Nicotine is a Selective Pharmacological Chaperone of Acetylcholine Receptor Number and Stoichiometry. Implications for Drug Discovery

Intracellular pH.

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A variant associated with nicotine dependence, lung cancer and peripheral arterial disease

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2008 • 1,287 citations

A susceptibility locus for lung cancer maps to nicotinic acetylcholine receptor subunit genes on 15q25

2008 • 1,264 citations

A missense mutation in the neuronal nicotinic acetylcholine receptor α4 subunit is associated with autosomal dominant nocturnal frontal lobe epilepsy

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Interaction of Tetraethylammonium Ion Derivatives with the Potassium Channels of Giant Axons

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Cholinergic nicotinic receptor genes implicated in a nicotine dependence association study targeting 348 candidate genes with 3713 SNPs

2006 • 838 citations

Brain nicotinic acetylcholine receptors: native subtypes and their relevance

2006 • 838 citations

Guidelines on nicotine dose selection for in vivo research

2006 • 783 citations

Nicotine Activation of α4* Receptors: Sufficient for Reward, Tolerance, and Sensitization

2004 • 685 citations

Variants in Nicotinic Receptors and Risk for Nicotine Dependence

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Novel genes identified in a high-density genome wide association study for nicotine dependence

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Nicotine binding and nicotinic receptor subunit RNA after chronic nicotine treatment

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Nicotinic Cholinergic Receptor Binding Sites in the Brain: Regulation in Vivo

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Nicotine's Defensive Function in Nature

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α-5/α-3 nicotinic receptor subunit alleles increase risk for heavy smoking

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Effects of chronic nicotine infusion on tolerance development and nicotinic receptors.

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Desensitization of neuronal nicotinic receptors

2002 • 447 citations

The pH of the Secretory Pathway: Measurement, Determinants, and Regulation

2004 • 441 citations

It is not “either/or”: Activation and desensitization of nicotinic acetylcholine receptors both contribute to behaviors related to nicotine addiction and mood

2007 • 427 citations

Alternate Stoichiometries of α4β2 Nicotinic Acetylcholine Receptors

2003 • 406 citations

Effect of smoking history on [3H]nicotine binding in human postmortem brain.

1997 • 382 citations

Nicotine-induced increase in neuronal nicotinic receptors results from a decrease in the rate of receptor turnover.

1994 • 381 citations

Chronic Exposure to Nicotine Upregulates the Human α4β2 Nicotinic Acetylcholine Receptor Function

2001 • 355 citations

Cigarette Smoking Saturates Brain α4β2 Nicotinic Acetylcholine Receptors

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Increased nicotinic receptors in brains from smokers: membrane binding and autoradiography studies.

1999 • 353 citations

Nicotine binding to brain receptors requires a strong cation–π interaction

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Nicotinic receptor subtypes and cognitive function

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Pooled Analysis of Tobacco Use and Risk of Parkinson Disease

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Smoking, nicotine and Parkinson's disease

2004 • 309 citations

Cation−π Interactions in Ligand Recognition by Serotonergic (5-HT_3A) and Nicotinic Acetylcholine Receptors: The Anomalous Binding Properties of Nicotine

2002 • 297 citations

Presynaptic Nicotinic Modulation of Dopamine Release in the Three Ascending Pathways Studied by In Vivo Microdialysis: Comparison of Naive and Chronic Nicotine‐Treated Rats

1997 • 288 citations

A Candidate Gene Approach Identifies the CHRNA5-A3-B4 Region as a Risk Factor for Age-Dependent Nicotine Addiction

2008 • 270 citations

Nicotine Acts as a Pharmacological Chaperone to Up-Regulate Human α4β2 Acetylcholine Receptors

2005 • 268 citations

Chronic Nicotine Cell Specifically Upregulates Functional α4* Nicotinic Receptors: Basis for Both Tolerance in Midbrain and Enhanced Long-Term Potentiation in Perforant Path

2007 • 263 citations

Nicotine Upregulates Its Own Receptors through Enhanced Intracellular Maturation

2005 • 255 citations

Nicotine addiction: the possible role of functional upregulation

2002 • 247 citations

Identification of SLURP-1 as an epidermal neuromodulator explains the clinical phenotype of Mal de Meleda

