The cholinergic system in Alzheimer's disease

Alzheimer's Disease: The Amyloid Cascade Hypothesis

1992 • 6,649 citations

The Cholinergic Hypothesis of Geriatric Memory Dysfunction

1982 • 5,422 citations

Alzheimer's Disease and Senile Dementia: Loss of Neurons in the Basal Forebrain

1982 • 3,563 citations

Correlation of cholinergic abnormalities with senile plaques and mental test scores in senile dementia.

1978 • 2,036 citations

Alzheimer disease: Evidence for selective loss of cholinergic neurons in the nucleus basalis

1981 • 1,701 citations

The human nervous system

2004 • 1,494 citations

Identification of a Family of Muscarinic Acetylcholine Receptor Genes

1987 • 1,439 citations

NEUROTRANSMITTER-RELATED ENZYMES AND INDICES OF HYPOXIA IN SENILE DEMENTIA AND OTHER ABIOTROPHIES

1976 • 1,272 citations

A Histochemical Method for Localizing Cholinesterase Activity.

1949 • 1,203 citations

Memory in monkeys severely impaired by combined but not by separate removal of amygdala and hippocampus

1978 • 1,196 citations

Oral Tetrahydroaminoacridine in Long-Term Treatment of Senile Dementia, Alzheimer Type

1986 • 1,148 citations

Acetylcholinesterase Accelerates Assembly of Amyloid-β-Peptides into Alzheimer's Fibrils: Possible Role of the Peripheral Site of the Enzyme

1996 • 1,058 citations

The Diversity of Neuronal Nicotinic Acetylcholine Receptors

1993 • 1,040 citations

Cloning, sequencing and expression of complementary DNA encoding the muscarinic acetylcholine receptor

1986 • 917 citations

Basal ganglia

1998 • 902 citations

Loss of neurons in the nucleus basalis of Meynert in Alzheimer's disease, paralysis agitans and Korsakoff's disease

1983 • 811 citations

Cloning and expression of the human and rat m5 muscarinic acetylcholine receptor genes

1988 • 792 citations

Distinct primary structures, ligand-binding properties and tissue-specific expression of four human muscarinic acetylcholine receptors.

1987 • 766 citations

The Efficacy and Safety of Donepezil in Patients with Alzheimer's Disease: Results of a US Multicentre, Randomized, Double-Blind, Placebo-Controlled Trial

1996 • 730 citations

Neurotransmitter enzyme abnormalities in senile dementia

1977 • 710 citations

Loss of M2 Muscarine Receptors in the Cerebral Cortex in Alzheimer's Disease and Experimental Cholinergic Denervation

1985 • 697 citations

Neurotransmitter-related enzymes in senile dementia of the alzheimer type

1979 • 638 citations

Antagonist binding properties of five cloned muscarinic receptors expressed in CHO-K1 cells.

1989 • 627 citations

Cholinergic function and intellectual decline in Alzheimer's disease

1986 • 605 citations

Atlas of cholinergic neurons in the forebrain and upper brainstem of the macaque based on monoclonal choline acetyltransferase immunohistochemistry and acetylcholinesterase histochemistry

1984 • 586 citations

Neurochemical Correlates of Dementia Severity in Alzheimer's Disease: Relative Importance of the Cholinergic Deficits

1995 • 572 citations

THE CHOLINERGIC HYPOTHESIS—TEN YEARS ON

1986 • 563 citations

The molecular basis of muscarinic receptor diversity

1989 • 544 citations

Nucleus basalis (Ch4) and cortical cholinergic innervation in the human brain: Observations based on the distribution of acetylcholinesterase and choline acetyltransferase

