On the nature of partial agonism in the nicotinic receptor superfamily

On the nature of allosteric transitions: A plausible model

1965 • 8,699 citations

Binding, gating, affinity and efficacy: The interpretation of structure‐activity relationships for agonists and of the effects of mutating receptors

1998 • 880 citations

Local anaesthetics transiently block currents through single acetylcholine‐receptor channels.

1978 • 864 citations

Nicotine and Carbamylcholine Binding to Nicotinic Acetylcholine Receptors as Studied in AChBP Crystal Structures

2004 • 778 citations

Fast events in single‐channel currents activated by acetylcholine and its analogues at the frog muscle end‐plate.

1985 • 768 citations

Structure of a glutamate-receptor ligand-binding core in complex with kainate

1998 • 672 citations

Structures of Aplysia AChBP complexes with nicotinic agonists and antagonists reveal distinctive binding interfaces and conformations

2005 • 617 citations

Interaction at end-plate receptors between different choline derivatives

1957 • 477 citations

Structural basis for partial agonist action at ionotropic glutamate receptors

2003 • 366 citations

Fluctuations in the microsecond time range of the current through single acetylcholine receptor ion channels

1981 • 366 citations

Mapping the conformational wave of acetylcholine receptor channel gating

2000 • 329 citations

Voltage jump analysis of procaine action at frog end‐plate

1977 • 230 citations

Activation of ion channels in the frog end‐plate by high concentrations of acetylcholine.

1988 • 214 citations

Single-Channel Behavior of Heteromeric α1β Glycine Receptors: An Attempt to Detect a Conformational Change before the Channel Opens

2004 • 186 citations

The problem of the heme interactions in hemoglobin and the basis of the bohr effect

1951 • 185 citations

Gating Dynamics of the Acetylcholine Receptor Extracellular Domain

2004 • 140 citations

A stepwise mechanism for acetylcholine receptor channel gating

2007 • 135 citations

The quality of maximum likelihood estimates of ion channel rate constants

2003 • 114 citations

A re‐examination of adult mouse nicotinic acetylcholine receptor channel activation kinetics

1999 • 103 citations

The quality of maximum likelihood estimates of ion channel rate constants

2003 • 102 citations

Gating of acetylcholine receptor channels: Brownian motion across a broad transition state

2005 • 92 citations

Properties of the human muscle nicotinic receptor, and of the slow-channel myasthenic syndrome mutant epsilonL221F, inferred from maximum likelihood fits

2003 • 89 citations

Properties of the human muscle nicotinic receptor, and of the slow-channel myasthenic syndrome mutant L221F, inferred from maximum likelihood fits

2003 • 72 citations

Conductances of single ion channels opened by nicotinic agonists are indistinguishable

1984 • 71 citations

Φ-Value Analysis of a Linear, Sequential Reaction Mechanism: Theory and Application to Ion Channel Gating

2005 • 68 citations

Achieving optimal expression for single channel recording: a plasmid ratio approach to the expression of α1 glycine receptors in HEK293 cells

2002 • 47 citations

Comparison of Taurine- and Glycine-induced Conformational Changes in the M2-M3 Domain of the Glycine Receptor

2004 • 19 citations

Drug Discovery and Drug Development

2021 • 17 citations