Ligand Selectivity for the Acetylcholine Binding Site of the Rat α4β2 and α3β4 Nicotinic Subtypes Investigated by Molecular Docking

PROCHECK: a program to check the stereochemical quality of protein structures

1993 • 23,689 citations

A Second Generation Force Field for the Simulation of Proteins, Nucleic Acids, and Organic Molecules

1995 • 12,826 citations

Crystal structure of an ACh-binding protein reveals the ligand-binding domain of nicotinic receptors

2001 • 1,736 citations

Evaluation of the FLEXX incremental construction algorithm for protein-ligand docking

1999 • 871 citations

Nicotine and Carbamylcholine Binding to Nicotinic Acetylcholine Receptors as Studied in AChBP Crystal Structures

2004 • 778 citations

Protein-Based Virtual Screening of Chemical Databases. 1. Evaluation of Different Docking/Scoring Combinations

2000 • 722 citations

A glia-derived acetylcholine-binding protein that modulates synaptic transmission

2001 • 564 citations

From ab initio quantum mechanics to molecular neurobiology: A cation–π binding site in the nicotinic receptor

1998 • 544 citations

Neuronal Nicotinic Acetylcholine Receptors as Targets for Drug Discovery

1997 • 440 citations

Allosteric Receptors after 30 Years

1998 • 430 citations

Molecular evolution of the nicotinic acetylcholine receptor: An example of multigene family in excitable cells

1995 • 422 citations

Epibatidine, a potent analgetic and nicotinic agonist.

1994 • 371 citations

Cation−π Interactions in Ligand Recognition by Serotonergic (5-HT_3A) and Nicotinic Acetylcholine Receptors: The Anomalous Binding Properties of Nicotine

2002 • 297 citations

Neuronal nicotinic acetylcholine receptors as novel drug targets.

2000 • 284 citations

Comparative pharmacology of epibatidine: a potent agonist for neuronal nicotinic acetylcholine receptors.

1995 • 284 citations

Models of the extracellular domain of the nicotinic receptors and of agonist- and Ca ²⁺ -binding sites

2002 • 262 citations

Nicotinic cholinergic receptors labeled by [3H]acetylcholine in rat brain.

1982 • 259 citations

Evidence for "preterminal" nicotinic receptors on GABAergic axons in the rat interpeduncular nucleus

1993 • 255 citations

Rat α3/β4 Subtype of Neuronal Nicotinic Acetylcholine Receptor Stably Expressed in a Transfected Cell Line: Pharmacology of Ligand Binding and Function

1998 • 240 citations

Novel Potent Ligands for the Central Nicotinic Acetylcholine Receptor: Synthesis, Receptor Binding, and 3D-QSAR Analysis

2000 • 235 citations

Novel 3-Pyridyl Ethers with Subnanomolar Affinity for Central Neuronal Nicotinic Acetylcholine Receptors

1996 • 227 citations

Neurotransmitter-gated ion channels as unconventional allosteric proteins

1994 • 197 citations

Multiple automatic base selection: protein-ligand docking based on incremental construction without manual intervention.

1997 • 191 citations

(S)-3-methyl-5-(1-methyl-2-pyrrolidinyl)isoxazole (ABT 418): a novel cholinergic ligand with cognition-enhancing and anxiolytic activities: II. In vivo characterization.

1994 • 178 citations

(+/-)-Epibatidine elicits a diversity of in vitro and in vivo effects mediated by nicotinic acetylcholine receptors.

1994 • 166 citations

Identification and Initial Structure−Activity Relationships of (R)-5-(2-Azetidinylmethoxy)-2-chloropyridine (ABT-594), a Potent, Orally Active, Non-Opiate Analgesic Agent Acting via Neuronal Nicotinic Acetylcholine Receptors

1998 • 128 citations

Hydrogen bonding properties of oxygen and nitrogen acceptors in aromatic heterocycles

1997 • 120 citations

Development of ligands for in vivo imaging of cerebral nicotinic receptors

2000 • 90 citations

A structural model of agonist binding to the α3β4 neuronal nicotinic receptor

2003 • 54 citations

Ligands for in vivo imaging of nicotinic receptor subtypes in Alzheimer brain

2000 • 45 citations

Chemical modification of epibatidine causes a switch from agonist to antagonist and modifies its selectivity for neuronal nicotinic acetylcholine receptors

2000 • 39 citations

Structural aspects of high affinity ligands for the α4β2 neuronal nicotinic receptor

2000 • 31 citations

Epibatidine: high potency and broad spectrum activity on neuronal and neuromuscular nicotinic acetylcholine receptors

1999 • 27 citations

Structure-activity studies on a novel series of cholinergic channel activators based on a heteroaryl ether framework

1999 • 14 citations

Eek, a XenoMouse

2000 • 4 citations