Modular Design of Cys-loop Ligand-gated Ion Channels: Functional 5-HT3 and GABA ρ1 Receptors Lacking the Large Cytoplasmic M3M4 Loop

Why are ?natively unfolded? proteins unstructured under physiologic conditions?

2000 • 2,020 citations

GABA_A Receptor Channels

1994 • 1,948 citations

Crystal structure of an ACh-binding protein reveals the ligand-binding domain of nicotinic receptors

2001 • 1,736 citations

Refined Structure of the Nicotinic Acetylcholine Receptor at 4Å Resolution

2004 • 1,626 citations

Structure and gating mechanism of the acetylcholine receptor pore

2003 • 1,261 citations

Sites of alcohol and volatile anaesthetic action on GABAA and glycine receptors

1997 • 1,223 citations

Primary Structure And Functional Expression of the 5HT ₃ Receptor, A Serotonin-gated Ion Channel

1991 • 976 citations

Emerging structure of the Nicotinic Acetylcholine receptors

2002 • 896 citations

The 5-HT3B subunit is a major determinant of serotonin-receptor function

1999 • 555 citations

A point mutation in a Drosophila GABA receptor confers insecticide resistance

1993 • 552 citations

Nicotinic acetylcholine receptor at 4.6 Å resolution: transverse tunnels in the channel 1 1Edited by J. Karn

1999 • 487 citations

Estimating single-channel kinetic parameters from idealized patch-clamp data containing missed events

1996 • 432 citations

Cys-loop receptors: new twists and turns

2004 • 426 citations

Mutations in the channel domain of a neuronal nicotinic receptor convert ion selectivity from cationic to anionic

1992 • 420 citations

Chimaeric nicotinic–serotonergic receptor combines distinct ligand binding and channel specificities

1993 • 401 citations

Location of functional regions of acetylcholine receptor α-subunit by site-directed mutagenesis

1985 • 390 citations

Evidence That the M2 Membrane-Spanning Region Lines the Ion Channel Pore of the Nicotinic Receptor

1988 • 379 citations

Effects of the 5‐HT₃ receptor antagonist, GR38032F, on raised dopaminergic activity in the mesolimbic system of the rat and marmoset brain

1987 • 354 citations

A prokaryotic proton-gated ion channel from the nicotinic acetylcholine receptor family

2006 • 302 citations

A cytoplasmic region determines single-channel conductance in 5-HT3 receptors

2003 • 273 citations

The C.elegansric-3 gene is required for maturation of nicotinic acetylcholine receptors

2002 • 241 citations

Identification of the prokaryotic ligand-gated ion channels and their implications for the mechanisms and origins of animal Cys-loop ion channels.

2004 • 237 citations

On the mechanism of action of picrotoxin on GABA receptor channels in dissociated sympathetic neurones of the rat.

1992 • 193 citations

Conservation within the RIC-3 Gene Family

2003 • 177 citations

GABA_A receptor associated proteins: a key factor regulating GABA_A receptor function

2006 • 173 citations

pH-Dependent Intramolecular Binding and Structure Involving Cx43 Cytoplasmic Domains

2002 • 172 citations

Structural model for γ-aminobutyric acid receptor noncompetitive antagonist binding: Widely diverse structures fit the same site

2006 • 152 citations

Multiple mechanisms of picrotoxin block of GABA‐induced currents in rat hippocampal neurons.

1993 • 144 citations

Interaction of picrotoxin with GABAA receptor channel-lining residues probed in cysteine mutants

1995 • 143 citations

Dual-Function Vector for Protein Expression in Both Mammalian Cells and Xenopus laevis Oocytes

2002 • 137 citations

The long internal loop of the α3 subunit targets nAChRs to subdomains within individual synapses on neurons in vivo

1998 • 134 citations

Conversion of the Ion Selectivity of the 5-HT3AReceptor from Cationic to Anionic Reveals a Conserved Feature of the Ligand-gated Ion Channel Superfamily

2001 • 127 citations

M2 Pore Mutations Convert the Glycine Receptor Channel from Being Anion- to Cation-Selective

2000 • 120 citations

Dual Role of the RIC-3 Protein in Trafficking of Serotonin and Nicotinic Acetylcholine Receptors

2005 • 106 citations

Natively Unstructured Loops Differ from Other Loops

2007 • 96 citations

Common Determinants of Single Channel Conductance within the Large Cytoplasmic Loop of 5-Hydroxytryptamine Type 3 and α4β2 Nicotinic Acetylcholine Receptors

2006 • 95 citations

Identification of Sequence Motifs That Target Neuronal Nicotinic Receptors to Dendrites and Axons

2006 • 94 citations

Cell Surface Expression of 5-Hydroxytryptamine Type 3 Receptors Is Promoted by RIC-3

2005 • 70 citations

Intrinsic disorder in the C-terminal domain of the Shaker voltage-activated K ⁺ channel modulates its interaction with scaffold proteins

2007 • 61 citations

A Role for the β₁-β₂Loop in the Gating of 5-HT₃Receptors

2005 • 59 citations

A single ring of charged amino acids at one end of the pore can control ion selectivity in the 5‐HT₃ receptor

2003 • 57 citations

Selective elimination of glutamate activation and introduction of fluorescent proteins into a Caenorhabditis elegans chloride channel

2002 • 56 citations

State-Dependent Cross-Linking of the M2 and M3 Segments: Functional Basis for the Alignment of GABA_Aand Acetylcholine Receptor M3 Segments

2006 • 56 citations

Noninvasive Imaging of 5-HT3 Receptor Trafficking in Live Cells

2004 • 56 citations

The Location of a Closed Channel Gate in the GABAA Receptor Channel

2007 • 55 citations

Untitled

2005 • 54 citations

Permeability and single channel conductance of human homomeric ρ1 GABA_C receptors

1999 • 51 citations

Receptor targeting and heterogeneity at interneuronal nicotinic cholinergic synapses in vivo

2000 • 44 citations

Assembly and clustering of acetylcholine receptors containing GFP‐tagged ε or γ subunits

2001 • 44 citations

Diltiazem causes open channel block of recombinant 5‐HT₃ receptors

1999 • 40 citations

The GABAA receptor antagonist picrotoxin inhibits 5-hydroxytryptamine type 3A receptors

2003 • 35 citations

Chlorpromazine and QX222 block 5-HT3 receptors in N1E-115 neuroblastoma cells

1994 • 22 citations

Intracellular domains of the δ-subunits of Torpedo and rat acetylcholine receptors—expression, purification, and characterization

2004 • 10 citations

The M3/M4 cytoplasmic loop of the α1 subunit restricts GABA_ARs lateral mobility: A study using fluorescence recovery after photobleaching

2006 • 9 citations