Thymic generation and regeneration

Hedgehog signaling in animal development: paradigms and principles

2001 • 2,919 citations

Wnt signaling: a common theme in animal development

1997 • 2,579 citations

Function of the chemokine receptor CXCR4 in haematopoiesis and in cerebellar development

1998 • 2,496 citations

The Biology of Chemokines and their Receptors

2000 • 2,416 citations

Projection of an Immunological Self Shadow Within the Thymus by the Aire Protein

2002 • 2,371 citations

CCR7 Coordinates the Primary Immune Response by Establishing Functional Microenvironments in Secondary Lymphoid Organs

1999 • 2,326 citations

TGF-β signaling in tumor suppression and cancer progression

2001 • 2,235 citations

Receptor Specificity of the Fibroblast Growth Factor Family

1996 • 1,871 citations

Induction by Antigen of Intrathymic Apoptosis of CD4 ⁺ CD8 ⁺ TCR ^lo Thymocytes in Vivo

1990 • 1,781 citations

β-Catenin Controls Hair Follicle Morphogenesis and Stem Cell Differentiation in the Skin

2001 • 1,304 citations

Fate of the mammalian cardiac neural crest

2000 • 1,123 citations

Induction of T Cell Development from Hematopoietic Progenitor Cells by Delta-like-1 In Vitro

2002 • 1,095 citations

T-cell apoptosis detected in situ during positive and negative selection in the thymus

1994 • 1,071 citations

Chemokines and Cell Migration in Secondary Lymphoid Organs

1999 • 1,046 citations

Promiscuous gene expression in medullary thymic epithelial cells mirrors the peripheral self

2001 • 1,043 citations

Mice Lacking Expression of Secondary Lymphoid Organ Chemokine Have Defects in Lymphocyte Homing and Dendritic Cell Localization

1999 • 1,030 citations

Tbx1 haploinsufficiency in the DiGeorge syndrome region causes aortic arch defects in mice

2001 • 996 citations

TBX1 Is Responsible for Cardiovascular Defects in Velo-Cardio-Facial/DiGeorge Syndrome

2001 • 963 citations

Notch1 Expression in Early Lymphopoiesis Influences B versus T Lineage Determination

1999 • 956 citations

Pax9-deficient mice lack pharyngeal pouch derivatives and teeth and exhibit craniofacial and limb abnormalities

1998 • 817 citations

Negative selection of lymphocytes

1994 • 810 citations

Wnt genes

1992 • 799 citations

Aire regulates negative selection of organ-specific T cells

2003 • 789 citations

FGFs, heparan sulfate and FGFRs: complex interactions essential for development

2000 • 771 citations

Thymic dendritic cells and T cells develop simultaneously in the thymus from a common precursor population

1993 • 673 citations

Thymic major histocompatibility complex antigens and the αβ T-cell receptor determine the CD4/CD8 phenotype of T cells

1988 • 671 citations

splotch (Sp2H), a mutation affecting development of the mouse neural tube, shows a deletion within the paired homeodomain of Pax-3

1991 • 664 citations

Cathepsin L: Critical Role in Ii Degradation and CD4 T Cell Selection in the Thymus

1998 • 654 citations

New member of the winged-helix protein family disrupted in mouse and rat nude mutations

1994 • 651 citations

Selective development of CD4+ T cells in transgenic mice expressing a class II MHC-restricted antigen receptor

1989 • 646 citations

Transforming Growth Factor-β Signaling Through the Smad Pathway: Role in Extracellular Matrix Gene Expression and Regulation

2002 • 622 citations

Positive Selection of Thymocytes

1995 • 604 citations

Positive selection of lymphocytes

1994 • 563 citations

Thymus cell migration: Quantitative aspects of cellular traffic from the thymus to the periphery in mice

1980 • 551 citations

New aspects of Wnt signaling pathways in higher vertebrates

2001 • 550 citations

Thymopoiesis independent of common lymphoid progenitors

2003 • 548 citations

The immunology of exceptional individuals: the lesson of centenarians

1995 • 538 citations

Mechanisms of TGF-β signaling in regulation of cell growth and differentiation

2002 • 521 citations

Crucial role of the pre-T-cell receptor α gene in development of ap but not γδ T cells

