Detection and trapping of intermediate states priming nicotinic receptor channel opening

Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches

1981 • 18,584 citations

Single-Channel Recording

1995 • 2,565 citations

Production of high-titer helper-free retroviruses by transient transfection.

1993 • 2,280 citations

Fitting and Statistical Analysis of Single-Channel Records

1983 • 1,098 citations

Nicotine and Carbamylcholine Binding to Nicotinic Acetylcholine Receptors as Studied in AChBP Crystal Structures

2004 • 778 citations

Fast events in single‐channel currents activated by acetylcholine and its analogues at the frog muscle end‐plate.

1985 • 768 citations

On the stochastic properties of single ion channels

1981 • 667 citations

Structures of Aplysia AChBP complexes with nicotinic agonists and antagonists reveal distinctive binding interfaces and conformations

2005 • 617 citations

Interaction at end-plate receptors between different choline derivatives

1957 • 477 citations

Estimating single-channel kinetic parameters from idealized patch-clamp data containing missed events

1996 • 432 citations

Fluctuations in the microsecond time range of the current through single acetylcholine receptor ion channels

1981 • 366 citations

On the nature of partial agonism in the nicotinic receptor superfamily

2008 • 335 citations

Congenital Myasthenic Syndrome Caused by Decreased Agonist Binding Affinity Due to a Mutation in the Acetylcholine Receptor ε Subunit

1996 • 234 citations

Activation of acetylcholine receptors on clonal mammalian BC3H‐1 cells by high concentrations of agonist.

1987 • 194 citations

Activation of Torpedo acetylcholine receptors expressed in mouse fibroblasts. Single channel current kinetics reveal distinct agonist binding affinities.

1990 • 193 citations

Single-Channel Behavior of Heteromeric α1β Glycine Receptors: An Attempt to Detect a Conformational Change before the Channel Opens

2004 • 186 citations

Functional differences among nonerythroid anion exchangers expressed in a transfected human cell line

1991 • 180 citations

Mutation in the M1 Domain of the Acetylcholine Receptor α Subunit Decreases the Rate of Agonist Dissociation

1997 • 137 citations

Activation of acetylcholine receptors on clonal mammalian BC3H‐1 cells by low concentrations of agonist.

1986 • 123 citations

Initial Coupling of Binding to Gating Mediated by Conserved Residues in the Muscle Nicotinic Receptor

2005 • 115 citations

Opening rate of acetylcholine receptor channels

1991 • 93 citations

Kinetic, Mechanistic, and Structural Aspects of Unliganded Gating of Acetylcholine Receptor Channels

2000 • 72 citations

The channel opening rate of adult‐ and fetal‐type mouse muscle nicotinic receptors activated by acetylcholine

1998 • 59 citations

Acetylcholine receptor activation by a site‐selective ligand: nature of brief open and closed states in BC3H‐1 cells.

1986 • 52 citations

Nicotinic Receptor Interloop Proline Anchors β1-β2 and Cys loops in Coupling Agonist Binding to Channel Gating

2008 • 49 citations

Invariant Aspartic Acid in Muscle Nicotinic Receptor Contributes Selectively to the Kinetics of Agonist Binding

2004 • 39 citations

An Intersubunit Trigger of Channel Gating in the Muscle Nicotinic Receptor

2007 • 37 citations