The subtypes of nicotinic acetylcholine receptors on dopaminergic terminals of mouse striatum

Autoradiographic localization of dopamine D1 and D2 receptors in rat nucleus accumbens: Resistance to differential rearing conditions

1991 • 3,177 citations

Presynaptic nicotinic ACh receptors

1997 • 1,313 citations

A meta-analysis of worldwide studies demonstrates an association between schizophrenia and tobacco smoking behaviors

2005 • 1,198 citations

Nicotinic Acetylcholine Receptors and Nicotinic Cholinergic Mechanisms of the Central Nervous System

2006 • 1,130 citations

Nicotinic binding in rat brain: autoradiographic comparison of [3H]acetylcholine, [3H]nicotine, and [125I]-alpha-bungarotoxin

1985 • 1,037 citations

A subtype of nicotinic cholinergic receptor in rat brain is composed of alpha 4 and beta 2 subunits and is up-regulated by chronic nicotine treatment.

1992 • 858 citations

Brain nicotinic acetylcholine receptors: native subtypes and their relevance

2006 • 838 citations

The mesolimbic dopaminergic system is implicated in the reinforcing effects of nicotine

1992 • 827 citations

Nicotinic effects on cognitive function: behavioral characterization, pharmacological specification, and anatomic localization

2005 • 797 citations

Abnormal avoidance learning in mice lacking functional high-affinity nicotine receptor in the brain

1995 • 659 citations

Molecular and physiological diversity of nicotinic acetylcholine receptors in the midbrain dopaminergic nuclei.

2001 • 640 citations

Nicotinic acetylcholine receptors and the regulation of neuronal signalling

2004 • 584 citations

Molecular and Physiological Diversity of Nicotinic Acetylcholine Receptors in the Midbrain Dopaminergic Nuclei

2001 • 574 citations

Nicotine amplifies reward-related dopamine signals in striatum

2004 • 566 citations

Both alpha- and beta-subunits contribute to the agonist sensitivity of neuronal nicotinic acetylcholine receptors

1991 • 552 citations

Reduced antinociception in mice lacking neuronal nicotinic receptor subunits

1999 • 546 citations

Nicotine binding and nicotinic receptor subunit RNA after chronic nicotine treatment

1992 • 540 citations

Systemic nicotine‐induced dopamine release in the rat nucleus accumbens is regulated by nicotinic receptors in the ventral tegmental area

1994 • 524 citations

Subunit Composition of Functional Nicotinic Receptors in Dopaminergic Neurons Investigated with Knock-Out Mice

2003 • 504 citations

A New α-Conotoxin Which Targets α3β2 Nicotinic Acetylcholine Receptors

1996 • 479 citations

Pentameric structure and subunit stoichiometry of a neuronal nicotinic acetylcholine receptor

1991 • 463 citations

The effects of acute and repeated nicotine treatment on nucleus accumbens dopamine and locomotor activity

1992 • 428 citations

Subunit Composition and Pharmacology of Two Classes of Striatal Presynaptic Nicotinic Acetylcholine Receptors Mediating Dopamine Release in Mice

2004 • 409 citations

Alternate Stoichiometries of α4β2 Nicotinic Acetylcholine Receptors

2003 • 406 citations

Identification of the Nicotinic Receptor Subtypes Expressed on Dopaminergic Terminals in the Rat Striatum

2002 • 400 citations

Neuronal Nicotinic Receptor a6 Subunit mRNA is Selectively Concentrated in Catecholaminergic Nuclei of the Rat Brain

1996 • 379 citations

Epibatidine, a potent analgetic and nicotinic agonist.

1994 • 371 citations

Anxiety, anxiety disorders, tobacco use, and nicotine: A critical review of interrelationships.

2007 • 365 citations

Frequency-dependent modulation of dopamine release by nicotine

2004 • 356 citations

Characterization of Nicotinic Receptor‐Mediated [³H]Dopamine Release from Synaptosomes Prepared from Mouse Striatum

1992 • 352 citations

Distribution and Pharmacology of α6-Containing Nicotinic Acetylcholine Receptors Analyzed with Mutant Mice

2002 • 342 citations

Alpha-7 nicotinic receptor agonists: potential new candidates for the treatment of schizophrenia

2004 • 338 citations

Stereospecific Nicotine Receptors on Rat Brain Membranes

1980 • 319 citations

Characterization of nicotine binding in mouse brain and comparison with the binding of alpha-bungarotoxin and quinuclidinyl benzilate.