2003 • 241 citations

Regulation of Nicotinic Acetylcholine Receptor Numbers and Function by Chronic Nicotine Exposure

2002 • 233 citations

Human and Rodent Bronchial Epithelial Cells Express Functional Nicotinic Acetylcholine Receptors

1998 • 233 citations

The role of mu opioid receptor desensitization and endocytosis in morphine tolerance and dependence

2007 • 229 citations

Decreased Signs of Nicotine Withdrawal in Mice Null for the β4 Nicotinic Acetylcholine Receptor Subunit

2004 • 221 citations

Genetic variation in the CHRNA5 gene affects mRNA levels and is associated with risk for alcohol dependence

2008 • 220 citations

Resistance management in a native plant: nicotine prevents herbivores from compensating for plant protease inhibitors

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Monte Carlo simulation of miniature endplate current generation in the vertebrate neuromuscular junction

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Human Tobacco Smokers in Early Abstinence Have Higher Levels of β₂* Nicotinic Acetylcholine Receptors than Nonsmokers

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Four Pharmacologically Distinct Subtypes of α4β2 Nicotinic Acetylcholine Receptor Expressed inXenopus laevisOocytes

1998 • 207 citations

Novel Modulation of Neuronal Nicotinic Acetylcholine Receptors by Association with the Endogenous Prototoxin lynx1

2002 • 201 citations

Differential Role of Nicotinic Acetylcholine Receptor Subunits in Physical and Affective Nicotine Withdrawal Signs

2008 • 197 citations

Chronic Nicotine Exposure Upregulates Nicotinic Receptors by a Novel Mechanism

2005 • 197 citations

Assembly of α4β2 Nicotinic Acetylcholine Receptors Assessed with Functional Fluorescently Labeled Subunits: Effects of Localization, Trafficking, and Nicotine-Induced Upregulation in Clonal Mammalian Cells and in Cultured Midbrain Neurons

2003 • 191 citations

Nicotinic Receptor Gene Variants Influence Susceptibility to Heavy Smoking

2008 • 190 citations

Roles of Accessory Subunits in α4β2^*Nicotinic Receptors

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Chronic Nicotine Treatment Up-regulates Human α3β2 but Not α3β4 Acetylcholine Receptors Stably Transfected in Human Embryonic Kidney Cells

1998 • 184 citations

Dose‐related neuroprotective effects of chronic nicotine in 6‐hydroxydopamine treated rats, and loss of neuroprotection in α4 nicotinic receptor subunit knockout mice

2001 • 182 citations

Smoking and Parkinson’s disease in twins

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Numerical reconstruction of the quantal event at nicotinic synapses

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Point mutant mice with hypersensitive α4 nicotinic receptors show dopaminergic deficits and increased anxiety

2001 • 180 citations

Stable expression, pharmacologic properties and regulation of the human neuronal nicotinic acetylcholine alpha 4 beta 2 receptor.

1996 • 172 citations

How Mutations in the nAChRs Can Cause ADNFLE Epilepsy

2002 • 172 citations

Human α4β2 Acetylcholine Receptors Formed from Linked Subunits

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An Adaptable Standard for Protein Export from the Endoplasmic Reticulum

2007 • 159 citations

The Prototoxin lynx1 Acts on Nicotinic Acetylcholine Receptors to Balance Neuronal Activity and Survival In Vivo

2006 • 153 citations

Subtype-Selective Up-Regulation by Chronic Nicotine of High-Affinity Nicotinic Receptors in Rat Brain Demonstrated by Receptor Autoradiography

2003 • 151 citations

Agonist-induced up-regulation of alpha4beta2 nicotinic acetylcholine receptors in M10 cells: pharmacological and spatial definition.