1988 • 496 citations

NEOCORTICAL CHOLINERGIC NEURONS IN ELDERLY PEOPLE

1977 • 490 citations

Nicotinic acetylcholine binding sites in Alzheimer's disease

1986 • 485 citations

Localization of a family of muscarinic receptor mRNAs in rat brain

1988 • 472 citations

Aging, Alzheimer's disease, and the cholinergic system of the basal forebrain

1984 • 454 citations

A POST-MORTEM STUDY OF THE CHOLINERGIC AND GABA SYSTEMS IN SENILE DEMENTIA

1982 • 449 citations

A new parcellation of the human thalamus on the basis of histochemical staining

1989 • 449 citations

Pathological changes in the nucleus of meynert in Alzheimer's and Parkinson's diseases

1983 • 447 citations

Physostigmine: Improvement of Long-Term Memory Processes in Normal Humans

1978 • 442 citations

Functional expression of two neuronal nicotinic acetylcholine receptors from cDNA clones identifies a gene family.

1987 • 431 citations

Visualization of detailed acetylcholinesterase fiber and neuron staining in rat brain by a sensitive histochemical procedure.

1986 • 429 citations

Neuronal loss in different parts of the nucleus basalis is related to neuritic plaque formation in cortical target areas in alzheimer's disease

1985 • 407 citations

Heterogeneity in Epidermal Basal Keratinocytes: Morphological and Functional Correlations

1982 • 396 citations

Members of a nicotinic acetylcholine receptor gene family are expressed in different regions of the mammalian central nervous system

1987 • 393 citations

The Cholinergic Hypothesis: A Historical Overview, Current Perspective, and Future Directions

1985 • 386 citations

Alteration in nicotine binding sites in Parkinson's disease, Lewy body dementia and Alzheimer's disease: Possible index of early neuropathology

1995 • 385 citations

Reduced number of [3H]nicotine and [3H]acetylcholine binding sites in the frontal cortex of Alzheimer brains

1986 • 360 citations

Muscarinic acetylcholine receptor expression in memory circuits: Implications for treatment of Alzheimer disease

1996 • 356 citations

Differential Alteration of Various Cholinergic Markers in Cortical and Subcortical Regions of Human Brain in Alzheimer's Disease

1988 • 334 citations

Persistence of cholinergic neurons in the basal nucleus in a brain with senile dementia of the Alzheimer's type demonstrated by immunohistochemical staining for choline acetyltransferase

1983 • 332 citations

ACCELERATED AGEING OR SELECTIVE NEURONAL LOSS AS AN IMPORTANT CAUSE OF DEMENTIA?

1979 • 326 citations

Transmitter deficits in Alzheimer's disease

1985 • 326 citations

Comparative Alterations of Nicotinic and Muscarinic Binding Sites in Alzheimer's and Parkinson's Diseases

1992 • 324 citations

Brain Cholinergic Systems

1990 • 324 citations

Nerve growth factor affects11C-nicotine binding, blood flow, EEG, and verbal episodic memory in an Alzheimer patient (Case Report)

1992 • 319 citations

Changes in acetylcholinesterase and butyrylcholinesterase in Alzheimer's disease resemble embryonic development—A study of molecular forms

1992 • 307 citations

Human reticular formation: Cholinergic neurons of the pedunculopontine and laterodorsal tegmental nuclei and some cytochemical comparisons to forebrain cholinergic neurons

1989 • 301 citations

A unique regulatory profile and regional distribution of [3H]pirenzepine binding in the rat provide evidence for distinct M1 and M2 muscarinic receptor subtypes

1983 • 298 citations

Cell loss and shrinkage in the nucleus basalis Meynert complex in Alzheimer's disease

1990 • 278 citations

ADVANCES IN BEHAVIORAL BIOLOGY

1972 • 271 citations

Alzheimer's disease: a correlative study.

1986 • 269 citations

The olfactory bulbs in Alzheimer's disease.

1984 • 261 citations

Changes in Nicotinic and Muscarinic Cholinergic Receptors in Alzheimer‐Type Dementia

1986 • 261 citations

Amygdaloid Changes in Aging and Dementia

1980 • 257 citations

Brain cholinergic systems

1991 • 240 citations

Extensive loss of choline acetyltransferase activity is not reflected by neuronal loss in the nucleus of meynert in Alzheimer's disease

1982 • 239 citations

An atlas of the regional and laminar distribution of choline acetyltransferase immunoreactivity in rat cerebral cortex

1989 • 237 citations

Genes expressed in the brain define three distinct neuronal nicotinic acetylcholine receptors.