1982 • 305 citations

Modulation of Presynaptic Store Calcium Induces Release of Glutamate and Postsynaptic Firing

2003 • 299 citations

Presynaptic Nicotinic Modulation of Dopamine Release in the Three Ascending Pathways Studied by In Vivo Microdialysis: Comparison of Naive and Chronic Nicotine‐Treated Rats

1997 • 288 citations

Release of [³H]‐noradrenaline from rat hippocampal synaptosomes by nicotine: mediation by different nicotinic receptor subtypes from striatal [³H]‐dopamine release

1996 • 263 citations

Nicotinic binding sites in rat and mouse brain: comparison of acetylcholine, nicotine, and alpha-bungarotoxin.

1986 • 262 citations

Nicotinic cholinergic receptors labeled by [3H]acetylcholine in rat brain.

1982 • 259 citations

Expression of neuronal nicotinic acetylcholine receptor subunit mRNAs within midbrain dopamine neurons

2002 • 259 citations

[3H]cytisine binding to nicotinic cholinergic receptors in brain.

1991 • 258 citations

Partial agonist properties of cytisine on neuronal nicotinic receptors containing the beta 2 subunit.

1994 • 255 citations

Autoradiographic distribution of nicotine receptors in rat brain

1984 • 253 citations

Regulation of dopamine release by presynaptic nicotinic receptors in rat striatal slices: Effect of nicotine in a low concentration

1979 • 250 citations

Characterization of bovine and human neuronal nicotinic acetylcholine receptors using monoclonal antibodies

1988 • 241 citations

α-Bungarotoxin-Sensitive Nicotinic Receptors Indirectly Modulate [³H]Dopamine Release in Rat Striatal Slices via Glutamate Release

2000 • 220 citations

Effect of nicotine and other drugs on the release of 3H-norepinephrine and 3H-dopamine from rat brain slices

1974 • 214 citations

Alpha-conotoxin MII blocks nicotine-stimulated dopamine release in rat striatal synaptosomes.

1997 • 210 citations

Stereoselective Nicotine‐Induced Release of Dopamine from Striatal Synaptosomes: Concentration Dependence and Repetitive Stimulation

1988 • 209 citations

Four Pharmacologically Distinct Subtypes of α4β2 Nicotinic Acetylcholine Receptor Expressed inXenopus laevisOocytes

1998 • 207 citations

The β3 Nicotinic Receptor Subunit: A Component of α-Conotoxin MII-Binding Nicotinic Acetylcholine Receptors that Modulate Dopamine Release and Related Behaviors

2003 • 205 citations

Characterization of (+/-)(-)[3H]epibatidine binding to nicotinic cholinergic receptors in rat and human brain.

1995 • 194 citations

Effect of nicotine on extracellular levels of neurotransmitters assessed by microdialysis in various brain regions: Role of glutamic acid

1992 • 193 citations

Single-channel currents of rat neuronal nicotinic acetylcholine receptors expressed in xenopus oocytes

1989 • 192 citations

α-Conotoxin MII Blocks Nicotine-Stimulated Dopamine Release in Rat Striatal Synaptosomes

1997 • 189 citations

Bimodal modulation by nicotine of anxiety in the social interaction test: Role of the dorsal hippocampus.

1998 • 182 citations

Smoking and Parkinson's disease: Systematic review of prospective studies

2004 • 180 citations

Neuronal nicotinic receptors: from structure to function

2001 • 174 citations

Genetic influences on nicotine responses

1989 • 167 citations

Neuronal nicotinic receptor beta2 and beta4 subunits confer large differences in agonist binding affinity.

1998 • 166 citations

Determinants of competitive antagonist sensitivity on neuronal nicotinic receptor beta subunits.

1996 • 166 citations

UB-165: A Novel Nicotinic Agonist with Subtype Selectivity Implicates the α4β2* Subtype in the Modulation of Dopamine Release from Rat Striatal Synaptosomes

2000 • 165 citations

Bimodal modulation by nicotine of anxiety in the social interaction test: Role of the dorsal hippocampus.