1995 • 519 citations

SELECTION OF THE T CELL REPERTOIRE

1999 • 507 citations

The Role of the Thymus in Immune Reconstitution in Aging, Bone Marrow Transplantation, and HIV-1 Infection

2000 • 506 citations

EXPERIMENTAL STUDIES ON THE DEVELOPMENT OF THE THYMUS

1967 • 504 citations

Cellular Interactions in Thymocyte Development

1996 • 503 citations

Induction of avian cardiac myogenesis by anterior endoderm

1995 • 475 citations

Signal transduction by the Wnt family of ligands

1998 • 474 citations

Dependence of Thymus Development on Derivatives of the Neural Crest

1984 • 463 citations

Robustness of the BMP morphogen gradient in Drosophila embryonic patterning

2002 • 463 citations

The homeobox gene Hex is required in definitive endodermal tissues for normal forebrain, liver and thyroid formation

2000 • 462 citations

Lymphostromal interactions in thymic development and function

2001 • 461 citations

The thymic microenvironment

1993 • 459 citations

Two Genetically Separable Steps in the Differentiation of Thymic Epithelium

1996 • 447 citations

Fgf8is required for pharyngeal arch and cardiovascular development in the mouse

2002 • 446 citations

Control points in early T-cell development

1993 • 429 citations

The role of Hoxa-3 in mouse thymus and thyroid development

1995 • 421 citations

Tracing of cells of the avian thymus through embryonic life in interspecific chimeras.

1975 • 409 citations

Patterning Mechanisms Controlling Vertebrate Limb Development

2001 • 403 citations

Shaping of the autoreactive T-cell repertoire by a splice variant of self protein expressed in thymic epithelial cells

2000 • 399 citations

Notch 1–Deficient Common Lymphoid Precursors Adopt a B Cell Fate in the Thymus

2001 • 392 citations

Transforming growth factor-beta is a potent immunosuppressive agent that inhibits IL-1-dependent lymphocyte proliferation.

1988 • 392 citations

Role of neural crest in congenital heart disease.

1990 • 390 citations

Unopposed positive selection and autoreactivity in mice expressing class II MHC only on thymic cortex

1996 • 378 citations

WNT Signals Control FGF-Dependent Limb Initiation and AER Induction in the Chick Embryo

2001 • 360 citations

AnFgf8mouse mutant phenocopies human 22q11 deletion syndrome

2002 • 359 citations

MHC class II-positive epithelium and mesenchyme cells are both required for T-cell development in the thymus

1993 • 359 citations

Early mouse endoderm is patterned by soluble factors from adjacent germ layers

2000 • 358 citations

The chemokine TECK is expressed by thymic and intestinal epithelial cells and attracts double- and single-positive thymocytes expressing the TECK receptor CCR9

2000 • 358 citations

Origin and development of the zebrafish endoderm

1999 • 352 citations

Differential Effects of Notch Ligands Delta-1 and Jagged-1 in Human Lymphoid Differentiation

2001 • 348 citations

CD4 expressed on earliest T-lineage precursor cells in the adult murine thymus

1991 • 343 citations

A novel disulfide-linked heterodimer on pre—T cells consists of the T cell receptor β chain and a 33 kd glycoprotein

1993 • 333 citations

Notch1 Signaling Promotes the Maturation of CD4 and CD8 SP Thymocytes

2000 • 317 citations

The status of Wnt signalling regulates neural and epidermal fates in the chick embryo

2001 • 315 citations

Stimulation of phosphatidylinositol 3-kinase by fibroblast growth factor receptors is mediated by coordinated recruitment of multiple docking proteins

2001 • 313 citations

Thymic involution in aging.

2000 • 305 citations

Cell-Mediated Immunity as a Predictor of Morbidity and Mortality in Subjects Over 60

1990 • 304 citations

IL-7 increases both thymic-dependent and thymic-independent T-cell regeneration after bone marrow transplantation

2001 • 302 citations

Tbx1, a DiGeorge Syndrome Candidate Gene, Is Regulated by Sonic Hedgehog during Pharyngeal Arch Development

2001 • 301 citations

Inhibition of gamma delta T cell development and early thymocyte maturation in IL-7 -/- mice.

