Bacterial Expression, NMR, and Electrophysiology Analysis of Chimeric Short/Long-chain α-Neurotoxins Acting on Neuronal Nicotinic Receptors

Tricine-sodium dodecyl sulfate-polyacrylamide gel electrophoresis for the separation of proteins in the range from 1 to 100 kDa

1987 • 11,491 citations

MOLMOL: A program for display and analysis of macromolecular structures

1996 • 7,169 citations

Nicotinic acetylcholine receptor α7 subunit is an essential regulator of inflammation

2002 • 2,972 citations

Crystal structure of an ACh-binding protein reveals the ligand-binding domain of nicotinic receptors

2001 • 1,736 citations

Refined Structure of the Nicotinic Acetylcholine Receptor at 4Å Resolution

2004 • 1,626 citations

Emerging structure of the Nicotinic Acetylcholine receptors

2002 • 896 citations

Nicotine and Carbamylcholine Binding to Nicotinic Acetylcholine Receptors as Studied in AChBP Crystal Structures

2004 • 778 citations

Nicotine Activation of α4* Receptors: Sufficient for Reward, Tolerance, and Sensitization

2004 • 685 citations

Structures of Aplysia AChBP complexes with nicotinic agonists and antagonists reveal distinctive binding interfaces and conformations

2005 • 617 citations

Crystal structure of nicotinic acetylcholine receptor homolog AChBP in complex with an α-conotoxin PnIA variant

2005 • 311 citations

Crystal structure of a Cbtx–AChBP complex reveals essential interactions between snake α-neurotoxins and nicotinic receptors

2005 • 304 citations

Snake venom α‐neurotoxins and other ‘three‐finger’ proteins

1999 • 272 citations

Human Bronchial Epithelial and Endothelial Cells Express α7 Nicotinic Acetylcholine Receptors

2001 • 217 citations

α4 but Not α3 and α7 Nicotinic Acetylcholine Receptor Subunits Are Lost from the Temporal Cortex in Alzheimer's Disease

1999 • 197 citations

Structural determinants of selective α-conotoxin binding to a nicotinic acetylcholine receptor homolog AChBP

2006 • 189 citations

Functional architectures of animal toxins: a clue to drug design?

1998 • 183 citations

Crystal Structure of Acetylcholine-binding Protein from Bulinus truncatus Reveals the Conserved Structural Scaffold and Sites of Variation in Nicotinic Acetylcholine Receptors

2005 • 182 citations

Nicotinic Acetylcholine Receptors of Muscles and Nerves

2003 • 173 citations

Only Snake Curaremimetic Toxins with a Fifth Disulfide Bond Have High Affinity for the Neuronal α7 Nicotinic Receptor

1997 • 150 citations

Acetylcholine Binding Protein (AChBP): A Secreted Glial Protein That Provides a High-Resolution Model for the Extracellular Domain of Pentameric Ligand-Gated Ion Channels

2003 • 138 citations

Molecular analysis of nicotinic receptor expression in autism

2004 • 136 citations

Snake and snail toxins acting on nicotinic acetylcholine receptors: fundamental aspects and medical applications

2003 • 129 citations

The Binding Site of Acetylcholine Receptor as Visualized in the X-Ray Structure of a Complex between α-Bungarotoxin and a Mimotope Peptide

2001 • 129 citations

Molecular Determinants by Which a Long Chain Toxin from Snake Venom Interacts with the Neuronal α7-Nicotinic Acetylcholine Receptor

2000 • 124 citations

Experimentally based model of a complex between a snake toxin and the α7 nicotinic receptor

2002 • 119 citations

Variability among the Sites by Which Curaremimetic Toxins Bind to Torpedo Acetylcholine Receptor, as Revealed by Identification of the Functional Residues of α-Cobratoxin

1999 • 110 citations

Ligand-Gated Ion Channels

2001 • 103 citations

Dementia rating and nicotinic receptor expression in the prefrontal cortex in schizophrenia