1988 • 232 citations

Neurotransmitter changes in alzheimer's disease: Implications to diagnostics and therapy

1990 • 225 citations

Differential Regulation of Molecular Subtypes of Muscarinic Receptors in Alzheimer's Disease

1995 • 221 citations

Kinetic Analysis of Regional (S)(-)11C-Nicotine Binding in Normal and Alzheimer Brains In Vivo Assessment Using Positron Emission Tomography

1995 • 211 citations

Nucleus basalis neuronal loss, neuritic plaques and choline acetyltransferase activity in advanced Alzheimer's disease

1986 • 210 citations

Molecular forms of acetylcholinesterase in senile dementia of Alzheimer type: Selective loss of the intermediate (10S) form

1983 • 209 citations

The cholinergic systems in brain and spinal cord

1986 • 206 citations

Choline acetyltransferase immunohistochemistry in brains of alzheimer's disease patients and controls

1983 • 206 citations

Heterogeneity and selectivity of the degeneration of cholinergic neurons in the basal forebrain of patients with Alzheimer's disease

1993 • 201 citations

The substantia innominata in alzheimer's disease: an histochemical and biochemical study of cholinergic marker enzymes

1982 • 200 citations

Cortical cholinergic fibers in aging and Alzheimer's disease: A morphometric study

1989 • 198 citations

GLUCOSE METABOLISM AND ACETYLCHOLINE SYNTHESIS IN RELATION TO NEURONAL ACTIVITY IN ALZHEIMER'S DISEASE

1980 • 196 citations

Evidence for high affinity choline transport in synaptosomes prepared from hippocampus and neocortex of patients with Alzheimer's disease

1983 • 194 citations

Topography of the Magnocellular Basal Forebrain System in Human Brain

1984 • 194 citations

A postmortem study of brain nicotinic receptors in Parkinson's and Alzheimer's disease

1991 • 191 citations

Involvement of free radicals in dementia of the Alzheimer type: A hypothesis

1990 • 191 citations

The nucleus basalis of Meynert in neurological disease: A quantitative morphological study

1985 • 191 citations

Reductions in [ ³ H]nicotinic acetylcholine binding in Alzheimer's disease and Parkinson's disease

1988 • 186 citations

Differential cholinergic innervation within functional subdivisions of the human cerebral cortex: A choline acetyltransferase study

1992 • 185 citations

[3H] pirenzepine selectively identifies a high affinity population of muscarinic cholinergic receptors in the rat cerebral cortex

1982 • 184 citations

Cholinergic enzymes in neocortex, hippocampus and basal forebrain of non-neurological and senile dementia of alzheimer-type patients

1983 • 174 citations

Banbury Report 15, Biological Aspects of Alzheimer's Disease

1984 • 173 citations

Tacrine: A pharmacological review

1991 • 168 citations

Is the neuronal basis of Alzheimer's disease cholinergic or glutamatergic?

1990 • 168 citations

Dynamics of Cholinergic Function

1986 • 161 citations

Neuroreceptor changes in Alzheimer disease.

1992 • 161 citations

Cholinergic innervation of the human striatum, globus pallidus, subthalamic nucleus, substantia nigra, and red nucleus

1992 • 159 citations

Neuronal pathology in the nucleus basalis and associated cell groups in senile dementia of the Alzheimer's type

1985 • 157 citations

THE NUCLEUS BASALIS IN ALZHEIMER'S DISEASE: CELL COUNTS AND CORTICAL BIOCHEMISTRY

1983 • 157 citations

Convergent cholinergic activities in aging and Alzheimer's disease

1992 • 156 citations

Nicotinic cholinoceptive neurons of the frontal cortex are reduced in Alzheimer's disease