1996 • 301 citations

Developmental control point in induction of thymic cortex regulated by a subpopulation of prothymocytes

1995 • 295 citations

Interdependence of cortical thymic epithelial cell differentiation and T-lineage commitment

1998 • 292 citations

Mice lacking the CCR9 CC-chemokine receptor show a mild impairment of early T- and B-cell development and a reduction in T-cell receptor γδ+ gut intraepithelial lymphocytes

2001 • 291 citations

Generation of a complete thymic microenvironment by MTS24+ thymic epithelial cells

2002 • 290 citations

Inhibition of Sonic hedgehog signaling in vivo results in craniofacial neural crest cell death

1999 • 289 citations

Sequential roles for Otx2 in visceral endoderm and neuroectoderm for forebrain and midbrain induction and specification

1998 • 284 citations

Development in the thymus: it takes two to tango

1993 • 281 citations

Keratinocyte growth factor induces proliferation of hepatocytes and epithelial cells throughout the rat gastrointestinal tract.

1994 • 276 citations

Identification and Characterization of Thymic Epithelial Progenitor Cells

2002 • 269 citations

Associations of FGF-3 and FGF-10 with signaling networks regulating tooth morphogenesis

2000 • 268 citations

Protection from thymic epithelial cell injury by keratinocyte growth factor: a new approach to improve thymic and peripheral T-cell reconstitution after bone marrow transplantation

2002 • 268 citations

Identity of cells that imprint H–2-restricted T-cell specificity in the thymus

1986 • 267 citations

Endoderm development: from patterning to organogenesis

2000 • 266 citations

FGF4, a direct target of LEF1 and Wnt signaling, can rescue the arrest of tooth organogenesis in Lef1^−/− mice

2002 • 266 citations

Development of thymus, parathyroids, and ultimo‐branchial bodies in NMRI and nude mice

1980 • 264 citations

Fibroblast Growth Factor Receptor 2-IIIb Acts Upstream of Shh and Fgf4 and Is Required for Limb Bud Maintenance but Not for the Induction of Fgf8, Fgf10, Msx1, or Bmp4

2001 • 262 citations

Normal Thymic Architecture and Negative Selection Are Associated with Aire Expression, the Gene Defective in the Autoimmune-Polyendocrinopathy-Candidiasis-Ectodermal Dystrophy (APECED)

2000 • 261 citations

Negative selection of CD4+CD8+ thymocytes by T cell receptor-induced apoptosis requires a costimulatory signal that can be provided by CD28.

1994 • 257 citations

Transplantation of Thymus Tissue in Complete DiGeorge Syndrome

1999 • 256 citations

Wnt glycoproteins regulate the expression of FoxN1, the gene defective in nude mice

2002 • 254 citations

Gli proteins and Hedgehog signaling: development and cancer

1999 • 249 citations

Cutting Edge: Developmental Switches in Chemokine Responses During T Cell Maturation

1999 • 247 citations

Thymic aging and T‐cell regeneration

1997 • 244 citations

Development of the Thymus Requires Signaling Through the Fibroblast Growth Factor Receptor R2-IIIb

2001 • 241 citations

The β-catenin–TCF-1 pathway ensures CD4+CD8+ thymocyte survival

2001 • 241 citations

A differential-avidity model for T-cell selection

1994 • 239 citations

Characterization of c-kit positive intrathymic stem cells that are restricted to lymphoid differentiation.

1993 • 233 citations

A cell-autonomous requirement for CXCR4 in long-term lymphoid and myeloid reconstitution

1999 • 233 citations

The nu gene acts cell-autonomously and is required for differentiation of thymic epithelial progenitors.

1996 • 225 citations

How Many Thymocytes Audition for Selection?

