Nicotinic interactions with antipsychotic drugs, models of schizophrenia and impacts on cognitive function

A meta-analysis of worldwide studies demonstrates an association between schizophrenia and tobacco smoking behaviors

2005 • 1,198 citations

Prevalence of smoking among psychiatric outpatients

1986 • 1,059 citations

The Effects of Clozapine, Risperidone, and Olanzapine on Cognitive Function in Schizophrenia

1999 • 1,012 citations

Nicotinic effects on cognitive function: behavioral characterization, pharmacological specification, and anatomic localization

2005 • 797 citations

Schizophrenia, Sensory Gating, and Nicotinic Receptors

1998 • 697 citations

Normalization of auditory physiology by cigarette smoking in schizophrenic patients

1993 • 689 citations

Evidence in postmortem brain tissue for decreased numbers of hippocampal nicotinic receptors in schizophrenia

1995 • 676 citations

Nicotine Dependence in Schizophrenia: Clinical Phenomena and Laboratory Findings

1998 • 502 citations

Nicotinic Cholinergic Receptor Binding Sites in the Brain: Regulation in Vivo

1983 • 478 citations

Effects of chronic nicotine infusion on tolerance development and nicotinic receptors.

1983 • 455 citations

Association of Promoter Variants in the α7 Nicotinic Acetylcholine Receptor Subunit Gene With an Inhibitory Deficit Found in Schizophrenia

2002 • 446 citations

Does risperidone improve verbal working memory in treatment-resistant schizophrenia?

1997 • 406 citations

Improvement in cognitive functions and psychiatric symptoms in treatment-refractory schizophrenic patients receiving clozapine

1993 • 403 citations

Effects of nicotinic stimulation on cognitive performance

2003 • 401 citations

Nicotine-Haloperidol Interactions and Cognitive Performance in Schizophrenics

1996 • 346 citations

Alpha-7 nicotinic receptor agonists: potential new candidates for the treatment of schizophrenia

2004 • 338 citations

Effects of Cigarette Smoking on Spatial Working Memory and Attentional Deficits in Schizophrenia

2005 • 331 citations

Decreased protein level of nicotinic receptor α7 subunit in the frontal cortex from schizophrenic brain

1999 • 280 citations

Nicotinic System Involvement in Alzheimer??s and Parkinson??s Diseases

1997 • 265 citations

Nicotine Induces Glutamate Release from Thalamocortical Terminals in Prefrontal Cortex

2003 • 259 citations

Effects of Cigarette Smoking and Nicotine Nasal Spray on Psychiatric Symptoms and Cognition In Schizophrenia

2002 • 245 citations

Effects of Nicotine on Cognitive Deficits in Schizophrenia

2004 • 239 citations

Effect of subtype selective nicotinic compounds on attention as assessed by the five-choice serial reaction time task

2000 • 235 citations

Presynaptic nicotinic receptors modulating dopamine release in the rat striatum

2000 • 234 citations

Haloperidol increases smoking in patients with schizophrenia

1995 • 230 citations

Effects of Smoking Abstinence on Visuospatial Working Memory Function in Schizophrenia

2002 • 229 citations

Nicotine effects on brain function and functional connectivity in schizophrenia

2004 • 228 citations

The Selective α7 Nicotinic Acetylcholine Receptor Agonist PNU-282987 [N-[(3R)-1-Azabicyclo[2.2.2]oct-3-yl]-4-chlorobenzamide Hydrochloride] Enhances GABAergic Synaptic Activity in Brain Slices and Restores Auditory Gating Deficits in Anesthetized Rats

2004 • 223 citations

The α7-nicotinic acetylcholine receptor and the pathology of hippocampal interneurons in schizophrenia

2000 • 216 citations

Nicotine Improves Sustained Attention in Mice: Evidence for Involvement of the α7 Nicotinic Acetylcholine Receptor

2004 • 213 citations

Improved learning and memory in aged rats with chronic administration of the nicotinic receptor agonist GTS-21

1995 • 203 citations

Genetic Correlation of Inhibitory Gating of Hippocampal Auditory Evoked Response and α-Bungarotoxin-Binding Nicotinic Cholinergic Receptors in Inbred Mouse Strains

1996 • 202 citations

Chapter 15 Presynaptic modulation of transmitter release by nicotinic receptors

1989 • 200 citations

Clozapine decreases smoking in patients with chronic schizophrenia

1995 • 200 citations

Nicotinic receptor mechanisms and cognition in normal states and neuropsychiatric disorders

2004 • 199 citations

AR-R 17779, an α7 nicotinic agonist, improves learning and memory in rats

1999 • 195 citations

Development of nicotinic drug therapy for cognitive disorders

2000 • 182 citations

Smoking and schizophrenia: abnormal nicotinic receptor expression

2000 • 179 citations

Higher Rates of Cigarette Smoking in Male Adolescents Before the Onset of Schizophrenia: A Historical-Prospective Cohort Study

2004 • 175 citations

The safety profile of nefazodone.