1991 • 149 citations

Pathological alterations in the amygdala in Alzheimer's disease

1990 • 149 citations

Cholinergic Receptors in Cognitive Disorders

1986 • 149 citations

Epibatidine and ABT 418 reveal selective losses of α4β2 nicotinic receptors in Alzheimer brains

1995 • 148 citations

Nicotinic acetylcholine receptor subtypes in human frontal cortex: Changes in Alzheimer's disease

1990 • 146 citations

Loss of high‐affinity agonist binding to M1 muscarinic receptors in Alzheimer's disease: Implications for the failure of cholinergic replacement therapies

1991 • 145 citations

Distribution of the molecular forms of acetylcholinesterase in human brain: Alterations in dementia of the Alzheimer type

1986 • 144 citations

Muscarinic and nicotinic cholinergic binding sites in alzheimer's disease cerebral cortex

1987 • 143 citations

Tacrine restores cholinergic nicotinic receptors and glucose metabolism in alzheimer patients as visualized by positron emission tomography

1992 • 142 citations

Decreased uptake and binding of11C-nicotine in brain of Alzheimer patients as visualized by positron emission tomography

1990 • 141 citations

A cytoarchitectonic and histochemical study of nucleus basalis and associated cell groups in the normal human brain

1984 • 130 citations

Cholinergic nicotinic and muscarinic receptors in dementia of Alzheimer, Parkinson and Lewy body types

1990 • 126 citations

The Distribution of Cerebral Muscarinic Acetylcholine Receptors In Vivo in Patients With Dementia

1991 • 125 citations

Cholinergic innervation of the human thalamus: Dual origin and differential nuclear distribution

1992 • 125 citations

Cholinergic receptor binding and autoradiography in brains of non-neurological and senile dementia of Alzheimer-type patients

1983 • 124 citations

The human amygdaloid complex: A cytologic and histochemical atlas using Nissl, myelin, acetylcholinesterase and nicotinamide adenine dinucleotide phosphate diaphorase staining

1990 • 122 citations

The cholinergic system of the human hindbrain studied by choline acetyltransferase immunohistochemistry and acetylcholinesterase histochemistry

1986 • 120 citations

Excitatory amino acid-releasing and cholinergic neurones in Alzheimer's disease

1986 • 118 citations

Alzheimer's disease : advances in clinical and basic research

1993 • 118 citations

Volumetric atrophy of the amygdala in Alzheimer's disease

1991 • 117 citations

Actions of snake venom toxins on neuronal nicotinic receptors and other neuronal receptors

1985 • 117 citations

Mapping of brain areas expressing RNA homologous to two different acetylcholine receptor alpha-subunit cDNAs.

1986 • 112 citations

Induction of immune system mediators in the hippocampal formation in Alzheimer's and Parkinson's diseases: Selective effects on specific interleukins and interleukin receptors

1994 • 111 citations

Human striatum: Chemoarchitecture of the caudate nucleus, putamen and ventral striatum in health and Alzheimer's disease

1994 • 110 citations

New specific sensory structures in hairy skin

1962 • 109 citations

Acetylcholine and choline levels in post-mortem human brain tissue: Preliminary observations in Alzheimer's disease

1980 • 104 citations

Immunohistochemical staining of cholinergic neurons in the human brain using a polyclonal antibody to human choline acetyltransferase

1985 • 102 citations

Postmortem stability of α-bungarotoxin binding sites in mouse and human brain

1981 • 101 citations

Acetylcholinesterase‐rich neurons of the human cerebral cortex: Cytoarchitectonic and ontogenetic patterns of distribution

1991 • 101 citations

Cholinergic receptors in human brain: Effects of aging and alzheimer disease

1990 • 100 citations

Neurotransmitter and Receptor Deficits in Senile Dementia of the Alzheimer Type

1986 • 100 citations

Neurofibrillary degeneration of cholinergic and noncholinergic neurons of the basal forebrain in Alzheimer's disease

1986 • 99 citations

Neuronal size and density in the nucleus basalis of Meynert in Alzheimer's disease

1987 • 99 citations

Muscarinic receptor subtypes in human neurodegenerative disorders: focus on Alzheimer's disease.