1997 • 222 citations

Stepwise development of thymic microenvironments in vivo is regulated by thymocyte subsets

2000 • 219 citations

Role for CCR7 Ligands in the Emigration of Newly Generated T Lymphocytes from the Neonatal Thymus

2002 • 218 citations

The Reduced Expression of 6ckine in the plt Mouse Results from the Deletion of One of Two 6ckine Genes

1999 • 217 citations

The thymus and negative selection

2002 • 216 citations

Visceral Endoderm Mediates Forebrain Development by Suppressing Posteriorizing Signals

2000 • 213 citations

Thymus medulla consisting of epithelial islets each derived from a single progenitor

2001 • 211 citations

Retinoid signaling is essential for patterning the endoderm of the third and fourth pharyngeal arches

2000 • 210 citations

Identification of pro-thymocytes in murine fetal blood: T lineage commitment can precede thymus colonization.

1994 • 206 citations

Analysis of thymic stromal cell populations using flow cytometry

2002 • 206 citations

Stimulation of chondrogenesis in limb bud mesoderm cells by recombinant human bone morphogenetic protein 2B (BMP-2B) and modulation by transforming growth factor ?1 and ?2*1

1991 • 205 citations

Direct induction of T lymphocyte-specific gene expression by the mammalian Notch signaling pathway

2002 • 204 citations

T cell receptor excision circle assessment of thymopoiesis in aging mice

2002 • 203 citations

Unexpectedly Complex Regulation of CD4/CD8 Coreceptor Expression Supports a Revised Model for CD4+CD8+ Thymocyte Differentiation

1996 • 199 citations

Promiscuous gene expression and central T-cell tolerance: more than meets the eye

2002 • 198 citations

Quantitative Impact of Thymic Clonal Deletion on the T Cell Repertoire

1997 • 198 citations

Expression pattern of Notch1, 2 and 3 and Jagged1 and 2 in lymphoid and stromal thymus components: distinct ligand–receptor interactions in intrathymic T cell development

1999 • 197 citations

The limb identity geneTbx5promotes limb initiation by interacting withWnt2bandFgf10

2002 • 197 citations

Cutting Edge: Thymocyte-Independent and Thymocyte-Dependent Phases of Epithelial Patterning in the Fetal Thymus

2002 • 195 citations

Keratinocyte growth factor preserves normal thymopoiesis and thymic microenvironment during experimental graft-versus-host disease

2002 • 195 citations

Pro-Thymocyte Expansion by c-kit and the Common Cytokine Receptor γ Chain Is Essential for Repertoire Formation

1997 • 195 citations

Wnt signaling is required for thymocyte development and activates Tcf-1 mediated transcription

2001 • 193 citations

Dynamics of Early T Cells: Prothymocyte Migration and Proliferation in the Adult Mouse Thymus

1986 • 188 citations

Expression of CXCR4, the receptor for stromal cell-derived factor-1 on fetal and adult human lymphohematopoietic progenitors

1999 • 188 citations

A Novel Mutant Gene Involved in T-Lymphocyte–Specific Homing Into Peripheral Lymphoid Organs on Mouse Chromosome 4

1998 • 187 citations

Estrogen influences the differentiation, proliferation, and survival of early B-lineage precursors

2000 • 187 citations

Thymic emigration: conveyor belts or lucky dips?

1995 • 186 citations

Pancreatic gene expression in rare cells of thymic medulla: evidence for functional contribution to T cell tolerance

1997 • 183 citations

Separation of Notch1 Promoted Lineage Commitment and Expansion/Transformation in Developing T Cells

2001 • 182 citations

Key roles of retinoic acid receptors alpha and beta in the patterning of the caudal hindbrain, pharyngeal arches and otocyst in the mouse

1999 • 180 citations

Towards Specific Functions of Lysosomal Cysteine Peptidases: Phenotypes of Mice Deficient for Cathepsin B or Cathepsin L

2001 • 173 citations

Expression of cyclin D1 in epithelial tissues of transgenic mice results in epidermal hyperproliferation and severe thymic hyperplasia.

1996 • 171 citations

Differential Chemotactic Behavior of Developing T Cells in Response to Thymic Chemokines

1998 • 169 citations

T-cell selection

1998 • 168 citations

A central role for thymic emigrants in peripheral T cell homeostasis

1999 • 167 citations

T-cell lineage commitment and cytokine responses of thymic progenitors

1995 • 164 citations

Thymus organogenesis and molecular mechanisms of thymic epithelial cell differentiation

2000 • 162 citations

CD4 T Cell Tolerance to Human C-reactive Protein, an Inducible Serum Protein, Is Mediated by Medullary Thymic Epithelium

1998 • 162 citations

Thymocytopoiesis is maintained by blood-borne precursors throughout postnatal life. A study in parabiotic mice.

