicotine self-administration in mice

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Endogenous cannabinoids are not involved in cocaine reinforcement and development of cocaine-induced behavioural sensitization

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Reinforcing Effects of Nicotinic Compounds Intravenous Self-administration in Drug-Naive Mice

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Decreased withdrawal symptoms but normal tolerance to nicotine in mice null for the α7 nicotinic acetylcholine receptor subunit

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Genetic dissociation of two behaviors associated with nicotine addiction: Beta-2 containing nicotinic receptors are involved in nicotine reinforcement but not in withdrawal syndrome

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The Neurobiology of Tobacco Dependence: A Commentary

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Reinforcing and Neurochemical Effects of Cocaine Differences Among C57, DBA, and 129 Mice

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Nicotine-induced decreases in VTA electrical self-stimulation thresholds: blockade by haloperidol and mecamylamine but not scopolamine or ondansetron

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Intravenous self‐administration of nicotine is altered by lesions of the posterior, but not anterior, pedunculopontine tegmental nucleus

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Isradipine inhibits nicotine intravenous self-administration in drug-naive mice

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Smoking Topography in Response to Denicotinized and High-Yield Nicotine Cigarettes in Adolescent Smokers

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Enhancement of morphine self-administration in drug naive, inbred strains of mice by acute emotional stress

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Modulation of cocaine intravenous self-administration in drug-naive animals by dihydropyridine Ca2+ channel modulators

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Gamma-hydroxybutyric acid An evaluation of its rewarding properties in rats and mice

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Changes in sensitivity to nicotine and brain nicotinic receptors following chronic nicotine and corticosterone treatments in mice

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Local Perfusion of Nicotine Differentially Modulates Somatodendritic Dopamine Release in the Rat Ventral Tegmental Area After Nicotine Preexposure

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Influence of buprenorphine, butorphanol and nalbuphine on the initiation of intravenous cocaine self-administration in drug naive mice

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Gamma-Hydroxybutyric Acid Decreases Intravenous Cocaine Self-Administration in Rats

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Intravenous Scopolamine Is Potently Self-Administered in Drug-Naive Mice

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