1989 • 98 citations

Prior parity reduces post-coital diurnal and nocturnal prolactin surges in rats

1993 • 97 citations

The pontomesencephalotegmental cholinergic system does not degenerate in Alzheimer's disease

1989 • 95 citations

Overlap between acetylcholinesterase-rich and choline acetyltransferase-positive (cholinergic) axons in human cerebral cortex

1992 • 94 citations

Nicotinic binding sites in cerebral cortex and hippocampus in alzheimer's dementia

1989 • 94 citations

Brain muscarinic receptors in senile dementia

1985 • 92 citations

Acetylcholinesterase‐rich pyramidal neurons in the human neocortex and hippocampus: Absence at birth, development during the life span, and dissolution in Alzheimer's disease

1988 • 90 citations

Distinctive, rapid, and easy labeling of diffuse plaques in the Alzheimer brains by a new methenamine silver stain

1990 • 89 citations

Chapter 30 Attempts to visualize nicotinic receptors in the brain of monkey and man by positron emission tomography

1989 • 88 citations

THE ROLE OF THE NUCLEUS BASALIS OF MEYNERT IN DEMENTIA: REVIEW AND RECONSIDERATION

1987 • 88 citations

The differential involvement of subcortical nuclei in senile dementia of Alzheimer's type.

1988 • 86 citations

Molecular forms of acetylcholinesterase in subcortical areas of normal and Alzheimer disease brain

1990 • 85 citations

Correlation between cortical plaque count and neuronal loss in the nucleus basalis in Alzheimer's disease

1984 • 81 citations

A post-mortem comparison of the cortical cholinergic system in Alzheimer's disease and Pick's disease

1983 • 80 citations

Nicotinic Receptors and Neurodegenerative Dementing Diseases

1995 • 79 citations

The Potential for Muscarinic Receptor Subtype-Specific Pharmacotherapy for Alzheimer's Disease

1991 • 77 citations

Characterization and quantitative autoradiographic distribution of [3H]acetylcholine muscarinic receptors in mammalian brain. Apparent labelling of an M2-like receptor sub-type

1989 • 77 citations

Regional patterns of cholinergic and glutamate activity in the developing and aging human brain

1993 • 77 citations

Brain muscarinic receptor subtypes are differently affected in Alzheimer's disease and Parkinson's disease

1989 • 76 citations

Neurotransmitter receptors in Alzheimer disease.

1993 • 75 citations

Decreased choline acetyltransferase mRNA expression in the nucleus basalis of Meynert in Alzheimer disease: an in situ hybridization study.

1992 • 75 citations

Olfactory bulb lesions in alzheimer's disease

1992 • 74 citations

Synaptic and non-synaptic cholinergic innervation of the various types of neurons in the main olfactory bulb of adult rat: Immunocytochemistry of choline acetyltransferase

1995 • 74 citations

Cholinergic markers in Alzheimer disease and the autoregulation of acetylcholine release.

1993 • 73 citations

Cellular distribution of nicotinic acetylcholine receptor subunit mRNAs in the human cerebral cortex as revealed by non-isotopic in situ hybridization

1994 • 72 citations

Muscarinic Cholinergic Receptor Subtypes in Hippocampus in Human Cognitive Disorders

1988 • 71 citations

Cholinergic receptors in aging and Alzheimer's disease

1986 • 71 citations

Alzheimer's disease: An olfactory connection?

