Proof-of-Concept Trial of an α7 Nicotinic Agonist in Schizophrenia

Linkage of a neurophysiological deficit in schizophrenia to a chromosome 15 locus

1997 • 1,142 citations

Normalization of auditory physiology by cigarette smoking in schizophrenic patients

1993 • 689 citations

Evidence in postmortem brain tissue for decreased numbers of hippocampal nicotinic receptors in schizophrenia

1995 • 676 citations

Neurocognitive Effects of Clozapine, Olanzapine, Risperidone, and Haloperidol in Patients With Chronic Schizophrenia or Schizoaffective Disorder

2002 • 536 citations

INPUT DYSFUNCTION IN SCHIZOPHRENIA.

1964 • 479 citations

Association of Promoter Variants in the α7 Nicotinic Acetylcholine Receptor Subunit Gene With an Inhibitory Deficit Found in Schizophrenia

2002 • 446 citations

Acetylcholine Activates an α-Bungarotoxin-Sensitive Nicotinic Current in Rat Hippocampal Interneurons, But Not Pyramidal Cells

1998 • 380 citations

Repeatable Battery for the Assessment of Neuropsychological Status as a Screening Test in Schizophrenia, I: Sensitivity, Reliability, and Validity

1999 • 307 citations

NIMH genetics initiative millennium schizophrenia consortium: Linkage analysis of African-American pedigrees

1998 • 269 citations

Selective α 7 -nicotinic agonists normalize inhibition of auditory response in DBA mice

1998 • 268 citations

Cholinergic gating of response to auditory stimuli in rat hippocampus

1992 • 264 citations

Increased levels of the nicotine metabolite cotinine in schizophrenic smokers compared to other smokers

1997 • 252 citations

Neuronal Nicotinic Receptors in Dementia with Lewy Bodies and Schizophrenia

1999 • 252 citations

Effects of Cigarette Smoking and Nicotine Nasal Spray on Psychiatric Symptoms and Cognition In Schizophrenia

2002 • 245 citations

Effects of Nicotine on Cognitive Deficits in Schizophrenia

2004 • 239 citations

Safety, Pharmacokinetics, and Effects on Cognitive Function of Multiple Doses of GTS-21 in Healthy, Male Volunteers

2002 • 236 citations

Effects of Smoking Abstinence on Visuospatial Working Memory Function in Schizophrenia

2002 • 229 citations

Nicotine effects on brain function and functional connectivity in schizophrenia

2004 • 228 citations

Nicotinic Acetylcholine Receptor α7 and α4β2 Subtypes Differentially Control GABAergic Input to CA1 Neurons in Rat Hippocampus

2001 • 228 citations

Neurophysiological and neuropsychological evidence for attentional dysfunction in schizophrenia

1993 • 213 citations

Varied Effects of Atypical Neuroleptics on P50 Auditory Gating in Schizophrenia Patients

2004 • 194 citations

Characterization of a series of anabaseine-derived compounds reveals that the 3-(4)-dimethylaminocinnamylidine derivative is a selective agonist at neuronal nicotinic alpha 7/125I-alpha-bungarotoxin receptor subtypes.

1995 • 192 citations

Effects of clozapine on smoking in chronic schizophrenic outpatients.

1995 • 180 citations

Nicotine and Behavioral Markers of Risk for Schizophrenia A Double-Blind, Placebo-Controlled, Cross-Over Study

2002 • 176 citations

Smoking and therapeutic response to clozapine in patients with schizophrenia

1999 • 174 citations

Test-Retest Stability of the Repeatable Battery for the Assessment of Neuropsychological Status in Schizophrenia

2002 • 155 citations

Tropisetron improves deficits in auditory P50 suppression in schizophrenia

2005 • 129 citations

Haplotype transmission disequilibrium and evidence for linkage of the CHRNA7 gene region to schizophrenia in Southern African Bantu families

2000 • 127 citations

Clozapine improves deficient inhibitory auditory processing in DBA/2 mice, via a nicotinic cholinergic mechanism

2003 • 123 citations

A nicotinic agonist (GTS-21), eyeblink classical conditioning and nicotinic receptor binding in rabbit brain

1994 • 121 citations

Hydroxy Metabolites of the Alzheimer's Drug Candidate 3-[(2,4-Dimethoxy)Benzylidene]-Anabaseine Dihydrochloride (GTS-21): Their Molecular Properties, Interactions with Brain Nicotinic Receptors, and Brain Penetration

2004 • 105 citations

Clozapine increases both acetylcholine and dopamine release in rat ventral hippocampus: role of 5-HT1A receptor agonism

2004 • 94 citations

Schizophrenia and smoking: Evidence for a common neurobiological basis?

2000 • 87 citations

Evidence for linkage disequilibrium between the alpha 7‐nicotinic receptor gene (CHRNA7) locus and schizophrenia in Azorean families*

2001 • 87 citations

Human α 7 nicotinic acetylcholine receptor responses to novel ligands

1995 • 87 citations

Nicotine improves delayed recognition in schizophrenic patients

2004 • 86 citations

Suggestive evidence for linkage of schizophrenia to markers at chromosome 15q13–14 in Taiwanese families

2001 • 86 citations

Examination of genetic linkage of chromosome 15 to schizophrenia in a large Veterans Affairs Cooperative Study sample*

2001 • 80 citations

The promoter −194 C polymorphism of the nicotinic alpha 7 receptor gene has a protective effect against the P50 sensory gating deficit

2003 • 68 citations

The effect of state on sensory gating: comparison of waking, REM and non-REM sleep

2001 • 60 citations

Linkage analysis of schizophrenia to chromosome 15

2001 • 57 citations

The Structural Basis for GTS-21 Selectivity between Human and Rat Nicotinic α7 Receptors

2004 • 54 citations

Pharmacokinetics and urinary excretion of DMXBA (GTS-21), a compound enhancing cognition

1998 • 42 citations