1996 • 165 citations

The in vivo effects of olanzapine and other antipsychotic agents on receptor occupancy and antagonism of dopamine D 1 , D 2 , D 3 , 5HT 2A and muscarinic receptors

1999 • 158 citations

Cognitive function in schizophrenia

1997 • 138 citations

The Effects of Clozapine on Symptom Reduction, Neurocognitive Function, and Clinical Management in Treatment-Refractory State Hospital Schizophrenic Inpatients

1996 • 135 citations

Nicotine dependence and symptoms in schizophrenia

2005 • 135 citations

Attentional effects of nicotinic agonists in rats

2003 • 133 citations

Tropisetron improves deficits in auditory P50 suppression in schizophrenia

2005 • 129 citations

Cognitive Function in Schizophrenia— Do Neuroleptics Make a Difference?

1997 • 128 citations

Clozapine improves deficient inhibitory auditory processing in DBA/2 mice, via a nicotinic cholinergic mechanism

2003 • 123 citations

Effects of neuroleptic medications on the cognition of patients with schizophrenia: a review of recent studies.

1996 • 121 citations

Muscarinic and nicotinic receptor modulation of object and spatial -back working memory in humans

2005 • 120 citations

A comparison of the effect of clozapine with typical neuroleptics on cognitive function in neuroleptic-responsive schizophrenia

1999 • 118 citations

The Cognitive Efficacy of Atypical Antipsychotics in Schizophrenia

1998 • 112 citations

Human post-mortem striatal α4β2 nicotinic acetylcholine receptor density in schizophrenia and Parkinson's syndrome

2000 • 111 citations

Evidence of Association between Smoking and α7 Nicotinic Receptor Subunit Gene in Schizophrenia Patients

2004 • 108 citations

Neuropsychologic Deficits in Schizophrenia Relation to Social Function and Effect of Antipsychotic Drug Treatment

1996 • 106 citations

Nicotinic Acetylcholine Receptors as Drug Targets

2004 • 106 citations

Nicotine and Nicotinic Receptor Involvement in Neuropsychiatric Disorders

2004 • 104 citations

Nicotinic receptors and schizophrenia

2004 • 103 citations

Differential effect of antipsychotics on place navigation of rats in the Morris water maze

1996 • 100 citations

The effects of clozapine on cognitive functioning in schizophrenia.

1999 • 94 citations

Nicotine–Dizocilpine Interactions and Working and Reference Memory Performance of Rats in the Radial-Arm Maze

1998 • 89 citations

Tobacco use in schizophrenia: a study of cotinine concentrations in the saliva of patients and controls

2004 • 87 citations

Schizophrenia and smoking: Evidence for a common neurobiological basis?

2000 • 87 citations

The effects of nicotine on specific eye tracking measures in schizophrenia

2002 • 86 citations

Nicotine improves delayed recognition in schizophrenic patients

2004 • 86 citations

Effects of Nicotine on Leading Saccades during Smooth Pursuit Eye Movements in Smokers and Nonsmokers with Schizophrenia

2003 • 83 citations

Improved P50 Auditory Gating With Ondansetron in Medicated Schizophrenia Patients

2005 • 82 citations

Differential effects of cigarette smoking on performance of a smooth pursuit and a saccadic eye movement task in schizophrenia

2003 • 77 citations

Transdermal nicotine administration enhances automatic auditory processing reflected by mismatch negativity

2005 • 75 citations

Group Treatment for Smoking Cessation Among Persons With Schizophrenia

1998 • 74 citations

Effects of antipsychotics on cognitive behaviour in rats using the delayed non-match to position paradigm

1995 • 72 citations

Nicotine Interactions with Haloperidol, Clozapine and Risperidone and Working Memory Function in Rats

2002 • 71 citations

Nicotine reduces antisaccade errors in task impaired schizophrenic subjects

2004 • 68 citations

Linkage of M5 Muscarinic and α7-Nicotinic Receptor Genes on 15q13 to Schizophrenia

2004 • 68 citations

Clozapine modulates midbrain dopamine neuron firing via interaction with the NMDA receptor complex

2004 • 67 citations

The effects of clozapine on neurocognition: an overview.

