Identification of a New Component of the Agonist Binding Site of the Nicotinic α7 Homooligomeric Receptor

High-efficiency transformation of mammalian cells by plasmid DNA.

1987 • 5,377 citations

Molecular cloning, functional properties, and distribution of rat brain alpha 7: a nicotinic cation channel highly permeable to calcium

1993 • 1,455 citations

A neuronal nicotinic acetylcholine receptor subunit (α7) is developmentally regulated and forms a homo-oligomeric channel blocked by α-BTX

1990 • 923 citations

α9: An acetylcholine receptor with novel pharmacological properties expressed in rat cochlear hair cells

1994 • 869 citations

Both alpha- and beta-subunits contribute to the agonist sensitivity of neuronal nicotinic acetylcholine receptors

1991 • 552 citations

Brain α-bungarotoxin binding protein cDNAs and MAbs reveal subtypes of this branch of the ligand-gated ion channel gene superfamily

1990 • 471 citations

Chimaeric nicotinic–serotonergic receptor combines distinct ligand binding and channel specificities

1993 • 401 citations

Rapid isolation of plasma membranes in high yield from cultured fibroblasts

1977 • 304 citations

Molecular basis of the two nonequivalent ligand binding sites of the muscle nicotinic acetylcholine receptor

1989 • 279 citations

d-Tubocurarine binding sites are located at alpha-gamma and alpha-delta subunit interfaces of the nicotinic acetylcholine receptor.

1990 • 256 citations

Equilibrium binding of [3H]tubocurarine and [3H]acetylcholine by torpedo postsynaptic membranes: stoichiometry and ligand interactions

1979 • 243 citations

Point mutations affecting antagonist affinity and agonist dependent gating of GABAA receptor channels.

1992 • 203 citations

Neurotransmitter-gated ion channels as unconventional allosteric proteins

1994 • 197 citations

Alpha 5, alpha 3, and non-alpha 3. Three clustered avian genes encoding neuronal nicotinic acetylcholine receptor-related subunits.

1990 • 191 citations

Molecular dissection of subunit interfaces in the acetylcholine receptor: identification of residues that determine curare selectivity.

1993 • 186 citations

Binding of Naja nigricollis (3H)alpha-toxin to membrane fragments from Electrophorus and Torpedo electric organs. I. Binding of the tritiated alpha-neurotoxin in the absence of effector.

1974 • 170 citations

Functional significance of aromatic amino acids from three peptide loops of the α7 neuronal nicotinic receptor site investigated by site‐directed mutagenesis

1991 • 168 citations

Identification of a [3H]muscimol photoaffinity substrate in the bovine gamma-aminobutyric acidA receptor alpha subunit.

1994 • 162 citations

Homomeric and native α7 acetylcholine receptors exhibit remarkably similar but non‐identical pharmacological properties, suggesting that the native receptor is a heteromeric protein complex

1993 • 122 citations

Negatively charged amino acid residues in the nicotinic receptor delta subunit that contribute to the binding of acetylcholine.

1993 • 117 citations

Promoter-cDNA-directed heterologous protein expression in Xenopus laevis oocytes.

1992 • 116 citations

Allosteric transitions of the acetylcholine receptor probed at the amino acid level with a photolabile cholinergic ligand.

1991 • 101 citations

Electrophysiology of Neuronal Nicotinic Acetylcholine Receptors Expressed in Xenopus Oocytes following Nuclear Injection of Genes or cDNAs

1991 • 91 citations

Agonist binding site of Torpedo electric tissue nicotinic acetylcholine receptor. A negatively charged region of the delta subunit within 0.9 nm of the alpha subunit binding site disulfide.

1991 • 80 citations

Crosslinking of α‐bungarotoxin to the acetylcholine receptor from Torpedo marmorata by ultraviolet light irradiation

1982 • 79 citations

Characterization of d-tubocurarine binding site of Torpedo acetylcholine receptor

1994 • 59 citations

Ligand-gated ion channels

1990 • 59 citations

Agonist and antagonist effects of nicotine on chick neuronal nicotinic receptors are defined by alpha and beta subunits

1994 • 58 citations