Desensitization of Nicotinic Acetylcholine Receptors as a Strategy for Drug Development

Long-term effects of Aβ42 immunisation in Alzheimer's disease: follow-up of a randomised, placebo-controlled phase I trial

2008 • 1,377 citations

Nicotine amplifies reward-related dopamine signals in striatum

2004 • 566 citations

A Novel Positive Allosteric Modulator of the α7 Neuronal Nicotinic Acetylcholine Receptor:In VitroandIn VivoCharacterization

2005 • 433 citations

It is not “either/or”: Activation and desensitization of nicotinic acetylcholine receptors both contribute to behaviors related to nicotine addiction and mood

2007 • 427 citations

Beneficial effects of nicotine administered prior to a delayed matching-to-sample task in young and aged monkeys

1991 • 163 citations

Sazetidine-A, A Novel Ligand That Desensitizes α4β2 Nicotinic Acetylcholine Receptors without Activating Them

2006 • 141 citations

Nicotinic receptor‐mediated enhancement of long‐term potentiation involves activation of metabotropic glutamate receptors and ryanodine‐sensitive calcium stores in the dentate gyrus

2006 • 118 citations

Mecamylamine is a selective non-competitive antagonist of and aspartate-induced currents in horizontal cells dissociated from the catfish retina

1988 • 110 citations

Sazetidine-A Is a Potent and Selective Agonist at Native and Recombinant α4β2 Nicotinic Acetylcholine Receptors

2008 • 107 citations

Inactivation of α7 ACh receptors and activation of non-α7 ACh receptors both contribute to long term potentiation induction in the hippocampal CA1 region

2000 • 105 citations

Evidence for a Complex Influence of Nicotinic Acetylcholine Receptors on Hippocampal Serotonin Release

2000 • 100 citations

Relationship between up-regulation of nicotine binding sites in rat brain and delayed cognitive enhancement observed after chronic or acute nicotinic receptor stimulation

1996 • 86 citations

Nicotinic Receptors on Local Circuit Neurons in Dentate Gyrus: A Potential Role in Regulation of Granule Cell Excitability

2003 • 82 citations

Cotinine, a Neuroactive Metabolite of Nicotine: Potential for Treating Disorders of Impaired Cognition

2005 • 74 citations

Modulation of Nicotinic Receptor Activity in the Central Nervous System

2001 • 70 citations

Cholinergic Axons Modulate GABAergic Signaling among Hippocampal Interneurons via Postsynaptic α7 Nicotinic Receptors

2007 • 69 citations

Differential effects of scopolamine and mecamylamine on working and reference memory in the rat

1993 • 68 citations

Neuronal Nicotinic Receptor Subtypes: DEFINING THERAPEUTIC TARGETS

2004 • 65 citations

Pharmacological comparison of transient and persistent [3H]dopamine release from mouse striatal synaptosomes and response to chronic L-nicotine treatment.

1997 • 63 citations

The potential role of cotinine in the cognitive and neuroprotective actions of nicotine

2003 • 63 citations

Deficiency in Methionine, Tryptophan, Isoleucine, or Choline Induces Apoptosis in Cultured Cells

2002 • 62 citations

Nicotine increases the expression of high affinity nerve growth factor receptors in both in vitro and in vivo

2002 • 53 citations

Pharmacological characteristics of facilitation of hippocampal population spikes by cholinomimetics

1982 • 52 citations

Nicotine stimulation of nerve growth factor receptor expression

1994 • 52 citations

Long-lasting inactivation of nicotinic receptor function in vitro by treatment with high concentrations of nicotine

1998 • 51 citations

Cotinine binding to nicotinic acetylcholine receptors in bovine chromaffin cell and rat brain membranes

2001 • 51 citations

Dose‐specific improvements in memory‐related task performance by rats and aged monkeys administered the nicotinic‐cholinergic antagonist mecamylamine

1999 • 47 citations

Cotinine Selectively Activates a Subpopulation of α3/α6β2 Nicotinic Receptors in Monkey Striatum

2008 • 47 citations

Chronic Nicotinic Agonist and Antagonist Effects on T-maze Alternation

1997 • 44 citations

Fear and escape reaction evoked by the intrahypothalamic injection of D-tubocurarine in unrestrained cats.

1969 • 44 citations

Dose-specific improvements in memory-related task performance by rats and aged monkeys administered the nicotinic-cholinergic antagonist mecamylamine

1999 • 39 citations

The effects of JWB1-84-1 on memory-related task performance by amyloid Aβ transgenic mice and by young and aged monkeys

2007 • 35 citations

Differential improvement in memory-related task performance with nicotine by aged male and female rhesus monkeys

1999 • 35 citations

Disconnection between activation and desensitization of autonomic nicotinic receptors by nicotine and cotinine

2006 • 34 citations

Beyond In Vitro Data: A Review of In Vivo Evidence Regarding the Allosteric Potentiating Effect of Galantamine on Nicotinic Acetylcholine Receptors in Alzheimer's Neuropathology

2007 • 31 citations

Gain of function mutation of the α7 nicotinic receptor: distinct pharmacology of the human α7V274T variant

1999 • 29 citations

Excitation of rat hippocampal interneurons via modulation of endogenous agonist activity at the α7 nicotinic ACh receptor

2006 • 28 citations

Neurotoxicity of channel mutations in heterologously expressed α7‐nicotinic acetylcholine receptors

2001 • 26 citations

Opposing influences on behavior mediated by muscarinic and nicotinic receptors in the rat posterior hypothalamic nucleus

1980 • 12 citations

MHP-133, a Drug with Multiple CNS Targets: Potential for Neuroprotection and Enhanced Cognition

2007 • 7 citations

Effect of lipopolysaccharide on the physical conformation of the erythrocyte cytoskeletal proteins

1994 • 5 citations