1994 • 66 citations

Cholinergic—dopaminergic interactions in radial-arm maze performance

1988 • 64 citations

Nicotinic–glutamatergic interactions and attentional performance on an operant visual signal detection task in female rats

2003 • 62 citations

Nicotine–antipsychotic drug interactions and attentional performance in female rats

2004 • 58 citations

DMXB, an ?7 nicotinic agonist, normalizes auditory gating in isolation-reared rats

2003 • 57 citations

fMRI of Response to Nicotine During a Smooth Pursuit Eye Movement Task in Schizophrenia

2005 • 56 citations

Measurement and treatment research to improve cognition in schizophrenia: neuropharmacological aspects

2004 • 56 citations

Reversal of isolation-rearing-induced PPI deficits by an α7 nicotinic receptor agonist

2005 • 54 citations

Occupancy of dopamine D2 receptors by antipsychotic drugs is related to nicotine addiction in young patients with schizophrenia

2005 • 53 citations

Nicotinic acetylcholine receptor system and neuropsychiatric disorders.

2004 • 51 citations

Chronic neuroleptics alter the effects of the D1 agonist SK&F 38393 and the D2 agonist LY171555 on oral movements in rats

1988 • 47 citations

Clozapine Reverses the Spatial Working Memory Deficits Induced by FG7142 in Monkeys

1997 • 47 citations

Discovery of the α7 Nicotinic Acetylcholine Receptor Agonists. (R)-3‘-(5-Chlorothiophen-2-yl)spiro-1-azabicyclo[2.2.2]octane-3,5‘-[1‘,3‘]oxazolidin-2‘-one as a Novel, Potent, Selective, and Orally Bioavailable Ligand

2005 • 46 citations

Chronic haloperidol effects on oral movements and radial-arm maze performance in rats

1987 • 43 citations

Nicotine and clozapine effects on attentional performance impaired by the NMDA antagonist dizocilpine in female rats

2007 • 42 citations

Antipsychotic clozapine inhibits the function of α7-nicotinic acetylcholine receptors

2006 • 39 citations

Anabasine, a selective nicotinic acetylcholine receptor agonist, antagonizes MK-801-elicited mouse popping behavior, an animal model of schizophrenia

2004 • 39 citations

Inhibitory Action of Clozapine on Rat Ventral Tegmental Area Dopamine Neurons Following Increased Levels of Endogenous Kynurenic Acid

2003 • 38 citations

Long-Term Upregulation of Protein Kinase A and Adenylate Cyclase Levels in Human Smokers

2007 • 36 citations

Nicotinic–serotonergic drug interactions and attentional performance in rats

2005 • 34 citations

Chronic nicotine interactions with clozapine and risperidone and attentional function in rats

2005 • 33 citations

Persistence of nicotinic agonist RJR 2403‐induced working memory improvement in rats

2002 • 32 citations

Ketanserin attenuates nicotine-induced working memory improvement in rats

2005 • 30 citations

Chronic Haloperidol Administration Does Not Block Acute Nicotine-Induced Improvements in Radial-Arm Maze Performance in the Rat

1997 • 30 citations

Olanzapine interactions with nicotine and mecamylamine in rats: Effects on memory function

2005 • 28 citations

Nicotinic receptor-mediated regulation of the dopamine transporter in rat prefrontocortical slices following chronic in vivo administration of nicotine

2003 • 28 citations

A Nicotinic Cholinergic Agonist (GTS - 21) andEyeblink Classical Conditioning: Acquisition, Retention, and Relearning in Older Rabbits

2000 • 27 citations

Therapeutic implications of a selective alpha7 nicotinic receptor abnormality in schizophrenia.

2005 • 23 citations

Lobeline-induced learning improvement of rats in the radial-arm maze

2003 • 18 citations

Does nicotine affect D2 receptor upregulation? A case–control study

2004 • 18 citations

[Clozapine: neuropsychological and neuroimaging studies].

1999 • 5 citations