1988 • 70 citations

Choline acetyltransferase-like immunoreactivity in the hippocampal formation of control subjects and patients with Alzheimer's disease

1989 • 70 citations

Cholinergic innervation in the human hippocampal formation including the entorhinal cortex

1994 • 69 citations

Clinical studies in Alzheimer patients with positron emission tomography

1993 • 69 citations

Differential alterations in muscarinic receptor subtypes in Alzheimer's disease: Implications for cholinergic-based therapies

1995 • 68 citations

Immunohistochemical staining of the human forebrain with monoclonal antibody to human choline acetyltransferase

1983 • 68 citations

Alzheimer's disease: Advances in clinical and basic research

1994 • 68 citations

Cholinergic System

1990 • 68 citations

Acetylcholinesterase fiber staining in the human hippocampus and parahippocampal gyrus

1988 • 68 citations

Decreased muscarinic receptor binding in cerebral cortex and hippocampus in alzheimer's disease

1987 • 66 citations

Biochemical characterization of two nicotinic receptors from the optic lobe of the chick.

1985 • 66 citations

Striosomes and extrastriosomal matrix contain different amounts of immunoreactive choline acetyltransferase in the human striatum

1989 • 66 citations

Alzheimer’s and Parkinson’s Diseases

1995 • 66 citations

Coupling of ml Muscarinic Receptors to G Protein in Alzheimer Disease

1991 • 65 citations

Cholinergic innervation of the amygdaloid complex in the human brain and its alterations in old age and Alzheimer's disease

1993 • 65 citations

Guanine nucleotide modulation of muscarinic cholinergic receptor binding in postmortem human brain — A preliminary study in Alzheimer's disease

1987 • 64 citations

Chapter 33 The cholinergic receptor system of the human brain: neurochemical and pharmacological aspects in aging and Alzheimer

1989 • 64 citations

In Vivo Imaging of Human Cerebral Acetylcholinesterase

1996 • 63 citations

Coupling of muscarinic receptors to GTP proteins in postmortem human brain — alterations in Alzheimer's disease

1993 • 62 citations

Alzheimer plaques and cortical cholinergic innervation

1986 • 62 citations

The Olfactory Bulb in Alzheimer Disease

1994 • 61 citations

Olfactory-related changes in Alzheimer's disease: A quantitative neuropathologic study

1993 • 61 citations

Distribution of neuronal nicotinic receptor subunits in human brain

1994 • 58 citations

Parameters of cholinergic neurotransmission in the thalamus in Parkinson's disease and Alzheimer's disease

1990 • 58 citations

A Brain Regional Analysis of Morphologic and Cholinergic Abnormalities in Alzheimer's Disease

1989 • 56 citations

Differential modification of muscarinic cholinergic receptors in the hippocampus of patients with Alzheimer's disease: an autoradiographic study

1988 • 53 citations

Increased muscarinic receptor messenger RNA in Alzheimer's disease temporal cortex demonstrated by in situ hybridization histochemistry

1991 • 53 citations

Receptor-mediated activation of G proteins is reduced in postmortem brains from Alzheimer's disease patients

1994 • 52 citations

Muscarinic Binding and Choline Acetyltransferase in Postmortem Brains of Demented Patients

1986 • 52 citations

Differential vulnerability of cholinergic projections to the mediodorsal nucleus of the thalamus in senile dementia of Alzheimer type and progressive supranuclear palsy

1991 • 51 citations

Regional Alterations in M., Muscarinic Receptor-G Protein Coupling in Alzheimerʼs Disease

1995 • 51 citations

Diminished muscarinic receptor-stimulated [3H]-PIP2 hydrolysis in alzheimer's disease

1993 • 51 citations

Acetylcholinesterase fibers and the development of senile plaques

1987 • 50 citations

Choline acetylase in the developing nervous system of the rabbit and guinea‐pig

1956 • 50 citations

Biological markers and the cholinergic hypothesis in Alzheimer's disease

1992 • 50 citations

Structure and Function of the Nicotinic Acetylcholine Receptor

1988 • 50 citations

MAMMALIAN BRAIN ACETYLCHOLINESTERASE

1966 • 49 citations

Immunohistochemical analyses of the human olfactory bulb

1993 • 48 citations

CHOLINERGIC INNERVATION IN THE HUMAN STRIATUM: A THREE-COMPARTMENT MODEL

1996 • 48 citations

Acetylcholinesterase staining of the human amygdala

1985 • 48 citations

VIP-sensitive adenylate cyclase, guanylate cyclase, muscarinic receptors, choline acetyltransferase and acetylcholinesterase, in brain tissue afflicted by alzheimer's disease/senile dementia of the Alzheimer type