1998 • 165 citations

Human α4β2 Acetylcholine Receptors Formed from Linked Subunits

2003 • 164 citations

125I-alpha-conotoxin MII identifies a novel nicotinic acetylcholine receptor population in mouse brain.

2000 • 162 citations

[3H]epibatidine labels nicotinic receptors in rat brain: an autoradiographic study.

1995 • 159 citations

Sensitization of the Mesoaccumbens Dopamine Response to Nicotine

1998 • 158 citations

Nicotinic agonists stimulate acetylcholine release from mouse interpeduncular nucleus: a function mediated by a different nAChR than dopamine release from striatum

2001 • 154 citations

Neuronal Nicotinic Receptor β2 and β4 Subunits Confer Large Differences in Agonist Binding Affinity

1998 • 153 citations

Pharmacology of α-Conotoxin MII-Sensitive Subtypes of Nicotinic Acetylcholine Receptors Isolated by Breeding of Null Mutant Mice

2007 • 152 citations

Involvement of the α3 Subunit in Central Nicotinic Binding Populations

2002 • 150 citations

Nicotine enhancement of contextual fear conditioning

1999 • 150 citations

Determinants of Competitive Antagonist Sensitivity on Neuronal Nicotinic Receptor β Subunits

1996 • 141 citations

Pharmacological characterization of nicotine-induced seizures in mice.

1999 • 139 citations

Systemic nicotine stimulates dopamine release in nucleus accumbens: re-evaluation of the role of N-methyl-D-aspartate receptors in the ventral tegmental area.

2000 • 135 citations

Pharmacological characterization of nicotinic receptor-stimulated GABA release from mouse brain synaptosomes.

1998 • 131 citations

Expression of Nigrostriatal α6-Containing Nicotinic Acetylcholine Receptors Is Selectively Reduced, but Not Eliminated, by β3 Subunit Gene Deletion

2005 • 130 citations

Two pharmacologically distinct components of nicotinic receptor-mediated rubidium efflux in mouse brain require the beta2 subunit.

1999 • 129 citations

Striatal α6^*Nicotinic Acetylcholine Receptors: Potential Targets for Parkinson's Disease Therapy

2005 • 129 citations

Desensitization of Nicotine‐Stimulated [³H]Dopamine Release from Mouse Striatal Synaptosomes

1994 • 122 citations

Neuroprotection by Nicotine in Mouse Primary Cortical Cultures Involves Activation of Calcineurin and L-Type Calcium Channel Inactivation

2003 • 121 citations

Strain comparison of nicotine-induced seizure sensitivity and nicotinic receptors

1989 • 121 citations

Selective nicotinic acetylcholine receptor subunit deficits identified in Alzheimer's disease, Parkinson's disease and dementia with Lewy bodies by immunoprecipitation

2006 • 118 citations

Dissociations between the locomotor stimulant and depressant effects of nicotinic agonists in rats

1995 • 112 citations

[3H]acetylcholine and [3H](-)nicotine label the same recognition site in rat brain.

1987 • 112 citations

Neuroadaptive changes in the mesoaccumbens dopamine system after chronic nicotine self-administration: A microdialysis study

2004 • 111 citations

Identification of a novel nicotinic binding site in mouse brain using [¹²⁵I]‐epibatidine

2000 • 109 citations

Characterization of Nicotinic Agonist-Induced [³H]Dopamine Release from Synaptosomes Prepared from Four Mouse Brain Regions

2002 • 109 citations

Neuroprotection by nicotine against hypoxia-induced apoptosis in cortical cultures involves activation of multiple nicotinic acetylcholine receptor subtypes

2003 • 104 citations

Pharmacological characterization of a nicotinic autoreceptor in rat hippocampal synaptosomes

1996 • 103 citations

The influence of genotype and sex on behavioral sensitivity to nicotine in mice

1980 • 102 citations

Cholinergic-dopaminergic interactions in cognitive performance

1990 • 102 citations

Central nicotinic cholinergic systems: A role in the cognitive dysfunction in Attention-Deficit/Hyperactivity Disorder?