1992 • 161 citations

Hedgehog Signaling Regulates Differentiation from Double-Negative to Double-Positive Thymocyte

2000 • 161 citations

Wnt signals are targets and mediators of Gli function

2001 • 160 citations

An Essential Role for Thymic Mesenchyme in Early T Cell Development

2000 • 157 citations

Requirement for Diverse, Low-Abundance Peptides in Positive Selection of T Cells

1999 • 151 citations

Regulation of thymic epithelium by keratinocyte growth factor

2002 • 150 citations

Thymus transplantation in complete DiGeorge syndrome: immunologic and safety evaluations in 12 patients

2003 • 148 citations

A pertussis toxin‐sensitive process controls thymocyte emigration

1991 • 147 citations

Neonatal Thymectomy Results in a Repertoire Enriched in T Cells Deleted in Adult Thymus

1989 • 146 citations

Two signals are required for negative selection of CD4+CD8+ thymocytes.

1993 • 143 citations

Notch1 Deficiency Dissociates the Intrathymic Development of Dendritic Cells and T Cells

2000 • 143 citations

Intrathymic T-cell migration: a combinatorial interplay of extracellular matrix and chemokines?

2002 • 137 citations

In Thymic Selection, Peptide Diversity Gives and Takes Away

1997 • 136 citations

Self-antigen presentation by thymic stromal cells: a subtle division of labor

2000 • 135 citations

Two distinct steps of immigration of hematopoietic progenitors into the early thymus anlage

2001 • 135 citations

A Recombinant Human TGF-β1 Fusion Protein with Collagen-Binding Domain Promotes Migration, Growth, and Differentiation of Bone Marrow Mesenchymal Cells

1999 • 134 citations

Stromal cell–derived factor 1/CXCR4 signaling is critical for early human T-cell development

2002 • 132 citations

Inefficient positive selection of T cells directed by haematopoietic cells

1992 • 132 citations

Expression of the mousecerberus-related gene,Cerr1, suggests a role in anterior neural induction and somitogenesis

1998 • 132 citations

Luteinizing Hormone-Releasing Hormone (LHRH) Agonist Restoration of Age-Associated Decline of Thymus Weight, Thymic LHRH Receptors, and Thymocyte Proliferative Capacity

1989 • 129 citations

Interleukin 7 worsens graft-versus-host disease

2002 • 125 citations

Pertussis Toxin-Sensitive Signal Controls the Trafficking of Thymocytes Across the Corticomedullary Junction in the Thymus

1999 • 123 citations

Radiosensitivity of thymic interleukin-7 production and thymopoiesis after bone marrow transplantation

2001 • 122 citations

undulated Phenotypes Suggest a Role of Pax-1 for the Development of Vertebral and Extravertebral Structures

1995 • 121 citations

Tolerance induction by thymic medullary epithelium.

1992 • 121 citations

Enhancement of Murine Intestinal Stem Cell Survival after Irradiation by Keratinocyte Growth Factor

1997 • 121 citations

CD11c+ Eosinophils in the Murine Thymus: Developmental Regulation and Recruitment upon MHC Class I-Restricted Thymocyte Deletion

2000 • 120 citations

Hypertrophy of the thymus and restoration of immune functions in mice and rats by gonadectomy

1989 • 120 citations

Medullary Thymic Epithelium: A Mosaic of Epithelial “Self”?

1998 • 114 citations

Wnt-1 and Wnt-4 regulate thymic cellularity

2002 • 113 citations

Thymic regeneration: teaching an old immune system new tricks

2002 • 113 citations

Impairment of lymphopoiesis and myelopoiesis in mice reconstituted with bone marrow–hematopoietic progenitor cells expressing SDF-1–intrakine

2000 • 112 citations

Cell-fate decisions in early T cell development: regulation by cytokine receptors and the pre-TCR

1999 • 110 citations

Antigen presenting cells in the thymus that can negatively select MHC class II-restricted T cells recognizing a circulating self antigen

1997 • 109 citations

Recent thymic emigrants are distinct from most medullary thymocytes

1997 • 108 citations

Sequential events in thymocyte differentiation and thymus regeneration revealed by a combination of bromodeoxyuridine DNA labeling and antimitotic drug treatment.