1988 • 48 citations

Cholinergic innervation of olfactory glomeruli in the rat: An ultrastructural immunocytochemical study

1993 • 47 citations

A detailed anatomical analysis of neurotransmitter receptors in the putamen and caudate in Parkinson's disease and Alzheimer's disease

1994 • 46 citations

The occurrence of large acetylcholinesterase-containing neurons in human neostriatum as disclosed in normal and Alzheimer-diseased brains

1984 • 46 citations

A comparison of FDG PET and IQNB SPECT in normal subjects and in patients with dementia

1992 • 45 citations

Selective involvement of large neurons in the neostriatum of Alzheimer's disease and senile dementia: a morphometric investigation

1987 • 45 citations

Immunocytochemical distribution of peptidergic and cholinergic fibers in the human amygdala: their depletion in Alzheimer's disease and morphologic alteration in non-demented elderly with numerous senile plaques

1993 • 44 citations

Amino acid sequence of .kappa.-flavitoxin: establishment of a new family of snake venom neurotoxins

1988 • 43 citations

Studies on Neurotransmitter Binding in Senile Dementia

1984 • 43 citations

[3H]AF-DX 116 labels subsets of muscarinic cholinergic receptors in rat brain and heart

1987 • 43 citations

Biochemistry and Pathophysiology of the Molecular Forms of Cholinesterases

1988 • 42 citations

Quantitative imaging of neuroreceptors in the living human brain

1986 • 42 citations

Substance P-like immunoreactivity, choline acetyltransferase activity and cholinergic muscarinic receptors in Alzheimer's disease and multi-infarct dementia

1990 • 41 citations

Reorganization of Cingulate Cortex in Alzheimer's Disease: Neuron Loss, Neuritic Plaques, and Muscarinic Receptor Binding

1992 • 41 citations

Correlative decrease of large neurons in the neostriatum and basal nucleus of Meynert in Alzheimer's disease

1989 • 41 citations

Monoaminergic and cholinergic synaptic markers in the nucleus basalis of meynert (nbM): Normal age‐related changes and the effect of heart disease and Alzheimer's disease

1992 • 39 citations

Differential inhibition of acetylcholinesterase molecular forms in normal and Alzheimer disease brain

1992 • 38 citations

Differential cholinergic regulation in Alzheimer's patients compared to controls following chronic blockade with scopolamine: a SPECT study

1995 • 36 citations

Thalamic nuclei in Alzheimer disease: evidence against the cholinergic hypothesis of plaque formation

1989 • 34 citations

Neuropeptide Y-like immunoreactive neurons in the human olfactory bulb

1988 • 34 citations

Some enzyme histochemical characteristics of the human hippocampus

1977 • 32 citations

Biochemical changes in the cholinergic system of the ageing brain and in senile dementia

1980 • 32 citations

Large neurons in the neostriatum in Alzheimer's disease and progressive supranuclear palsy: a topographic, histologic and ultrastructural investigation

1991 • 32 citations

Diminished [3H]inositol(1,4,5)P3 but not [3H]inositol(1,3,4,5)P4 binding in Alzheimer's disease brain

1995 • 31 citations

Alzheimer's disease: Is the decrease of the cholinergic innervation of the hippocampus related to intrinsic hippocampal pathology?

1992 • 31 citations

Neurotransmitters in the Human Brain

1995 • 31 citations

Quantitative analysis of immunohistochemical distributions of cholinergic and catecholaminergic systems in the human brain

1994 • 31 citations

Monoclonal antibodies to human brain acetylcholinesterase: properties and applications

1988 • 30 citations

Nicotinic and muscarinic cholinergic receptors in Alzheimer's disease and related disorders.