1998 • 150 citations

A Risk Allele for Nicotine Dependence in CHRNA5 Is a Protective Allele for Cocaine Dependence

2008 • 149 citations

Familial Aggregation of Common Sequence Variants on 15q24-25.1 in Lung Cancer

2008 • 148 citations

Association of a single nucleotide polymorphism in neuronal acetylcholine receptor subunit alpha 5 (CHRNA5) with smoking status and with ‘pleasurable buzz’ during early experimentation with smoking

2008 • 142 citations

Biological Effects of SLURP-1 on Human Keratinocytes

2005 • 142 citations

The Permeation Pathway of Neurotransmitter-Gated Ion Channels

1992 • 142 citations

Rapsyn Escorts the Nicotinic Acetylcholine Receptor Along the Exocytic Pathway via Association with Lipid Rafts

2002 • 140 citations

Risk and protective factors for Parkinson's disease: A study in Swedish twins

2004 • 134 citations

Mice Homozygous for the L250T Mutation in the α7 Nicotinic Acetylcholine Receptor Show Increased Neuronal Apoptosis and Die Within 1 Day of Birth

2000 • 133 citations

Activated Cholinergic Signaling Provides a Target in Squamous Cell Lung Carcinoma

2008 • 132 citations

Developmental regulation of nicotinic acetylcholine receptors within midbrain dopamine neurons

2006 • 131 citations

Nicotine prevents striatal dopamine loss produced by 6-hydroxydopamine lesion in the substantia nigra11Published on the World Wide Web on 1 December 2000.

2001 • 131 citations

The α4β2α5 nicotinic cholinergic receptor in rat brain is resistant to up‐regulation by nicotine in vivo

2007 • 130 citations

Two pharmacologically distinct components of nicotinic receptor-mediated rubidium efflux in mouse brain require the beta2 subunit.

1999 • 129 citations

Chronic nicotine and mecamylamine treatment increase brain nicotinic receptor binding without changing alpha 4 or beta 2 mRNA levels.

1996 • 126 citations

Using Physical Chemistry To Differentiate Nicotinic from Cholinergic Agonists at the Nicotinic Acetylcholine Receptor

2004 • 117 citations

Developmental Excitation of Corticothalamic Neurons by Nicotinic Acetylcholine Receptors

2008 • 98 citations

The channel‐blocking action of methonium compounds on rat submandibular ganglion cells

1997 • 98 citations

Subcellular Trafficking, Pentameric Assembly, and Subunit Stoichiometry of Neuronal Nicotinic Acetylcholine Receptors Containing Fluorescently Labeled α6 and β3 Subunits

2007 • 97 citations

An Angstrom Scale Interaction between Plasma Membrane ATP-Gated P2X₂and α₄β₂Nicotinic Channels Measured with Fluorescence Resonance Energy Transfer and Total Internal Reflection Fluorescence Microscopy

2005 • 97 citations

The channel‐blocking action of methonium compounds on rat submandibular ganglion cells

1984 • 97 citations

Brain nicotinic acetylcholine receptor occupancy: effect of smoking a denicotinized cigarette

2008 • 95 citations

Identification of Sequence Motifs That Target Neuronal Nicotinic Receptors to Dendrites and Axons

2006 • 94 citations

The role of nicotinic receptors in B-lymphocyte development and activation

2007 • 92 citations

Nicotine neuroprotection against nigrostriatal damage: importance of the animal model

2007 • 90 citations

Patterns of internal and external tetraethylammonium block in four homologous K+ channels.

1991 • 87 citations

Temporal Change in Human Nicotinic Acetylcholine Receptor After Smoking Cessation: 5IA SPECT Study

2007 • 85 citations

Binding and functional activity of nicotinic cholinergic receptors in selected rat brain regions are increased following long‐term but not short‐term nicotine treatment

2004 • 84 citations

Nicotinic α5 subunit deletion locally reduces high‐affinity agonist activation without altering nicotinic receptor numbers

2007 • 84 citations

Five ADNFLE Mutations Reduce the Ca²⁺ Dependence of the Mammalian α4β2 Acetylcholine Response

2003 • 82 citations

The Quaternary Lidocaine Derivative, QX-314, Produces Long-lasting Local Anesthesia in Animal Models In Vivo

2007 • 82 citations

Nicotinic receptors regulate B lymphocyte activation and immune response

2005 • 80 citations

An Extracellular Protein Microdomain Controls Up-regulation of Neuronal Nicotinic Acetylcholine Receptors by Nicotine

2004 • 79 citations

Heterogeneity of Nicotinic Cholinergic Receptors in Rat Superior Cervical and Nodose Ganglia

2006 • 77 citations

Exocytic Trafficking Is Required for Nicotine-induced Up-regulation of α4β2 Nicotinic Acetylcholine Receptors

