Nicotinic receptors, allosteric proteins and medicine

On the nature of allosteric transitions: A plausible model

1965 • 8,699 citations

Comparison of Experimental Binding Data and Theoretical Models in Proteins Containing Subunits^*

1966 • 2,956 citations

Allosteric proteins and cellular control systems

1963 • 2,187 citations

3D structure of Alzheimer's amyloid-β(1–42) fibrils

2005 • 1,916 citations

Crystal structure of the human β2 adrenergic G-protein-coupled receptor

2007 • 1,885 citations

Crystal structure of an ACh-binding protein reveals the ligand-binding domain of nicotinic receptors

2001 • 1,736 citations

Refined Structure of the Nicotinic Acetylcholine Receptor at 4Å Resolution

2004 • 1,626 citations

Regulation of NMDA receptor trafficking by amyloid-β

2005 • 1,484 citations

Acetylcholine receptors containing the β2 subunit are involved in the reinforcing properties of nicotine

1998 • 1,304 citations

Transvascular delivery of small interfering RNA to the central nervous system

2007 • 1,176 citations

Acetylcholine receptor channel imaged in the open state

1995 • 1,002 citations

THE HEMOGLOBIN SYSTEM

1925 • 813 citations

Nicotinic Receptors at the Amino Acid Level

2000 • 795 citations

β-Amyloid1–42 Binds to α7 Nicotinic Acetylcholine Receptor with High Affinity

2000 • 781 citations

Nicotine and Carbamylcholine Binding to Nicotinic Acetylcholine Receptors as Studied in AChBP Crystal Structures

2004 • 778 citations

Coarse-grained normal mode analysis in structural biology

2005 • 718 citations

Allosteric Mechanisms of Signal Transduction

2005 • 710 citations

Structures of Aplysia AChBP complexes with nicotinic agonists and antagonists reveal distinctive binding interfaces and conformations

2005 • 617 citations

Nicotine reinforcement and cognition restored by targeted expression of nicotinic receptors

2005 • 544 citations

Neuronal Nicotinic Acetylcholine Receptors: Structural Revelations, Target Identifications, and Therapeutic Inspirations

2005 • 534 citations

Recent advances in Cys-loop receptor structure and function

2006 • 505 citations

Interaction at end-plate receptors between different choline derivatives

1957 • 477 citations

Cis–trans isomerization at a proline opens the pore of a neurotransmitter-gated ion channel

2005 • 445 citations

A Novel Positive Allosteric Modulator of the α7 Neuronal Nicotinic Acetylcholine Receptor:In VitroandIn VivoCharacterization

2005 • 433 citations

Crystal structure of the extracellular domain of nAChR α1 bound to α-bungarotoxin at 1.94 Å resolution

2007 • 395 citations

Varenicline, an α4β2 nicotinic acetylcholine receptor partial agonist, selectively decreases ethanol consumption and seeking

2007 • 361 citations

On the nature of allosteric transitions: Implications of non-exclusive ligand binding

1966 • 336 citations

Muscle and neuronal nicotinic acetylcholine receptors

2007 • 316 citations

Crystal structure of nicotinic acetylcholine receptor homolog AChBP in complex with an α-conotoxin PnIA variant

2005 • 311 citations

Coupling of agonist binding to channel gating in the GABAA receptor

2003 • 310 citations

Ivermectin: A Positive Allosteric Effector of the α7 Neuronal Nicotinic Acetylcholine Receptor

1998 • 308 citations

Crystal structure of a Cbtx–AChBP complex reveals essential interactions between snake α-neurotoxins and nicotinic receptors

2005 • 304 citations

A prokaryotic proton-gated ion channel from the nicotinic acetylcholine receptor family

2006 • 302 citations

Smoking and the Sudden Infant Death Syndrome

1993 • 286 citations

Heterogeneity and complexity of native brain nicotinic receptors

2007 • 277 citations

Coupling of agonist binding to channel gating in an ACh-binding protein linked to an ion channel

2004 • 264 citations

Models of the extracellular domain of the nicotinic receptors and of agonist- and Ca ²⁺ -binding sites

2002 • 262 citations

Genetic mechanisms that underlie epilepsy

2004 • 260 citations

Allosteric modulation of nicotinic acetylcholine receptors

2007 • 243 citations

The Feedback Control Mechanism of Biosynthetic L-Threonine Deaminase by L-Isoleucine

1961 • 243 citations

The membrane protein universe: what's out there and why bother?

2007 • 222 citations

An Allosteric Modulator of the α7 Nicotinic Acetylcholine Receptor Possessing Cognition-Enhancing Properties in Vivo

2007 • 216 citations

Neuronal nicotinic receptors: A perspective on two decades of drug discovery research

2007 • 203 citations

Potentiation of nicotinic receptor response by external calcium in rat central neurons

1992 • 191 citations

Structural determinants of selective α-conotoxin binding to a nicotinic acetylcholine receptor homolog AChBP

2006 • 189 citations

Normal Mode Analysis Suggests a Quaternary Twist Model for the Nicotinic Receptor Gating Mechanism

2005 • 187 citations

Nicotinic Treatment for Cognitive Dysfunction

2002 • 185 citations

Identification of calcium binding sites that regulate potentiation of a neuronal nicotinic acetylcholine receptor.