1988 • 107 citations

DiGeorge syndrome: an historical review of clinical and cytogenetic features.

1993 • 106 citations

Effects of keratinocyte growth factor in the squamous epithelium of the upper aerodigestive tract of normal and irradiated mice

1999 • 106 citations

The phenotypic heterogeneity of mouse thymic stromal cells.

1990 • 104 citations

Macrophage-Derived Chemokine Is Localized to Thymic Medullary Epithelial Cells and Is a Chemoattractant for CD3+, CD4+, CD8low Thymocytes

1999 • 103 citations

Microenvironmental regulation of T cell development in the thymus

2000 • 102 citations

Anergy induced by thymic medullary epithelium

1992 • 101 citations

Murine CCR9, a Chemokine Receptor for Thymus-Expressed Chemokine That Is Up-Regulated Following Pre-TCR Signaling

2000 • 101 citations

Analysis of Neural Crest Cell Migration in Splotch Mice Using a Neural Crest-Specific LacZ Reporter

1997 • 99 citations

Sampling of complementing self-antigen pools by thymic stromal cells maximizes the scope of central T cell tolerance

2001 • 98 citations

Factors Regulating Stem Cell Recruitment to the Fetal Thymus

1999 • 97 citations

Early Growth Response Transcription Factors Are Required for Development of CD4−CD8− Thymocytes to the CD4+CD8+ Stage

2002 • 95 citations

Epithelial heterogeneity in the murine thymus: a cell surface glycoprotein expressed by subcapsular and medullary epithelium.

1991 • 93 citations

Antigen-presenting cells in the thymus that can negatively select MHC class II-restricted T cells recognizing a circulating self antigen.

1997 • 93 citations

Tracing lymphopoiesis with the aid of a pTα-controlled reporter gene

2002 • 93 citations

Class II-positive hematopoietic cells cannot mediate positive selection of CD4+ T lymphocytes in class II-deficient mice.

1993 • 92 citations

Phosphatidylinositol-3 kinase acts in parallel to the ERK MAP kinase in the FGF pathway during Xenopus mesoderm induction

2001 • 92 citations

A developmental look at thymus organogenesis: where do the non-hematopoietic cells in the thymus come from?

2003 • 89 citations

The thymic compartment responsible for positive selection of CD4⁺ T cells

1992 • 89 citations

Thymocyte selection: not by TCR alone

1998 • 88 citations

Expansion of mature thymocyte subsets before emigration to the periphery.

1997 • 86 citations

The embryonic thymus produces chemotactic peptides involved in the homing of hemopoietic precursors

1986 • 86 citations

Differing roles for B7 and intercellular adhesion molecule-1 in negative selection of thymocytes.

1996 • 84 citations

Role of chemokines in thymocyte development

2000 • 83 citations

Presentation of antigen, foreign major histocompatibility complex proteins and self by thymus cortical epithelium

1989 • 83 citations

CD69 Expression Discriminates MHC-Dependent and -Independent Stages of Thymocyte Positive Selection

1999 • 83 citations

Understanding the Mechanism of the Age-Related Decline in Immune Function

2009 • 82 citations

Hoxa3 and Pax1 Transcription Factors Regulate the Ability of Fetal Thymic Epithelial Cells to Promote Thymocyte Development

2000 • 80 citations

Reversal of ageing changes in the thymus of rats by chemical or surgical castration

1990 • 79 citations

Fibroblast dependency during early thymocyte development maps to the CD25⁺ CD44⁺ stage and involves interactions with fibroblast matrix molecules

1997 • 78 citations

The Developmentally Regulated Expression of Twisted Gastrulation Reveals a Role for Bone Morphogenetic Proteins in the Control of T Cell Development