2005 • 76 citations

Adjacent Basic Amino Acid Residues Recognized by the COP I Complex and Ubiquitination Govern Endoplasmic Reticulum to Cell Surface Trafficking of the Nicotinic Acetylcholine Receptor α-Subunit

2001 • 75 citations

Nicotine as an Antiepileptic Agent in ADNFLE: An N‐of‐One Study

2003 • 75 citations

β3 Subunits Promote Expression and Nicotine-Induced Up-Regulation of Human Nicotinic α6^* Nicotinic Acetylcholine Receptors Expressed in Transfected Cell Lines

2006 • 70 citations

Single-Molecule Imaging of a Fluorescent Unnatural Amino Acid Incorporated Into Nicotinic Receptors

2009 • 69 citations

Smoking and Parkinson's disease

1994 • 64 citations

SLURP-1 and -2 in normal, immortalized and malignant oral keratinocytes

2007 • 62 citations

Family-based case-control study of cigarette smoking and Parkinson disease

2005 • 59 citations

Tobacco habits modulate autosomal dominant nocturnal frontal lobe epilepsy

2006 • 58 citations

Chronic nicotine treatment partly protects against the 1‐methyl‐4‐phenyl‐2, 3, 6‐tetrahydropyridine‐induced degeneration of nigrostriatal dopamine neurons in the black mouse

1988 • 57 citations

The nicotinic receptor antagonists abolish pathobiologic effects of tobacco-derived nitrosamines on BEP2D cells

2006 • 53 citations

Chronic neonatal nicotine upregulates heteromeric nicotinic acetylcholine receptor binding without change in subunit mRNA expression

2006 • 52 citations

Quaternary Ammonium Derivative of Lidocaine as a Long-acting Local Anesthetic

1995 • 51 citations

Nicotine partially protects against paraquat‐induced nigrostriatal damage in mice; link to α6β2* nAChRs

2006 • 50 citations

Regulation of nicotinic receptors in rat brain following quasi‐irreversible nicotinic blockade by chlorisondamine and chronic treatment with nicotine

1994 • 50 citations

Pharmacological and kinetic properties of alpha 4 beta 2 neuronal nicotinic acetylcholine receptors expressed in Xenopus oocytes.

1992 • 48 citations

Attenuated disruption of prepulse inhibition by dopaminergic stimulation after maternal deprivation and adolescent corticosterone treatment in rats

2007 • 47 citations

Rapid Activity-Driven SNARE-Dependent Trafficking of Nicotinic Receptors on Somatic Spines

2005 • 43 citations

Cell autonomy, receptor autonomy, and thermodynamics in nicotine receptor up-regulation

2007 • 41 citations

Nicotine responses in hypersensitive and knockout α4 mice account for tolerance to both hypothermia and locomotor suppression in wild-type mice

2007 • 40 citations

Mutations Linked to Autosomal Dominant Nocturnal Frontal Lobe Epilepsy Affect Allosteric Ca²⁺ Activation of the α4β2 Nicotinic Acetylcholine Receptor

2005 • 39 citations

Untranslated Region-Dependent Exclusive Expression of High-Sensitivity Subforms of α4β2 and α3β2 Nicotinic Acetylcholine Receptors

2006 • 35 citations

Selective deletion of the α5 subunit differentially affects somatic–dendritic versus axonally targeted nicotinic ACh receptors in mouse

2004 • 32 citations

Expression of lynx1 in developing lung and its modulation by prenatal nicotine exposure

2005 • 31 citations

Cyclic AMP-dependent protein kinase A and protein kinase C phosphorylate α4β2 nicotinic receptor subunits at distinct stages of receptor formation and maturation

2008 • 30 citations

Role of the Agonist Binding Site in Up-Regulation of Neuronal Nicotinic α4β2 Receptors

2006 • 29 citations

Demonstration of functional α4-containing nicotinic receptors in the medial habenula

2008 • 25 citations

Chronic pre-treatment with nicotine enhances nicotine-evoked striatal dopamine release and α6 and β3 nicotinic acetylcholine receptor subunit mRNA in the substantia nigra pars compacta of the rat

2005 • 23 citations

On the mechanisms of 14C-nicotine distribution in rat submaxillary gland in vitro.

1971 • 22 citations