1996 • 173 citations

Brain Neuronal Nicotinic Receptors as New Targets for Drug Discovery

2006 • 173 citations

Allosteric enhancers, allosteric agonists and ago-allosteric modulators: where do they bind and how do they act?

2007 • 173 citations

Nootropic α7 nicotinic receptor allosteric modulator derived from GABA _A receptor modulators

2007 • 165 citations

Executive and social behaviors under nicotinic receptor regulation

2003 • 160 citations

Current understanding of congenital myasthenic syndromes

2005 • 156 citations

The Prototoxin lynx1 Acts on Nicotinic Acetylcholine Receptors to Balance Neuronal Activity and Survival In Vivo

2006 • 153 citations

Kinetics of unliganded acetylcholine receptor channel gating

1986 • 146 citations

Acetylcholine Binding Protein (AChBP): A Secreted Glial Protein That Provides a High-Resolution Model for the Extracellular Domain of Pentameric Ligand-Gated Ion Channels

2003 • 138 citations

Acetylcholine receptor channel structure in the resting, open, and desensitized states probed with the substituted-cysteine-accessibility method

2001 • 137 citations

Crystal structure of a Cbtx-AChBP complex reveals essential interactions between snake alpha-neurotoxins and nicotinic receptors,

2005 • 127 citations

Experimentally based model of a complex between a snake toxin and the α7 nicotinic receptor

2002 • 119 citations

Targeted Molecular Dynamics Study of C-Loop Closure and Channel Gating in Nicotinic Receptors

2006 • 118 citations

Molecular tuning of fast gating in pentameric ligand-gated ion channels

2005 • 115 citations

Galanthamine and Non-competitive Inhibitor Binding to ACh-binding Protein: Evidence for a Binding Site on Non-α-subunit Interfaces of Heteromeric Neuronal Nicotinic Receptors

2007 • 113 citations

Channel Opening Motion of α7 Nicotinic Acetylcholine Receptor as Suggested by Normal Mode Analysis

2005 • 108 citations

The Croonian Lecture 2000. Nicotinic acetylcholine receptor and the structural basis of fast synaptic transmission,Lecture delivered 5 October 2000 at University College London

2000 • 105 citations

Long-term effects of chronic nicotine exposure on brain nicotinic receptors

2007 • 102 citations

Allosteric transitions of the acetylcholine receptor probed at the amino acid level with a photolabile cholinergic ligand.

1991 • 101 citations

Implications of the quaternary twist allosteric model for the physiology and pathology of nicotinic acetylcholine receptors

2006 • 94 citations

Nicotine enhances intracellular nicotinic receptor maturation: A novel mechanism of neural plasticity?

2006 • 85 citations

β2 nicotinic acetylcholine receptor subunit modulates protective responses to stress: A receptor basis for sleep-disordered breathing after nicotine exposure

2002 • 83 citations

Pore conformations and gating mechanism of a Cys-loop receptor

2005 • 71 citations

Toxin insights into nicotinic acetylcholine receptors

2006 • 60 citations

Cell autonomy, receptor autonomy, and thermodynamics in nicotine receptor up-regulation

2007 • 41 citations

A chimera encoding the fusion of an acetylcholine-binding protein to an ion channel is stabilized in a state close to the desensitized form of ligand-gated ion channels

2005 • 37 citations

The α7 nicotinic acetylcholine receptor: Molecular modelling, electrostatics, and energetics

2005 • 34 citations

[³H]Benzophenone Photolabeling Identifies State-Dependent Changes in Nicotinic Acetylcholine Receptor Structure

2007 • 30 citations

Dynamic Structural Investigations on the Torpedo Nicotinic Acetylcholine Receptor by Time‐Resolved Photoaffinity Labeling

2006 • 23 citations

Computer modeling of binding of diverse weak toxins to nicotinic acetylcholine receptors

2007 • 22 citations

Probing the Reorganization of the Nicotinic Acetylcholine Receptor during Desensitization by Time-Resolved Covalent Labeling Using [³H]AC5, a Photoactivatable Agonist

2005 • 22 citations

Structural Reorganization of the Acetylcholine Binding Site of the Torpedo Nicotinic Receptor as Revealed by Dynamic Photoaffinity Labeling

2002 • 16 citations

Docking of α-cobratoxin suggests a basal conformation of the nicotinic receptor

2007 • 15 citations

Opened by a twist: a gating mechanism for the nicotinic acetylcholine receptor

2007 • 13 citations

Molecular Dynamics of Nicotinic Acetylcholine Receptor Correlating Biological Functions

2006 • 11 citations

Inaugural Article: Acetylcholine receptor channel structure in the resting, open, and desensitized states probed with the substituted-cysteine-accessibility method

2001 • 11 citations