2003 • 97 citations

Expression of the α7 nicotinic acetylcholine receptor in human lung cells

2005 • 91 citations

Non-neuronal nicotinic alpha 7 receptor, a new endothelial target for revascularization

2005 • 80 citations

Single Amino Acid Substitutions in α-Conotoxin PnIA Shift Selectivity for Subtypes of the Mammalian Neuronal Nicotinic Acetylcholine Receptor

1999 • 78 citations

Mutation causing severe myasthenia reveals functional asymmetry of AChR signature cystine loops in agonist binding and gating

2003 • 75 citations

Crystal Structure of .kappa.-Bungarotoxin at 2.3-.ANG. Resolution

1994 • 70 citations

NMR Structural Analysis of α-Bungarotoxin and Its Complex with the Principal α-Neurotoxin-binding Sequence on the α7 Subunit of a Neuronal Nicotinic Acetylcholine Receptor

2002 • 67 citations

Identification of Pairwise Interactions in the α-Neurotoxin-Nicotinic Acetylcholine Receptor Complex through Double Mutant Cycles

1998 • 67 citations

The Mechanism for Acetylcholine Receptor Inhibition by α-Neurotoxins and Species-Specific Resistance to α-Bungarotoxin Revealed by NMR

2002 • 63 citations

Molecular characterization of the specificity of interactions of various neurotoxins on two distinct nicotinic acetylcholine receptors

2000 • 60 citations

α-Conotoxins PnIA and [A10L]PnIA Stabilize Different States of the α7-L247T Nicotinic Acetylcholine Receptor

2003 • 56 citations

Ethanol modulates nicotine-induced upregulation of nAChRs

2003 • 53 citations

Solution structure of neuronal bungarotoxin determined by two-dimensional NMR spectroscopy: sequence-specific assignments, secondary structure, and dimer formation

1991 • 49 citations

The Solution Structure of the Complex Formed between α-Bungarotoxin and an 18-mer Cognate Peptide Derived from the α1 Subunit of the Nicotinic Acetylcholine Receptor from Torpedo californica

2001 • 47 citations

Differential Roles for Disulfide Bonds in the Structural Integrity and Biological Activity of κ-Bungarotoxin, a Neuronal Nicotinic Acetylcholine Receptor Antagonist

1998 • 43 citations

Amino acid sequence of .kappa.-flavitoxin: establishment of a new family of snake venom neurotoxins

1988 • 43 citations

How Do Short Neurotoxins Bind to a Muscular-type Nicotinic Acetylcholine Receptor?

2002 • 41 citations

A model for short α-neurotoxin bound to nicotinic acetylcholine receptor from Torpedo californica: Comparison with long-chain α-neurotoxins and α-conotoxins

2005 • 37 citations

Chemical engineering of a three-fingered toxin with anti-α7 neuronal acetylcholine receptor activity

2000 • 28 citations

Nicotinic receptors in the putamen of patients with dementia with Lewy bodies and Parkinson's disease: relation to changes in α-synuclein expression

2002 • 25 citations

Biotinylation of Substituted Cysteines in the Nicotinic Acetylcholine Receptor Reveals Distinct Binding Modes for α-Bungarotoxin and Erabutoxin a

2000 • 22 citations

Neuronal Nicotinic Acetylcholine Receptors and Epilepsy

2002 • 22 citations

How do snake curaremimetic toxins discriminate between nicotinic acetylcholine receptor subtypes

1998 • 17 citations

Neuronal nicotinic receptors and epilepsy, from genes to possible therapeutic compounds

2004 • 14 citations

Resonance assignment of13C−15N-labeled snake neurotoxin II fromNaja oxiana

2003 • 12 citations

C-terminus of a long α-neurotoxin is highly mobile when bound to the nicotinic acetylcholine receptor: A time-resolved fluorescence anisotropy approach

2005 • 7 citations