2002 • 74 citations

One for all and all for one: thymic epithelial stem cells and regeneration

2002 • 72 citations

Positive selection of thymocytes: the long and winding road

1999 • 71 citations

Differential expression of various cytokine receptors in the brain after stimulation with LPS in young and old mice

2002 • 71 citations

Negative Selection of T Cells Occurs Throughout Thymic Development

1999 • 70 citations

Macrophage-Derived Chemokine and EBI1-Ligand Chemokine Attract Human Thymocytes in Different Stage of Development and Are Produced by Distinct Subsets of Medullary Epithelial Cells: Possible Implications for Negative Selection

2000 • 70 citations

Positive selection of thymocytes involves sustained interactions with the thymic microenvironment.

1995 • 70 citations

Emergence of T Cell Progenitors Without B Cell or Myeloid Differentiation Potential at the Earliest Stage of Hematopoiesis in the Murine Fetal Liver

1999 • 68 citations

Deletion of high-avidity T cells by thymic epithelium.

1995 • 67 citations

Entry into the Thymic Microenvironment Triggers Notch Activation in the Earliest Migrant T Cell Progenitors

2003 • 65 citations

Foregut endoderm is required at head process stages for anteriormost neural patterning in chick

2001 • 65 citations

Differential Effects of Peptide Diversity and Stromal Cell Type in Positive and Negative Selection in the Thymus

1998 • 64 citations

In vitro induction systems for analyses of amphibian organogenesis and body patterning.

2001 • 62 citations

Transgenic Expression of Cyclin D1 in Thymic Epithelial Precursors Promotes Epithelial and T Cell Development

2000 • 62 citations

Using thymus anatomy to dissect T cell repertoire selection

1999 • 62 citations

Premature TCRαβ Expression and Signaling in Early Thymocytes Impair Thymocyte Expansion and Partially Block Their Development

2001 • 62 citations

Dissociation of thymic positive and negative selection in transgenic mice expressing major histocompatibility complex class I molecules exclusively on thymic cortical epithelial cells

2001 • 60 citations

Cell migration and the anatomic control of thymocyte precursor differentiation

2000 • 59 citations

The effects of repeated doses of keratinocyte growth factor on cell proliferation in the cellular hierarchy of the crypts of the murine small intestine.

2001 • 58 citations

Impaired development of the thyroid and thymus in endothelin-1 knockout mice.

1995 • 56 citations

The majority of postselection CD4+ single-positive thymocytes requires the thymus to produce long-lived, functional T cells.

1995 • 55 citations

Total lymphoid irradiation leads to transient depletion of the mouse thymic medulla and persistent abnormalities among medullary stromal cells.

1988 • 54 citations

Ontogeny of a novel CD4⁺CD8⁻CD3⁻thymocyte subpopulation: a comparison with CD4⁻ CD8⁺ CD3⁻thymocytes

1990 • 54 citations

Developmental changes in the differentiation capacity of haematopoietic stem cells

1998 • 53 citations

The role of the activin-follistatin system in the developmental and regeneration processes of the kidney

2001 • 53 citations

Articular cartilage repair: the role of bone morphogenetic proteins

2002 • 49 citations

A Common Stem Cell for Murine Cortical and Medullary Thymic Epithelial Cells?

1994 • 49 citations

Intermediate steps in thymic positive selection. Generation of CD4-8+ T cells in culture from CD4+8+, CD4int8+, and CD4+8int thymocytes with up-regulated levels of TCR-CD3.

1995 • 48 citations

Impaired Development of the Thyroid and Thymus in Endothelin-1 Knockout Mice

1995 • 48 citations

The human thymic microenvironment: new approaches to functional analysis

1999 • 48 citations

Distinct Mechanisms Contribute to Generate and Change the CD4:CD8 Cell Ratio During Thymus Development: A Role for the Notch Ligand, Jagged1

2001 • 46 citations

Fibroblast growth factor receptor–dependent morphogenesis of theDrosophilamesoderm

2000 • 45 citations

The nature of the peptide/MHC ligand involved in positive selection

1996 • 44 citations

Aromatase inhibitors regenerate the thymus in aging male rats

1992 • 44 citations

CD28-B7 interactions function to co-stimulate clonal deletion of double-positive thymocytes

1996 • 43 citations

Defects of the body plan of mutant embryos lacking Lim1, Otx2 or Hnf3beta activity.