2006 • 99 citations

Smoking patterns and abstinence effects in smokers with no ADHD, childhood ADHD, and adult ADHD symptomatology

2002 • 98 citations

Nicotine Effect on Cardiovascular System and Ion Channels

2006 • 96 citations

Nicotine neuroprotection against nigrostriatal damage: importance of the animal model

2007 • 90 citations

Time-course of changes in the social interaction test of anxiety following acute and chronic administration of nicotine

1999 • 87 citations

An autoradiographic analysis of cholinergic receptors in mouse brain

1989 • 87 citations

Differential Declines in Striatal Nicotinic Receptor Subtype Function after Nigrostriatal Damage in Mice

2003 • 86 citations

Subunit Composition of Nicotinic Receptors in Monkey Striatum: Effect of Treatments with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine or l-DOPA

2004 • 85 citations

Nicotinic α5 subunit deletion locally reduces high‐affinity agonist activation without altering nicotinic receptor numbers

2007 • 84 citations

Subsets of acetylcholine-stimulated 86Rb+ efflux and [125I]-epibatidine binding sites in C57BL/6 mouse brain are differentially affected by chronic nicotine treatment

2004 • 83 citations

Binding of [125I]-α bungarotoxin to particulate fractions of rat and guinea pig brain

1973 • 80 citations

Fear conditioning and latent inhibition in mice lacking the high affinity subclass of nicotinic acetylcholine receptors in the brain

2000 • 74 citations

Nicotine‐evoked transmitter release from synaptosomes: functional association of specific presynaptic acetylcholine receptors and voltage‐gated calcium channels

2001 • 73 citations

Antinociceptive action of nicotine and its methiodide derivatives in mice and rats

1983 • 73 citations

Influence of tetrodotoxin and calcium on changes in extracellular dopamine levels evoked by systemic nicotine

1993 • 68 citations

The subunit composition and pharmacology of α-Conotoxin MII-binding nicotinic acetylcholine receptors studied by a novel membrane-binding assay

2005 • 66 citations

Nicotinic receptor agonists facilitate retention of avoidance training: Participation of dopaminergic mechanisms

1993 • 64 citations

Pharmacological comparison of transient and persistent [3H]dopamine release from mouse striatal synaptosomes and response to chronic L-nicotine treatment.

1997 • 63 citations

Deletion of the α7, β2, or β4 Nicotinic Receptor Subunit Genes Identifies Highly Expressed Subtypes with Relatively Low Affinity for [³H]Epibatidine

2006 • 57 citations

Characterization of Nicotinic Acetylcholine Receptors That Modulate Nicotine-Evoked [³H]Norepinephrine Release from Mouse Hippocampal Synaptosomes

2006 • 56 citations

Pharmacological and null mutation approaches reveal nicotinic receptor diversity

2000 • 56 citations

Involvement of calcium and L-type channels in nicotine-induced antinociception.

1993 • 54 citations

Nicotinic acetylcholine receptor system and neuropsychiatric disorders.

2004 • 51 citations

Nicotine partially protects against paraquat‐induced nigrostriatal damage in mice; link to α6β2* nAChRs

2006 • 50 citations

S(‐)‐Nornicotine Increases Dopamine Release in a Calcium‐Dependent Manner from Superfused Rat Striatal Slices

1993 • 48 citations

Protective effects of nicotine on ethanol-induced toxicity in cultured cerebellar granule cells

2003 • 47 citations

Deficiency of Nicotinic Acetylcholine Receptor β4 Subunit Causes Autonomic Cardiac and Intestinal Dysfunction

2003 • 43 citations

Acetylcholine receptor extracellular domain determines sensitivity to nicotine-induced inactivation

2000 • 40 citations

First and Second Transmembrane Segments of α3, α4, β2, and β4 Nicotinic Acetylcholine Receptor Subunits Influence the Efficacy and Potency of Nicotine

2002 • 38 citations

Characterization of [¹²⁵I]epibatidine binding and nicotinic agonist‐mediated ⁸⁶Rb⁺ efflux in interpeduncular nucleus and inferior colliculus of β2 null mutant mice

2002 • 34 citations

Nicotinic-agonist stimulated 86Rb+ efflux and [3H]epibatidine binding of mice differing in β2 genotype

2000 • 26 citations

Effects of nicotine and epibatidine on locomotor activity and conditioned place preference in rats

2005 • 23 citations

Nicotinic receptor mutations in human epilepsy

2004 • 15 citations