1987 • 30 citations

Comparison of the concentration of messenger RNA encoding four muscarinic receptor subtypes in control and Alzheimer brains

1992 • 27 citations

MOLECULAR FORMS OF ACETYLCHOLINESTERASE IN ALZHEIMERʼS DISEASE

1986 • 27 citations

Immunocytochemical demonstration of axonal and perikaryal acetylcholinesterase in human cerebral cortex

1991 • 27 citations

Acetylcholinesterase‐containing Intrinsic Neurons in the Rat Main Olfactory Bulb: Cytological and Neurochemical Features

1994 • 27 citations

Functional and biochemical basis for multiple muscarinic acetylcholine receptors

1985 • 26 citations

α4 is a major acetylcholine binding subunit of cholinergic ligand affinity-purified nicotinic acetylcholine receptor from rat brains

1991 • 26 citations

Neurochemical Deficits in Pathological Brain Aging: Specificity and Possible Relevance for Treatment Strategies

1990 • 26 citations

Muscarinic receptors and novel strategies for the treatment of age-related brain disorders

1994 • 25 citations

Alzheimer's disease. A critical review.

1988 • 24 citations

Compartmental ordering of cholinergic innervation in the mediodorsal nucleus of the thalamus in human brain

1990 • 22 citations

Subcellular distribution of acetylcholinesterase in Alzheimer’s disease: abnormal localization and solubilization

1990 • 21 citations

Acetylcholinesterase provides deeper insights into Alzheimer's disease

1994 • 21 citations

Cellular Distribution and Expression of Cortical Acetylcholine Receptors in Aging and Alzheimer's Diseasea

1991 • 21 citations

Relationships between Choline Acetyltransferase and Muscarinic Binding in Aging Rodent Brain and in Alzheimer’s Disease

1986 • 19 citations

Human striatal cholinergic neurons in development, aging and Alzheimer's disease

1990 • 17 citations

Mammalian Brain Acetylcholinesterase

2003 • 17 citations

Nucleus basalis neuronal loss and neuritic plaques in advanced Alzheimer's disease

1986 • 16 citations

Preservation of acetylcholine muscarinic M2 receptor G-protein interactions in the neocortex of patients with Alzheimer's disease

1995 • 14 citations

Neurotransmitters in the human brain

1996 • 14 citations

Somatostatin-14-like immunoreactive neurons and fibres in the human olfactory bulb

1988 • 14 citations

Cholinoceptive neurons without acetylcholinesterase activity and enzyme-positive neurons without cholinergic synaptic innervation are present in the main olfactory bulb of adult rat

1996 • 14 citations

Dynamics of Cholinergic function

1987 • 11 citations

Neuropathologic changes in the olfactory bulb in Alzheimer's disease.

1996 • 11 citations

Correlation of choline acetyltransferase activity between the nucleus basalis of Meynert and the cerebral cortex

1987 • 9 citations

Nicotinic Cholinergic Receptors in Human Brain: Effects of Aging and Alzheimer

1991 • 9 citations

Correlation of choline acetyltransferase activity between the nucleus basalis of meynert and the cerebral cortex

1987 • 9 citations

Normal sequences of muscarinic acetylcholine receptors (m1 and m2) in patients with Alzheimer's disease and vascular dementia

1994 • 8 citations

Neurotransmitter Changes in Alzheimer’s Disease

1995 • 8 citations

Examination of Cholinergic and Neuropeptide Receptor Alterations in Senile Dementia of the Alzheimer’s Type (SDAT)

1986 • 7 citations

Muscarinic autoreceptors are differentially affected by selective muscarinic antagonists in rat hippocampus

1989 • 5 citations

Morphometric study on the CH4 of the nucleus basalis of meynert in Alzheimer’s disease

1991 • 5 citations

[New receptor ligands for single-photon emission tomography of the brain].

1992 • 1 citations