2001 • 43 citations

Opening a Window on Thymic Positive Selection: Developmental Changes in the Influence of Cosignaling by Integrins and CD28 on Selection Events Induced by TCR Engagement

2000 • 43 citations

Precursor Thymocyte Proliferation and Differentiation Are Controlled by Signals Unrelated to the Pre-TCR

2000 • 43 citations

Differentiation of thymocytes from CD3-CD4-CD8- through CD3-CD4-CD8+ into more mature stages induced by a thymic stromal cell clone.

1990 • 43 citations

A Low Affinity TCR Ligand Restores Positive Selection of CD8+ T Cells In Vivo

2001 • 42 citations

Control of early thymocyte development by the pre-T cell receptor complex: A receptor without a ligand?

1999 • 41 citations

Effect of Highly Active Antiretroviral Therapy and Thymic Transplantation on Immunoreconstitution in HIV Infection

2000 • 41 citations

Identification of a Late Stage of Small Noncycling pTα− Pre-T Cells as Immediate Precursors of T Cell Receptor α/β+ Thymocytes

1998 • 40 citations

Competition for Specific Intrathymic Ligands Limits Positive Selection in a TCR Transgenic Model of CD4+ T Cell Development

2000 • 39 citations

Class I MHC molecules on hematopoietic cells can support intrathymic positive selection of T cell receptor transgenic T cells

1999 • 38 citations

Limited development capacity of the earliest embryonic murine thymus

1995 • 35 citations

The agonist-antagonist balance in positive selection

1997 • 35 citations

Costimulatory signals are required for induction of transcription factor Nur77 during negative selection of CD4⁺CD8⁺thymocytes

1999 • 35 citations

The Suppression of Peritoneal Cellular Immunity in Women With Endometriosis Could Be Restored After Gonadotropin Releasing Hormone Agonist Treatment

1996 • 35 citations

Fate mapping study of the endoderm of the 1.5-day-old chick embryo

1996 • 34 citations

Animal models and possible human application of immunological restoration in the elderly

2002 • 33 citations

Hypothalamic control of thymic function.

2001 • 31 citations

The ontogeny of B cells in the thymus of normal, CD3ε knockout (KO), RAG-2 KO and IL-7 transgenic mice

2002 • 28 citations

Regulation of pepsinogen gene expression in epithelial cells of vertebrate stomach during development.

1994 • 27 citations

The antigen presentation pathway in medullary thymic epithelial cells, but not that in cortical thymic epithelial cells, conforms to the endocytic pathway

1998 • 26 citations

Thymic stromal cells and positive selection

2001 • 26 citations

Regulation and kinetics of premigrant thymocyte expansion

2000 • 23 citations

Affinity of thymic self-peptides for the TCR determines the selection of CD8+ T lymphocytes in the thymus

2000 • 21 citations

Thymic stromal cells and positive selection. Review article

2001 • 19 citations

A Comparative Analysis of the Murine Thymic Microenvironment in Normal, Autoimmune, and Immunodeficiency States

1996 • 17 citations

TCR alpha-chain repertoire in pTalpha-deficient mice is diverse and developmentally regulated: implications for pre-TCR functions and TCRA gene rearrangement.

1999 • 15 citations

Specialisation of thymic epithelial cells for positive selection of CD4+8+ thymocytes.

2001 • 14 citations

TCR α-Chain Repertoire in pTα-Deficient Mice Is Diverse and Developmentally Regulated: Implications for Pre-TCR Functions and TCRA Gene Rearrangement

1999 • 14 citations

Piecing together the thymic puzzle

1997 • 13 citations

Epithelial cell differentiation during stomach development.

2000 • 11 citations

Intrathymic activation events and the generation of IL-4 producer CD4+8- thymocytes.

1992 • 10 citations

Differential expression of MHC class II antigens and cathepsin L by subtypes of cortical epithelial cells in the rat thymus: an immunoelectron microscopic study

2002 • 8 citations

Analysis of Heterologous Gene Expression in Xenopus Blastomeres

2003 • 1 citations